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Vagus Nerve Stimulation - UnitedHealthcareOnline.com
Vagus Nerve Stimulation - UnitedHealthcareOnline.com

... nerve. The effect of the AutoStim Mode on reducing the number of seizures is being evaluated. CLINICAL EVIDENCE Epilepsy In a Cochrane review, Panebianco et al. (2015) evaluated the current evidence for the efficacy and tolerability of vagus nerve stimulation when used as an adjunctive treatment for ...
Postoperative nausea and vomiting
Postoperative nausea and vomiting

... effects of dexamethasone, such as pain relief or reduced systemic inflammatory reaction, in addition to PONV prevention. However, considering the relation between dexamethasone and the possibility of wound infection, whether dexamethasone can be safely used in cases of hip or knee surgery that are a ...
Med-Psych Drug-Drug Interactions Update Triptans
Med-Psych Drug-Drug Interactions Update Triptans

... et al., no significant clinical events occurred, and the authors suggested that no dose adjustment was necessary. These modest findings reflect almotriptan’s multiple avenues of metabolism, which allow the drug to be biotransformed despite “roadblocks” at some of its metabolic sites. We could not fi ...
SENATE BILL 15-053 BY SENATOR(S) Aguilar, Crowder, Guzman
SENATE BILL 15-053 BY SENATOR(S) Aguilar, Crowder, Guzman

... PRACTICE NURSE WHO HAS PRESCRIPTIVE AUTHORITY PURSUANT TO SECTION 12-38-111.6, C.R.S., physician assistant, or pharmacist; or (e) "Opiate-related drug overdose event" means an acute condition, including but not limited to a decreased level of consciousness or respiratory depression, resulting THAT: ...
Vandetanib - Therapeutic Goods Administration
Vandetanib - Therapeutic Goods Administration

... intravenous (IV) formulation could be formulated. Nevertheless, the sponsor argued that an IV formulation would have tolerability problems (inflammation at the infusion site and QT prolongation concerns). Given the very close similarity of the 100 mg and 300 mg tablet formulations, bioequivalence of ...
51th ICAAC Chicago, IL September 17
51th ICAAC Chicago, IL September 17

... relative to wild-type (nonmutant) virus of 1.4 +/- 0.8 [1]. In contrast, raltegravir and elvitegravir had more than a 260-fold change in EC50 against these recombinant viruses. These investigators also tested 224436 against HIV-1 isolates from 100 US and 100 European people naive to antiretroviral t ...
Development and Validation of Gas Chromatographic Method for
Development and Validation of Gas Chromatographic Method for

... Residual Solvent should either be absent in the product or should be present only below acceptable levels [2-3]. Literature [47] points out development of various Headspace GC methods for the identification of organic volatile impurities in pharmaceuticals drugs. However, we could not find a single ...
simvastatin tablets usp - Lupin Pharmaceuticals, Inc.
simvastatin tablets usp - Lupin Pharmaceuticals, Inc.

... activity or fenofibric acid; there was a modest reduction (approximately 35%) of simvastatin acid which was not considered clinically significant (see WARNINGS, Myopathy/Rhabdomyolysis and PRECAUTIONS, Drug Interactions). Simvastatin is a substrate for CYP3A4 (see PRECAUTIONS, Drug Interactions). Gr ...
12146005
12146005

... 2008). A conventional dosage form of the drug usually do not maintain the therapeutic range of plasma drug level for extended period of time and often require multiple-dose therapy. This approach of repetitive dosing, however, exhibits some drawbacks such as frequent administration especially for dr ...
Denosumab: A New Therapy for Osteoporosis
Denosumab: A New Therapy for Osteoporosis

... Teriparatide: Teriparatide (Forteo®) is a human recombinant peptide of the N-terminal fragment of human parathyroid hormone (PTH).31 Teriparatide is FDA-approved for the treatment of osteoporosis in postmenopausal women.32 It is also approved for the treatment of primary or hypogonadal osteoporosis ...
enclosure - Rajiv Gandhi University of Health Sciences
enclosure - Rajiv Gandhi University of Health Sciences

... accomplish this by two mechanisms: histamine released by ECL cells in the stomach is ...
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET CONTAINING AMLODIPINE  Research Article
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET CONTAINING AMLODIPINE Research Article

... (equivalent to 10 mg of drug) were dispersed in medium. Aliquots of 10 ml from the dissolution medium were withdrawn at different time intervals and replenished by an equal volume of fresh dissolution medium. The samples were filtered through whatman filter paper and analyzed for amlodipine besylate ...
Role of azathioprine in preventing recurrences in a patient of
Role of azathioprine in preventing recurrences in a patient of

... gradually increased in size. Within 2 years of the appearance of these lesions, she developed multiple, tender, erythematous nodules on both the extremities associated with fever, joint pain and redness of both eyes. She was diagnosed to have multibacillary leprosy, and started on (WHO) MB MDT by a ...
Document
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... formation in uveitis (inflammation of the middle layer of the eye ) and iritis. The longer-lasting preparations, especially homatropine, are valuable for this indication ...
Product Monograph - AstraZeneca Canada
Product Monograph - AstraZeneca Canada

... In the case of acute or rapidly worsening dyspnea, a doctor should be consulted immediately. Increasing use of β2-agonists to control symptoms of bronchial obstruction, especially administration on a regular basis or in high amounts, indicates deterioration of asthma control. Under these conditions, ...
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF

... Patients should be instructed in the proper use of the inhaler and their technique checked, to ensure that the active substance reaches the target areas within the lungs. The management of asthma should normally follow a stepwise programme, and the patient’s response should be monitored clinically a ...
Bulletin #106
Bulletin #106

... REQUIREMENTS FOR DRUGS FOR NON-APPROVED INDICATIONS Occasionally drugs are required for non-approved indications on a case by case basis. In order to conduct a timely review of these requests the drug review committees request the following information be provided by the prescriber: ● the disease or ...
Haloperidol and Slot Machine Gambling
Haloperidol and Slot Machine Gambling

... prospective relationship between Payoff and Bet Size on consecutive trials, along with potential moderating effects of Cumulative Winnings and Phase of game (early/late) under drug and placebo. Payoff predicted Bet Size on the next trial regardless of other factors, consistent with an instrumental v ...
Central Nervous System Activity Studies of Baptisia tinctoria (L.) R
Central Nervous System Activity Studies of Baptisia tinctoria (L.) R

... Abstract. The present investigations were undertaken with a view to evaluate Baptisia tinctoria roots (Wild Indigo; family – Fabaceae) systematically for neuropharmacological activities. The methanol extract (ME) of plant was prepared by extracting properly identified plant in a Soxhlet apparatus wi ...
Pediatric/Neonatal Doses of Antiretroviral Drugs
Pediatric/Neonatal Doses of Antiretroviral Drugs

... May open capsule and give in small portion of food or 5-10 mL cool tap water. Should not be administered with zidovudine due to poor antiretroviral effect. Combination of d4T and ddI is not recommended (unless benefits outweigh the risks) due to overlapping toxicities. Tenofovir (VIREAD®, TDF) Neona ...
23 2.1 INTRODUCTION TO SOLID DISPERSION: The enhancement
23 2.1 INTRODUCTION TO SOLID DISPERSION: The enhancement

... Enhancement in solubility and dissolution rate of poorly soluble drugs is related to the ability of carrier matrix to improve local drug solubility as well as wettability[107]. c) Wettability and Dispersibility: The carrier material may also have an enhancing effect on the wettability and dispersibi ...
Assessment and management of chronic pain in the older adult
Assessment and management of chronic pain in the older adult

... to the safe use of analgesics and other psychoactive drugs. Dosing of acetaminophen should be limited to avoid liver toxicity, and topical analgesics are preferred for focal pain. Full-dose nonsteroidal anti-inflammatory drugs should not be used for more than short periods, in order to avoid gastroi ...
Triumeq - ViiV Healthcare
Triumeq - ViiV Healthcare

... Patients who carry the HLA-B*5701 allele are at high risk for experiencing a hypersensitivity reaction to abacavir. All patients should be screened for the HLA-B*5701 allele prior to initiating therapy with abacavir or reinitiation of abacavir therapy unless HLA-B*5701 information is available. Do n ...
Marijuana use: implications for life insurance Marianne E Cumming
Marijuana use: implications for life insurance Marianne E Cumming

... at 15 to 30 minutes and last up to 4 hours. An estimated 2 to 3 mg of inhaled THC may produce psychoactive effects. Non-medical (recreational) use commonly involves smoking of the dried plant. THC content in the dried plant has increased compared to 40 years ago and may range from 1 to 20%. One join ...
Thymidylate Synthase Inhibitors
Thymidylate Synthase Inhibitors

... analogue. However, such studies are difficult to perform; interpretation of the data has in the past produced conflicting results; and this issue has been a subject of considerable debate (27, 36). TS Catalytic Activity. Methylene tetrahydrofolate is the source of the methyl group to be transferred ...
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Bad Pharma



Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.
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