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Pedigree analysis
Pedigree analysis

... The pedigree chart below shows inheritance of the gene that causes albinism. A and B represent a couple who had five children, including C and E. Only one of the children, E, was albino. E and her husband had five children, including G. In the pedigree below write the genotypes of the individuals w ...
MP16z - Appendix 2 - NMP approval to practice form.dot
MP16z - Appendix 2 - NMP approval to practice form.dot

... inconvenience to patients and delay in supplying the necessary medicine. A prescription for a Controlled Drug in Schedules 2, 3, or 4 is valid for 28 days from the date stated thereon. Prescriptions ordering ‘repeats’ on the same form are not permitted for Controlled Drugs in S2 or 3. Guidance (June ...
Heart Rhythm Disturbances Associated With Rupatadine
Heart Rhythm Disturbances Associated With Rupatadine

... most of the other newer antihistamines and are well established for the older ones. The case of torsade de pointes included in this study has been described in detail elsewhere.8 Some of these adverse reactions are cause for concern because these drugs are commonly used for prolonged periods to trea ...
SAFETY OF ORAL IBUPROFEN ñ ANALYSIS OF DATA FROM THE
SAFETY OF ORAL IBUPROFEN ñ ANALYSIS OF DATA FROM THE

... for the relief of fever, headaches, menstrual and other minor pains as well as a major active ingredient in numerous cold preparations. We analyzed sales volume and data obtained from the monitoring of spontaneous reports on the adverse effects of IBUM soft capsules, IBUM Forte soft capsules, and IB ...
Folie 1 - Tresch Group
Folie 1 - Tresch Group

... (Beyer, Ideker et al., PlOS Comp. Biol 2006) ...
a paper on crystal methamphetamine
a paper on crystal methamphetamine

... now. They knew we had each been in private practice for about 20 years at that time. In 1975, when this psychologist was doing her post doctoral work in a local psychiatric hospital, her first patient was a very handsome man who was exhibiting a fascinating symptom she had only read about, known as ...
cdec final recommendation
cdec final recommendation

...  Patient groups identified the prevention of fractures as the most important outcome for patients with osteoporosis. The included study evaluated efficacy using change in BMD rather than the incidence of fractures; however, CDEC noted that BMD is a widely used outcome for clinical trials of osteopo ...
Antifungal Agents
Antifungal Agents

... Voriconazole (Vfend) ...
adrian2004_1acbPosterDataAnalysis34by51
adrian2004_1acbPosterDataAnalysis34by51

... 1. Retrieve gene expression microarray data for specified set of patients. A web form is used to retrieve microarray data form the DORA database. In the resulting Excel file (Figure 1), each column holds gene expression data for a patient and each row holds gene expression data for a gene. Each colu ...
SAQ - Severe asthma - SCHHS Emergency Department
SAQ - Severe asthma - SCHHS Emergency Department

business case request - Heart of England NHS Foundation Trust
business case request - Heart of England NHS Foundation Trust

...  Dispensing take home medication (TTO) for patient discharge  Operation of clinical research trials  Provision of aseptic dispensing services e.g. cancer chemotherapy The services are delivered by a wide range of specialist and generalist pharmacy and administrative staff based at Heartlands, Sol ...
drugs acting on the respiratory system bronchial asthma
drugs acting on the respiratory system bronchial asthma

... Of the three natural xanthenes agents, theophylline is most selective in its smooth muscle effect, while caffeine has the most marked central effect. Pharmacokinetics Only slightly soluble in water so has been administered as several salts containing varying amounts of theophylline base. Most prepar ...
Vincent Klapper Dr. Ely Genetics 303 Revised term paper 11/15/13
Vincent Klapper Dr. Ely Genetics 303 Revised term paper 11/15/13

... genes that regulate the immune system. They wanted to examine what genes are affected by MS. Studies by Sawcer et al. and Kemppinen et al. (cited in Cox et al. 2013) have indicated a strong genetic component to MS, particularly in the HLA-DR2 gene. The HLA gene had been implicated in many autoimmune ...
Lithium Adverse Effects
Lithium Adverse Effects

... quetiapine, olanzapine/fluoxetine) “Antidepressant monotherapy is not recommended.” Add lamotrigine or bupropion if needed ECT if severely depressed or pregnant CBT and Behavioral Activation ...
OAHKS radiology learning guide - Section 5 (1.7mb, ppt)
OAHKS radiology learning guide - Section 5 (1.7mb, ppt)

... Main issue is upper GI tract irritation, bleeding etc. Greater risk when combined with high doses paracetamol (OASRI) To reduce risk, COX-2 selective NSAIDs are used or non-selective NSAIDs with a proton pump inhibitor eg Omeprezole (Losec)(halves risk hospitalisation for GIT complications-OASRI) or ...
Herbal / Drug Interactions PHARM 512: Clinical Applications of Drug
Herbal / Drug Interactions PHARM 512: Clinical Applications of Drug

... From: Anderson and Elmer, Clinical Pharmacology and Therapeutics 43:643-648 (2003). ...
Use of Atypical Antipsychotic Agents for Symptom Control in Patients
Use of Atypical Antipsychotic Agents for Symptom Control in Patients

... a useful strategy, as patients respond differently to these medications. Because such low doses are used, often a direct switch to another agent can be completed without tapering the dosage of the offending medication. For example, a patient who develops daytime somnolence with risperidone (0.5 mg ...
Pharmacology Objectives 12
Pharmacology Objectives 12

... due to risk of hemorrhage. Heparin does not cross the placenta and is not excreted in milk. LMWH is eliminated by the kidney and is not given in renal insufficiency. Warfarin – is given orally because it is promptly and completely absorbed in the GI tract. Warfarin is highly protein bound (98-99%) a ...
Routes of drug administration
Routes of drug administration

Rivotril
Rivotril

... The safety and efficacy of clonazepam in patients with renal impairment has not been studied, however based on pharmacokinetic considerations no dose adjustment is required in these patients (see 3.2.5 Pharmacokinetics in Special Populations). Hepatic Impairment The safety and efficacy of clonazepam ...
Mutation analysis of bigH3 gene in patients with corneal dystrophy
Mutation analysis of bigH3 gene in patients with corneal dystrophy

... the CYP1B1 gene in the GLC3A locus have been found in about 50% of PCG patients. No genetic locus has been identified for PCAG, but there is a possible site on chromosome 10. For POAG, more than 10 chromosomal loci have been mapped. But there are only 2 confirmed genes, MYOC and OPTN. Over 60 MYOC m ...
PAC 16 Pharmacology II
PAC 16 Pharmacology II

... 1. Discuss the pharmacological class, therapeutic indications and contraindications, pharmacodynamics and pharmacokinetics, routes of administration, potential side effects and toxicities, and drug interactions of the various drugs listed in the course outline. 2. Describe the altered pharmacokineti ...
Acute Care Patient Case Example
Acute Care Patient Case Example

... Monitor the patient, as above, to optimize pharmacotherapy. Round with the medical team and provide recommendations. Provision of medicines information to health professionals None needed at this time Provision of medicines information to patients This is not as applicable in a hospital setting. The ...
Rational Use and Interpretation of Urine Drug Testing in
Rational Use and Interpretation of Urine Drug Testing in

... methods to screen for drugs in urine are not limited to antibody-based assays. Other analytical methods exist, including thin-layer chromatography, highpressure liquid chromatography, and gas chromatography [33]. These methods offer distinct advantages, primarily with regard to specificity, over imm ...
Document
Document

...  Local drug levels can be high and systemic ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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