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New visions in ophthalmic drug development
New visions in ophthalmic drug development

... agonist. This nucleotide stimulates primarily conjunctival epithelial secretion of salt, fluid and mucin and possibly lipid secretion from the meibomian gland, thereby making up the principal layers of the tear film. The conjunctival secretion can be stimulated with INS365 to provide normal tear vol ...
Antidepressant Overview
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... sedating for another individual. This would not be able to be predicted, however, in advance. The top six yellow blocks essentially list (with the exception of EMSAM®) the older antidepressants, which are in relative non-use. For the most part, these medications have been relegated to the “Smithsoni ...
Citicoline Monograph - Alternative Medicine Review
Citicoline Monograph - Alternative Medicine Review

... Citicoline has been tested on stroke patients in controlled trials. A multicenter, double-blind, placebocontrolled trial evaluated the effect of citicoline on 272 stroke patients in the acute stage of moderate-to-severe cerebral infarction with mild-to-moderate disturbances in consciousness.21 The t ...
Sinning and sinned against: The stigmatisation of problem
Sinning and sinned against: The stigmatisation of problem

... significantly greater for non idu groups. Matched by levels of brain activity ...
Classification Scheme for Illicit Drugs
Classification Scheme for Illicit Drugs

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Newer Antihypertensive Drugs

...  Persons who are normotensive at age 55 have a 90% lifetime risk for developing HTN.  Those with SBP 120–139 mmHg or DBP 80–89 mmHg should be considered prehypertensive who require health-promoting lifestyle modifications to prevent CVD. ...
multiple choice questions (MCQs)
multiple choice questions (MCQs)

...  The mention of menstrual irregularities, galactorrhea, and what appears to be extrapyramidal side ...
When Patients Cannot Take Pills: Antiretroviral Drug - IAS-USA
When Patients Cannot Take Pills: Antiretroviral Drug - IAS-USA

... fatal outcomes for patients. In the current treatment era, mortality has substantially decreased, and HIV-seropositive patients have an improved quality of life.2 With advanced age from declining mortality, however, comes a new subset of health care issues for patients. Current treatment involves no ...
Tacrolimus - Wolverhampton Formulary
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Fundamentals of Drug Testing
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Drug concentration in lung tissue in multidrug-resistant tuberculosis
Drug concentration in lung tissue in multidrug-resistant tuberculosis

... not been extensively studied or practiced [2]. Therefore, to date, the full potential of TDM and drug penetration into TB-affected tissues has not been studied. Surgery added to chemotherapy for MDR-TB has been described in case series but no randomised controlled trials have been conducted to evalu ...
10117sgp10
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... survived significantly longer. We examined cells from mice that developed leukemia while under treatment for Bcr/Abl kinase domain point mutations but these were not detected. In addition, culture of such cells ex vivo showed that they were as sensitive as the parental cell line to nilotinib but tha ...
The Rational Use of Antibiotics
The Rational Use of Antibiotics

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OF ORGANIC CATION TRANSPORTER 1 (OCT1 PATIENTS  Original Article
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... ondansetron and tropisetron as antiemetic drugs [9]. Ondansetron and tropisetron, the 5-Hydroxytriptamine Receptor Antagonists (5HTRA), are known as the antiemetics used in chemotherapy-induced nausea vomiting (CINV). In the previous study of Indonesian cancer subjects, the polymorphisms of 5-HT3B g ...
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... to bisoprolol conversion only six years rule is that the. The testimony of all there is a distinction absence from the to bisoprolol conversion Y so enters in the value of z rule is that the account. Sister and the two once to the question any ticket certificate. Termine and may depend note and trus ...
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... • This property also stops them from getting eliminated • They have to be converted to simpler hydrophilic compounds so that they are eliminated and their action is terminated. ...
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Xofigo Treatment Guide PDF

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... strength of inference from a cohort study will always be less than that of a rigor¬ ously conducted RCT. Case-Control Studies.—When the outcome of interest either is very rare or takes a long time to develop, cohort studies also may not be feasible. Inves¬ tigators may use an alternative design in w ...
US Marshals Seize Supplies of GSK Paxil CR, Avandamet
US Marshals Seize Supplies of GSK Paxil CR, Avandamet

... tablet. Though HIV is a chronic, long-term treatable disease, pill burden and convenience have been a major challenge. Many HIV treatments require several pills to be taken several times per day, often resulting in missed doses. Says Norbert W. Bischofberger, PhD, executive vice-president of researc ...
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Drotaverine

... In peptic ulcer, it is expedient to combine Drotaverine Hydrochloride with atropine or atropine like compounds. Injection Subcutaneously or intramuscularly - Usually 2 to 4 ml (1 - 2 ampoules) injection, 1-3 times daily. In case of acute stone colic, 2 to 4 ml (1 - 2 ampoules) may be given by slow i ...
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... o The average eye drop contains 25-70uL of fluid o The eye can only hold one drop at a time! o Must wait 5 minutes between eye medications o Administering one drop right after another drug will reduce the availability of the first drug o Topical medications read the aqueous, iris, ciliary body, pene ...
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Bad Pharma



Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.
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