Drug Therapy Protocols: Atropine
... retrieval system or transmit in any form, or by any means, part or the whole of the Queensland Ambulance Service (‘QAS’) Clinical practice manual (‘CPM’) without the priorwritten permission of the Commissioner. The QAS accepts no responsibility for any modification, redistribution or use of the CPM ...
... retrieval system or transmit in any form, or by any means, part or the whole of the Queensland Ambulance Service (‘QAS’) Clinical practice manual (‘CPM’) without the priorwritten permission of the Commissioner. The QAS accepts no responsibility for any modification, redistribution or use of the CPM ...
DIOVAN
... In rare cases, valsartan may be associated with decreases in haemoglobin and haematocrit. In controlled clinical trials, 0.8% and 0.4% of patients receiving Diovan showed significant decreases (>20%) in haematocrit and haemoglobin, respectively. In comparison, 0.1 % of patients receiving placebo sho ...
... In rare cases, valsartan may be associated with decreases in haemoglobin and haematocrit. In controlled clinical trials, 0.8% and 0.4% of patients receiving Diovan showed significant decreases (>20%) in haematocrit and haemoglobin, respectively. In comparison, 0.1 % of patients receiving placebo sho ...
novinky v léčbě chronického srdečního selhání na prahu
... • fluid retention (heart failure, pulmonary congestion, edemas, ascites, hydrothorax) • hypertension • Main clinical effects: • in heart failure they improve the quality of life, but we do not have enough information about their influence on the life prognosis • In hypertension they decrease the inc ...
... • fluid retention (heart failure, pulmonary congestion, edemas, ascites, hydrothorax) • hypertension • Main clinical effects: • in heart failure they improve the quality of life, but we do not have enough information about their influence on the life prognosis • In hypertension they decrease the inc ...
White paper Natriuretic peptides, heart failure and
... Natriuretic peptides (NPs) – such as B-type natriuretic peptide precursor (BNP) and its N-terminal fragment (NT-proBNP) – are well-known and widely accepted as both useful and cost-effective biomarkers for heart failure (HF) diagnosis and therapy monitoring. Both BNP and NT-proBNP are considered to ...
... Natriuretic peptides (NPs) – such as B-type natriuretic peptide precursor (BNP) and its N-terminal fragment (NT-proBNP) – are well-known and widely accepted as both useful and cost-effective biomarkers for heart failure (HF) diagnosis and therapy monitoring. Both BNP and NT-proBNP are considered to ...
ANTIHYPERLIPIDAEMIC DRUGS
... problems). The effects of high cholesterol do not cause problems for many years or even decades. Therefore, if a woman does not take her statin or other cholesterol medications during breastfeeding, it will likely have only a minimal impact on her long-term risks. Therefore, it is best to wait until ...
... problems). The effects of high cholesterol do not cause problems for many years or even decades. Therefore, if a woman does not take her statin or other cholesterol medications during breastfeeding, it will likely have only a minimal impact on her long-term risks. Therefore, it is best to wait until ...
63rd FIP Congress Sydney, Australia
... Senior Research Scientist in the Office of Pharmaceutical Science, Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA). The pharmacy practice symposia, as has come to be expected, covered important and sometimes controversial topics. A 2001 report by the United States ...
... Senior Research Scientist in the Office of Pharmaceutical Science, Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA). The pharmacy practice symposia, as has come to be expected, covered important and sometimes controversial topics. A 2001 report by the United States ...
Prodrugs: Effective Solutions for Solubility, Permeability and
... and from the use of transporters and receptor-mediated endocytosis in prodrug delivery to the use of gene therapy for enzyme delivery to cancer cells and tissues. Several case studies were presented including improved pharmaceutical products in the clinic and at various stages of development. ...
... and from the use of transporters and receptor-mediated endocytosis in prodrug delivery to the use of gene therapy for enzyme delivery to cancer cells and tissues. Several case studies were presented including improved pharmaceutical products in the clinic and at various stages of development. ...
Promising Therapies for Treating and/or Preventing Androgenic
... light sources of varying wavelengths and with different suggested modes of use. While some laser machines are designed for use at home on a daily basis, others are only available through clinics for weekly or monthly use. Whilst there is evidence that laser light can stimulate hair growth at some wa ...
... light sources of varying wavelengths and with different suggested modes of use. While some laser machines are designed for use at home on a daily basis, others are only available through clinics for weekly or monthly use. Whilst there is evidence that laser light can stimulate hair growth at some wa ...
Proton radiotherapy for pediatric tumors: review of
... Recent therapy progress has improved life expectancy in pediatric cancer patients, with a 5-year overall survival (OS) that increased from 39% in 1960 higher than 80% in 2004 [1]. Radiotherapy (RT) is a fundamental part of the multimodality treatment applied to achieve local (LC) and regional contro ...
... Recent therapy progress has improved life expectancy in pediatric cancer patients, with a 5-year overall survival (OS) that increased from 39% in 1960 higher than 80% in 2004 [1]. Radiotherapy (RT) is a fundamental part of the multimodality treatment applied to achieve local (LC) and regional contro ...
Calculating posterior probability of the maximum contrast using proc iml
... Suppose that a dose-response clinical trial consisting of several doses of a compound is conducted to investigate dose-response relationship with the objective to determine a dose-response pattern. Pre-study information with respect to response pattern is not precise prior to the clinical trial in g ...
... Suppose that a dose-response clinical trial consisting of several doses of a compound is conducted to investigate dose-response relationship with the objective to determine a dose-response pattern. Pre-study information with respect to response pattern is not precise prior to the clinical trial in g ...
[Product Monograph Template
... cardiac defects) and rabbits (i.e. increased post-implantation loss and a small number of fetuses with ectrodactylia) at exposure levels comparable to the clinical exposure (based on AUC). The potential risk for humans is unknown. Therefore, LANCORATM is contraindicated during pregnancy (see CONTRAI ...
... cardiac defects) and rabbits (i.e. increased post-implantation loss and a small number of fetuses with ectrodactylia) at exposure levels comparable to the clinical exposure (based on AUC). The potential risk for humans is unknown. Therefore, LANCORATM is contraindicated during pregnancy (see CONTRAI ...
ICH M3 (R2): Non-Clinical Safety Studies for the Conduct of Human
... at least 2 weeks in at least one species (generally rodents) have been completed with careful histopathological evaluation of the ovary. In the EU, studies of 6 month duration in non-rodents are considered acceptable. However, where studies with a longer duration have been conducted, it would not be ...
... at least 2 weeks in at least one species (generally rodents) have been completed with careful histopathological evaluation of the ovary. In the EU, studies of 6 month duration in non-rodents are considered acceptable. However, where studies with a longer duration have been conducted, it would not be ...
Racemic beta-blockers - Krause und Pachernegg
... l-enantiomers being markedly more potent than the respective d-forms. Therefore, and in clear contrast to the racemic betablockers widely used in therapeutics, the human organism stereoselectively synthesises and uses the active enantiomers, ie, l-epinephrine and l-norepinephrine. Hence, it is not s ...
... l-enantiomers being markedly more potent than the respective d-forms. Therefore, and in clear contrast to the racemic betablockers widely used in therapeutics, the human organism stereoselectively synthesises and uses the active enantiomers, ie, l-epinephrine and l-norepinephrine. Hence, it is not s ...
Paracetamol and Ibuprofen for Paediatric Pain and Fever
... ibuprofen clearance, the clinical consequences remain to be elucidated.15 Elevation of liver transaminases following exposure to ibuprofen have been reported, with levels returning to normal following discontinuation. 16 Ibuprofen’s capacity to bind plasma proteins raises several issues, such as whe ...
... ibuprofen clearance, the clinical consequences remain to be elucidated.15 Elevation of liver transaminases following exposure to ibuprofen have been reported, with levels returning to normal following discontinuation. 16 Ibuprofen’s capacity to bind plasma proteins raises several issues, such as whe ...
Driving Ability in Patients with Severe Chronic Low Back
... severe low back or osteoarthritis pain. After at least 6 weeks of dose stability, patients continued taking tapentadol PR (50–250 mg twice daily) and could take supplemental immediate-release tapentadol 50 mg, except on the day before or day of the driving test (before the test). Pain intensity was ...
... severe low back or osteoarthritis pain. After at least 6 weeks of dose stability, patients continued taking tapentadol PR (50–250 mg twice daily) and could take supplemental immediate-release tapentadol 50 mg, except on the day before or day of the driving test (before the test). Pain intensity was ...
achieving treatment optimization with sildenafil citrate
... underlying, serious diseases, and can have a significant effect on a patient’s quality of life. Because ED and cardiovascular disease share many common risk factors, men seeing a primary care physician (PCP) for their ED should be screened for underlying cardiovascular disease. Conversely, men seeki ...
... underlying, serious diseases, and can have a significant effect on a patient’s quality of life. Because ED and cardiovascular disease share many common risk factors, men seeing a primary care physician (PCP) for their ED should be screened for underlying cardiovascular disease. Conversely, men seeki ...
view article pdf
... Legal Disclaimer: The CE provider uses reasonable care in selecting and providing content that is accurate. The CE provider does not represent that the instructional materials are error-free or that the content or materials are comprehensive. Any opinions expressed in the materials are those of the ...
... Legal Disclaimer: The CE provider uses reasonable care in selecting and providing content that is accurate. The CE provider does not represent that the instructional materials are error-free or that the content or materials are comprehensive. Any opinions expressed in the materials are those of the ...
organisms was completely prevented and since it is an
... patients themselves did not know that the series being controlled and were under the impression ...
... patients themselves did not know that the series being controlled and were under the impression ...
Synergistic Interaction between the Two Mechanisms of Action of
... such applications the individual compounds are administered in graded doses by themselves and subsequently in dose combinations that are often fixed-ratio combinations of the two compounds (Tallarida, 2001, 2006, 2007; Tallarida et al., 2003; Tallarida and Raffa, 2010). In the present case, we were ...
... such applications the individual compounds are administered in graded doses by themselves and subsequently in dose combinations that are often fixed-ratio combinations of the two compounds (Tallarida, 2001, 2006, 2007; Tallarida et al., 2003; Tallarida and Raffa, 2010). In the present case, we were ...
Minor Tranquillizers – Use and Abuse
... their patients. On the other hand, many medical practitioners, or even some pharmacies, may find the administrative side of using the benzodiazepines so tedious and troublesome that they begin to use less in quantity, in kinds, or in strength. Meanwhile, some patients may not be able to get their pr ...
... their patients. On the other hand, many medical practitioners, or even some pharmacies, may find the administrative side of using the benzodiazepines so tedious and troublesome that they begin to use less in quantity, in kinds, or in strength. Meanwhile, some patients may not be able to get their pr ...
Classification of Drug Hypersensitivity into Allergic, p
... clinical phenotypes is the basis for the (revised) Coombs and Gell [13] classification [14]. The immediate-appearing symptoms (urticaria, anaphylaxis) were classified as being due to IgE and mast cell degranulation, and the delayed-appearing symptoms (exanthems, hepatitis) as dependent on T-cell act ...
... clinical phenotypes is the basis for the (revised) Coombs and Gell [13] classification [14]. The immediate-appearing symptoms (urticaria, anaphylaxis) were classified as being due to IgE and mast cell degranulation, and the delayed-appearing symptoms (exanthems, hepatitis) as dependent on T-cell act ...
EFFECT OF POLOXAMER 188 ON IN VITRO DISSOLUTION
... indicates the solvent properties of poloxamer 188 for the drug. Poloxamer 188 causes a decrease of interfacial tension between the drug and dissolution medium. These results could be explained that the reduction in crystallinity of drug led to a decrease of the energy required in the dissolving proc ...
... indicates the solvent properties of poloxamer 188 for the drug. Poloxamer 188 causes a decrease of interfacial tension between the drug and dissolution medium. These results could be explained that the reduction in crystallinity of drug led to a decrease of the energy required in the dissolving proc ...
arsenic trioxide - Cancer Care Ontario
... and continue for at least 3 days or longer until resolution. Hold arsenic trioxide treatment for patients who develop severe APL differentiation syndrome. Most cases of elevated transaminases have been reported to resolve without interruption of treatment. Although most cases of peripheral neurop ...
... and continue for at least 3 days or longer until resolution. Hold arsenic trioxide treatment for patients who develop severe APL differentiation syndrome. Most cases of elevated transaminases have been reported to resolve without interruption of treatment. Although most cases of peripheral neurop ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.