Molecular architecture of the glomerular slit
... protein. In autosomal dominant familial focal segmental glomerulosclerosis, a-actinin-4 is typically mutated [38], suggesting that a-actinin-4 is a robust linker molecule, mediating and modulating interactions of the slit diaphragm domain molecules with the actin cytoskeleton of podocytes. Densin is ...
... protein. In autosomal dominant familial focal segmental glomerulosclerosis, a-actinin-4 is typically mutated [38], suggesting that a-actinin-4 is a robust linker molecule, mediating and modulating interactions of the slit diaphragm domain molecules with the actin cytoskeleton of podocytes. Densin is ...
Hemoglobin
... HEMOGLOBIN As deoxygenated hemoglobin becomes oxygenated, significant structural changes take place the proximal hisitidine and its helix shift one heterodimer rotates and slides relative to the other existing noncovalent bonds are broken and replaced by new ...
... HEMOGLOBIN As deoxygenated hemoglobin becomes oxygenated, significant structural changes take place the proximal hisitidine and its helix shift one heterodimer rotates and slides relative to the other existing noncovalent bonds are broken and replaced by new ...
Personal details Current position Name: Lilah Glazer, PhD E-mail:
... documented worldwide and are a cause for concern for both human health and wildlife conservation. Over the past several years there has been increased recognition that the earlylife environment can strongly influence the trajectory of developmental pathways, and that perturbations at critical stages ...
... documented worldwide and are a cause for concern for both human health and wildlife conservation. Over the past several years there has been increased recognition that the earlylife environment can strongly influence the trajectory of developmental pathways, and that perturbations at critical stages ...
iirachhemoglobin
... Molluscans have also hemoglobin. Special kind are water gasteropoda. The other molluscan have as blood pigment HEMOCYANIN. Well treated diabetic has the value of glycate hemoglobin up to 7%. Velues up to 4,5% represent an excellent compensation, up to 6% comfortable compensation. Bad compensation ex ...
... Molluscans have also hemoglobin. Special kind are water gasteropoda. The other molluscan have as blood pigment HEMOCYANIN. Well treated diabetic has the value of glycate hemoglobin up to 7%. Velues up to 4,5% represent an excellent compensation, up to 6% comfortable compensation. Bad compensation ex ...
Cholecystokinin and Trypsin Responses of Larval Red Drum
... our lab has begun to investigate the role of the digestive hormone cholecystokinin (CCK). While there are a number of other labs also investigating CCK and other digestive hormones such as bombesin, PPY, and gastrin; research into the roles of these hormones in fish is still in its infancy. Previous ...
... our lab has begun to investigate the role of the digestive hormone cholecystokinin (CCK). While there are a number of other labs also investigating CCK and other digestive hormones such as bombesin, PPY, and gastrin; research into the roles of these hormones in fish is still in its infancy. Previous ...
The Pepsin Story - Penn Arts and Sciences
... In figure (a) above, we see the carboxyl ends of the aspartic acid residues at 215 and 32. Even though they have the same formula, they have different pKa values. This is due to the different residues surrounding each aspartic acid. In figure a, the Asp32 is deprotenated while Asp215 still retains i ...
... In figure (a) above, we see the carboxyl ends of the aspartic acid residues at 215 and 32. Even though they have the same formula, they have different pKa values. This is due to the different residues surrounding each aspartic acid. In figure a, the Asp32 is deprotenated while Asp215 still retains i ...
Tissue Regeneration Factor
... is actually the bone morphogenetic proteins that are osteoinductive, as they stimulate mesenchymal stem cells and differentiate them into osteoblasts (produce bone tissue) and chondrocytes (produce cartilage). Oral supplementation of TRF has been shown to have a direct effect on bone metabolism, aff ...
... is actually the bone morphogenetic proteins that are osteoinductive, as they stimulate mesenchymal stem cells and differentiate them into osteoblasts (produce bone tissue) and chondrocytes (produce cartilage). Oral supplementation of TRF has been shown to have a direct effect on bone metabolism, aff ...
Gene Section LCK (lymphocyte-specific protein tyrosine kinase) Atlas of Genetics and Cytogenetics
... Lck associates with the inner face of the plasma membrane through its amino-terminus. This interaction is mediated by both myristic acid and palmitic acid that are bound to the amino terminal glycine and Cys-3 and/or Cys-5. The Unique region of Lck represents the domain possessing the greatest seque ...
... Lck associates with the inner face of the plasma membrane through its amino-terminus. This interaction is mediated by both myristic acid and palmitic acid that are bound to the amino terminal glycine and Cys-3 and/or Cys-5. The Unique region of Lck represents the domain possessing the greatest seque ...
Basic Local Alignment Search Tool
... The p-value relates the score returned for an alignment to the likelihood of it having arisen by chance In general, the closer the value approaches zero the greater the condence that the match is real = 4e-45 (4 x 10−45 ), 4e-16 (4 x 10−16 ), or 1e-05 (1 x 10−05 ) 1e-05 (1 x 10−5 ) indicates that t ...
... The p-value relates the score returned for an alignment to the likelihood of it having arisen by chance In general, the closer the value approaches zero the greater the condence that the match is real = 4e-45 (4 x 10−45 ), 4e-16 (4 x 10−16 ), or 1e-05 (1 x 10−05 ) 1e-05 (1 x 10−5 ) indicates that t ...
Characterization of Phosphorylation Sites from the Activation Loop
... a. Phosphorylation of the “TEY” phosphosites is insufficient for activation of ERK1. Substitution of T207 to alanine significantly increased the autophosphorylation of the “TEY” phosphosites, but not the ability of ERK1 to phosphorylate MBP; b. Phosphorylation of T207, but not T198, plays an impor ...
... a. Phosphorylation of the “TEY” phosphosites is insufficient for activation of ERK1. Substitution of T207 to alanine significantly increased the autophosphorylation of the “TEY” phosphosites, but not the ability of ERK1 to phosphorylate MBP; b. Phosphorylation of T207, but not T198, plays an impor ...
Chapter 1: Biological Introduction: RING domain proteins
... enzyme forms a thiol ester with the carboxyl terminal group of the small protein ubiquitin at position Gly76. The ubiquitin is then transferred to the ubiquitin conjugating enzyme (E2). Finally, ubiquitin ligase (E3) transfers the ubiquitin from E2 to the target protein promoting the ubiquitination ...
... enzyme forms a thiol ester with the carboxyl terminal group of the small protein ubiquitin at position Gly76. The ubiquitin is then transferred to the ubiquitin conjugating enzyme (E2). Finally, ubiquitin ligase (E3) transfers the ubiquitin from E2 to the target protein promoting the ubiquitination ...
Overview of Urea and Creatinine
... rate (GFR.) Creatinine is produced endogenously within the body and is freely filtered by the glomerulus. These characteristics make creatinine a useful endogenous marker for creatinine clearance. If the GFR is decreased, as is in renal disease, creatinine clearance via the renal system is compromis ...
... rate (GFR.) Creatinine is produced endogenously within the body and is freely filtered by the glomerulus. These characteristics make creatinine a useful endogenous marker for creatinine clearance. If the GFR is decreased, as is in renal disease, creatinine clearance via the renal system is compromis ...
Reivew, Hemoglobin
... Blood transports two forms of CO2 to the lungs: carbamino-hemoglobin and H2CO3/HCO3- (carbonic acidconjugate base pair) 1. Carbamino-hemoglobin: exposure to low pCO2 results in the reversal of the carbamination reaction by mass action and O2 binding is again favored. CO2 is expelled by the lungs. ...
... Blood transports two forms of CO2 to the lungs: carbamino-hemoglobin and H2CO3/HCO3- (carbonic acidconjugate base pair) 1. Carbamino-hemoglobin: exposure to low pCO2 results in the reversal of the carbamination reaction by mass action and O2 binding is again favored. CO2 is expelled by the lungs. ...
Amino acids
... • Each amino acid does not bind or give off protons or participate in hydrogen or ionic bonds. • These amino acids promote hydrophobic interactions. • In proteins found in aqueous solution, the side chains of the nonpolar amino acids tend to cluster together in the interior of the protein. • The non ...
... • Each amino acid does not bind or give off protons or participate in hydrogen or ionic bonds. • These amino acids promote hydrophobic interactions. • In proteins found in aqueous solution, the side chains of the nonpolar amino acids tend to cluster together in the interior of the protein. • The non ...
Amino acids
... • Amino acids play central roles: as building blocks of proteins and as intermediates in metabolism. ...
... • Amino acids play central roles: as building blocks of proteins and as intermediates in metabolism. ...
Linkage Novel Type of Antigen with an Isopeptide Peptide Splicing
... that can be scanned by the T cell repertoire. Development of sensitive methods that can be used to detect such isopeptide linked Ags will be of value to further probe their potential role. ...
... that can be scanned by the T cell repertoire. Development of sensitive methods that can be used to detect such isopeptide linked Ags will be of value to further probe their potential role. ...
AlgaVia® Whole Algae Ingredients
... This vegan protein option contains all essential amino acids and has a high digestibility of 88%. Natural encapsulation allows increased protein fortification, whilst remaining stable in a low pH environment and no impact on viscosity. This makes it suitable for a wide range of applications includin ...
... This vegan protein option contains all essential amino acids and has a high digestibility of 88%. Natural encapsulation allows increased protein fortification, whilst remaining stable in a low pH environment and no impact on viscosity. This makes it suitable for a wide range of applications includin ...
2. Yi-Kuo Yu, John C. Wootton, and Stephen F. Altschul The compositional adjustment of amino acid substitution matrices PNAS 2003 100: 15688-15693.
... methods have been developed to derive these target frequencies from large collections of alignments of homologous proteins. There is a degree of circularity in this, because these alignments themselves are generally constructed with the aid of a substitution matrix. The two most widely used series o ...
... methods have been developed to derive these target frequencies from large collections of alignments of homologous proteins. There is a degree of circularity in this, because these alignments themselves are generally constructed with the aid of a substitution matrix. The two most widely used series o ...
Materials and Methods
... upwards into the teat canal. Milk samples were collected daily, (up to day 7), from which the SCC and viable cell numbers of S. aureus were determined. The number of replications depended on the number of available mastitis-free cows at a specific stage of lactation. Since the microbial challenge wi ...
... upwards into the teat canal. Milk samples were collected daily, (up to day 7), from which the SCC and viable cell numbers of S. aureus were determined. The number of replications depended on the number of available mastitis-free cows at a specific stage of lactation. Since the microbial challenge wi ...
A Positive Selection Function for miRNA
... Difficulty in using BLAST because on requires combinatorial matches of GU base pairing in addition to GC base pairing. BLAST is not suited for this type of search. ...
... Difficulty in using BLAST because on requires combinatorial matches of GU base pairing in addition to GC base pairing. BLAST is not suited for this type of search. ...
EMBL-EBI Powerpoint Presentation
... • Homology can be reliably inferred from statistically significant similarity Homology = common 3D structure Homology - NOT common function ...
... • Homology can be reliably inferred from statistically significant similarity Homology = common 3D structure Homology - NOT common function ...
TSE diagnostics 4
... brain stem. The homogenized brain sample is incubated with an optimized reagent mixture consisting of digestion enzymes and a buffer solution (I). This solution degrades the normal prion protein. Only the TSEspecific prion protein remains in the test sample. 2) Separation of proteins by gel electrop ...
... brain stem. The homogenized brain sample is incubated with an optimized reagent mixture consisting of digestion enzymes and a buffer solution (I). This solution degrades the normal prion protein. Only the TSEspecific prion protein remains in the test sample. 2) Separation of proteins by gel electrop ...
Poster
... Mutations of Mb from Sperm Whales. In the wild type at position 64, there is a distal histidine, but this can be exchanged for different amino acids (as shown in graph). This changes the ratio of myoglobin’s binding affinity for CO to O2. The amino acid mutants are organized from small to large, ill ...
... Mutations of Mb from Sperm Whales. In the wild type at position 64, there is a distal histidine, but this can be exchanged for different amino acids (as shown in graph). This changes the ratio of myoglobin’s binding affinity for CO to O2. The amino acid mutants are organized from small to large, ill ...
Antimicrobial peptides in crustaceans
... AMPs are classically described as small cationic, amphipathic, gene-encoded molecules (<10 kDa, 15-100 amino acids) that differ considerably in amino acid sequence and structural conformation. They are commonly found in the blood or epithelial (mucosal) surfaces that are most exposed to microorganis ...
... AMPs are classically described as small cationic, amphipathic, gene-encoded molecules (<10 kDa, 15-100 amino acids) that differ considerably in amino acid sequence and structural conformation. They are commonly found in the blood or epithelial (mucosal) surfaces that are most exposed to microorganis ...
Lecture 11 AMINO ACIDS AND PROTEINS The word "Protein" was
... Proteins are macromolecular polymers composed of amino acids as the basic unit linked by peptide bonds. Amino acids are the fundamental structural units of all proteins. These biopolymers contain carbon, hydrogen, oxygen, nitrogen and sulphur. The elementary composition of most proteins is v ...
... Proteins are macromolecular polymers composed of amino acids as the basic unit linked by peptide bonds. Amino acids are the fundamental structural units of all proteins. These biopolymers contain carbon, hydrogen, oxygen, nitrogen and sulphur. The elementary composition of most proteins is v ...
Protein mass spectrometry
Protein mass spectrometry refers to the application of mass spectrometry to the study of proteins. Mass spectrometry is an important emerging method for the characterization of proteins. The two primary methods for ionization of whole proteins are electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI). In keeping with the performance and mass range of available mass spectrometers, two approaches are used for characterizing proteins. In the first, intact proteins are ionized by either of the two techniques described above, and then introduced to a mass analyzer. This approach is referred to as ""top-down"" strategy of protein analysis. In the second, proteins are enzymatically digested into smaller peptides using a protease such as trypsin. Subsequently these peptides are introduced into the mass spectrometer and identified by peptide mass fingerprinting or tandem mass spectrometry. Hence, this latter approach (also called ""bottom-up"" proteomics) uses identification at the peptide level to infer the existence of proteins.Whole protein mass analysis is primarily conducted using either time-of-flight (TOF) MS, or Fourier transform ion cyclotron resonance (FT-ICR). These two types of instrument are preferable here because of their wide mass range, and in the case of FT-ICR, its high mass accuracy. Mass analysis of proteolytic peptides is a much more popular method of protein characterization, as cheaper instrument designs can be used for characterization. Additionally, sample preparation is easier once whole proteins have been digested into smaller peptide fragments. The most widely used instrument for peptide mass analysis are the MALDI time-of-flight instruments as they permit the acquisition of peptide mass fingerprints (PMFs) at high pace (1 PMF can be analyzed in approx. 10 sec). Multiple stage quadrupole-time-of-flight and the quadrupole ion trap also find use in this application.