IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... Rosuvastatin calcium and Atorvastatin were kind gift from MSN Laboratories, Hyderabad, India. 2.1 Experimental Methods The HPLC Waters system Model no. 2695 auto injector, with a PDA detector Model no. 2996 was used for analysis. The data were acquired and processed using EMPOWER 2.0 software. The a ...
... Rosuvastatin calcium and Atorvastatin were kind gift from MSN Laboratories, Hyderabad, India. 2.1 Experimental Methods The HPLC Waters system Model no. 2695 auto injector, with a PDA detector Model no. 2996 was used for analysis. The data were acquired and processed using EMPOWER 2.0 software. The a ...
Myers Samantha Myers Paige French General Medical Conditions 5
... Paige French General Medical Conditions 5 December 2016 Where do We go from Here: Legalization of Marijuana The most commonly used illegal drug in the United States is marijuana.1 Even though some states have legalized marijuana, it is still considered an illicit drug because the federal government ...
... Paige French General Medical Conditions 5 December 2016 Where do We go from Here: Legalization of Marijuana The most commonly used illegal drug in the United States is marijuana.1 Even though some states have legalized marijuana, it is still considered an illicit drug because the federal government ...
Positive and negative ion mode ESI-MS and MS/MS for - ORBi
... complexes in a given A/T rich site. Intercalators bind to DNA by insertion of their planar aromatic chromophore between DNA base pairs [13,14]. Simple intercalators have few substituents, but others like Actinomycin D and doxorubicin are more complex, and substituents can interact with the minor or ...
... complexes in a given A/T rich site. Intercalators bind to DNA by insertion of their planar aromatic chromophore between DNA base pairs [13,14]. Simple intercalators have few substituents, but others like Actinomycin D and doxorubicin are more complex, and substituents can interact with the minor or ...
FIP GUIDELINES FOR DISSOLUTION TESTING OF SOLID ORAL
... a number of sparingly soluble drugs and for some dosage forms, particularly aerophilic multiple unit dosage forms that, tend to float initially. Proposals have been made to increase solubility by addition of an appropriate amount of surfactant. With the flow-through cell (apparatus 4, USP) the speci ...
... a number of sparingly soluble drugs and for some dosage forms, particularly aerophilic multiple unit dosage forms that, tend to float initially. Proposals have been made to increase solubility by addition of an appropriate amount of surfactant. With the flow-through cell (apparatus 4, USP) the speci ...
Pharmacogenetic Testing Prior to Initiation of Warfarin
... due to a number of different genetic factors. Genetic variants may influence drug response by altering (1) drug metabolizing enzymes, (2) drug target(s) or receptor(s), and/or (3) drug transport protein(s) or a combination thereof.1 Pharmacogenetics is the investigation of the genetic basis of drug ...
... due to a number of different genetic factors. Genetic variants may influence drug response by altering (1) drug metabolizing enzymes, (2) drug target(s) or receptor(s), and/or (3) drug transport protein(s) or a combination thereof.1 Pharmacogenetics is the investigation of the genetic basis of drug ...
An Endocrine Society Clinical
... Force has confidence that persons who receive care according to the strong recommendations will derive, on average, more good than harm. Weak recommendations require more careful consideration of the person’s circumstances, values, and preferences to determine the best course of action. Linked to ea ...
... Force has confidence that persons who receive care according to the strong recommendations will derive, on average, more good than harm. Weak recommendations require more careful consideration of the person’s circumstances, values, and preferences to determine the best course of action. Linked to ea ...
Role of sotalol in rhythm control of atrial fibrillation
... Sotalol is an AAD with class II (b-adrenoceptor blocking) and class III (cardiac action potential duration prolongation) properties. This peculiar feature makes this drug an attractive option for the treatment and prevention of AF. Comparative trials have demonstrated that sotalol has a similar effi ...
... Sotalol is an AAD with class II (b-adrenoceptor blocking) and class III (cardiac action potential duration prolongation) properties. This peculiar feature makes this drug an attractive option for the treatment and prevention of AF. Comparative trials have demonstrated that sotalol has a similar effi ...
PAXIL CR™ PRODUCT MONOGRAPH
... PAXIL CR™ is indicated for the symptomatic treatment of premenstrual dysphoric disorder (PMDD). The efficacy of PAXIL CR™ in the treatment of PMDD was established in 3 placebo-controlled trials (see CLINICAL TRIALS). The essential features of PMDD, according to DSM-IV, include markedly depressed moo ...
... PAXIL CR™ is indicated for the symptomatic treatment of premenstrual dysphoric disorder (PMDD). The efficacy of PAXIL CR™ in the treatment of PMDD was established in 3 placebo-controlled trials (see CLINICAL TRIALS). The essential features of PMDD, according to DSM-IV, include markedly depressed moo ...
sued
... application or which claims a method of using such drug and with respect to which a claim of patent infringement could reasonably be asserted if a person not licensed by the owner engaged in the manufacture, use, or sale of the drug.” Id. § 355(b)(1); see also 21 C.F.R. § 314.50(h) (citing § 314.53( ...
... application or which claims a method of using such drug and with respect to which a claim of patent infringement could reasonably be asserted if a person not licensed by the owner engaged in the manufacture, use, or sale of the drug.” Id. § 355(b)(1); see also 21 C.F.R. § 314.50(h) (citing § 314.53( ...
Oculocardiac reflex as a predictive sign of postoperative nausea and
... . However, using more than ...
... . However, using more than ...
PRODUCT MONOGRAPH Frisium® (clobazam) Tablets, 10 MG
... hyperacusis, hypersensitivity to light, noise and physical contact, convulsions, as well as epileptic seizures. ...
... hyperacusis, hypersensitivity to light, noise and physical contact, convulsions, as well as epileptic seizures. ...
The Pharmacological Basis of Cannabis Therapy for Epilepsy
... (Iannotti et al., 2014). For the remaining 30% of epileptic patients, who suffer from intractable seizures that cannot be controlled by antiepileptic medications, treatment is often invasive, requiring surgical resection or neurostimulation. There is a large unmet need for novel therapies that provi ...
... (Iannotti et al., 2014). For the remaining 30% of epileptic patients, who suffer from intractable seizures that cannot be controlled by antiepileptic medications, treatment is often invasive, requiring surgical resection or neurostimulation. There is a large unmet need for novel therapies that provi ...
Cleocin Pediatric
... Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by CLEOCIN PEDIATRIC or other antibacterial drugs in the future. Diarrhea is a com ...
... Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by CLEOCIN PEDIATRIC or other antibacterial drugs in the future. Diarrhea is a com ...
Effects of ramipril on left ventricular mass and function in
... and August 1995 from three Canadian HOPE study centers, selected based on expertise and interest in the study. The study protocol was approved by the ethics board of each participating institution, and all patients provided informed consent. All of the HOPE study participants from these centers who ...
... and August 1995 from three Canadian HOPE study centers, selected based on expertise and interest in the study. The study protocol was approved by the ethics board of each participating institution, and all patients provided informed consent. All of the HOPE study participants from these centers who ...
TITLE: 1000 mg versus 600/650 mg Acetaminophen for Pain or
... Two systematic reviews of reviews,12,13 and one RCT14 were included. One systematic review12 included systematic reviews or meta-analyses comparing ibuprofen and different doses of oral acetaminophen in different pain conditions in adults and children. One systematic review13 included Cochrane revie ...
... Two systematic reviews of reviews,12,13 and one RCT14 were included. One systematic review12 included systematic reviews or meta-analyses comparing ibuprofen and different doses of oral acetaminophen in different pain conditions in adults and children. One systematic review13 included Cochrane revie ...
Pharmacological Management of Neuropathic Pain
... PHN. However, based on a meta-analysis, the therapeutic gain is modest compared to placebo,16 and one recent trial using an enriched-enrollment design failed to show a difference between lidocaine and placebo on the primary outcome measure.17 Lidocaine patches are generally safe, with a low systemic ...
... PHN. However, based on a meta-analysis, the therapeutic gain is modest compared to placebo,16 and one recent trial using an enriched-enrollment design failed to show a difference between lidocaine and placebo on the primary outcome measure.17 Lidocaine patches are generally safe, with a low systemic ...
Ranitidine Relief
... Long-term use: The risk of ulcer recurrence is determined by many factors. In some cases, long periods of treatment may be necessary and/or repeated. Evidence from controlled clinical trials of up to 18 months continuous treatment with ranitidine has not revealed any undue untoward effects. Porphyri ...
... Long-term use: The risk of ulcer recurrence is determined by many factors. In some cases, long periods of treatment may be necessary and/or repeated. Evidence from controlled clinical trials of up to 18 months continuous treatment with ranitidine has not revealed any undue untoward effects. Porphyri ...
Treatment of Tics and Tourette Syndrome | SpringerLink
... etiology for TS is controversial. Finally, it is important to note that most patients with tic disorders have few difficulties secondary to their tics; parents are often more concerned about tics than their affected child. Decisions regarding the treatment of tics need to be individualized, especial ...
... etiology for TS is controversial. Finally, it is important to note that most patients with tic disorders have few difficulties secondary to their tics; parents are often more concerned about tics than their affected child. Decisions regarding the treatment of tics need to be individualized, especial ...
An Exploratory Human Laboratory Experiment Evaluating Vaporized
... expectation of benefit. As a result, the placebo effect may increase thereby reducing the ability of a clinical trial to differentiate between an effective treatment (e.g., an active drug) and a less effective or ineffective treatment (e.g., placebo). The flexible dose design emulates clinical pract ...
... expectation of benefit. As a result, the placebo effect may increase thereby reducing the ability of a clinical trial to differentiate between an effective treatment (e.g., an active drug) and a less effective or ineffective treatment (e.g., placebo). The flexible dose design emulates clinical pract ...
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... In the central nervous system, most psychoactive drugs affect neurotransmitters. Drugs can stimulate, inhibit, or halt the release of neurotransmitters. For example, some neurotransmitters inhibit rather than convey impulses. Certain amino acids that appear to function in an inhibitory manner will r ...
... In the central nervous system, most psychoactive drugs affect neurotransmitters. Drugs can stimulate, inhibit, or halt the release of neurotransmitters. For example, some neurotransmitters inhibit rather than convey impulses. Certain amino acids that appear to function in an inhibitory manner will r ...
“Robo-Tripping”: Dextromethorphan Abuse and its Anesthetic
... dextromethorphan. Respiratory depression, tachycardia, hypertension, seizures, and death may result from severe acute dextromethorphan intoxication (1, 4, 7, 8, 16) whereas chronic abuse of the drug has been associated with frank psychosis (2). These actions are very similar to those described with ...
... dextromethorphan. Respiratory depression, tachycardia, hypertension, seizures, and death may result from severe acute dextromethorphan intoxication (1, 4, 7, 8, 16) whereas chronic abuse of the drug has been associated with frank psychosis (2). These actions are very similar to those described with ...
Adherence to the NASPE guideline for amiodarone monitoring
... careful patient selection and frequent monitoring. The purpose of this study was to quantify adherence to published recommendations for baseline monitoring when initiating inpatient amiodarone therapy at a university teaching hospital and determine whether appropriate serial monitoring of chronic am ...
... careful patient selection and frequent monitoring. The purpose of this study was to quantify adherence to published recommendations for baseline monitoring when initiating inpatient amiodarone therapy at a university teaching hospital and determine whether appropriate serial monitoring of chronic am ...
Publication
... According to estimates of the Joint United Nations Program on HIV/AIDS (UNAIDS), there were about 33 million people living with HIV (PLHIV) and approximately 2 million deaths from HIV-related causes worldwide in 2007 [1]. HIV epidemics vary significantly from region to region, both in scale and scop ...
... According to estimates of the Joint United Nations Program on HIV/AIDS (UNAIDS), there were about 33 million people living with HIV (PLHIV) and approximately 2 million deaths from HIV-related causes worldwide in 2007 [1]. HIV epidemics vary significantly from region to region, both in scale and scop ...
The Importance of Opioid Tolerance
... bad thing because increasing opioid doses are required to maintain analgesia. Although tolerance to the analgesic effects of opioids can present a challenge to providing pain relief, the same capacity of developing tolerance to other opioid effects such as sedation and respiratory depression make th ...
... bad thing because increasing opioid doses are required to maintain analgesia. Although tolerance to the analgesic effects of opioids can present a challenge to providing pain relief, the same capacity of developing tolerance to other opioid effects such as sedation and respiratory depression make th ...
Bad Pharma
Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.