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Accenture Life Sciences Rethink Reshape Restructure...for better patient outcomes Turning science into value High Performers deliver on the commercial promise of new science through outcome-driven operating models Accenture Research Note: Biopharmaceutical High Performance Business Study Since Accenture’s last High Performance Business (HPB) Study of the Pharmaceutical Sector, released in January 2014, the industry outlook has continued to improve with a rise in the industry’s Enterprise Value1 driven by improved growth expectations. A wave of new science has driven the output of new drug launches to levels not seen since the mid-1990s2, especially in high-value specialty indications. The industry’s Future Value3 has moved back into positive territory for the first time since 2007, albeit only slightly, reflecting greater investor confidence and a predicted return to sustainable, profitable industry growth. However, at the same time, operating margins have been deteriorating, owing to the greater cost of investing in more latestage development and new launches as well as reshaping operations and strategy. Pressures from payers and governments continue to mount, as they seek to slow drug spending growth while linking pricing directly with benefits. Furthermore, the return to growth is polarized between the High Performers, whose pipelines are poised to deliver new science-based growth, and the rest of the peer group, who are in various stages of restructuring to find a path back to sustainable growth. 2 | Turning science into value The uptick in the innovation-driven growth forecast is coming at a potential cost. Looking ahead, the challenge will be to ensure that operating models keep up with this exciting pace of innovation and can fulfill the commercial promise of the new science in a more assertive payer and patient outcome-based environment. The High Performers identified in our research are further advanced in achieving this goal with innovation strategies focused on building dominant positions in growth areas of the market. They couple this with new commercial capabilities that differentiate their products’ value at an outcome level and provide support services to patients and healthcare professionals. The companies that sustain high performance in the future will marry the best innovation with the most nimble operations and continue to fine-tune offerings to the health economic and patient outcome realities of today’s market. Key Findings Summary 1 Confidence is back; expectations are high with companies making strategic moves Enterprise Value (EV)1 continues to rise. 11% Future Value (FV)3 is positive for the first time since 2007. +2% + EV Mergers, acquisitions and divestitures are restructuring the industry.4 $364B Q3 2014 $131B 177% 2007 2014 17% -15% - 2013 Q3 2013 2014 2 Return to growth is predicted but polarized between High Performers and the rest Industry growth is forecast to return in 2016, with the High Performers expecting to see significantly higher growth than their peers.5 High Performers have significantly higher Compound Annual Growth Rates (CAGR) than their peers.5 Six companies are now a step change ahead of the pack, with Astellas joining for the first time and Novartis re-joining. 6.5% High Performers 2016 1.3% Novartis 1.1% Rest of peer group Rest of peer group 2015-19 CAGR Roche Astellas BristolMyers Amgen Squibb Novo Nordisk 4.7% High Performers 3 Capturing the value of innovation is stretching margins and the markets' capacity to pay The operating margins6 at 11 of the 16 companies have fallen over the last two years. There is an estimated $65B gap between the predicted growth in pharma spend in developed markets and NME growth forecast.7 $190B $125B 3% Operating Margins Recent and Upcoming NME Launches Drug price inflation in the US is running high at 13.2% and particularly high for specialty drugs.8 25.2% Specialty Drug Price $65B 13.2% US Drug Price Developed Market Net Sales 2014-19 $ Growth Forecast 4 High Performers are focusing on building dominant growth positions and reshaping operations Several operational attributes and capabilities are distinguishing High Performers9: 1. Collaborating to get the best science and breakthrough speed to approval and launch. 2. Transforming their organizations by leveraging partnerships, acquisitions, divestitures and asset swaps. 3. Developing new business models in response to the consumerization of healthcare. 4. Mastering flexible pricing and market access while demonstrating superior outcomes. 3 1 Confidence is back; expectations are high with companies making strategic moves Our research shows a continued recovery in the first 10 months of 2014 with Enterprise Value1 up 11 percent, and reaching 36 percent above the pre-recession peak of 2007 (see Figure 1). Share prices have had a mixed performance at the company level, but overall the ARCA Pharma Index has outperformed the S&P 500 by approximately five percent over a two year period. This improvement in valuation has increased the industry’s Future Value3 as a percentage of Enterprise Value from -6 percent of Enterprise Value, at the end of 2013, to +2 percent this year. This marks the first time Future Value as a percentage of Enterprise Value has been positive since 2007. In addition, the five year replacement revenue ratio forecast has risen from 1.7 in 2010-14 to 2.8 over the next five years (2015-19)10. This shift reflects increased investor confidence in the pharmaceutical sector returning to sustainable future growth, driven by recent and upcoming new launches. Nine of the 16 companies in the peer group analyzed had positive Future Value, up from seven companies in the previous year. This is the first time since 2007 that more than half of the peer group had positive Future Value. This marks the first time Future Value as a percentage of Enterprise Value has been positive since 2007. With this increased confidence and expectation, there has been a significant uptake in major strategic moves being made. In particular, companies are acquiring and divesting businesses, and partnering, to re-focus their portfolios and operations for accelerated growth. This is evidenced by a record year of deal making in 2014 4. Figure 1. Future Value (FV) shifts back to positive for the first time since 2007 Future Value and Enterprise Value ($ billion) for Pharmaceutical Group Studied (2007-2014) $88.4 $80.2 $88.5 $83.5 $66.9 $83.5 $70.3 $1,770 $971 $1,306 $1,157 $1,094 $1,421 $1,204 $1,322 $1,116 $1,560 $1,359 $1,705 $1,606 -13% $77.3 $1,735 $1,776 +31% $1,229 $335 FV/EV = -$63 -$217 -$206 -$331 -$411 2007 2008 2009 2010 2011 2012 2013 25.6% -5.8% -18.0% -18.5% -26.9% -30.2% -6.1% Enterprise value (EV) Net Operating Profit Less Adjusted Taxes (NOPLAT) Current value (CV) -$99 $41 November 2014 +2.3% Future value (FV) Note: 16 pure play biopharma companies only. Japanese companies have March year end (YE13 = Mar-14). Constant USD FOREX used from Oct-14. Oct 31st share price used in latest EV and TTMQ4-14 NOPLAT. EV = MCAP + Net Debt, CV = NOPLAT / WACC, FV = EV – CV. Source: Accenture Research, December 2014. 4 | Turning science into value 2 Return to growth is predicted but polarized between High Performers and the rest Our analysis shows that after four years of negative revenue growth, the peer group studied is poised to return to revenue growth beginning in 2016 with a 2.3 percent CAGR between 2015 and 2019 (see Figure 2). That expected revenue growth is primarily fueled by the High and Near High Performers who have a 4.7 percent average 2015-19 CAGR compared to just 1.1 percent for the rest of the peer group. As shown in Figure 3, the growth is polarized between the High and Near High Performers with 3-8 percent 2014-17 CAGR versus the rest of the peer group (Moderate Performers and Low Performers) with (2)-3 percent 2014-17 CAGR. The High and Near High Performers are keeping up with or exceeding the global pharmaceutical market forecast growth of 4-7 percent from 2015 through 201911. The peer group studied is poised to return to revenue growth beginning in 2016. Figure 2. The return to growth forecast Total Revenue and Earnings Growth for Pharmaceutical Group Studied (2008-2019E) 13.1% +2.3% $429 $450 7.7% 7.0% 5.3% $462 $464 $454 $450 $448 $440 4.8% 2.8% $454 $469 $487 3.1% 3.5% 3.8% 2016E 2017E 2018E $502 3.1% 0.4% -2.3% -2.3% -0.8% -2.3% -1.5% -3.9% -1.7% 2014 2015E -6.9% 2008 2009 2010 2011 2012 2013 2019E OPERATING MARGIN: 32.1% 32.7% 36.0% 35.0% 35.0% 32.9% 32.0% Group revenue growth Group earnings growth (EBITDA) Group revenue ($B) Total Peer Group Revenue and Earnings (NOPLAT) in USD at constant FOREX is analyzed—meaning larger companies performance does skew trends Source: Source: Accenture Research based on Capital IQ January 2015. 5 Figure 3. High Performers are pulling away from the pack in terms of future growth prospects High Performance Business Score December 2014* Versus Group Revenue Forecast CAGR (2014-17) 8% Novo Nordisk 7% High Performers 6% Astellas 5% Amgen 4% 4 Year Growth Forecast (CAGR 2014-17) BMS Novartis Roche 3% Near High Performers 2% 1% Average Performers 0% -1% -2% -3% Low Performers 1.0 1.5 2.0 2.5 High Performance Business Score* *Based on seven year performance methodology Source: Accenture Research, December 2014. 6 | Turning science into value 3.0 3.5 4.0 3 Capturing the value of innovation is stretching margins and the markets’ capacity to pay Operating margins have been falling for the last two years with industry core EBITDA/ revenue down three percentage points to 32 percent in Q3 2014 (see Figure 2). The operating margin6 at a majority of the peer group companies studied (11 of the 16 companies) fell over the last two years. There continues to be a wide range of margins across the peer group companies studied. In addition to slipping operating margins, there is also the issue of affordability. Current forecasts estimate that developed markets12 will spend an additional $125 billion on pharmaceuticals between 2014 and 2019. This is 34 percent less than the $190B12 analyst growth forecast for recent and upcoming NME launches over the same period (see Figure 4). With most of the forecasted spending on NME Prior to the peak of the patent cliff in 2012, launches coming from developed markets, earnings growth was exceeding falling the gap between predicted spend growth revenue growth with companies engineering and analyst forecasted NME growth is margin improvement through operating particularly wide when considering the efficiency programs. This trend was reversed significant economic and demographic after the patent cliff, as companies consciously pressures on health budgets. Payers and stepped up investment in late-stage governments will continue to seek greater development, prepared for new launches savings from generics, since their drug and invested in transforming their strategy spending as a proportion of total health and operations in the face of falling spending is already creeping up. However, revenue growth. reimbursement is continuing to shift to those new products that differentiate most clearly on patient health and economic outcomes, as payers seek to further control drug spending growth. For example, the Hepatitis C space has seen intense price negotiations with AbbVie and Gilead vying to form partnerships with payers as they try to demonstrate the best balance of patient outcomes and affordability. Meanwhile Germany’s Health Technology Assessment body IQWIG has made recent (separate) judgments finding Gilead’s Zydelig, Bayer’s Eylea and Bristol-Meyers Squibb’s Daklinza13, as well as several newer diabetes drugs, have not provided incremental benefits in target indications. These challenges are making these companies’ cases for reimbursement and premium pricing with payers much more difficult. Figure 4. The affordability of new product launches There is an estimated $65B gap between the projected growth for spend on pharmaceuticals in developed markets and sales forecasts for recent and upcoming NME approvals. Developed Markets Pharmaceutical Spend Growth Versus Recent & Upcoming New Molecular Entity Launch Forecasts $190B Pharmaceutical Spend as % Total Health 16.2% Expenditure 2014 17.3% Upcoming Launches $65B 2019 $125B $91B Recent Launches $99B Developed Markets Pharmaceutical Net Sales* Recent & Upcoming New Molecular Entity Launches* 2014-19 $ Growth Forecast 2014-19 $ Growth Forecast There will be new launch winners and losers in the battle to command a share of fixed healthcare funding growth in increasingly crowded and price-competitive therapeutic categories. In this climate, successfully bringing new products to market will require pharmaceutical companies to develop new operating models that can turn new science into realized value. *Developed Markets is defined as US, CA, JP, SKor, SP, IT, FR, GY, IT - Pharma Market Spend forecast is extrapolated from IMS forecasts Nov-14. Forecast growth of Recent & Upcoming launches is based on Evaluate Pharma consensus forecasts for First Introductions 2010-19E. Estimates of Pharma spend as a % THE are taken from Economist Intelligence unit and are based on Retail pricing. Source: Accecnture Research, January 2015. 7 4 High Performers are focusing on building dominant growth positions and reshaping operations The rapid improvements in growth forecasts for the High Performers9 reflects their ongoing commitment to a strategic focus on bringing innovative new science to market in key growth therapeutic areas. However, it also reflects their ability to do so in a cost effective way that clearly delivers improved patient outcomes for specific patient segments. The High Performers are outperforming their peers by driving structural and operational change that helps them keep up with the fast pace of innovation by developing new commercial and operational capabilities. This adaptability is essential given the high cost of innovation and the need for commercial launches to realize their anticipated potential and offset recent falls in operating margins. The wave of M&A and restructuring sweeping the sector is indicative of the rest of the industry following the success of the High Performers. Several operational attributes and capabilities are distinguishing High Performers: High Performers distinguish themselves on five important metrics: Higher proportion of growth forecast to come from recent and upcoming launches15 as a percentage of revenue 1. Collaborating to get the best science and breakthrough speed to approval and launch. 2. Transforming their organizations by leveraging partnerships, acquisitions, divestitures and asset swaps. 3. Developing new business models in response to the consumerization of healthcare. 4. Mastering flexible pricing and market access while demonstrating superior outcomes. Higher average five year revenue forecast5 CAGR 2015-2019 2016 6.5% High Performers 4.7% 1.1% 1.3% Rest of peer group 27.3% Rest of peer group Higher average operating margins6 27.7% Rest of peer group 33.4% High Performers Higher five year forecast replacement revenue ratio10 average (ability to replace revenue lost to patent expired drugs) 3.0 1.7 Rest of peer group High Performers 33.1% High Performers Higher average sales forecast for NME launches five years after launch14 High Performers Rest of peer group 7.1 NME launches $0.4B Sales 8 | Turning science into value 5.3 NME launches $1.1B Sales 1 Collaborating to get the best science and breakthrough speed to approval and launch. Collaboration means a commitment to finding, partnering and developing the best external and internal science, wherever it arises—academia, biotech or other pharmaceutical companies. This includes having processes to expedite early decision making on choosing the best drug candidates and responding to regulatory changes with strategies to more rapidly and successfully bring differentiated products to market in areas of significant unmet clinical need. Examples include: • Bristol-Myers Squibb (BMS) is forming partnerships that blend the strengths of its leading immuno-oncology drugs with other companies’ existing and investigational cancer drugs to explore enhanced efficacy and expanded labels. For example, they have partnered with Seattle Genetics’ Adcetris to explore several blood cancer therapies and have other immuno-oncology partnerships with Incyte, Eli Lilly, Novartis, Celgene and Pharmacyclics. BMS’s strength in the immuno-oncology field stems from its acquisition of Medarex, part of its “String of Pearls” externalization strategy. • Roche has partnered with 23andMe to access anonymized Parkinson’s disease patient records and has partnered with Foundation Medicine to access proprietary cancer genetic-screening technology to enhance the specificity of Roche’s early-stage research. • Amgen has several notable partnership deals including a strategic collaboration with Kite Pharma in next-generation Chimeric Antigen Receptor (CAR) T-cell immunotherapies and a collaboration with AstraZeneca covering five Monoclonal Antibody (MAb) inflammatory programs including anti-IL-17 MAb Brodalumab in psoriasis. • BMS and Merck both used the FDA’s breakthrough therapy designation to accelerate their development programs which led to successful approval of the first PD-1 inhibitor cancer immunotherapies in 2014 in melanoma. Both are now in a race to investigate the efficacy of their drugs in expanded labels, including lung cancer. 2 Transforming their organizations to focus on growth, leveraging partnerships, acquisitions, divestitures and asset swaps. High performers have been transforming their business through strategic deals in recent years. Acquisitions, divestitures and partnerships, both large and small, have sharpened their focus and differentiation in high growth segments. They have also committed to continuous operational change to meet the demands of investing for growth. Examples include: • Novartis underwent a large scale refocusing through a three-way asset swap deal with Eli Lilly and GlaxoSmithKline in 2014. This enabled them to refine their focus to three growth segments. At the same time, they announced operational efficiency plans to generate more flexible funding for innovation. • BMS acquired Medarex in 2009 which leapfrogged it into the cancer immunotherapy field and divested diabetes to AstraZeneca in 2014. • Astellas entered into a large partnership with Medivation in 2009 to co-develop and co-commercialize novel androgen receptor antagonist Xtandi in prostate cancer. They are continuing to develop the drug for expanded labels. • Amgen acquired Onyx in 2013 gaining access to an exciting oncology pipeline and portfolio, including fast growing Kyprolis approved in multiple myeloma. Amgen also signed a strategic alliance with Astellas that year to provide new medicines to help address serious unmet medical needs of Japanese patients. It also struck a partnership with AstraZeneca’s biologics arm Medimmune in 2012 to jointly develop and commercialize its clinical-stage inflammation portfolio. 9 3 Developing new business models in response to the consumerization of healthcare. High Performers demonstrate mastery of new channels geared towards the changing needs and behavior of healthcare professionals and patients. Technology-enabled healthcare professionals increasingly require on-demand information and support to accompany their patient interactions and prescribing decisions. Similarly, patients’ appetite for information and support is almost insatiable—for example, disease information, access to online communities and support groups, financial assistance and medication adherence advice. High Performers have become trusted and value-adding information partners through digital channels and are moving well beyond the pill to provide additional services and technologies that will help make their products accessible and contribute to improved outcomes at scale. Examples include: • Novartis has established a joint investment company with leading wireless investor Qualcomm Ventures where a $100 million investment will support early stage technologies that “go beyond the pill” and assist Novartis in capturing data on the right medicine for the right patient. Novartis also has a partnership with Google that explores measuring patients’ glucose levels via smart contact-lens technology, as well as a partnership with Avella Specialty Pharmacy that offers GlowCap adherence technology to oncology patients. • Roche recently signed a five year agreement with PatientsLikeMe’s global online patient network, to explore real world experience and incorporate patient insights into decision making. Roche has also recently signed a partnership with Qualcomm Ventures to use remote patient monitoring and management to advance chronic-care management using connected therapies that improve patient engagement and outcomes. 4 Mastering flexible pricing and market access while demonstrating superior outcomes. High performing companies bring a portfolio of flexibly priced products tailored to specific patient segment needs. They also carefully plan their development strategies to yield robust outcomes data clearly differentiating their health economic value in defined patient segments relative to the current standard of care. On top of this, they provide a range of patient services that help patients and healthcare professionals realize these outcomes in practice and at scale. This more focused approach is accompanied with financial assistance that together maximize accessibility and value to payers. • Astellas and BMS secured reimbursement recommendations from the UK Health Technology Assessment body NICE for its cancer drugs Xtandi and Yervoy by providing a patient access arrangement and discounted pricing in specific patient groups. • Novo Nordisk initiated the Cities Changing Diabetes program, partnering with Houston, Mexico City and Copenhagen, to better understand the driving forces behind the epidemic of diabetes and obesity in urban populations and to develop and share prevention and management strategies. • Several pharmaceutical companies have real-world data partnerships with health insurance companies. Boehringer Ingelheim recently partnered with WellPoint and HealthCore to study the long-term health economics of novel oral anticoagulants (NOACs), looking for gaps in care and best practices to improve quality and cost of care. 10 | Turning science into value Conclusion Since our study in January 2014, confidence has continued to return to the sector as a result of innovative new drug approvals on the rise. Investors continue to reward the best differentiating science, particularly in specialty areas of the market. New sciencedriven launches are today capturing more attention from investors than emerging markets despite the continued double-digit growth forecasts in the latter. While growth is expected to come back in 2016, it continues to be polarized between a group of High Performers who have great science innovation and the capabilities to differentiate new launches with payers, and the remaining peer group, which struggles at various points in returning to sustainable growth. However, this innovation-driven growth boom comes at a cost and eyes will soon again be back on sliding operating margins and delivering on launch expectations. Sustained high performance in the sector will come from those companies that can drive operational change that keep pace with innovation. The challenge ahead will be turning science into value by developing new operating models that can deliver on the commercial promise of new launches in a changing healthcare economy. Research notes and sources 8 Express Scripts 2014 Drug Trend Report. Per member per year spending trends, unit cost inflation running at 13.2%, with Speciality drugs running at 25.2%. 1 Industry Enterprise Value (EV) is calculated as the sum total of Market Capitalization and Net Debt for each company across the peer group. Current Value (CV) is calculated as Net Operating Profit Less Adjusted Taxes divided by Weighted Average Cost of Capital (WACC), totalled across each company in the peer set. 2 41 New Molecular Entities (NMEs) were approved by the FDA in 2014, the highest level since 1996. 3 Industry Future Value (FV) is calculated as the difference between Industry Enterprise Value and Industry Current Value (CV), based on a total of 16 pure-play Biopharmaceutical companies studied. 4 Accenture Research analysis of Announced Life Sciences M&A deal value in 2014, based on Capital IQ. 5 Group Revenue Forecasts are sourced from Evaluate Pharma Jan-15. The Average position is shown for High and Near High Performers vs Average for the rest of the peer group. 6 Core EBITDA margin trailing 12 months to Q3 2014, and two year change versus trailing 12 months to December 2013. 7 Developed Markets Pharmaceutical Net Sales growth IMS Health Nov-14, and forecast growth of recent and upcoming NME launches EvaluatePharma Jan-15 (see fig. 4 and note 14. for detail). 9 High Performers are defined as having a performance score greater than one standard deviation above the peer-group mean. Near High Performers have a performance score greater than 0.3 standard deviation above the peer-group mean. 10 Replacement Revenue Ratio is calculated as the estimated sales growth from patented marketed products divided by estimated sales lost to patentexpired products (including those products whose patents expired in the year in question). Only “defined products” have sales lost to patent expiry estimated—that is, those with a defined patent expiration date and sales estimates in Evaluate Pharma’s database. They represent the majority but not all sales of marketed products, and exclude smaller undefined products. Replacement Revenue Ratio is considered a good directional indicator of pipeline-driven growth over time, measured at an industry and company level. 11 IMS Health November 2014 Report Global Outlook for Medicines. 12 According to IMS Health definitions, developed markets are Germany, France, the United Kingdom, Spain, Italy, Japan, South Korea, the United States, and Canada. IMS Health November 2014 forecasts for developed-market growth are extrapolated and adjusted to net sales levels. The Economist Intelligence Unit forecasts for pharmaceutical spend as a percentage of total health expenditures are used. Comparison is made to Evaluate Pharma forecasts for growth from recent (2010-14) and upcoming (2015-19) NME launches. The comparison is not precise, since methodologies differ slightly, but considered to offer a directionally valid comparison. 13 Iqwig decisions on Daklinza (https://www.iqwig.de/ en/press/press-releases/press-releases/daclatasvir-forhepatitis-c-added-benefit-not-proven.6460.html) and Zydelig (https://www.iqwig.de/en/press/pressreleases/press-releases/added-benefit-of-idelalisibis-not-proven.6516.html) 14 NMEs as defined by FDA (excluding plasma expanders and imaging agents). High and Near High Performers are not launching more NMEs but are expected to achieve greater sales from those they are launching. High Performers averaged 5.3 NME launches in 2010-14, versus an average of 7.1 for the rest of the peer group, but have a higher average sales forecast at five years after launch (High Performers average $1.1B versus $0.4B for the rest). 15 5 year Sales growth forecast 2014-19, for recent (2010-14) and upcoming (2015-19) NME launches, as a % of 2014 Group Rev, based on Evaluate Pharma Jan-15. 11 Contact Us Anne O’Riordan Global Life Sciences Industry Senior Managing Director Accenture Life Sciences [email protected] Andrea Brueckner Managing Director, EALA Accenture Life Sciences [email protected] Thomas D. Schwenger Senior Managing Director, North America Accenture Life Sciences [email protected] Author Philip J. Davis Head of Healthcare & Life Sciences Research Accenture Research [email protected] Stay Connected www.facebook.com/accenture http://twitter.com/accenture @AccentureLifSci www.youtube.com/accenture www.linkedin.com/company/ accenture Visit Our Blog www.accenture.com/lifesciencesblog Copyright © 2015 Accenture All rights reserved. Accenture, its logo, and High Performance Delivered are trademarks of Accenture. About Accenture’s High Performance Business Research Program Accenture embarked on its High Performance Business Program in 2003. We have studied thousands of companies across multiple industries and industry segments and come up with definitive answers regarding business performance. Our High Performance Business research methodology is a proprietary approach for analyzing relative peer company performance across five key metrics. For each company, we capture the metrics for profitability, growth, positioning for the future, longevity and consistency with scores graded along a bell curve. In our 2010 research, we added a forward-looking dimension to our research methodology that analyzed a company’s revenue growth forecast and strength of its pipeline relative to its intellectual property exposure. Composite scores demonstrate relative performance within the peer set and highlight the High Performers. About Accenture’s High Performance Business Research for the Biopharmaceutical Industry Accenture’s study of the Biopharmaceutical industry is in its 10th year and has analyzed the long-term performance of “pure-play” pharmaceutical companies (those with more than 75 percent of their revenue derived from pharmaceutical products). Our 2015 update is based on trailing 12-month Q3 2014 financials and analyzes 16 of the largest pure-play Pharmaceutical companies in the world over an eight year period. Collectively these companies had $444 billion in aggregate revenue, representing more than half the global pharmaceutical market by net sales. The results have been compared with our 2014 and 2013 studies (based on trailing 12-month Q3 2013 and year-end 2012 financials, respectively) to identify relative movements in the performance rankings. The analysis pro forma adjusts for the impact of major M&A deals and removes the impact of exceptional costs to reveal a normalized picture of ongoing core business operations. A detailed analysis of historic financial performance averaged over 1, 3, 5 and 7 year timeframes is combined with consensus analyst forecasts to gain a forwardlooking global picture of forecasted revenue growth from portfolio and new product launches as well as to gauge the impact of patent expirations and mature products. About Accenture Life Sciences Practice Accenture’s Life Sciences group is dedicated to helping companies rethink, reshape or restructure their businesses to deliver better patient outcomes and drive shareholder returns. We provide end-to-end business services as well as individual strategy, digital, technology and operations projects around the globe in all strategic and functional areas— with a strong focus on R&D, Sales & Marketing and the Supply Chain. We have decades of experiences working hand-in-hand with the world’s most successful companies to improve their performance across the entire Life Sciences value chain. Accenture’s Life Sciences group connects more than 10,000 skilled professionals in over 50 countries who are personally committed to helping our clients achieve their business objectives and deliver better health outcomes for people around the world. About Accenture Accenture is a global management consulting, technology services and outsourcing company, with approximately 323,000 people serving clients in more than 120 countries. Combining unparalleled experience, comprehensive capabilities across all industries and business functions, and extensive research on the world’s most successful companies, Accenture collaborates with clients to help them become highperformance businesses and governments. The company generated net revenues of US$30.0 billion for the fiscal year ended Aug. 31, 2014. Its home page is www.accenture.com.