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Gene Therapy and Genetic Engineering: Frankenstein is Still a Myth
Gene Therapy and Genetic Engineering: Frankenstein is Still a Myth

... The Molecular Basis of Inheritance Having examined a few basic genetic principles, let us turn now to the mechanism by which genetic information is carried. It is probably universal knowledge that genetic information is carried by molecules of deoxyribonucleic acid (DNA).' The molecule is composed o ...
Dewormer Chart for Goats
Dewormer Chart for Goats

... days  for  milk  Do  NOT  use  in  pregnant  does  in  the  first  trimester  of  pregnancy     Safe-­‐Guard/  Panacur  Suspension  (10%  or  100  mg/ml):  the  label  dose  in  goats  is  5  mg/kg,  but  a  10  mg/kg  dosage   ...
WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update WHO GUIDELINES
WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update WHO GUIDELINES

... A DST for isoniazid and rifampicin or rifampicin alone that provides a diagnosis within a day or two of testing was considered rapid for this recommendation. Currently, only molecular tests can detect resistance so quickly, of which two technologies, line probe assay and Xpert MTB/RIF, are recommend ...
Attention Deficit/Hyperactivity Disorder: Case
Attention Deficit/Hyperactivity Disorder: Case

... Diagnosis of ADHD and the subtype in all patients is based on an assessment of nine specific symptoms of hyperactivity-impulsivity and nine symptoms of inattention. Symptoms of hyperactivity and impulsivity, particularly in children, include fidgeting or squirming; leaving one’s seat or running and ...
Explaining the role of genetics and risk factors for
Explaining the role of genetics and risk factors for

... A family history of Alzheimer’s disease requires a post-mortem confirmation of the reported premortem diagnosis, as studies report a 10% discrepancy between clinical and pathological diagnosis. Many clinical conditions can produce confusion in the older patient and the family history is only as accu ...
pps
pps

bnn0998 color - Bipolar Network News
bnn0998 color - Bipolar Network News

... of design and has not yet been submitted for approval by the appropriate institutional review boards and other review panels. Therefore, it is not likely to be available for active patient recruitment and randomization to treatment for approximately one year. However, we are very interested in acqui ...
Sample pages 1 PDF
Sample pages 1 PDF

... A recently published review suggested that oral mucosal drug delivery systems are actively being conceptualized and invented, and significant time is being devoted in both academia and industry to research this route of drug delivery [7]. The same review highlights that there are less than 50 regist ...
Psychopharmacology - the Peninsula MRCPsych Course
Psychopharmacology - the Peninsula MRCPsych Course

... • Please divide into two groups. The left hand side of the room (your left) will be Group One and right hand side of the room will be Group Two. • Look at both clinical scenarios. I will invite each group to feedback in turn ...
Case Report Section
Case Report Section

... trisomy 8 as a secondary abnormality in a subpopulation of cells. NUP98 gene rearrangement as a result of t(2;11)(q31;p15) is rare, described in only 8 patients (including the present one). This translocation resulting in NUP98-HOXD13 gene fusion was first described in a 10 year-old patient with the ...
Demystifying Analytical Approaches for Urine Drug Testing to
Demystifying Analytical Approaches for Urine Drug Testing to

... Pharmacotherapy is integral to the clinical management of most chronic pain patients.1 When deciding which medications to prescribe, providers must be aware of both prescribed and nonprescribed substances (licit and illicit) that a patient may, or may not, be using. This information helps guide drug ...
Commentary: Mendelian randomization, 18 years on
Commentary: Mendelian randomization, 18 years on

... apoE4 phenotype. I was a molecular biologist by training, and although I was new to the lipid field I felt at ease with genetics. So it was obvious to me that there were plenty of people who carried one or two copies of the apoE2 gene, and that the large majority of them had relatively low cholester ...
Yanyan Cui, Mona I. Churchwell, Letha H. Couch, Daniel
Yanyan Cui, Mona I. Churchwell, Letha H. Couch, Daniel

... metabolism of PY74 by 3-MC-induced microsomes plateaued between 5 and 10 mg/ml BSA (results not shown) and, therefore, we used 5 mg/ml BSA in subsequent studies. The metabolic activity increased significantly when the concentration of microsomal protein was increased from 100 ␮g/ml to 500 ␮g/ml, pla ...
Geriatric Pain Management: 101
Geriatric Pain Management: 101

... make pain evaluation more complex, geriatrics are more likely to experience medication-related side effects/complications Despite these challenges pain can usually be effectively managed. (American Geriatrics Society, 2009) ...
Variation and Evolution of Genetic Networks
Variation and Evolution of Genetic Networks

... ~3M PM/MM features ...
Topic guide 7.5: Patterns of inheritance
Topic guide 7.5: Patterns of inheritance

... a specific base pair sequence that codes for one (or sometimes more) polypeptide (protein). Some genes code for mRNA and this acts to regulate other genes. Allele: A version of a gene. If the original gene has undergone a mutation then the nucleotide base sequence is altered which may result in a di ...
Genetic Crosses
Genetic Crosses

... By the end of this lesson you should be able to: Know what a dihybrid cross is Know how many alleles for each gene there is in a diploid organism Know how to use a Punnett Square for a dihybrid cross Know what a testcross is Know how to carry out a testcross ...
1 - Yimg
1 - Yimg

... External/Internal milieu => Body response => S/S ...
Explaining The Role Of Genetics And Risk Factors For Dementia To
Explaining The Role Of Genetics And Risk Factors For Dementia To

... A family history of Alzheimer’s disease requires a post-mortem confirmation of the reported premortem diagnosis, as studies report a 10% discrepancy between clinical and pathological diagnosis. Many clinical conditions can produce confusion in the older patient and the family history is only as accu ...
Clavis Pharma and Clovis Oncology Sign $380 Million Partnership
Clavis Pharma and Clovis Oncology Sign $380 Million Partnership

... superior targeting of an established drug, gemcitabine, as well as providing a new, rational treatment option, CP-4126, to hENT1-low patients.” About CP-4126 CP-4126 is a new, patented, cytotoxic drug, consisting of an anti-cancer nucleoside analogue coupled to a lipid chain. It was generated using ...
International LGMD Patient Registries - LGMD-Info
International LGMD Patient Registries - LGMD-Info

... Have you &/or a family member received genetic confirmation of your Limb Girdle Muscular Dystrophy (LGMD) sub-type? If so, please be sure to have your name and information entered in the PATIENT REGISTRY for that diagnosis. When you register, you may have access to the following services, depending ...
Safety in Using Promethazine (Phenergan)
Safety in Using Promethazine (Phenergan)

... product labeling refers to promethazine as an irritant drug, some sources consider it a lesser-known vesicant that can be highly caustic to the intima of blood vessels and surrounding tissue.2,4-7 Although deep intramuscular injection into a large muscle is the preferred parenteral route of administ ...
Probability and Punnet Squares
Probability and Punnet Squares

... In beagles the trait for droopy ears (D) is dominant to the trait for perky ears (d). What would be the expected offspring if two heterozygous droopy-eared dogs were mated? ...
adrenergic agents - NC State Veterinary Medicine
adrenergic agents - NC State Veterinary Medicine

... hypotensive effects of these drugs is not known. It is suspected that the tonic sympathetic stimulation, provided by norepinephrine, is inhibited through β-blockade, resulting in decreased activation of adenylate cyclase, inhibited production of cAMP in the CB, and ultimately decreased AH production ...
Print - Philosophical Transactions of the Royal Society B
Print - Philosophical Transactions of the Royal Society B

... out. All the metabolites isolated from urine had no antimalaria activity due to the loss of an endoperoxide bridge. This suggests that the endoperoxide bridge is the active group responsible for its biological activity (figure 1). Thus, scientists synthesized a series of derivatives of artemisinin ( ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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