Eicosanoids
... Eicosanoids, like hormones, display profound effects at extremely low concentrations ...
... Eicosanoids, like hormones, display profound effects at extremely low concentrations ...
myelin sheath
... and because they had come from the prostate gland, he named them prostaglandins -are like hormones in that they act as chemical messengers, but do not move to other sites, but work right within the cells where they are synthesized -are unsaturated carboxylic acids, consisting of of a 20 carbon skele ...
... and because they had come from the prostate gland, he named them prostaglandins -are like hormones in that they act as chemical messengers, but do not move to other sites, but work right within the cells where they are synthesized -are unsaturated carboxylic acids, consisting of of a 20 carbon skele ...
Engineering of human 3D vascularized tissues including disease
... To ensure consumer safety, products must be tested for their safety, and efficacy. Although animal models and two dimensional in vitro models have been widely used, the relevance of these models is limited due to species specific differences and the lack of cell matrix interactions. As an ethical al ...
... To ensure consumer safety, products must be tested for their safety, and efficacy. Although animal models and two dimensional in vitro models have been widely used, the relevance of these models is limited due to species specific differences and the lack of cell matrix interactions. As an ethical al ...
Hebbel Research Day abstract
... CYP3A4 promotes clonogenicity of ER+ breast cancer cells through epoxyeicosatrienoic acid (EET) biosynthesis, but CYP3A4 effects on breast tumor growth are unknown. Silencing of CYP3A4 in breast cancer cells suppressed EETs, promoting tumor dormancy. In breast cancer cells, soluble epoxide hydrolase ...
... CYP3A4 promotes clonogenicity of ER+ breast cancer cells through epoxyeicosatrienoic acid (EET) biosynthesis, but CYP3A4 effects on breast tumor growth are unknown. Silencing of CYP3A4 in breast cancer cells suppressed EETs, promoting tumor dormancy. In breast cancer cells, soluble epoxide hydrolase ...
Poster
... Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by epoxygenases of the cytochrome P450 superfamily. In humans, EETs promote vasodilation and angiogenesis, and act to inhibit systemic antiinflammatory response (1). The enzyme soluble epoxide hydrolase (sEH) breaks down EETs into ...
... Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by epoxygenases of the cytochrome P450 superfamily. In humans, EETs promote vasodilation and angiogenesis, and act to inhibit systemic antiinflammatory response (1). The enzyme soluble epoxide hydrolase (sEH) breaks down EETs into ...
Epoxyeicosatrienoic acid
The epoxyeicosatrienoic acids or EETs are signaling molecules formed by the action of Cytochrome P450 epoxygenase on 20-carbon essential fatty acids, such as arachidonic acid, from which it is produced by the enzyme epoxygenase. These nonclassic eicosanoids act as short-range hormones, (i.e. they are autocrine and paracrine mediators) of the cardiovascular system and kidney. They produce vasorelaxation as well as anti-inflammatory and pro-fibrinolytic effects.EETs are metabolized by the soluble epoxide hydrolase to the corresponding vicinal diol, or dihydroxyeicosatrienoic acids (DHETs), which are biologically less active.