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Engineering primary metabolic pathways of industrial
Engineering primary metabolic pathways of industrial

... Biochemical systems theory (Savageau, 1969), which is based on kinetic models and accounts for regulatory signals, e.g. feedback inhibition allows new kinetic models to be set up to quantify fluxes through pathways, not only at steady state but also under transient conditions. The so-called ‘–omics’ ...
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...  Urine FeCl3 test and DNPH test used in clinical screening for PKU  Blood Phe measurement  Urinary pterin analysis by HPLC  BH4 loading test  PAH gene analysis, common PAH gene mutations are in exon 7 in Chinese PKUs ...
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afl controlled treatments list

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Metabolomic and flux‐balance analysis of age‐related decline of
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Warren 2 Sib Pairs (Wiltshire et al 2001)

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A multi-tissue type genome-scale metabolic network for analysis of
A multi-tissue type genome-scale metabolic network for analysis of

... systemic diseases however cannot be achieved unless an integrated multilevel and comprehensive modeling approach is undertaken and the appropriate computational infrastructure is fully developed and utilized. Genome-scale metabolic network reconstructions have been shown to provide an appropriate co ...
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... formation of NADH and FADH2. These electron carriers then transfer their high potential electrons to the respiratory chain. ...
Supplemental notes in pdf
Supplemental notes in pdf

... regulation) and 3) bioavailability of substrates (nutritional supplies or cell comparmentalization). One of the best ways to understand how flux through various catabolic and anabolic pathways changes in response to substrate concentration and enzyme activity levels, is to look at glucose metabolism ...
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Pharmacometabolomics

Pharmacometabolomics, also known as pharmacometabonomics, is a field which stems from metabolomics, the quantification and analysis of metabolites produced by the body. It refers to the direct measurement of metabolites in an individual’s bodily fluids, in order to predict or evaluate the metabolism of pharmaceutical compounds, and to better understand the pharmacokinetic profile of a drug. Alternatively, pharmacometabolomics can be applied to measure metabolite levels following the administration of a pharmaceutical compound, in order to monitor the effects of the compound on certain metabolic pathways(pharmacodynamics). This provides detailed mapping of drug effects on metabolism and the pathways that are implicated in mechanism of variation of response to treatment. In addition, the metabolic profile of an individual at baseline (metabotype) provides information about how individuals respond to treatment and highlights heterogeneity within a disease state. All three approaches require the quantification of metabolites found in bodily fluids and tissue, such as blood or urine, and can be used in the assessment of pharmaceutical treatment options for numerous disease states.
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