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NAME: Carbamazepine (Tegretol)
NAME: Carbamazepine (Tegretol)

... Matzke GR. Wells BG. Posey LM. 2005. New York. pgs 1023-1048. ...
Synthesis of polyphosphazenes with different side
Synthesis of polyphosphazenes with different side

... a Visiting Professor at University of Washington, Seattle, WA, USA. He currently holds the title of professor and doctor tutor at Zhejiang University. His research interests mainly focus on functional polymers, nanomaterials, and novel catalysts for olen polymerization. ...
Suggestion from clinicians
Suggestion from clinicians

... No study provided first or second tier evidence for any outcome. Only one study reported our primary outcome of people with at least 50% reduction in pain. There was no indication that either nortriptyline or gabapentin was more effective in postherpetic neuralgia (very low quality evidence). Two st ...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF DONEPEZIL HYDROCHLORIDE  TABLETS BY RP­HPLC  Research Article  T. SENTHIL KUMAR
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF DONEPEZIL HYDROCHLORIDE  TABLETS BY RP­HPLC  Research Article  T. SENTHIL KUMAR

... 2, 3­dihydro­5, 6­dimethoxy­2­[[1­(phenyl methyl)­4­piperidinyl] methyl]­1H­inden­1­one hydrochloride USP‐Donepezil  hydrochloride  RS  (142057‐77‐0)  is  a  cholinesterase  inhibitor  used  to  treat  Alzheimer's  disease  where  neurons  are  damaged  in  part  of  the  brain  that  is  involved  ...
0.9% Sodium Chloride Injection, USP
0.9% Sodium Chloride Injection, USP

... Clinical studies of 0.9% Sodium Chloride injection, USP did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in the responses between elderly and younger ...
FLOVENT DISKUS (fluticasone propionate inhalation
FLOVENT DISKUS (fluticasone propionate inhalation

... fatal course in susceptible children or adults using corticosteroids. In such children or adults who have not had these diseases or been properly immunized, particular care should be taken to avoid exposure. How the dose, route, and duration of corticosteroid administration affect the risk of develo ...
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington

... taking over-the-counter or prescribed medications—there are many drug interactions  Assess liver function before beginning therapy  Teach patient to take medications every night on a continuous schedule, even if symptoms improve ...
Acyclovir Tablets USP Acyclovir Tablets USP
Acyclovir Tablets USP Acyclovir Tablets USP

... nephrotoxic agents since this may increase the risk of renal dysfunction and/or the risk of reversible central nervous system symptoms such as those that have been reported in patients treated with intravenous acyclovir. Adequate hydration should be maintained. ...
http://www.fda.gov/downloads/Drugs/G.../ucm073389.pdf
http://www.fda.gov/downloads/Drugs/G.../ucm073389.pdf

... more than (≤) the identification threshold (Attachment 1) for any unspecified degradation product and an acceptance criterion for total degradation products should also be included. For a given degradation product, its acceptance criterion should be established by taking into account its acceptance ...
Inconspicuous and Miscalculated Opioid Risks
Inconspicuous and Miscalculated Opioid Risks

... Methadone 40mg; Oxycodone 120mg;  Hydromorphone 48mg Rennick A, Atkinson T, Cimino N, McPherson ML, Fudin J. Variability in Opioid  Equivalence. (Poster: 9‐236). American Society of Health‐System Pharmacists (ASHP)  2013 Midyear Clinical Meeting and Exhibition in Orlando FL. ...
Inhaled formoterol  during  one  year  in ... a  comparison  with  salbutamol P.
Inhaled formoterol during one year in ... a comparison with salbutamol P.

... In the previous study no evidence was found of tachyphylaxis to the bronchodilating effect of betaagonists after formoterol treatment. Similarly, WALIJN et al. [11) found no evidence of tachyphylaxis after one month of treatment with formotero!. The same conclusion must be drawn from the present stu ...
19 Improving  the  Oral  Absorption  of S-SEDDS Formulations
19 Improving the Oral Absorption of S-SEDDS Formulations

... SEDDS and S-SEDDS are self-emulsifying formulations of poorly soluble drugs that contain both a surfactant and lipid, along with a co-solvent, and they are usually formulated in gelatin capsules. Dilution of SEDDS or S-SEDDS formulations with water results in the generation of a microemulsion with a ...
nausea and vomiting - KSU Faculty Member websites
nausea and vomiting - KSU Faculty Member websites

... Figure 3. Phylogenetic trees for human dopamine (D) and serotonin (5-HT) G protein–coupled receptors. A, Phenogram representing genetic distances. This analysis supports the suggestion that dopamine, 5-HT1, 5-HT5, 5-HT7, and 5-HT4 receptors evolved from a common ancestor after the initial divergence ...
HIGH-MOLECULAR WEIGHT OF BIOPOLYMER
HIGH-MOLECULAR WEIGHT OF BIOPOLYMER

... for glass + uronic acid, and it was discovered and investigated in 1934 by Karl Meyer and his colleague John Palmer. Firstly, they isolated a previously unknown chemical substance from the vitreous body of cows’ eyes as an acid form but it behaved like a salt in physiological conditions (sodium hyal ...
Sofosbuvir: A New Oral Once-Daily Agent for The Treatment of
Sofosbuvir: A New Oral Once-Daily Agent for The Treatment of

... To determine whether a longer treatment duration would have an effect on SVR, 201 patients received either SOF+RBV for 12 weeks followed by four weeks of placebo or a full 16 weeks of SOF+RBV. Among the patients who were enrolled in the study, 34% had HCV genotype 2 infection and 63% had genotype 3 ...
Aalborg Universitet
Aalborg Universitet

... Discussion: Pharmacotherapy is a mainstay in chronic pain treatment. Antidepressants, anticonvulsants and opioids are frequently prescribed in a “trial and error” fashion, without knowledge however, which drug suits best which patient. The present study addresses the important need to translate rece ...
SPINRAZA READINESS KIT
SPINRAZA READINESS KIT

... Obtaining approval for your patient’s treatment for spinal muscular atrophy (SMA) often requires your practice or facility to complete several steps, including conducting a thorough Benefit Investigation to determine if an authorization and/or exception is needed prior to treatment approval. In addi ...
Vancomycin Assay - Beckman Coulter
Vancomycin Assay - Beckman Coulter

... Note: To convert from µg/mL to µmol/L vancomycin, multiply by 0.67. ...


... -2Similarly, the incidence of adverse effects associated with LORATADINE (CLARITIN*) Syrup has been comparable to that of placebo. In controlled pediatric clinical trials, the incidence of treatment-related headache, sedation and nervousness, which were rarely reported events, was similar to that o ...
Country Health SA Local Health Network :: SA Health
Country Health SA Local Health Network :: SA Health

... One of the major causes of medication errors is the ongoing use of potentially dangerous abbreviations and dose expressions.1 This is a critical patient safety issue. A study to identify and quantify prescribing errors in a large US urban teaching hospital found that 29% of prescriptions contained a ...
HIGHLIGHTS OF PRESCRIBING INFORMATION discontinuation (5.4, 9.2)
HIGHLIGHTS OF PRESCRIBING INFORMATION discontinuation (5.4, 9.2)

... Complex behaviors such as “sleep-driving” (i.e., driving while not fully awake after ingestion of a sedative-hypnotic, with amnesia for the event) have been reported with sedative-hypnotics, including zolpidem. These events can occur in sedative-hypnotic-naive as well as in sedativehypnotic-experien ...
1. Immediate 2. Delayed 3. Cumulative
1. Immediate 2. Delayed 3. Cumulative

... ©NHG Holford, 2014, all rights reserved. ...
brufen sustained release (sr)
brufen sustained release (sr)

... Combination use of ACE inhibitors or angiotensin receptor antagonists, antiinflammatory drugs and thiazide diuretics: The use of an ACE inhibiting drug (ACE-inhibitor or angiotensin receptor antagonist, an antiinflammatory drug (NSAID or COX-2 inhibitor) and thiazide diuretic at the same time increa ...
Antiplatelet Drugs - OSU Center for Continuing Medical Education
Antiplatelet Drugs - OSU Center for Continuing Medical Education

... obtained has been modest when examined in randomized clinical trials.14 In addition, some patients with an inadequate response to aspirin may also have an inadequate response to clopidogrel (i.e., dual “resistance”), which may be particularly prevalent among women and diabetics.96 The term “aspirin ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008.
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008.

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Bad Pharma



Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.
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