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Cancer - National Cancer Registry Ireland
Cancer - National Cancer Registry Ireland

... Ireland vs. EU-27* in 2012 • The cancer incidence rate in Irish males (excluding NMSC) was 10% higher than the EU average (453/100,000), partly due to increased diagnosis of prostate cancer in Ireland • The mortality rate estimate from cancer in males was slightly lower (9%) than the EU27 average pa ...
cancer prevention today: from healthy lifestyle and early detection to
cancer prevention today: from healthy lifestyle and early detection to

... Another talk of high interest was by Charis Eng (The Cleveland Clinic, OH) who has described her scientific activity as “genetics to keep healthy people healthy”, paying special attention in her report to the analysis of heritable predisposition to cancer and the need of genomics-based personalized ...
Prognosis, Cost, and Occurrence of Colorectal, Lung, Breast
Prognosis, Cost, and Occurrence of Colorectal, Lung, Breast

... in the study from January 1, 2000, to December 31, 2012, in which there were 1. at least two consecutive ICD codes from those listed above, with a minimum of 30-day difference between their establishment, or 2. one of these ICD codes, and the patient died within 60 days. Multiple different cancer co ...
Non-human prostate cancer cell lines
Non-human prostate cancer cell lines

... specific markers such as Ki67, p63, CD44, ETS-2, glutathione S-transferase P and Maspin.[11,14,15] These cells rarely express androgen receptors (AR).[15] In normal prostate, Neuroendocrine (NE) cells express both luminal and basal cytokeratins (CK 5, 14, 8 and 18), and the neuroendocrine marker, ch ...
Double Jeopardy? Age, Race, and HRQOL in Older Adults with
Double Jeopardy? Age, Race, and HRQOL in Older Adults with

... and Asian Americans [11]. Another study, focused on disparities in older cancer survivors and non-cancer-managed care enrollees, found physical and mental function were lower in Hispanic cancer survivors compared with Caucasian and African Americans [8]. Deimling and colleagues found older, African ...
American Society of Clinical Oncology and Cancer C
American Society of Clinical Oncology and Cancer C

... setting of newly diagnosed metastatic androgen-sensitive prostate cancer, primarily in men with a high burden of metastatic disease at presentation (visceral disease and/or > four bone metastatic lesions). The additive benefits or toxicities associated with subsequently retreating such patients with ...
- EBioMedicine
- EBioMedicine

... Fig. 1. Reciprocal gene expression signatures identify a core set of clinically relevant androgen-regulated target genes. (A) RNA-Seq expression analysis of LNCaP cells treated with or without 10 nM R1881 (a synthetic androgen) for 24 h in triplicate, and of 7 PCa patient prostate biopsies before an ...
Nessun titolo diapositiva
Nessun titolo diapositiva

... is site dependent. For some sites (like lung) the expected value of the indicator is lower than 100%, but comparisons among countries are still informative. ...
Lycopene and prostate cancer
Lycopene and prostate cancer

... such that the National Research Council of the Academy of Sciences,63 the National Cancer Institute64 and the World Cancer Research Fund and the American Institute for Cancer Research65 have all recommended increasing dietary intake of citrus fruits, cruciferous vegetables, green and yellow vegetabl ...
030724 Prostate Cancer - New England Journal of Medicine
030724 Prostate Cancer - New England Journal of Medicine

... men in the United States and Western Europe. Autopsy series have revealed small prostatic carcinomas in up to 29 percent of men 30 to 40 years of age and 64 percent of men 60 to 70 years of age.1 Moreover, the risk of prostate cancer is 1 in 6 and the risk of death due to metastatic prostate cancer ...
Mechanisms Behind Growth Of Castration-Resistant Prostate Cancer Bone Metastases
Mechanisms Behind Growth Of Castration-Resistant Prostate Cancer Bone Metastases

Cancer/Tumor Markers - American Association for Clinical Chemistry
Cancer/Tumor Markers - American Association for Clinical Chemistry

... prostate-specific antigen (PSA) is widely used as an aid for screening, diagnosis, and patient management of PCa. However, the low specificity of PSA results in unnecessary invasive biopsy and high negative biopsy rate. Prostate cancer antigen 3 (PCA3) is a non-coding prostate-specific mRNA that is ...
Genetic and Epigenetic Changes in Human Prostate Cancer
Genetic and Epigenetic Changes in Human Prostate Cancer

Targeted Radiotherapy for Prostate Cancer with an Oncolytic
Targeted Radiotherapy for Prostate Cancer with an Oncolytic

... disease is usually fatal. Therefore, there is a need for developing new antitumor approaches for androgen-independent prostate cancer. The main target for prostate cancer metastasis is bone, but dissemination to lung and liver is also common (1). Although prostate cancer metastases are not insensiti ...
A Multiparametric Serum Kallikrein Panel for Diagnosis of Non
A Multiparametric Serum Kallikrein Panel for Diagnosis of Non

... disease at presentation. When lung cancer is diagnosed at a localized stage, the 5-year survival is f50%, whereas this rate drops to f5% when diagnosis is made at the time of lymph node involvement or metastasis (2). To supplement advances in surgical treatment, many studies have focused on the deve ...
Understanding Urinary Problems Following Prostate Cancer
Understanding Urinary Problems Following Prostate Cancer

... LDR. These may be minimal or mild, and usually peak at approximately 6 to 8 weeks, after which side effects then gradually ease and resolve. A small percentage of men still may experience urinary side effects 6 months or longer following implantation. For men who had HDR, urinary side effects usuall ...
Module 5 – Cancer Diagnosis and Staging
Module 5 – Cancer Diagnosis and Staging

... Certain forms of cancer disproportionately affect AI/AN when compared to the whole U.S. population. These cancers include stomach, gallbladder, kidney, cervix, and liver cancers (Kaur, 1999; Cobb, 1996; Baquet, 1996). Although more research needs to be done to determine the cause of the excess incid ...
Major Donors - Cancer Society Wellington
Major Donors - Cancer Society Wellington

... Cancer is the country’s single biggest cause of death. Most New Zealanders will have some experience of it – either personally or through a relative or friend. More people are developing cancer – mainly because the population is growing and getting older. Many cancers can be cured if they’re found a ...
Cancer Inequality Report - National Cancer Registry Ireland
Cancer Inequality Report - National Cancer Registry Ireland

... Summary Figure 2 Age-standardised cancer incidence, Ireland, 2008-2012: comparison between the most and the least deprived 20% of the population. Arrows indicate significant differences. Note different scale for all-cancer graph. Interaction between deprivation and urban/rural status: For lung cance ...
Barriers preventing early detection of prostate cancer in Black
Barriers preventing early detection of prostate cancer in Black

... cancer death in the UK after lung cancer. Age standardised incidence rates in the UK in 2007 were 97.3 per 100,000. (1) In England, the age standardised average death rate from prostate cancer in 2007 was 26.6 per 100,000 people. (2) The Department of Health estimates that hospital costs for treatin ...
latest update on the Cigarette Restitution Fund Program at the Johns Hopkins Kimmel Cancer Center
latest update on the Cigarette Restitution Fund Program at the Johns Hopkins Kimmel Cancer Center

Mitochondrial b-Carotene 9`,10` Oxygenase Modulates Prostate
Mitochondrial b-Carotene 9`,10` Oxygenase Modulates Prostate

... and used for immunization of rabbits. Polyclonal antibodies to BCO2 were characterized by an ELISA using the synthetic peptide as an antigen as described previously and by Western blot analysis (25). Polyclonal and monoclonal antibodies to NF-kB p65, IkBa, and Histone H3 were obtained from Cell Sign ...
Document
Document

National Cancer Institute Fact Sheet 7.34, Cryosurgery in Cancer
National Cancer Institute Fact Sheet 7.34, Cryosurgery in Cancer

... What are the advantages of cryosurgery? Cryosurgery offers advantages over other methods of cancer treatment. It is less invasive than surgery, involving only a small incision or insertion of the cryoprobe through the skin. Consequently, pain, bleeding, and other complications of surgery are minimiz ...
The Role of Radiotherapy in Node
The Role of Radiotherapy in Node

... disease after radical prostatectomy,[29] and compared outcomes of patients who received no adjuvant radiotherapy vs those who received radiotherapy within 12 months of surgery. Patients in the two groups were propensity score–matched by age, comorbidities, Gleason score, pathologic T stage, PSA leve ...
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Prostate-specific antigen

Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely. It is also believed to be instrumental in dissolving cervical mucus, allowing the entry of sperm into the uterus.PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer or other prostate disorders. The United States Preventive Services Task Force (USPSTF, 2012) does not recommend PSA screening, noting that the test may result in “overdiagnosis” and “overtreatment” because ""most prostate cancer is asymptomatic for life"" and treatments involve risks of complications including impotence (erectile dysfunction) and incontinence. The USPSTF concludes ""the potential benefit does not outweigh the expected harms."" PSA is not a unique indicator of prostate cancer, but may also detect prostatitis or benign prostatic hyperplasia. 30 percent of patients with high PSA have prostate cancer diagnosed after biopsy.
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