Lipoprotein disorders and cardiovascular disease
... • Adjunctive therapy in patients with severe hypercholesterolemia due to increased LDL cholesterol. • Because bile acid–binding resins are not absorbed systemically (they remain in the intestine and are eliminated in the stool), they are considered safe in children. • Cholestyramine (Questran) is us ...
... • Adjunctive therapy in patients with severe hypercholesterolemia due to increased LDL cholesterol. • Because bile acid–binding resins are not absorbed systemically (they remain in the intestine and are eliminated in the stool), they are considered safe in children. • Cholestyramine (Questran) is us ...
Modafinil for Narcolepsy - Amber Shared Care ESHUT
... considered as red on the traffic light system. Modafinil should be used only in patients who have had a complete evaluation of their excessive sleepiness, and in whom a diagnosis of narcolepsy, has been made in accordance with ICSD diagnostic criteria. Such an evaluation usually consists, in additio ...
... considered as red on the traffic light system. Modafinil should be used only in patients who have had a complete evaluation of their excessive sleepiness, and in whom a diagnosis of narcolepsy, has been made in accordance with ICSD diagnostic criteria. Such an evaluation usually consists, in additio ...
Drug treatment of hypertensive emergencies
... UpToDate performs a continuous review of over 350 journals and other resources. Updates are added as important new information is published. The literature review for version 14.2 is current through April 2006; this topic was last changed on May 8, 2006. The next version of UpToDate (14.3) will be r ...
... UpToDate performs a continuous review of over 350 journals and other resources. Updates are added as important new information is published. The literature review for version 14.2 is current through April 2006; this topic was last changed on May 8, 2006. The next version of UpToDate (14.3) will be r ...
Ace to arb equivalent dose
... Conversion to ACE-Is and ARBs *Approximate dosing was based off of ratios from known equivalent lisinopril doses **If cough with lisinopril. The results the authors obtained and reported above indicate that ACE inhibitors and ARBs have different effects on mortality reduction in hypertension, althou ...
... Conversion to ACE-Is and ARBs *Approximate dosing was based off of ratios from known equivalent lisinopril doses **If cough with lisinopril. The results the authors obtained and reported above indicate that ACE inhibitors and ARBs have different effects on mortality reduction in hypertension, althou ...
FAQS - Istituto Superiore di Sanità
... number of participants is usually low, even though higher than in Phase I. The major aim of Phase II trial is to assess the efficacy of the drug at inducing a specific immune response. Nonetheless, safety and tolerability evaluation is not disregarded. The results of this Phase are aimed to demonst ...
... number of participants is usually low, even though higher than in Phase I. The major aim of Phase II trial is to assess the efficacy of the drug at inducing a specific immune response. Nonetheless, safety and tolerability evaluation is not disregarded. The results of this Phase are aimed to demonst ...
Provisional PDF - Malaria Journal
... Kinetic solubility is the measurement of the solubility of a pre-dissolved compound (typically in DMSO, a strong organic solvent) in an aqueous buffer [10]. Solubility, one of the most important properties in a drug discovery process, is a determinant factor in intestinal absorption and oral bioavai ...
... Kinetic solubility is the measurement of the solubility of a pre-dissolved compound (typically in DMSO, a strong organic solvent) in an aqueous buffer [10]. Solubility, one of the most important properties in a drug discovery process, is a determinant factor in intestinal absorption and oral bioavai ...
F' M a y IO , 1 9... ,- ,- Dr. W illiam
... to which the subject is otherwise entitled, A statement indicating that medical records will be made available to Thompson and describing the extent, if any, to'which confidentiality orrecords identifying the subject will be maintained. An explanation as to whether any compensation and an explanatio ...
... to which the subject is otherwise entitled, A statement indicating that medical records will be made available to Thompson and describing the extent, if any, to'which confidentiality orrecords identifying the subject will be maintained. An explanation as to whether any compensation and an explanatio ...
The Rockefeller University Center for Clinical and Translational
... direct cost requested year 1, $132,450 direct cost requested year – Knut Wittkowski(secondary PI)- Pilot Project aimed at using the NCBI CASP data base of Genotypes and Phenotypes (dbGAP) (1) to empirically validate a methodology by comparing its results to those from traditional approaches (2) to c ...
... direct cost requested year 1, $132,450 direct cost requested year – Knut Wittkowski(secondary PI)- Pilot Project aimed at using the NCBI CASP data base of Genotypes and Phenotypes (dbGAP) (1) to empirically validate a methodology by comparing its results to those from traditional approaches (2) to c ...
RESTASIS® (cyclosporine ophthalmic emulsion) 0.05%
... RESTASIS® ophthalmic emulsion has not been studied in patients with a history of herpes keratitis. PRECAUTIONS General: For ophthalmic use only. Information for Patients The emulsion from one individual single-use vial is to be used immediately after opening for administration to one or both eyes, a ...
... RESTASIS® ophthalmic emulsion has not been studied in patients with a history of herpes keratitis. PRECAUTIONS General: For ophthalmic use only. Information for Patients The emulsion from one individual single-use vial is to be used immediately after opening for administration to one or both eyes, a ...
Efficacy and tolerability of the new antiepileptic drugs I - Doctors
... and adults with newly diagnosed partial and generalized epilepsies. Methods: A 23-member committee, including general neurologists, pediatric neurologists, epileptologists, and doctors in pharmacy, evaluated the available evidence based on a structured literature review including MEDLINE, Current Co ...
... and adults with newly diagnosed partial and generalized epilepsies. Methods: A 23-member committee, including general neurologists, pediatric neurologists, epileptologists, and doctors in pharmacy, evaluated the available evidence based on a structured literature review including MEDLINE, Current Co ...
A New Therapeutic Applications for Drug Repositioning
... may be new uses for existing drugs as repositioning candidates have frequently been through several phases of development (ADMET, absorption, distribution, metabolism, excretion and toxicity; EMEA, European Medicines Agency; FDA, Food and Drug Administration; IP, intellectual property; MHLW, Ministr ...
... may be new uses for existing drugs as repositioning candidates have frequently been through several phases of development (ADMET, absorption, distribution, metabolism, excretion and toxicity; EMEA, European Medicines Agency; FDA, Food and Drug Administration; IP, intellectual property; MHLW, Ministr ...
- Dr. Robert Fox
... placebo-controlled study of cevimeline in Sjogren's syndrome patients with xerostomia and keratoconjunctivitis sicca. Arthritis Rheum. Mar 2002;46(3):748-754. 5. Fife RS, Chase WF, Dore RK, et al. Cevimeline for the treatment of xerostomia in patients with Sjogren syndrome: a randomized trial. Arch ...
... placebo-controlled study of cevimeline in Sjogren's syndrome patients with xerostomia and keratoconjunctivitis sicca. Arthritis Rheum. Mar 2002;46(3):748-754. 5. Fife RS, Chase WF, Dore RK, et al. Cevimeline for the treatment of xerostomia in patients with Sjogren syndrome: a randomized trial. Arch ...
Gold - Walker Bioscience
... • Dozens of clinical trials have examined the cognitive effects of gingko in humans. • Great majority of studies have involved subjects with mild to moderate impairment, usually an early diagnosis of Alzheimer's. • Most experiments test learning and memory; less often attention, motivation or anxie ...
... • Dozens of clinical trials have examined the cognitive effects of gingko in humans. • Great majority of studies have involved subjects with mild to moderate impairment, usually an early diagnosis of Alzheimer's. • Most experiments test learning and memory; less often attention, motivation or anxie ...
22-7. Antibacterials
... selective toxicity for targets that are either unique to microorganisms or much more important in them than in animals or humans. Among these targets are bacterial and fungal cell wall-synthesizing enzymes, the bacterial ribosome, the enzymes required for nucleotide synthesis and DNA replication, th ...
... selective toxicity for targets that are either unique to microorganisms or much more important in them than in animals or humans. Among these targets are bacterial and fungal cell wall-synthesizing enzymes, the bacterial ribosome, the enzymes required for nucleotide synthesis and DNA replication, th ...
n/2
... pharmacodynamics, metabolic, and microdose assessments based on human, not extrapolated from animal studies More of a discovery, rather than development Number of patients: 10-15 Dose: subtherapeutic ...
... pharmacodynamics, metabolic, and microdose assessments based on human, not extrapolated from animal studies More of a discovery, rather than development Number of patients: 10-15 Dose: subtherapeutic ...
High-Dose, Short-Course Levofloxacin for Community
... and to help maintain treatment blinding, patients with a calculated creatinine clearance of !50 mL/min were excluded from participation. Study design. This was a randomized, double-blind, active treatment–controlled, noninferiority study conducted in the United States, with 70 sites enrolling patien ...
... and to help maintain treatment blinding, patients with a calculated creatinine clearance of !50 mL/min were excluded from participation. Study design. This was a randomized, double-blind, active treatment–controlled, noninferiority study conducted in the United States, with 70 sites enrolling patien ...
CHIRALITY (AS PREFORMULATION ASPECTS)
... Tao and Cooks recently reported that quantitative chiral analysis could be done by tandem MS. The method is rapid and requires very little sample. Lou recently reported that it would be useful to determine enantiomers and other structurally similar drug impurities using one rather than two analytica ...
... Tao and Cooks recently reported that quantitative chiral analysis could be done by tandem MS. The method is rapid and requires very little sample. Lou recently reported that it would be useful to determine enantiomers and other structurally similar drug impurities using one rather than two analytica ...
LACHMANCONSULTANTSERVICES,INC Westbury, NY 11590
... isoproterenol-induced tachycardia. The malcimal effect occurred within 1-4 hours postdosing. Effects generally persisted for 24 hours at doses of 5 mg or greater. In controlled clinical trials, bisoprolol fumarate given as a single daily dose has been shown to be an effec6ve antihypertensive agent w ...
... isoproterenol-induced tachycardia. The malcimal effect occurred within 1-4 hours postdosing. Effects generally persisted for 24 hours at doses of 5 mg or greater. In controlled clinical trials, bisoprolol fumarate given as a single daily dose has been shown to be an effec6ve antihypertensive agent w ...
Clinical Evaluation of Topical Application of Doxycycline 3% +
... Medical history was recorded for the selected patients, also all the clinical periodontal parameters were noted at the baseline which was followed by SRP. In each patient, on the completion of SRP, selected sites with probing depths more than 4 mm were randomly designated to either the A or B group, ...
... Medical history was recorded for the selected patients, also all the clinical periodontal parameters were noted at the baseline which was followed by SRP. In each patient, on the completion of SRP, selected sites with probing depths more than 4 mm were randomly designated to either the A or B group, ...
now - Diamond Pharmacy Services
... not inferior to) the current recommended UTI prophylaxis of sulfamethoxazole-trimethoprim. Women in the Lactobacillus group were more likely to contract a UTI (14% more women contracted a UTI in the Lactobacillus group), contracted a UTI more quickly (three vs. six months at onset), and had a higher ...
... not inferior to) the current recommended UTI prophylaxis of sulfamethoxazole-trimethoprim. Women in the Lactobacillus group were more likely to contract a UTI (14% more women contracted a UTI in the Lactobacillus group), contracted a UTI more quickly (three vs. six months at onset), and had a higher ...
Drugs and the kidney
... balance. The indications for diuretic use include heart failure (acute or chronic), pulmonary oedema, hypertension, nephritic syndrome, hypercalcaemia and hypercalciuria. Diuretic drugs increase urine output by the kidney, i.e. they promote diuresis. This is accomplished by altering the manner in wh ...
... balance. The indications for diuretic use include heart failure (acute or chronic), pulmonary oedema, hypertension, nephritic syndrome, hypercalcaemia and hypercalciuria. Diuretic drugs increase urine output by the kidney, i.e. they promote diuresis. This is accomplished by altering the manner in wh ...
Patient-Centered Management of Atrial Fibrillation: Applying
... drawbacks to therapy, according to other characteristics of In 2010, to recognize higher-risk subpopulations, the the agent. European Society of Cardiology offered a revision to the CHADS2 score, commonly known as CHADS2-vascular Suppose that C.S. chooses metoprolol, with the idea that it will be be ...
... drawbacks to therapy, according to other characteristics of In 2010, to recognize higher-risk subpopulations, the the agent. European Society of Cardiology offered a revision to the CHADS2 score, commonly known as CHADS2-vascular Suppose that C.S. chooses metoprolol, with the idea that it will be be ...
Fuzzy Controller for Automatic Drug Infusion in Cardiac Patients Dr
... presence of a ‘dead zone’ at the low infusions. It should be noted that our model does not simulate conditions corresponding to low infusion rates of DPM. At the higher contractilities, the MAP and CO steady state curves exhibit input multiplicities, with maxima near a DPM infusion of 3.5 ug/lcg/mi ...
... presence of a ‘dead zone’ at the low infusions. It should be noted that our model does not simulate conditions corresponding to low infusion rates of DPM. At the higher contractilities, the MAP and CO steady state curves exhibit input multiplicities, with maxima near a DPM infusion of 3.5 ug/lcg/mi ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.