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... The transport of metabolites requires energy involved in the pmf relevant to membrane-bound ATPase and the transport rate coefficient of metabolites, as shown in Figure S4. The calculation of transport energy is shown in Eq. S6, in which, pmf energy is 1/4 ATP, Vi is the producing rate of metabolic ...
عرض تقديمي من PowerPoint
عرض تقديمي من PowerPoint

...  Normally pseudocholinesterase hydrolysis S.C.,but some patients have abnormal plasma pseudocholinesterase which result in reduced metabolism of S.C and causes marked respiratory muscle paralysis and apnea. 3) Glucose-6-phosphate dehydogenase deficiency  Subject who deficient in G-6-DP may suffer ...
Metabolic Disorders
Metabolic Disorders

... Inborn Errors Of Metabolism (IEM) - A large group of hereditary biochemical diseases ...
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7.6 Enzymes – summary of mark schemes

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Drug Metabolism
Drug Metabolism

... • Twelve CYP gene families have been identified in humans, and the categories are based upon protein sequence homology • Most of the drug metabolizing enzymes are in CYP 1, 2, & 3 families . • CYPs have molecular weights of 45-60 kDa. • Frequently, two or more enzymes can catalyze the same type of o ...
Metanx in Type 2 Diabetes with Peripheral Neuropathy: A
Metanx in Type 2 Diabetes with Peripheral Neuropathy: A

...  Multiple centers (6 research clinics and hospitals throughout the US).  Patients were randomized to receive Metanx or placebo via a computer-generated randomization number list. LIMITATIONS:  Study was funded and conducted by Pamlab LLC, manufacturer of Metanx.  Bias appeared to be present in h ...
Herpetology 483/583
Herpetology 483/583

... the other 30-40% will focus on the last fourth of the course). For this cumulative material, we suggest you refer primarily to your previous exams and review sheets, as well as other course-related materials. Exam format will be similar to the first three exams, but perhaps slightly longer. ...
Herpetology 483/583
Herpetology 483/583

... the other 30-40% will focus on the last fourth of the course). For this cumulative material, we suggest you refer primarily to your previous exams and review sheets, as well as other course-related materials. Exam format will be similar to the first three exams, but perhaps slightly longer. Feeding, ...
Full Text  - Middle East Journal of Rehabilitation and Health
Full Text - Middle East Journal of Rehabilitation and Health

... cases of reported disease. Differential diagnosis of this disease includes propionic academia, methylmalonic aciduria (MMA) and poisoning with sodium valproate that should be refused before confirming the diagnosis. Existence of acidosis in the first two diseases, and normalizing glycine after disco ...
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Environmental Toxicology

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УДК: 547

... mTOR-dependent mechanism, signaling molecules and biological response modifiers, as well as precursors of a wide range of bio-regulators, which play a key role in the integration major metabolic fluxes [10-11]. Based on the positions of metabolomics, the amino acid pool of biological fluids and tiss ...
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Sample pages 2 PDF

... extensive data on gene expression patterns and metabolic activities that occur during nitrogen fixation. However, interpreting data from multiple high-throughput technologies (e.g., fluxomics, sequencing, microarrays, protein interaction data, and metabolomics) is not a trivial task due to the varyi ...
Chapter 1 - Research Explorer
Chapter 1 - Research Explorer

... treatment interventions. Treatment is in general aimed to reduce metabolic decompensation as well as to prevent neurological damage and developmental delay. The phenotypical presentation of the organic acidemias is broad. Isovaleric acidemia (IVA), which is the result of the defective isovaleryl-CoA ...
Apresentação do PowerPoint
Apresentação do PowerPoint

... campaign in the summer of 2014 , and also to verify the presence of toxic genes in the samples. This technique allows the identification of the major toxin biosynthesis genes not requiring axenic cultures, since such cultures are difficult to obtain (Choit al., 2008). This molecular approach subsequ ...
Proficiency Test Lyon 2008
Proficiency Test Lyon 2008

... - 10 splice site mutation in the L2HGDH gene (IVS6+1G>A) and her sister, who died at the age of 11 months after a first episode of gastroenteritis, had the same genotype. L-2-hydroxyglutaric aciduria is a rare inborn error of metabolism (> 100 patients described). The biochemical diagnosis relies o ...
Medical Chemistry and Biochemistry Exam Questions 2008/09
Medical Chemistry and Biochemistry Exam Questions 2008/09

... synthesis, degradation, activation, deactivation, and role in signaling pathways. 90. G-proteins: types, significance, mechanism of function, their GTPase activity. 91. The basic cellular signaling pathways: cAMP, phosphatidylinositols, calcium, Ras/MAPKinases, connection to transcription factors. 9 ...
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... Human plasma was fractionated by standard methods. The heparin column-absorbed fraction was used as a starting fraction, as it was most effective on suppression of DNA fragmentation in CCL. The heparin column-absorbed fraction was purified using 3 column chromatographies (anion exchange, cation exch ...
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metabolism

... structure Site for substrate binding is active site, or catalytic site A temporary enzyme-substrate union occurs when substrate moves into active site – induced fit Appropriate reaction occurs; product is formed and released ...
Chemotaxonomic Metabolite Profiling of 62 Indigenous Plant
Chemotaxonomic Metabolite Profiling of 62 Indigenous Plant

... comparing differences in properties of plant species, such as morphological [14], physiological [15], and chemical characteristics [16]. Among the various plant taxonomic methods, chemotaxonomy, a method based on differences in chemical compounds, is a useful tool for classification of plant species ...
Amino Acid Regulation of RNA Synthesis
Amino Acid Regulation of RNA Synthesis

...  The driving force in this type of transportation is the concentration gradient in the case of non-electrolytes or in the case of ions the difference in electrical charge across the membrane between the internal of the cell and the outside.  Yeasts take up sugar by this method.  However, few comp ...
Lecture 39 - Amino Acid Metabolism 2
Lecture 39 - Amino Acid Metabolism 2

... metabolites, metabolic genetic disorders Bioc 460 Spring 2008 - Lecture 39 (Miesfeld) ...
CHM 326 LECTURE NOTE
CHM 326 LECTURE NOTE

... metabolites are generally built from primary metabolites. Secondary metabolites have restricted distribution and are characteristics of individual genera or species. Secondary metabolites are essential to the existence of the organism but play an important role to the survival of the plant. Reports ...
PloS one
PloS one

... To investigate the regulation between central metabolites during seed development, we utilized an established gas chromatography-mass spectrometry (GC-MS)-based protocol [28]. The relative contents of over 70 annotated metabolites from seeds at 14 different time points from early, through mid to lat ...
Biochemistry - CEU Cardenal Herrera
Biochemistry - CEU Cardenal Herrera

... relationship with other subjects such as physiology, pathology and nutrition. In the first part of the course we will describe the structures of the major biomolecules and their physical and chemical properties, with particular emphasis on the structure / function. The second part is focused in the ...
Metabolic reaction network approach for CHO
Metabolic reaction network approach for CHO

... Animal cell culture has provided several beneficial improvements in the field of biotechnology. Nowadays, the engineers have focused their work in the optimization of cell cultures techniques. One important tool used is the simulation by computer since it is inexpensive, requires less time than othe ...
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Pharmacometabolomics

Pharmacometabolomics, also known as pharmacometabonomics, is a field which stems from metabolomics, the quantification and analysis of metabolites produced by the body. It refers to the direct measurement of metabolites in an individual’s bodily fluids, in order to predict or evaluate the metabolism of pharmaceutical compounds, and to better understand the pharmacokinetic profile of a drug. Alternatively, pharmacometabolomics can be applied to measure metabolite levels following the administration of a pharmaceutical compound, in order to monitor the effects of the compound on certain metabolic pathways(pharmacodynamics). This provides detailed mapping of drug effects on metabolism and the pathways that are implicated in mechanism of variation of response to treatment. In addition, the metabolic profile of an individual at baseline (metabotype) provides information about how individuals respond to treatment and highlights heterogeneity within a disease state. All three approaches require the quantification of metabolites found in bodily fluids and tissue, such as blood or urine, and can be used in the assessment of pharmaceutical treatment options for numerous disease states.
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