enzyme-linked immunosorbent assay (ELISA) of this antigen became avail-
... PSA and another two genes, hKLK1 and hKLK2 (McCormack et al. 1995). The gene for PSA is also known as human kallikrein 3 (hKLK3). All three genes are clustered within a 60-kb genomic region on chromosome 19q13.3–q13.4. The coding and promoter–enhancer regions of the PSA gene have been well character ...
... PSA and another two genes, hKLK1 and hKLK2 (McCormack et al. 1995). The gene for PSA is also known as human kallikrein 3 (hKLK3). All three genes are clustered within a 60-kb genomic region on chromosome 19q13.3–q13.4. The coding and promoter–enhancer regions of the PSA gene have been well character ...
Role of Endoplasmic Reticulum Aminopeptidases in Health and
... other cytokine receptors, the type I IL-6 cytokine receptor (IL-6Rα) [12] and the type II IL-1 decoy receptor (IL-1RII) [11]. Based on these functions, ERAP1 has been proposed to play an important role in regulating innate and inflammatory immune responses by increasing the shedding of these cytokin ...
... other cytokine receptors, the type I IL-6 cytokine receptor (IL-6Rα) [12] and the type II IL-1 decoy receptor (IL-1RII) [11]. Based on these functions, ERAP1 has been proposed to play an important role in regulating innate and inflammatory immune responses by increasing the shedding of these cytokin ...
Atypical serological profiles in hepatitis B virus infection Robério A
... response to HBc in infants born to HBe-positive carrier mothers [14]. It has been postulated that HBeAg may have an immunoregulatory function in promoting viral persistence [15]. The HBcAg and HBeAg are distinctly recognized by antibodies but, due to their extensive amino acid homology, are highly c ...
... response to HBc in infants born to HBe-positive carrier mothers [14]. It has been postulated that HBeAg may have an immunoregulatory function in promoting viral persistence [15]. The HBcAg and HBeAg are distinctly recognized by antibodies but, due to their extensive amino acid homology, are highly c ...
Epitope Masking in a Murine Model Independently from Red Cell
... immunization to D+ RBCs has come from seminal studies dating back to the 1960s on human male D2 volunteers immunized with D+ RBCs. In many of these studies and others that have followed, it was noticed that the dose of anti-D that caused clearance of the D+ RBCs from the circulation was related to i ...
... immunization to D+ RBCs has come from seminal studies dating back to the 1960s on human male D2 volunteers immunized with D+ RBCs. In many of these studies and others that have followed, it was noticed that the dose of anti-D that caused clearance of the D+ RBCs from the circulation was related to i ...
HIV-1 Envelope gp41 Is a Potent Inhibitor of Chemoattractant
... At the highest concentration (100 nM) tested, the gp41 preparations had , 0.2 ng/ml of endotoxin activity. The gp41 MN used in the study was more than 98% pure as confirmed by SDS-PAGE and silver staining (H. Ueda, data not shown). Monoclonal anti CD4 antibodies were purchased from Biogenesis (Poole ...
... At the highest concentration (100 nM) tested, the gp41 preparations had , 0.2 ng/ml of endotoxin activity. The gp41 MN used in the study was more than 98% pure as confirmed by SDS-PAGE and silver staining (H. Ueda, data not shown). Monoclonal anti CD4 antibodies were purchased from Biogenesis (Poole ...
Analysis of the Original Antigenic Sin Antibody Response to the
... trachomatis MOMP is diverse at the genetic level [19]. Among eight different hybridomas recognizing the same nominal epitope, four different antibody variable gene assemblages were identified. Fine-specificity analysis using systematic amino acid substitutions within the peptide epitope recognized b ...
... trachomatis MOMP is diverse at the genetic level [19]. Among eight different hybridomas recognizing the same nominal epitope, four different antibody variable gene assemblages were identified. Fine-specificity analysis using systematic amino acid substitutions within the peptide epitope recognized b ...
Immunity to Intracellular Salmonella Depends on Surface
... and changing Salmonella serovar spectrum. Novel vaccines with broad serovar coverage are needed, but suitable protective antigens remain largely unknown. Here, we tested 37 broadly conserved Salmonella antigens in a mouse typhoid fever model, and identified antigen candidates that conferred partial ...
... and changing Salmonella serovar spectrum. Novel vaccines with broad serovar coverage are needed, but suitable protective antigens remain largely unknown. Here, we tested 37 broadly conserved Salmonella antigens in a mouse typhoid fever model, and identified antigen candidates that conferred partial ...
Climate, environment and transmission of malaria
... is the most geographically widespread. Compared with the more virulent P. falciparum, P. vivax tolerates a wide range of temperature environmental (minimum: 16°C vs. 21°C for P. falciparum), which may explain its broader distribution. Alternatively, this distribution may reflect a longer historical ...
... is the most geographically widespread. Compared with the more virulent P. falciparum, P. vivax tolerates a wide range of temperature environmental (minimum: 16°C vs. 21°C for P. falciparum), which may explain its broader distribution. Alternatively, this distribution may reflect a longer historical ...
Adverse Transfusion Reactions
... © Copyright College of Licensed Practical Nurses of Alberta-2013 All rights reserved. This module is intended for Licensed Practical Nurses continuing learning purposes. This document may be produced, reproduced and published in its entirety only, in any form, including in electronic form, for educa ...
... © Copyright College of Licensed Practical Nurses of Alberta-2013 All rights reserved. This module is intended for Licensed Practical Nurses continuing learning purposes. This document may be produced, reproduced and published in its entirety only, in any form, including in electronic form, for educa ...
Malaria - National Institute for Communicable Diseases
... drug resistance, vector insecticide resistance, a large HIV epidemic, and many health provision challenges that stand in the way of this objective. ...
... drug resistance, vector insecticide resistance, a large HIV epidemic, and many health provision challenges that stand in the way of this objective. ...
Neutrophils in tuberculosis
... experiments with RB6-8C5 monoclonal antibodies to deplete granulocyte receptor positive cells, in addition to the target (Ly6G antigen) on neutrophils, it also target Ly6C on plasmocytoid dendritic cells, mono118 ...
... experiments with RB6-8C5 monoclonal antibodies to deplete granulocyte receptor positive cells, in addition to the target (Ly6G antigen) on neutrophils, it also target Ly6C on plasmocytoid dendritic cells, mono118 ...
Immune System
... identical clones). Plasma cells will make and secrete antibodies to fight the current virus, while many, many memory B-cells will sit in lymph nodes and the spleen for the rest of your life possibly, with the same antibody on their surface awaiting the return of the virus/antigen. Initially there wa ...
... identical clones). Plasma cells will make and secrete antibodies to fight the current virus, while many, many memory B-cells will sit in lymph nodes and the spleen for the rest of your life possibly, with the same antibody on their surface awaiting the return of the virus/antigen. Initially there wa ...
Definition of the disease
... Description of the disease: In humans, the disease exhibits a large polymorphism. Q fever occurs either as an acute form or a severe chronic form following an early infection that may go unnoticed. The acute form resolves quite quickly after appropriate antibiotic therapy, but the chronic form requi ...
... Description of the disease: In humans, the disease exhibits a large polymorphism. Q fever occurs either as an acute form or a severe chronic form following an early infection that may go unnoticed. The acute form resolves quite quickly after appropriate antibiotic therapy, but the chronic form requi ...
(ProHeart 6) and Ivermectin (Heartgard Plus)
... 11,699,672 office visits for dogs seen at 517 Banfield hospitals operating during the period from January 1, 2002 to December 31, 2005 were transferred to Purdue University as pipe-delimited ASCII files and were converted into SAS format (SAS Inc, Cary, NC) for analysis. Medical records included in ...
... 11,699,672 office visits for dogs seen at 517 Banfield hospitals operating during the period from January 1, 2002 to December 31, 2005 were transferred to Purdue University as pipe-delimited ASCII files and were converted into SAS format (SAS Inc, Cary, NC) for analysis. Medical records included in ...
Accurate pan-specific prediction of peptide-MHC class II
... binding of peptidic antigens by major histocompatibility complex class II (MHC class II) molecules. The bound peptide is then presented on the cell surface where it can be recognized by T helper lymphocytes. NetMHCIIpan is a state-of-the-art method for the quantitative prediction of peptide binding ...
... binding of peptidic antigens by major histocompatibility complex class II (MHC class II) molecules. The bound peptide is then presented on the cell surface where it can be recognized by T helper lymphocytes. NetMHCIIpan is a state-of-the-art method for the quantitative prediction of peptide binding ...
Vaccination with recombinant fusion proteins incorporating Toll
... result in the activation and maturation of APC’s including the regulated processing and presentation of antigens, upregulation of major histocompatibity complex (MHC) and costimulatory molecules, and secretion of proinflammatory chemokines and cytokines. These APCs then mediate the activation of ant ...
... result in the activation and maturation of APC’s including the regulated processing and presentation of antigens, upregulation of major histocompatibity complex (MHC) and costimulatory molecules, and secretion of proinflammatory chemokines and cytokines. These APCs then mediate the activation of ant ...
Monoclonal Antibodies for Therapeutic Use: Specific Characteristics
... The use of animal models during the development of MoAb is difficult due to the between-species differences of the “partners” of the MoAb, i.e. target antigen and immune effectors (including FcγR receptors).[19] MoAb do not usually recognise target antigens in the mouse. These models therefore requi ...
... The use of animal models during the development of MoAb is difficult due to the between-species differences of the “partners” of the MoAb, i.e. target antigen and immune effectors (including FcγR receptors).[19] MoAb do not usually recognise target antigens in the mouse. These models therefore requi ...
An Approach to the Patient Refractory to Platelets Transfusion
... HLA-antigen negative "compatible" platelets This is a similar approach to the technique used to provide compatible RBCs for patients who have RBC antibodies. The laboratory finds units lacking only those antigens to which the patient has antibodies This approach was described in 29 HLA-alloimmunized ...
... HLA-antigen negative "compatible" platelets This is a similar approach to the technique used to provide compatible RBCs for patients who have RBC antibodies. The laboratory finds units lacking only those antigens to which the patient has antibodies This approach was described in 29 HLA-alloimmunized ...
Autoimmune Responses to the Brain After Stroke Are Associated
... exists. In fact, studies have shown increased titers of circulating antibodies to neurofilaments and a portion of the N-methyl-D-aspartic acid receptor in individuals with a history of stroke.6,7 Cellular immune responses to myelinassociated antigens and other brain antigens are also seen in stroke ...
... exists. In fact, studies have shown increased titers of circulating antibodies to neurofilaments and a portion of the N-methyl-D-aspartic acid receptor in individuals with a history of stroke.6,7 Cellular immune responses to myelinassociated antigens and other brain antigens are also seen in stroke ...
The age-dependent expression of the F18 E. coli receptor
... found to express H-2 HBGAs on the intestinal epithelial cells, 25 pigs were A-2 positive and 19 pigs were blood group AO negative (Table 1). No pigs were observed to be positive for both the H-2 and A-2 HBGAs, indicating that in A-2 positive animals, the precursor H-2 antigen is masked for detection ...
... found to express H-2 HBGAs on the intestinal epithelial cells, 25 pigs were A-2 positive and 19 pigs were blood group AO negative (Table 1). No pigs were observed to be positive for both the H-2 and A-2 HBGAs, indicating that in A-2 positive animals, the precursor H-2 antigen is masked for detection ...
Studying HLA antigens in immune incompatible
... to the fetus but in some cases fetal antigens in mother’s body may cause immune conflict, which mostly appears as anti-Rhesus sensibilisation and is developed in antigen noncompatibility of ABO, Kell and Kidd blood groups, which can cause hemolytic anemia in newborns. On the other hand mother’s body ...
... to the fetus but in some cases fetal antigens in mother’s body may cause immune conflict, which mostly appears as anti-Rhesus sensibilisation and is developed in antigen noncompatibility of ABO, Kell and Kidd blood groups, which can cause hemolytic anemia in newborns. On the other hand mother’s body ...
Licentiate thesis from the Department of Immunology,
... pathogen associated molecular patterns (PAMPs) on pathogens. The germ line encoded Toll-like receptors (TLRs) allow the direct recognition of distinct microbial structures that are shared by microorganisms, such as lipopolysaccharide (LPS), lipoteichoic acid (LTA), flagellin and bacterial DNA. Toll- ...
... pathogen associated molecular patterns (PAMPs) on pathogens. The germ line encoded Toll-like receptors (TLRs) allow the direct recognition of distinct microbial structures that are shared by microorganisms, such as lipopolysaccharide (LPS), lipoteichoic acid (LTA), flagellin and bacterial DNA. Toll- ...
Really Essential Medical Immunology Arthur Rabson
... genes Figure 1.3 Activation of a phagocytic cell by a Gram-negative lipopolysaccharide (LPS) (endotoxin) danger signal. Circulating LPS is complexed by LPS-binding protein (LBP) and captured by the CD14 surface scavenging receptor. This signals internalization of the complex and activates the Toll-l ...
... genes Figure 1.3 Activation of a phagocytic cell by a Gram-negative lipopolysaccharide (LPS) (endotoxin) danger signal. Circulating LPS is complexed by LPS-binding protein (LBP) and captured by the CD14 surface scavenging receptor. This signals internalization of the complex and activates the Toll-l ...
fulltext
... antibody responses. C1q is primarily activated by antibody-antigen complexes. Antigen-specific IgM in complex with an antigen is able to enhance the antibody response against that antigen. This is dependent on the ability of IgM to activate complement. Naïve mice have very low amounts of specific an ...
... antibody responses. C1q is primarily activated by antibody-antigen complexes. Antigen-specific IgM in complex with an antigen is able to enhance the antibody response against that antigen. This is dependent on the ability of IgM to activate complement. Naïve mice have very low amounts of specific an ...