FROM DISULFIRAM TO ANTABUSE: THE INVENTION OF A DRUG
... was also known in the Swedish rubber boot industry, without any one in Sweden suggesting its possible use as a drug against alcoholism (8). It is also relevant to point out that since the early years of the twentieth century it had been known that cyanamides produce hypersensitivity to alcohol in wo ...
... was also known in the Swedish rubber boot industry, without any one in Sweden suggesting its possible use as a drug against alcoholism (8). It is also relevant to point out that since the early years of the twentieth century it had been known that cyanamides produce hypersensitivity to alcohol in wo ...
triumeq - GSK Source
... who have stopped abacavir for reasons other than symptoms of hypersensitivity have also experienced life-threatening reactions within hours of reinitiating abacavir therapy. Therefore, reintroduction of TRIUMEQ, or any other abacavir-containing product, is recommended only if medical care can be re ...
... who have stopped abacavir for reasons other than symptoms of hypersensitivity have also experienced life-threatening reactions within hours of reinitiating abacavir therapy. Therefore, reintroduction of TRIUMEQ, or any other abacavir-containing product, is recommended only if medical care can be re ...
formulation and delivery strategies
... Box 1 | Challenges in the design of injectable formulations The formulation and handling of biopharmaceutical drugs poses unique challenges that are not often experienced with small molecules. One of the key challenges is overcoming the instability of the biologic, which is caused by aggregation, de ...
... Box 1 | Challenges in the design of injectable formulations The formulation and handling of biopharmaceutical drugs poses unique challenges that are not often experienced with small molecules. One of the key challenges is overcoming the instability of the biologic, which is caused by aggregation, de ...
the meaning of medications: another look at compliance
... There have been a series of diverse studies suggesting that noncompliance is a result of some problem in doctor-patient interaction (see [IO]). Researchers have found higher compliance rates are associated with physicians giving explicit and appropriate instructions, more and clearer information, an ...
... There have been a series of diverse studies suggesting that noncompliance is a result of some problem in doctor-patient interaction (see [IO]). Researchers have found higher compliance rates are associated with physicians giving explicit and appropriate instructions, more and clearer information, an ...
Prescribing Information including Medication Guide
... Reconstituted XEOMIN is intended for intramuscular injection only. If proposed injection sites are marked with a pen, the product must not be injected through the pen marks; otherwise a permanent tattooing effect may occur. The number of injection sites is dependent upon the size of the muscle to be ...
... Reconstituted XEOMIN is intended for intramuscular injection only. If proposed injection sites are marked with a pen, the product must not be injected through the pen marks; otherwise a permanent tattooing effect may occur. The number of injection sites is dependent upon the size of the muscle to be ...
CHLOROMYCETIN CAPSULES
... thrombocytopenia, anemia, or any other hematologic findings attributable to chloramphenicol. However, it should be noted that such determinations do not exclude the possible later appearance of the irreversible type of bone marrow depression. 2. Repeated courses of the drug should be avoided if at a ...
... thrombocytopenia, anemia, or any other hematologic findings attributable to chloramphenicol. However, it should be noted that such determinations do not exclude the possible later appearance of the irreversible type of bone marrow depression. 2. Repeated courses of the drug should be avoided if at a ...
quality control lect..
... Not more than two of the individual weights deviate from the average weight by more than the percentage deviation shown in the table below, and none deviates by more than twice that percentage. ...
... Not more than two of the individual weights deviate from the average weight by more than the percentage deviation shown in the table below, and none deviates by more than twice that percentage. ...
The effects of herbal teas on drug permeability
... Inhibition and induction of the metabolic enzyme CYP can also affect the pharmacokinetics of treatment with these medications. This should be of concern since CYP3A4 is associated with the metabolism of many drugs. It is well known that there is overlap in the substrate specificities of CYP3A4 and P ...
... Inhibition and induction of the metabolic enzyme CYP can also affect the pharmacokinetics of treatment with these medications. This should be of concern since CYP3A4 is associated with the metabolism of many drugs. It is well known that there is overlap in the substrate specificities of CYP3A4 and P ...
RECENT TECHNOLOGIES FOR THE TASTE MASKING OF BITTER
... employed for use as taste masking agents for dosage forms that are not dissolved in water prior to administration. A chewable gum composition of bitter medicament was formulated to supply the medicament to oral cavity for local application or buccal absorption. It comprise a chewing base, an orally ...
... employed for use as taste masking agents for dosage forms that are not dissolved in water prior to administration. A chewable gum composition of bitter medicament was formulated to supply the medicament to oral cavity for local application or buccal absorption. It comprise a chewing base, an orally ...
aldactone
... Management of Cirrhosis: Although high doses of ALDACTONE are required to treat edema and ascites in patients with cirrhosis, the drug dosage may be decreased before diuresis is complete to avoid the possibility of dehydration. Neurologic: Lithium generally should not be given with diuretics (See D ...
... Management of Cirrhosis: Although high doses of ALDACTONE are required to treat edema and ascites in patients with cirrhosis, the drug dosage may be decreased before diuresis is complete to avoid the possibility of dehydration. Neurologic: Lithium generally should not be given with diuretics (See D ...
Development of Discriminative Dissolution Media for Marketed
... he release of active pharmaceutical ingredient from drug product, the dissolution of the drug under physiological conditions, and the permeability across the gastrointestinal tract determine drug absorption. Based on this, in vitro dissolution may be vital in assessing in vivo performance. Dissoluti ...
... he release of active pharmaceutical ingredient from drug product, the dissolution of the drug under physiological conditions, and the permeability across the gastrointestinal tract determine drug absorption. Based on this, in vitro dissolution may be vital in assessing in vivo performance. Dissoluti ...
Geriatric Pain Management: 101
... insufficiency, chronic alcohol abuse or dependence. Maximum daily dose 3 gm/daily. For chronic daily use consider max daily dose of 2 gm/daily. ...
... insufficiency, chronic alcohol abuse or dependence. Maximum daily dose 3 gm/daily. For chronic daily use consider max daily dose of 2 gm/daily. ...
stromectol
... In children less than 6 years of age, tablets should be crushed before swallowing. Treatment is one single oral dose taken with water on an empty stomach. The dose may be taken at any time of the day, but no food should be taken within two hours before or after administration, as the influence of fo ...
... In children less than 6 years of age, tablets should be crushed before swallowing. Treatment is one single oral dose taken with water on an empty stomach. The dose may be taken at any time of the day, but no food should be taken within two hours before or after administration, as the influence of fo ...
The paradox of drug taking: The role of the aversive... ⁎ Anthony L. Riley
... influences on the aversive effects of drugs include drug-induced taste aversion learning in transgenic mice and quantitative trait loci mapping relative to aversions and drug intake (for reviews, see [10,32]). On area that has received considerable attention in aversion learning is the analysis of in ...
... influences on the aversive effects of drugs include drug-induced taste aversion learning in transgenic mice and quantitative trait loci mapping relative to aversions and drug intake (for reviews, see [10,32]). On area that has received considerable attention in aversion learning is the analysis of in ...
Drug Dosing Adjustments in Patients with Chronic Kidney
... errors are common in patients with renal impairment and can cause adverse effects and poor outcomes. Dosages of drugs cleared renally should be adjusted according to creatinine clearance or glomerular filtration rate and should be calculated using online or electronic calculators. Recommended method ...
... errors are common in patients with renal impairment and can cause adverse effects and poor outcomes. Dosages of drugs cleared renally should be adjusted according to creatinine clearance or glomerular filtration rate and should be calculated using online or electronic calculators. Recommended method ...
Sibutramine - Practical Diabetes
... Key points • Sibutramine is a drug that can be used to facilitate weight loss in obese patients, including those with type 2 diabetes mellitus • The response to treatment should be reviewed on a regular basis and the drug discontinued if no efficacy is demonstrated • Although side effects of increas ...
... Key points • Sibutramine is a drug that can be used to facilitate weight loss in obese patients, including those with type 2 diabetes mellitus • The response to treatment should be reviewed on a regular basis and the drug discontinued if no efficacy is demonstrated • Although side effects of increas ...
Herbal Medicine: The Knowledge Base Grous
... and Education Act (1994) • Removed supplements from food additive regulations • Burden of proof on FDA ...
... and Education Act (1994) • Removed supplements from food additive regulations • Burden of proof on FDA ...
ASHP Technical Assistance Bulletin on Compounding Nonsterile
... is not available, the pharmacist should use professional judgment and may have to obtain the highest-grade chemical possible. Chemical grades that may be considered in this situation are ACS grade (meeting or exceeding specifications listed for reagent chemicals by the American Chemical Society) and ...
... is not available, the pharmacist should use professional judgment and may have to obtain the highest-grade chemical possible. Chemical grades that may be considered in this situation are ACS grade (meeting or exceeding specifications listed for reagent chemicals by the American Chemical Society) and ...
Antifungal drugs and resistance: Current concepts
... Recently, clinical failure and relapses have been observed in patients treated with antifungals. Drug resistance has become an important problem leading to significant negative social, psychological, and occupational health effects and quality of life. Early recognition and treatment is essential to ...
... Recently, clinical failure and relapses have been observed in patients treated with antifungals. Drug resistance has become an important problem leading to significant negative social, psychological, and occupational health effects and quality of life. Early recognition and treatment is essential to ...
... extensive work-up for such abnormalities before the proper diagnosis was suggested. We interpret this as evidence that many physicians are unfamiliar with ergoline-induced pleuropulmonary changes. Notably, the pleuropulmonary pattern of adverse reaction induced by ergolines is quite distinctive, as ...
... included relief of pain, itching, or burning. Cloderm Cream statistically significantly out-performed its vehicle base in both objective and subjective measures at all time points. It is interesting to note, however, that there was an appreciable level of patient satisfaction with the vehicle base a ...
... Buela-Casal (1996) did not find any residual effects with diazepam, using a maintained attention task (Toulose Piéron test) and Stanford´s somnolence scale. A possible explanation for these results could be that benzodiazepine elimination half-life has not much relation with the psychophysiological ...
Calcium Channel Blocker Toxicity and Treatment Issues In This Issue
... There is more good news! Three of our Specialists in Poison Information (SPI) took and passed the Certified Specialist in Poison Information (CSPI) examination in May of this year. Currently, 75% of the UPCC’s specialists in poison information are CSPI’s. The CSPI Exam is administered by the America ...
... There is more good news! Three of our Specialists in Poison Information (SPI) took and passed the Certified Specialist in Poison Information (CSPI) examination in May of this year. Currently, 75% of the UPCC’s specialists in poison information are CSPI’s. The CSPI Exam is administered by the America ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.