Available Online through - International Journal of Pharmacy and
... found to be satisfactory and within the official limits. All the tablets shown hardness 3-4.5kg/cm2, friability of all the formulations was less than 1%, weight variation and drug content was found to be within official limits. Amongst all formulations, the optimized formulation F9 was prepared with ...
... found to be satisfactory and within the official limits. All the tablets shown hardness 3-4.5kg/cm2, friability of all the formulations was less than 1%, weight variation and drug content was found to be within official limits. Amongst all formulations, the optimized formulation F9 was prepared with ...
ToxTidbits (March/April 2013)
... Did you know? National Prescription Drug Take-Back Day is April 27th. The Drug Enforcement Administration and local law enforcement agencies will collect unused prescription drugs for safe disposal from 10am to 2pm on Saturday April 27th. This will be the DEA’s sixth event in three years to prevent ...
... Did you know? National Prescription Drug Take-Back Day is April 27th. The Drug Enforcement Administration and local law enforcement agencies will collect unused prescription drugs for safe disposal from 10am to 2pm on Saturday April 27th. This will be the DEA’s sixth event in three years to prevent ...
Turning science into value
... In addition to slipping operating margins, there is also the issue of affordability. Current forecasts estimate that developed markets12 will spend an additional $125 billion on pharmaceuticals between 2014 and 2019. This is 34 percent less than the $190B12 analyst growth forecast for recent and upc ...
... In addition to slipping operating margins, there is also the issue of affordability. Current forecasts estimate that developed markets12 will spend an additional $125 billion on pharmaceuticals between 2014 and 2019. This is 34 percent less than the $190B12 analyst growth forecast for recent and upc ...
Oral contraceptives: 50 years ago introduction of Enovid
... Phenytoin and OCs • Remember I said phenytoin will induce CYP3A4, but OCs increase levels of phenytoin through CYP2C19 inhibition- thus the strategy of increasing OC dosage to overcome phenytoin induction will lead to ...
... Phenytoin and OCs • Remember I said phenytoin will induce CYP3A4, but OCs increase levels of phenytoin through CYP2C19 inhibition- thus the strategy of increasing OC dosage to overcome phenytoin induction will lead to ...
Alternatives for High Risk Medications in the Elderly
... Potential Risks Elderly patients on longterm oral estrogens are at increased risk for breast and endometrial cancer. In addition, results from the Women’s Health Initiative (WHI) hormone trial suggest these medications may increase the risk of heart attack, stroke, blood clots, and dementia. ...
... Potential Risks Elderly patients on longterm oral estrogens are at increased risk for breast and endometrial cancer. In addition, results from the Women’s Health Initiative (WHI) hormone trial suggest these medications may increase the risk of heart attack, stroke, blood clots, and dementia. ...
Multiple Drug Ingestion For Suicidal Purpose Alprazolam
... overdose intake with these agents is increasingly being reported, no case of co-ingestion including alprazolam, citalopram, risperidone, oxcarbazepine and alcohol has been demonstrated so far. As prescription of these drugs continues to increase in developing countries, it is necessary to evaluate t ...
... overdose intake with these agents is increasingly being reported, no case of co-ingestion including alprazolam, citalopram, risperidone, oxcarbazepine and alcohol has been demonstrated so far. As prescription of these drugs continues to increase in developing countries, it is necessary to evaluate t ...
Reimbursement Guide
... Rapivab is indicated for the treatment of acute uncomplicated influenza in patients 18 years and older who have been symptomatic for no more than 2 days. • E fficacy of Rapivab was based on clinical trials in which the predominant influenza virus type was influenza A; a limited number of subjects i ...
... Rapivab is indicated for the treatment of acute uncomplicated influenza in patients 18 years and older who have been symptomatic for no more than 2 days. • E fficacy of Rapivab was based on clinical trials in which the predominant influenza virus type was influenza A; a limited number of subjects i ...
Press Release Sun Pharma launches first branded ophthalmic
... SARL, Sun Ophthalmics expanded its pipeline to include Seceira, a cyclosporine A-based drug undergoing clinical trials for the treatment of dry eye disease. Sun Ophthalmics’ dedicated team is focused solely on the needs of eye care professionals, offering timely, knowledgeable support at every turn. ...
... SARL, Sun Ophthalmics expanded its pipeline to include Seceira, a cyclosporine A-based drug undergoing clinical trials for the treatment of dry eye disease. Sun Ophthalmics’ dedicated team is focused solely on the needs of eye care professionals, offering timely, knowledgeable support at every turn. ...
Drug Doses in Renal Failure
... residual renal function above which the major symptoms of uremia usually supervene: ...
... residual renal function above which the major symptoms of uremia usually supervene: ...
Alan Goldhammer, PhD
... illnesses and, for the purposes of that part, the term “life-threatening” is defined. Subpart E, however, also includes a section on treatment protocols (§ 312.83), which refers to current § 312.34 and 35. Revision of the rule governing expanded access provides an opportunity to clear up some of the ...
... illnesses and, for the purposes of that part, the term “life-threatening” is defined. Subpart E, however, also includes a section on treatment protocols (§ 312.83), which refers to current § 312.34 and 35. Revision of the rule governing expanded access provides an opportunity to clear up some of the ...
Medicines for the Treatment of Obesity
... anti-obesity drug therapy, orlistat is most likely to benefit those who: Do not feel hungry Are not preoccupied with food Eat out or order-in often Have increased cardiovascular disease risk or multiple cardiovascular risk factors Are older Take multiple medications ...
... anti-obesity drug therapy, orlistat is most likely to benefit those who: Do not feel hungry Are not preoccupied with food Eat out or order-in often Have increased cardiovascular disease risk or multiple cardiovascular risk factors Are older Take multiple medications ...
Risk factors for uncontrolled hypertension in Italy
... outside the hospital, who is delegated by the National Health System to provide care for a known number of subjects. Each GP was asked to enrol two hypertensive patients per week in the study, starting on 01/01/1996. When this study was carried out, the GPs participating in the Pandora project had a ...
... outside the hospital, who is delegated by the National Health System to provide care for a known number of subjects. Each GP was asked to enrol two hypertensive patients per week in the study, starting on 01/01/1996. When this study was carried out, the GPs participating in the Pandora project had a ...
The Ethics of Regulatory Mandates for Pediatric Research
... for a significant portion of pediatric drug dosing.7 The phrase “off-label” is simply a way of stating that a drug is given to a person or group for a use that has not undergone the full scientific and regulatory rigor available for a so-called “on-label” use. While this may seem innocuous, the pote ...
... for a significant portion of pediatric drug dosing.7 The phrase “off-label” is simply a way of stating that a drug is given to a person or group for a use that has not undergone the full scientific and regulatory rigor available for a so-called “on-label” use. While this may seem innocuous, the pote ...
ANNE ARUNDEL MEDICAL CENTER
... Blood pressure & heart rate should be monitored at 15 min., 30 min., 1 hr., 2 hrs., 3 hrs., 6 hrs., then every 4 hours while on nesiritide In patients with right heart catheters, hemodynamic measurements should be done and documented as clinically indicated. ...
... Blood pressure & heart rate should be monitored at 15 min., 30 min., 1 hr., 2 hrs., 3 hrs., 6 hrs., then every 4 hours while on nesiritide In patients with right heart catheters, hemodynamic measurements should be done and documented as clinically indicated. ...
Medicines for the Treatment of Obesity
... anti-obesity drug therapy, orlistat is most likely to benefit those who: Do not feel hungry – Are not preoccupied with food – Eat out or order-in often – Have increased cardiovascular disease risk or – multiple cardiovascular risk factors Are older – Take multiple medications – ...
... anti-obesity drug therapy, orlistat is most likely to benefit those who: Do not feel hungry – Are not preoccupied with food – Eat out or order-in often – Have increased cardiovascular disease risk or – multiple cardiovascular risk factors Are older – Take multiple medications – ...
Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine A randomized trial Articles
... Abstract—Background: Patients with ALS commonly exhibit pseudobulbar affect. Methods: The authors conducted a multicenter, randomized, double-blind, controlled, parallel, three-arm study to test a defined combination of dextromethorphan hydrobromide (DM) and quinidine sulfate (Q) (AVP-923) for the t ...
... Abstract—Background: Patients with ALS commonly exhibit pseudobulbar affect. Methods: The authors conducted a multicenter, randomized, double-blind, controlled, parallel, three-arm study to test a defined combination of dextromethorphan hydrobromide (DM) and quinidine sulfate (Q) (AVP-923) for the t ...
US Pharmacy Policy: A Public Health Perspective on Safety and Cost
... to conduct such studies voluntarily in the absence of enforcement. As a result postmarketing surveillance in the US today was mediocre compared to that of other countries (Avorn, 2007). It is too soon to assess whether or not the “FDA Amendment Act” of 2007 will make a difference. The public health ...
... to conduct such studies voluntarily in the absence of enforcement. As a result postmarketing surveillance in the US today was mediocre compared to that of other countries (Avorn, 2007). It is too soon to assess whether or not the “FDA Amendment Act” of 2007 will make a difference. The public health ...
Principles of Drug Action
... Clozapine's plasma concentration has been observed to vary from patient to patient. Various individual factors may vary response such as smoking, hepatic metabolism, gastric absorption, age, and possibly gender. Clozapine is rapidly distributed; it crosses the blood-brain barrier and is distributed ...
... Clozapine's plasma concentration has been observed to vary from patient to patient. Various individual factors may vary response such as smoking, hepatic metabolism, gastric absorption, age, and possibly gender. Clozapine is rapidly distributed; it crosses the blood-brain barrier and is distributed ...
Drug Repositioning Approaches for the Discovery of New ’s Disease REVIEW
... productivity issues in drug development, including increasing development costs, generic competition due to the patent expiry of several blockbuster drugs, increasingly conservative regulatory policies, and insufficient breakthrough innovations. Increasing research and development expenditures are m ...
... productivity issues in drug development, including increasing development costs, generic competition due to the patent expiry of several blockbuster drugs, increasingly conservative regulatory policies, and insufficient breakthrough innovations. Increasing research and development expenditures are m ...
Clindoxyl Gel For The Treatment Of Acne Vulgaris
... methylprednisolone. Clarithromycin, unlike azithromycin, can also inhibit this enzyme system.2 Pharmacokinetics of the HIV drug zidovudine (Retrovir®) are not altered by azithromycin, but clarithromycin reduced absorption by 20% and is best given 2 hours before or after zidovudine.2 Adverse Effects ...
... methylprednisolone. Clarithromycin, unlike azithromycin, can also inhibit this enzyme system.2 Pharmacokinetics of the HIV drug zidovudine (Retrovir®) are not altered by azithromycin, but clarithromycin reduced absorption by 20% and is best given 2 hours before or after zidovudine.2 Adverse Effects ...
2015 ESC Guidelines for the diagnosis and management of
... the risk of upper gastrointestinal bleeding and might compromise the anti-platelet effects of aspirin.4,5,6,7,8 Indomethacin and other NSAIDs should be avoided in patients with coronary artery disease; in fact, most non-aspirin NSAIDs may have a small cardiovascular risk, which was revealed in sever ...
... the risk of upper gastrointestinal bleeding and might compromise the anti-platelet effects of aspirin.4,5,6,7,8 Indomethacin and other NSAIDs should be avoided in patients with coronary artery disease; in fact, most non-aspirin NSAIDs may have a small cardiovascular risk, which was revealed in sever ...
Indigenous drug combination in the treatment of rhinosinal infections
... Re: Antral lavage + Septilin: Recovery was much speedier when an antral lavage was combined with treatment by Septilin. The control series required repeated washings while in those with Septilin and lavage, only a single puncture was necessary and often the recovery set in by the next day. Clinical ...
... Re: Antral lavage + Septilin: Recovery was much speedier when an antral lavage was combined with treatment by Septilin. The control series required repeated washings while in those with Septilin and lavage, only a single puncture was necessary and often the recovery set in by the next day. Clinical ...
Setor 11. Farmacologia Clínica, Farmacocinética
... Introduction: According to World Health Organization the infertility reaches 15% of active sex life population and 50 % of these cases are caused by male factor as primary factor or in association with female ones. About one-third of reproductive age people smoke cigarettes and it can also be involv ...
... Introduction: According to World Health Organization the infertility reaches 15% of active sex life population and 50 % of these cases are caused by male factor as primary factor or in association with female ones. About one-third of reproductive age people smoke cigarettes and it can also be involv ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.