• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Iontophoresis - Provider - Group Health Cooperative
Iontophoresis - Provider - Group Health Cooperative

... electrodes. Iontophoresis uses a low current and patients have little or no sensation during the procedure. Drugs used in iontophoresis should be those that ionize. Dexamethasone sodium phosphate, a negative ion, is a commonly used drug used for iontophoresis treatment of joint pain. Possible advant ...
CHAPTER 14 MENDEL AND THE GENE IDEA
CHAPTER 14 MENDEL AND THE GENE IDEA

...  Alternatively, the two alleles may differ. 3. If the two alleles at a locus differ, then one, the dominant allele, determines the organism’s appearance. The other, the recessive allele, has no noticeable effect on the organism’s appearance.  In the flower-color example, the F1 plants inherited a ...
Epilim Chrono
Epilim Chrono

... Liver function should be measured before and then periodically monitored during the first 6 months of therapy, especially in those who seem most at risk, and those with a prior history of liver disease. Amongst usual investigations, tests which reflect protein synthesis, particularly prothrombin rat ...
Pfizer, Inc - Pearson Higher Education
Pfizer, Inc - Pearson Higher Education

... to treat trachoma, a common cause of blindness; however, Pfizer’s donation of Diflucan to South Africa to treat some AIDS-related infections had left the company open to criticism from those who charged that it both placed too many restrictions on how the drug was to be used and failed in its moral ...
Amphetamine withdrawal
Amphetamine withdrawal

... Objective: The aim of this study was to examine the benefits of amineptine, a dopamine agonist antidepressant, in treating amphetamine withdrawal. Method: Inpatients with amphetamine withdrawal were recruited to participate in this placebo-controlled, randomised, double-blind, parallel group, 2-week ...
2013 Practice guidelines for the management of arterial
2013 Practice guidelines for the management of arterial

... alert physicians on recommendations that are based on the opinions of the experts rather than on evidence (Tables 1 and 2). When appropriately recognized, this can avoid guidelines being perceived as prescriptive and favour the performance of studies wherein opinion prevails and evidence is lacking. ...
Detection of cystic fibrosis transmembrane conductance regulator
Detection of cystic fibrosis transmembrane conductance regulator

... mutational spectrum in CBAVD Four large CFTR gene rearrangements were identified in four of 61 CBAVD patients investigated (Tables II and III). We have included all the patients with one or no detected mutation after complete screening for point mutations (57 unidentified alleles), as well as patien ...
Transferrin receptor 2 (TfR2) and HFE mutational analysis in non
Transferrin receptor 2 (TfR2) and HFE mutational analysis in non

... www.bcgsc.bc.ca/fg/hemoc). Five HFE single nucleotide polymorphisms were identified (www.bcgsc.bc.ca/fg/hemoc). With respect to HFE mutations, a high percentage of patients carried the HFE H63D allele (48 of 89; 54%). This value is above that expected as compared to carrier rates for H63D ranging fr ...
14 Medicines management Janet Krska and Brian Godman Sample chapter copyright Pharmaceutical Press
14 Medicines management Janet Krska and Brian Godman Sample chapter copyright Pharmaceutical Press

... compromising efficacy.3,4 Improving the use of medicines in individuals also has the potential to improve cost-effectiveness, by reducing waste and improving health outcomes, including minimising adverse drug reactions and drug–drug interactions. All require interventions designed to influence behav ...
Enzyme Catalysis
Enzyme Catalysis

... This simulation uses a random number generator to sample genes from a parental population and pass them on to offspring. Population size is assumed to remain constant from generation to generation. Suppose that a population consists of one male and one female, and that both are heterozygous at a loc ...
Mycophenolate Mofetil in Autoimmune Hepatitis Patients Not
Mycophenolate Mofetil in Autoimmune Hepatitis Patients Not

... quarters of patients normalized their liver enzyme levels, and the inflammatory and fibrosis scores decreased significantly on MMF treatment. Only 2 patients developed significant side effects from the use of MMF, 1 of whom had symptom resolution on dose adjustment. No significant bone marrow toxici ...
Linkage
Linkage

... modern times, we can use the locations to clone the genes so we can better understand what they do and why they cause genetic diseases when mutated. The basis of linkage mapping is that since crossing over occurs at random locations, the closer two genes are to each other, the less likely it is that ...
Natural Versus Synthetic Chemicals: Regulation And Toxicology
Natural Versus Synthetic Chemicals: Regulation And Toxicology

... There are no rules on serving size or amounts of ingredients in dietary supplements ...
DEVELOPMENT AND VALIDATION OF DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR
DEVELOPMENT AND VALIDATION OF DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR

... mixed standard solutions were scanned over 400-200nm and derivatised to measure substantial absorbance at 241 for AT and at 250 for AM respectively. Calibration curves for both drugs were plotted using absorbance values and concentrations of each drug in the mixed standard solutions. It was found th ...
illicit drugs and driving
illicit drugs and driving

... same drug analysis performed on a control population consisting of matched drivers or non-responsible subjects. Very few epidemiological studies have included a control population. Pharmaco-epidemiological studies are very useful as they compare the number of accidents in drivers for whom medicines ...
Examining the Systemic Safety of Anti-VEGF Agents
Examining the Systemic Safety of Anti-VEGF Agents

... the agents in the bloodstream correlating with reduction in circulating free VEGF levels, provide biologic plausibility for potential systemic effects of these agents. Fortunately, all the registration trials and meta-analyses have shown good safety in the general population; however, it is difficul ...
manuscript_rajeev k singla
manuscript_rajeev k singla

... pharmaceutical industry is required to take a strong interest in polymorphism and solvatomorphism as per the regulations laid down by the regulatory authorities. Polymorphism is the term used to indicate crystal system where substances can exist in different crystal packing arrangements, all of whic ...
Pain control in cancer: recent findings and trends
Pain control in cancer: recent findings and trends

... The second-order neurons are classified as wide dynamic range (WDR) and nociceptive specific (NS) neurons that spatially and temporally transform the afferent input. A small percentage of the axons from these neurons ascend ipsilateral in the spinal cord, but most project contralateral to form the s ...
Patterns of Heredity
Patterns of Heredity

... Identical twins are more closely related than fraternal twins. ...
Cholesterol
Cholesterol

... combination with Fibrates(苯氧酸类降脂药) – Cyp3A4 or CYP2C9 drug interactions with many statins – Hepatotoxicity ...
Ketamine
Ketamine

... anesthetic level doses, Ketamine has also been found to bind to opioid receptors and sigma receptors.  The drug was first given to American soldiers during the Vietnam War. * NB not associated with MDMA ...
RCPsych Literature Search OPIOIDS 2010
RCPsych Literature Search OPIOIDS 2010

... Publication: 2010. Abstract BACKGROUND: Withdrawal (detoxification) is necessary prior to drug-free treatment or as the end point of long-term substitution treatment. OBJECTIVES: To assess the effectiveness of opioid antagonists to induce opioid withdrawal with concomitant heavy sedation or anaesthe ...
Carpenter, A.T.C.
Carpenter, A.T.C.

... but complement Df(3R)ro80b and therefore are located beween 97B1-lO and 9701 (Figure 1). The dt6, dt12, and dt14 mutations fail to complement one another and also fail to complement 1(3)673, a previously identified lethal in the region (K. Anderson, unpublished). These mutations have recently been s ...
4 TtGg
4 TtGg

... studying identical twins, geneticists genes seem to have a learned that _______ environment greater influence than the ________________ on such traits as height, weight, blood pressure, speech patterns, and gestures. ...
50 FDA ACRONYMS
50 FDA ACRONYMS

... importance of complying with U.S. Food and Drug Administration regulations. Whether you lead research and development of new therapies, manage a manufacturing facility, or oversee storage and distribution of regulated drugs and devices, understanding the FDA’s Title 21 regulations is your best assur ...
< 1 ... 373 374 375 376 377 378 379 380 381 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report