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NEW SPECTROPHOTOMETRIC ESTIMATION OF PRULIFLOXACIN USING 2,4- DINITROPHENYL HYDRAZINE REAGENT Research Article
NEW SPECTROPHOTOMETRIC ESTIMATION OF PRULIFLOXACIN USING 2,4- DINITROPHENYL HYDRAZINE REAGENT Research Article

... Objective: A new, simple, and reproducible spectrophotometric analytical method was developed for the estimation of Prulifloxacin, from its tablet dosage form. Methods: The method is based on the oxidation of (2,4-DNP) 2,4- dinitrophenyl hydrazine and coupling of the oxidized product with drug to gi ...
July 2015 Monitoring International Trends
July 2015 Monitoring International Trends

... from a phase I/II trial of ACE910, a first-in-class factor mimetic. ACE910 is a humanized bispecific monoclonal antibody designed to bind factors IXa and X simultaneously, thus mimicking the factor VIII cofactor function in haemophilia. "ACE910 mimics the function of the protein without being a fac ...
Drugs prescription during pregnancy
Drugs prescription during pregnancy

... and drug effects on the fetus : (1) Physicochemical properties of drug (2) The rate at which drug crosses placenta and the amount of drug reaching fetus (3) Duration of exposure to drug (4) Distribution characteristics in different fetal tissues (5) Stage of placental and fetal development at time o ...
A Randomized Clinical Trial of Single
A Randomized Clinical Trial of Single

... (mITT) analysis including only those receiving study drug, and adjustments to the confidence interval (CI) based on the stratification variables. Clinical status, defined as improvement in lesion size as well as resolution or improvement of clinical signs and symptoms, was performed at day 14 and day 2 ...
The Pharmaceutical Industry Presented to Geoffrey Poitras Bus 417
The Pharmaceutical Industry Presented to Geoffrey Poitras Bus 417

... Angiotensin is a hormone that causes blood vessels to narrow Cozaar is 2nd most prescribed AIIA in US and the top-seller in Europe Hyzaar, Cozaar and a diuretic, removing water from the blood and lessens blood ...
Herbal Remedies and Drug Interactions
Herbal Remedies and Drug Interactions

... two hours after taking other meds.  Concurrent use with laxatives and stool softeners should be avoided because of possible potentiation of the laxative effect. ...
Epilepsy and Anti-epileptic Therapy Veterinarians generally
Epilepsy and Anti-epileptic Therapy Veterinarians generally

... Veterinarians generally diagnose idiopathic epilepsy (IE) based primarily upon signalment and history. Since there is no diagnostic test for IE, the arrival at a diagnosis is done by excluding other disorders that may have caused the seizures. The minimum database for any animal presenting for evalu ...
HYOSCYAMINE - Capellon Pharmaceuticals
HYOSCYAMINE - Capellon Pharmaceuticals

... age. Infants and young children are especially susceptible to the toxic effects of anticholinergics. Close supervision is recommended for infants and children with spastic paralysis or brain damage since an increased response to anticholinergics has been reported in these patients and dosage adjustm ...
Potent Direct Vasodilators
Potent Direct Vasodilators

... Sodium retention requires co-treatment with diuretic in most. A loop diuretic, sometimes at high dosage, may be necessary, particularly if there is renal impairment. These agents should not be administered to hypertensive patients with heart failure, myocardial infarction, angina or aortic dis secti ...
Children`s dosage forms
Children`s dosage forms

... - Infancy (from one to three years) - Preschool age (from three to seven years old) - School age (from seven to eighteen years). ...
Nebinor  Nebivolol 5 mg
Nebinor Nebivolol 5 mg

... Nebinor 5 tablet: Each box contains 30 tablets in blister pack. Each film coated tablet contains Nebivolol Hydrochloride INN eqv. to Nebivolol 5.0 mg ...
Ezetimibe
Ezetimibe

KOREA PHARM 2015 hostED BUYER Program
KOREA PHARM 2015 hostED BUYER Program

... Boryung Pharmaceutical Co., Ltd founded in 1963, has put a strong presence in Korean market as one of TOP leading pharmaceutical companies. Boryung has invested continually on research and development and made continuous efforts to produce high-quality products in the specialty areas such as cardiov ...
Untitled
Untitled

... Revised II semester syllabus paper-II (2014-2015) Unit:I Drug Design and Drug Discovery (15 periods) Introduction to drug discovery. Folklore drugs, stages involved in drug discovery- disease, drug targets, bioassay. Chiral drugs: Role of chirality on biological activity: examples of Distomers – a) ...


... dates, as well as potential future results, of our future clinical trials, anticipated designs of our future clinical trials, and anticipated future regulatory submissions and events. Uncertainties and risks may cause actual results to be materially different than those expressed in or implied by ou ...
Memory Medications
Memory Medications

Presentation - Faculty of pain medicine
Presentation - Faculty of pain medicine

Antiarrhythmic drugs
Antiarrhythmic drugs

... was less striking than with flecainide and encainide. A meta-analysis10 and a non-randomised post-hoc analysis11 suggested that quinidine or procainamide treatment in patients with atrial fibrillation was associated with a higher mortality than among patients not receiving these agents. The role of ...
Disorders Of The Scrotum
Disorders Of The Scrotum

... 2. AMINOAMIDES (s. “amides”) – hydrolyzed in liver (contraindicated in liver dysfunction; use procaine!) 1) LIDOCAINE – most popular prototype drug (synthesized in 1943 by Löfgren); also may be used as antiarrhythmic agent i/v. 2) PRILOCAINE – may produce MetHb. 3) ETIDOCAINE 4) MEPIVACAINE 5) BUPIV ...
CAFFEINE (ANHYDROUS) Product Number C0750 Storage
CAFFEINE (ANHYDROUS) Product Number C0750 Storage

... Extensive analytical data have been published. ...
02. DRC2010-10-01 03:482.4 MB
02. DRC2010-10-01 03:482.4 MB

... Advantages of semi log Dose-Response Curve ...
Public release of clinical information in drug submissions and
Public release of clinical information in drug submissions and

... trial reporting for drugs, biologics, and medical devices that provided defined timelines for reporting of summary trial results including specified levels required for outcome measures, and submission of full protocols and statistical analysis plans. These new requirements will come into force in s ...
Study title: A series of N-of-1 trials to assess therapeutic
Study title: A series of N-of-1 trials to assess therapeutic

... production and commercialization of preparations with the pharmacological name of the drug with the same dose, presentation and administration route as the reference drug. Because of their lower cost, use of generic drugs is supported by healthcare systems, which recommend physicians to prescribe th ...
Therapeutic drug monitoring
Therapeutic drug monitoring

... patient’s serum creatinine concentration and the rate of urinary excretion of creatinine.  The approach is similar to that used in the determination of drug clearance. In practice, the rate of urinary excretion of creatinine is measured by the entire day to obtain a reliable excretion rate.  The s ...
Epilepsy is a chronic brain disorder of various etiologies
Epilepsy is a chronic brain disorder of various etiologies

... interactions with carbamazepine often are very significant. Drugs that inhibit CYP 3A4 potentially may increase carbamazepine ...
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Bad Pharma



Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.
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