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Study Session 8 Malaria Case Management
Study Session 8 Malaria Case Management

... This study session will describe the procedures of malaria treatment, the antimalaria medicines used under different situations, and the procedure of providing pre-referral care to patients that cannot be managed at your Health Post level. Providing early and effective treatment is one of the most i ...
Management of IBD in Pregnancy
Management of IBD in Pregnancy

... No fetal adrenocortical insufficiency ...
Questions about some uses of genetic engineering
Questions about some uses of genetic engineering

... could iron out all environmental differences, any residual variations would be 100 per cent genetic. It is only if we make the highly artificial assumption that different groups at different times all have an identical spread of relevant environmental differences that we can expect to find statement ...
Antimicrobial Agents
Antimicrobial Agents

... therefore, not absorbed orally • Parenteral administration is required for systemic effect. • They do not enter the CNS even when the meninges are inflamed. • They are not metabolized. ...
Lecture PPT - Carol Eunmi LEE
Lecture PPT - Carol Eunmi LEE

... • Neutral theory is not incompatible with Darwin's theory of evolution by natural selection: adaptive changes are acknowledged as present and important, but hypothesized to be a small minority of evolutionary change. • Recent tests of selection have found that in many cases evolution is not neutral, ...
Equivalent dose ratios for opioids Oral morphine
Equivalent dose ratios for opioids Oral morphine

... e.g. 20mg injectable diamorphine : 2mg injectable alfentanil Reminder If a drug is stronger, the dose required is smaller For conversions from one alternate opioid to another, direct conversion ratios are not so reliable. The preferred method is to convert drug A to oral morphine then go from oral m ...
The pathophysiology of Alzheimer`s disease
The pathophysiology of Alzheimer`s disease

... promise in preventing or delaying AD progression, although more data are needed. There are now several published guidelines for the treatment of AD. Although some may argue that the effect of these drugs is modest, any preservation of function and delay of nursing home placement has important and pe ...
Digital Edition
Digital Edition

... the risk associated with drug-drug interactions. And patients should be advised to communicate with their prescribers before starting new medications — even shortterm antibiotics from urgent care. A common scenario that could occur is when a patient on oxycodone goes to an urgent-care facility for a ...
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... – > 200 mgs/kg or > 10 grams in 24 hours – > 150 mgs/kg or > 6 grams in each 24 hours (48 hours) – > 100 mgs/kg or > 4 grams per day chronic at risk ...
Neyroleptiklər
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... Is a rare but serious side effect of neuroleptic (antipsychotic) therapy that can be lethal. It can arise at any time in the course of treatment and shows no predilection for age, duration of treatment, antipsychotic medication, or dose. ...
Use of medicines outside of their UK marketing authorisation in pain
Use of medicines outside of their UK marketing authorisation in pain

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maximizing the effectiveness of highly active
maximizing the effectiveness of highly active

... rise significantly (Figure). Quadruple regimens raise issues as well as opportunities regarding sequencing of therapy. For example, 2class quadruple regimens may be better at preserving future treatment options compared with 3-class regimens. Also, the induction/maintenance strategy could limit expo ...
Genetics - Cobb Learning
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... • Sickle Cell Anemia – Autosomal Recessive – sickle-shaped blood cells – can’t move through bloodstream as easily – not fatal – typically found in African Americans ...
AHA Scientific Statement - CHOC Children`s Specialists
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... products were discussed, raising concerns regarding their cardiac safety. Long-term safety trials and targeted cardio- ...
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... healthy lifestyle habits. Appropriate identification and treatment of risk factors will prevent not only the development of CAD, but also disease progression in patients with existing CAD. Smoking cessation, treatment of lipid abnormalities, and effective control of blood pressure have all reduced t ...
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... Spironolactone Onset and duration of action are determined by the kinetic of aldosterone response in target tissue. Slow onset (48 hr) Canrenone is the active metabolized which has very long t12.than parent drug. ...
INDEX S.No Categories 1 Applications for Investigational New
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... 3. In case the application is for clinical trial permission: a. Adequate chemical and pharmaceutical information should be provided to ensure the proper identity, purity, quality & strength of the investigational product, the amount of information needed may vary with the Phase of clinical trials, p ...
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... cycle control (G1 progression and G1/S transition); 5' BCL1 translocated on chromosome 14 near JH, resulting in promoter exchange; the immunoglobulin gene enhancer stimulates the expression of BCL1, and overexpression of BCL1 which accelerates passage through the G1 phase. Trisomy 3: gene unknown bu ...
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...  The SHARP trial establish the clinical benefits of eze/simv consistently with meta-analysis of statin trials  Beyond its LDL-lowering effects, other potential benefits of ezetimibe have been recently described: ...
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C. papyracea exercise - Wesleyan College Faculty
C. papyracea exercise - Wesleyan College Faculty

... frequencies will remain constant from generation to generation within the population. This static condition is called Hardy-Weinberg-Castle equilibrium. These five assumptions of H-W-C equilibrium define the null hypothesis for microevolution. The observation that these conditions are never all met ...
02/20/2009 - Medical University of South Carolina
02/20/2009 - Medical University of South Carolina

... of relationship between two variables. Values of correlation coefficients range from -1.00 through zero to +1.00. A correlation coefficient of 0.00 indicates no relationship between the variables. Correlations approaching -1.00 or +1.00 indicate strong relationships between the variables. However, c ...
A. Treating the outpatient with severe ulcerative colitis: case studies
A. Treating the outpatient with severe ulcerative colitis: case studies

... • Immunologic mechanisms for the protective effect of cigarette smoking in UC remain unclear • Immunologic and clinical studies in IBD have focused on nicotine • Therapeutic trial experience in UC with nicotine gum, ...
11_Bioequivalence
11_Bioequivalence

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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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