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“hormone-refractory” prostate cancer. a putative new mechanism
“hormone-refractory” prostate cancer. a putative new mechanism

... In this paper we survey the diversity of the molecular mechanisms suspected to be responsible for the androgen-independent growth of prostate cancer. It has been shown that some prostate cancers, which escape endocrine therapy, are composed of androgen-sensitive cells. We focus on the results from o ...
Molecular Features of Hormone-Refractory Prostate Cancer Cells by
Molecular Features of Hormone-Refractory Prostate Cancer Cells by

... reproducible clusters for classification of the 35 tumors, we selected 254 genes (about one percentile of the whole human transcripts) for which valid data were obtained in 80% of the experiments and whose expression ratios varied by SDs of >1.75. We log transformed the fluorescence ratio for each s ...
male hormone profiles
male hormone profiles

Prostate Cancer
Prostate Cancer

... recurrent prostate cancer. It is not yet available in all hospitals in the UK. It involves placing a number of metal probes through the skin and into the affected area of the prostate gland. The probes contain liquid nitrogen, which freezes and destroys the cancer cells. High-intensity focused ultra ...
WHO report: alarming increase in cancer rates
WHO report: alarming increase in cancer rates

... Rectal cancer According to the groundbreaking research, individuals exposed to natural sunlight, which is the most abundant source of natural vitamin D, are nearly 50 percent less likely to develop pancreatic cancer than others who are not exposed. Dr. Rachel Neale, Ph.D., and her colleagues from th ...
CANCER SCREENING LATEST EVIDENCE
CANCER SCREENING LATEST EVIDENCE

...  Two large population-based studies  388,535 women  no statistically significant difference in breast cancer mortality  Results did not suggest a beneficial effect of screening by breast self-examination  There is evidence for harms At present, BSE cannot be recommended routinely. CBE:  no ran ...
2014 Priority-driven Collaborative Cancer
2014 Priority-driven Collaborative Cancer

... Project grants will be awarded in any field of research (including basic laboratory, epidemiology, psychosocial, translational, and clinical) into malignant disease; ...


1 CORRELAÇÕES ENTRE FATORES DE RISCOS PARA O
1 CORRELAÇÕES ENTRE FATORES DE RISCOS PARA O

... that involves several steps and these are reflected in genetic alterations that lead to the gradual transformation of human cells.19 Thus, the initiation and progression of carcinogenesis involving the accumulation of many mutations.20 In Table 3 are presented the epidemiological data relating to th ...
Endocrine therapy for prostate cancer: review of the latest clinical
Endocrine therapy for prostate cancer: review of the latest clinical

... Prostate cancer, the most common nonskin cancer in men, is estimated to cause 27,000 deaths annually in the USA [1] . While the introduction of widespread prostate-specific antigen (PSA) screening has significantly increased cancer detection, approximately 2% of men have metastatic disease at the ti ...
MOC Question Packet - American College of Preventive Medicine
MOC Question Packet - American College of Preventive Medicine

... 22.1 In a sample of 100 subjects we are comparing time to walk one mile before and after drinking a cup of coffee. 22.2 We are comparing customer satisfaction scores (on a scale of 1 to 5) before and after a new billing system is added. 22.3 We would like to compare two treatments for migraine, Drug ...
Website: http://www.grants.gov/web/grants/search
Website: http://www.grants.gov/web/grants/search

... The Biomedical Advanced Research and Development Authority (BARDA), within the Office of the Assistant Secretary for Preparedness and Response (ASPR) in the U.S. Department of Health and Human Services (HHS), supports advanced development and availability of medical countermeasures (MCMs) for chemic ...
Company Profile - World Cancer Day
Company Profile - World Cancer Day

... to 11 million new cases are diagnosed. In today's world, everyone will be touched by cancer as a patient, a family member or a friend. In 2020, if current trends continue, more than 10 million people will die of cancer and the number of new cases will increase to 16 million per year. If these rising ...
Investments in Cancer Prevention, Early Detection, Outreach, and
Investments in Cancer Prevention, Early Detection, Outreach, and

... The National Program of Cancer Registries (NPCR) is the backbone of our nation’s cancer prevention and control initiatives. State-based cancer registries are data systems designed to gather, manage, and analyze data about incidence, stage at diagnosis, and treatment. This information is used to guid ...
Investments in Cancer Prevention, Early Detection, and Awareness
Investments in Cancer Prevention, Early Detection, and Awareness

... Gynecologic Cancer and Education and Awareness $10 million (+$3.5 million) Early detection is a key element to surviving gynecological cancers. The survival rates for the most common gynecologic cancers are 90 percent when diagnosed early, dropping to 50 percent or less for cancers diagnosed in late ...
Erectile function, incontinence, and other quality of life outcomes
Erectile function, incontinence, and other quality of life outcomes

A. Breast cancer
A. Breast cancer

... *corresponding author: [email protected] Abstract—Recent studies indicate that microRNA may play an important role in human cancer, where microRNA targets tumor suppressor genes or oncogenes. To study this hypothesis, breast and prostate cancers are selected as illustrations. Differentially expressed ...
Cancer in Men - Philippine Cancer Society
Cancer in Men - Philippine Cancer Society

... Two standard tests are used for early detection of prostate cancer: Digital rectal exam (DRE) -- in this test, the physician inserts a gloved, lubricated finger into the patient's rectum in order to feel the prostate for bumps or other abnormalities. Many malignant tumors originate in the outer part ...
Click to add ttle - Amazon Web Services
Click to add ttle - Amazon Web Services

MINISTRY OF HEALTH OF UKRAINE VINNITSA NATIONAL
MINISTRY OF HEALTH OF UKRAINE VINNITSA NATIONAL

... may be performed according to the findings on this initial evaluation and an individual's risk of getting the disease on the basis of other factors such as race, ethnicity, and family history of prostate cancer. As mentioned, most urologists currently would advise some form of screening in men with ...
Molecular Markers in Key Steroidogenic Pathways, Circulating
Molecular Markers in Key Steroidogenic Pathways, Circulating

... prognosis in patients with aggressive form of the disease are urgently needed to better personalize treatment approaches. The objective was to identify host genetic variations in candidate steroidogenic genes affecting hormone levels and prostate cancer progression. Experimental Design: The study ex ...
Brief presentation of feasibility study on prostate cancer
Brief presentation of feasibility study on prostate cancer

... Nowadays with the new improved techniques on disease detection, the prostate specific antigen test, prostate cancer is often diagnosed at an early stage: More than 90% of patients with a newly diagnosed prostate cancer have non-metastatic tumours20. Prostate cancer is typically diagnosed in elderly ...
Gene Section KLK11 (Kallikrein-related peptidase 11) Atlas of Genetics and Cytogenetics
Gene Section KLK11 (Kallikrein-related peptidase 11) Atlas of Genetics and Cytogenetics

Do statins prevent or promote cancer?
Do statins prevent or promote cancer?

... randomized to pravastatin in the CARE trial 11. Thereafter, cancer was an exclusion criterion in randomized statin trials. In clinical practice, however, it is not infrequent to find an association between recurrence of breast cancer and concurrent statin therapy 15. Long-term follow-up (10 years af ...
The prognostic value of expression of HIF1α, EGFR and VEGF
The prognostic value of expression of HIF1α, EGFR and VEGF

... ADT administration did not improve the biological outcome of patients with low or high HIF1α expression (Table 5). ...
< 1 ... 65 66 67 68 69 70 71 72 73 ... 133 >

Prostate-specific antigen

Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely. It is also believed to be instrumental in dissolving cervical mucus, allowing the entry of sperm into the uterus.PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer or other prostate disorders. The United States Preventive Services Task Force (USPSTF, 2012) does not recommend PSA screening, noting that the test may result in “overdiagnosis” and “overtreatment” because ""most prostate cancer is asymptomatic for life"" and treatments involve risks of complications including impotence (erectile dysfunction) and incontinence. The USPSTF concludes ""the potential benefit does not outweigh the expected harms."" PSA is not a unique indicator of prostate cancer, but may also detect prostatitis or benign prostatic hyperplasia. 30 percent of patients with high PSA have prostate cancer diagnosed after biopsy.
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