Top 300 Drug List
... Pregnancy category D (Cat C during first trimester). Drugs that act on the ReninAngiotensin system may result in injury and death to the developing fetus. D/C as soon as possible once pregnancy is detected or in a female who desires conception. May cause a dry cough, first-dose hypotension (especial ...
... Pregnancy category D (Cat C during first trimester). Drugs that act on the ReninAngiotensin system may result in injury and death to the developing fetus. D/C as soon as possible once pregnancy is detected or in a female who desires conception. May cause a dry cough, first-dose hypotension (especial ...
international journal of universal pharmacy and bio sciences
... cyclooxygenase (COX), recent findings suggest that it is highly selective for COX-2.Because of its selectivity for COX-2 it does not significantly inhibit the production of the pro-clotting thromboxanes [1]. Pamabrom is a xanthine derivative drug and it might increase the renal blood flow by virtue ...
... cyclooxygenase (COX), recent findings suggest that it is highly selective for COX-2.Because of its selectivity for COX-2 it does not significantly inhibit the production of the pro-clotting thromboxanes [1]. Pamabrom is a xanthine derivative drug and it might increase the renal blood flow by virtue ...
Hepatotoxicity of Antituberculosis Therapy
... of tuberculosis (TB) infection. The liver has a central role in drug metabolism and detoxification, and is consequently vulnerable to injury. The pathogenesis and types of DILI are presented, ranging from hepatic adaptation to hepatocellular injury. Knowledge of the metabolism of anti-TB medications ...
... of tuberculosis (TB) infection. The liver has a central role in drug metabolism and detoxification, and is consequently vulnerable to injury. The pathogenesis and types of DILI are presented, ranging from hepatic adaptation to hepatocellular injury. Knowledge of the metabolism of anti-TB medications ...
EryTab PI 03-A919-R2 Rev. July 2013 Final2
... not be treatable by ERY-TAB® or other antibacterial drugs in the future. Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stom ...
... not be treatable by ERY-TAB® or other antibacterial drugs in the future. Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stom ...
Vasoconstrictors: Myths and Realities
... eight-hour efficacy and duration of action of 0.025% oxymetazoline, the goldstandard vasoconstrictor approved for use every six hours. Surprisingly, for the only vasoconstrictor with claims of being long-acting, no significant effect on prevention of redness was shown at any time point. This lack of ...
... eight-hour efficacy and duration of action of 0.025% oxymetazoline, the goldstandard vasoconstrictor approved for use every six hours. Surprisingly, for the only vasoconstrictor with claims of being long-acting, no significant effect on prevention of redness was shown at any time point. This lack of ...
Hydrocortisone -Iodoquinol Cream 1% 1%
... dressings. Iodoquinol may be absorbed through the skin and interfere with thyroid function tests. If such tests are contemplated, wait at least one month after discontinuance of therapy to perform these tests. The ferric chloride test for phenylketonuria (PKU) can yield a false positive result if io ...
... dressings. Iodoquinol may be absorbed through the skin and interfere with thyroid function tests. If such tests are contemplated, wait at least one month after discontinuance of therapy to perform these tests. The ferric chloride test for phenylketonuria (PKU) can yield a false positive result if io ...
Oral midazolam – grapefruit juice drug interaction
... available, some practitioners continue to use the IV midazolam as an oral medication. If the injectible form of midazolam is administered orally, its bitter taste requires the use of a flavoring agent. Grapefruit juice is contraindicated for this purpose as it inhibits cytochrome P450 (CYP) 3A4. CYP ...
... available, some practitioners continue to use the IV midazolam as an oral medication. If the injectible form of midazolam is administered orally, its bitter taste requires the use of a flavoring agent. Grapefruit juice is contraindicated for this purpose as it inhibits cytochrome P450 (CYP) 3A4. CYP ...
Poisoning.Comm Volume 1 , Issue 4 (OCT 2006)
... Laboratory studies show elevated PT and APTT that are corrected on a 1:1 mixing study with normal plasma; depleted levels of vitamin K-dependent clotting factors (factors II, VII, IX, X) and presence of superwarfarin in blood on special assays. Superwarfarin exposure should be suspected in patients ...
... Laboratory studies show elevated PT and APTT that are corrected on a 1:1 mixing study with normal plasma; depleted levels of vitamin K-dependent clotting factors (factors II, VII, IX, X) and presence of superwarfarin in blood on special assays. Superwarfarin exposure should be suspected in patients ...
Antiepileptic drugs for neuropathic pain and fibromyalgia
... depression or epilepsy can be very effective in some people with neuropathic pain. Our understanding of fibromyalgia (a condition of persistent, widespread pain and tenderness, sleep problems, and fatigue) is lacking, but fibromyalgia can respond to the same medicines as neuropathic pain. Antiepilep ...
... depression or epilepsy can be very effective in some people with neuropathic pain. Our understanding of fibromyalgia (a condition of persistent, widespread pain and tenderness, sleep problems, and fatigue) is lacking, but fibromyalgia can respond to the same medicines as neuropathic pain. Antiepilep ...
EA_QA47.7Methylphenidateinadults
... Evidence based guidelines for the pharmacological management of ADHD from the British Association for Psychopharmacology in 2014 recommend use of methylphenidate as a first line stimulant drug. Response to treatment should be assessed in follow up visits using rating scales to objectively check symp ...
... Evidence based guidelines for the pharmacological management of ADHD from the British Association for Psychopharmacology in 2014 recommend use of methylphenidate as a first line stimulant drug. Response to treatment should be assessed in follow up visits using rating scales to objectively check symp ...
Vancomycin Injection, USPFor Intravenous Use Only
... Specimens for bacteriologic cultures should be obtained in order to isolate and identify causative organisms and to determine their susceptibilities to vancomycin. To reduce the development of drug-resistant bacteria and maintain the effectiveness of vancomycin and other antibacterial drugs, vancomy ...
... Specimens for bacteriologic cultures should be obtained in order to isolate and identify causative organisms and to determine their susceptibilities to vancomycin. To reduce the development of drug-resistant bacteria and maintain the effectiveness of vancomycin and other antibacterial drugs, vancomy ...
National Conference on “Recent Advances in Herbal Drug Technology”
... Abstract: Tectona grandis Linn. (Verbenaceae) is an important medicinal plant commonly known as sagwan. The bark of this plant is acrid and useful in the treatment of bronchitis. Aim of the present study is to validate traditional asthmatic action of the bark. Dried powdered bark was extracted using ...
... Abstract: Tectona grandis Linn. (Verbenaceae) is an important medicinal plant commonly known as sagwan. The bark of this plant is acrid and useful in the treatment of bronchitis. Aim of the present study is to validate traditional asthmatic action of the bark. Dried powdered bark was extracted using ...
Liquid Chromatography/Tandem Mass Spectrometry Detection of
... molecular ion with an m/z of 515.2. The reconstructed ion chromatogram of the summed ions corresponding to specific fragments of the synthetic adduct revealed the presence of two NAPQI-CPF adducts in the reaction mixture (peaks 1 and 2 in Fig. 3A). Their product ion spectra were comparable with that ...
... molecular ion with an m/z of 515.2. The reconstructed ion chromatogram of the summed ions corresponding to specific fragments of the synthetic adduct revealed the presence of two NAPQI-CPF adducts in the reaction mixture (peaks 1 and 2 in Fig. 3A). Their product ion spectra were comparable with that ...
SIMULTANEOUS DETERMINATION OF CLOPIDOGREL AND
... selectivity. Initially methanol: water in the ratio of (80: 20) was tried but both the peaks merged. Later methanol: water: Acetonitrile in the ratio of (80: 10:10) was tried and it was found that both the peaks were well separated with acceptable resolution. Hence methanol: water: Acetonitrile in t ...
... selectivity. Initially methanol: water in the ratio of (80: 20) was tried but both the peaks merged. Later methanol: water: Acetonitrile in the ratio of (80: 10:10) was tried and it was found that both the peaks were well separated with acceptable resolution. Hence methanol: water: Acetonitrile in t ...
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS 1
... riociguat metabolism and excretion (see section 5.2). Concomitant administration of 400 mg once daily ketoconazole led to a 150% (range up to 370%) increase in riociguat mean AUC and a 46% increase in mean Cmax. Terminal half-life increased from 7.3 to 9.2 hours and total body clearance decreased fr ...
... riociguat metabolism and excretion (see section 5.2). Concomitant administration of 400 mg once daily ketoconazole led to a 150% (range up to 370%) increase in riociguat mean AUC and a 46% increase in mean Cmax. Terminal half-life increased from 7.3 to 9.2 hours and total body clearance decreased fr ...
Imodium Liquid, 2 mg/15 ml Oral Solution PL 15513/0182
... The use of loperamide as an anti-diarrhoeal agent is well established. The Clinical Overview details the pharmacokinetics of loperamide, providing relevant bibliographic references on the clinical pharmacology, efficacy and safety of loperamide hydrochloride. The applicant has given an adequate desc ...
... The use of loperamide as an anti-diarrhoeal agent is well established. The Clinical Overview details the pharmacokinetics of loperamide, providing relevant bibliographic references on the clinical pharmacology, efficacy and safety of loperamide hydrochloride. The applicant has given an adequate desc ...
INVITED REVIEW
... in one third3,33,51 and at times in more than one half of subjects.10 Although statistically significant differences may be demonstrated between active treatment and placebo arms, the actual clinical benefit of a 1- or 2-point drop on a 10-point visual analogue scale (VAS) for pain intensity may be a ...
... in one third3,33,51 and at times in more than one half of subjects.10 Although statistically significant differences may be demonstrated between active treatment and placebo arms, the actual clinical benefit of a 1- or 2-point drop on a 10-point visual analogue scale (VAS) for pain intensity may be a ...
clinical pharmacology of a urotensin-II receptor antagonist in Type 2
... resistance in order to lower blood glucose levels. The initial therapy is targeted towards improving tissue insulin sensitivity due to its fundamental role in the pathogenesis of Type 2 DM and its relationship to adverse cardiovascular outcomes. This includes life style intervention with modest exer ...
... resistance in order to lower blood glucose levels. The initial therapy is targeted towards improving tissue insulin sensitivity due to its fundamental role in the pathogenesis of Type 2 DM and its relationship to adverse cardiovascular outcomes. This includes life style intervention with modest exer ...
Bulletin #126
... NOTE: The Drug Identification Numbers (DINs) and Natural Product Numbers (NPNs) listed above have been benefits for Plan Three patients in the past. Effective September 20, 2010, these DINs and NPNs will be listed as Full Formulary benefits. Additional DINs and NPNs will not be added. ...
... NOTE: The Drug Identification Numbers (DINs) and Natural Product Numbers (NPNs) listed above have been benefits for Plan Three patients in the past. Effective September 20, 2010, these DINs and NPNs will be listed as Full Formulary benefits. Additional DINs and NPNs will not be added. ...
MAGNEX Injection
... Only small quantities of sulbactam and cefoperazone are excreted in human milk. Although both drugs pass poorly into breast milk of nursing mothers, caution should be exercised when sulbactam/cefoperazone is administered to a nursing mother. 4.7 Effects on Ability to Drive and Use Machines Clinical ...
... Only small quantities of sulbactam and cefoperazone are excreted in human milk. Although both drugs pass poorly into breast milk of nursing mothers, caution should be exercised when sulbactam/cefoperazone is administered to a nursing mother. 4.7 Effects on Ability to Drive and Use Machines Clinical ...
Adverse Effects of Antiepileptic Drugs
... is not universal, and a list of AED adverse effects may include terms taken from other sources, such as the World Health Organization’s Adverse Reaction Terminology (WHO-ART), International Classification of Diseases (ICD) 9, and ICD9-CM. To improve the terminology used to describe adverse effects, ...
... is not universal, and a list of AED adverse effects may include terms taken from other sources, such as the World Health Organization’s Adverse Reaction Terminology (WHO-ART), International Classification of Diseases (ICD) 9, and ICD9-CM. To improve the terminology used to describe adverse effects, ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.