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13 - epilepsy09
13 - epilepsy09

... increasing brain excitability such as sleep deprivation, drug or alcohol ingestion or withdrawal or hypoglycemia. Rare patients have their seizures provoked consistently by specific sensory stimuli (e.g. flickering lights, video games or television, a specific piece of music, reading, immersion in h ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... inferior alveolar nerve. The lingual nerve (tongue) is approximately twice as often involved as the inferior alveolar nerve (lip), 92 versus 42 cases. This finding is confirmed by Progrei and Thamby, which found the same distributes for the paresthesia (2000).17 The reason for this finding might be ...
ketamine - Yorkshire and the Humber Deanery
ketamine - Yorkshire and the Humber Deanery

... given advance notice of at least a week so that the drug may be ordered. The patient should be given an information leaflet about Ketamine that should include on it who they should contact in the event of any problems ...
Drug allergy – diagnosis and management: briefing paper
Drug allergy – diagnosis and management: briefing paper

... Understanding of drug allergy signs and symptoms A stakeholder highlighted that as there is limited availability of specialist allergy services, most diagnoses will continue to be made in primary care by non-experts so improved record keeping of symptoms, signs and other relevant factors at the time ...
The genetics of self- incompatibility in white clover
The genetics of self- incompatibility in white clover

... and 339 AFLP markers. The presence of SSR markers from previously published maps of white clover on the maps of S1S4 and R3R4 allowed the identification of resulting linkage groups (LGs) belonging to the eight homoeologue groups (HGs or chromosomes) of white clover. Plants in the mapping population, ...
Solving the University Timetabling Problem with
Solving the University Timetabling Problem with

... is difficult to find only two students with the same timetable, thus solving the problem becomes very complex. In order to be able to deal with individual timetables of students we designed an algorithm for optimization of enrollment of students that effectively decrease the number of constraints fo ...
MINI REVIEW - “What Is The Safety Of Fluoroquinolones For...  Dorothy Koech
MINI REVIEW - “What Is The Safety Of Fluoroquinolones For... Dorothy Koech

... The fluoroquinolone class of antimicrobials has been in clinical use for over 17 years now [14]. For a long time quinolones had not been approved for use in children, primarily because of concerns they could cause irreversible damage to growing cartilage in weight bearing joints, concerns resulting ...
Methadone - Center for Substance Abuse Research
Methadone - Center for Substance Abuse Research

... “maintenance” is used in describing these programs because the goal is to “maintain” a narcotics abuser for the purpose of helping him or her avoid the negative and sometimes severe withdrawal symptoms.17 This type of treatment views addiction as a disease rather than a psychological disorder or cha ...
ZYRTEC® (cetirizine hydrochloride) Tablets and
ZYRTEC® (cetirizine hydrochloride) Tablets and

... 65 years and older, and 39 patients were 75 years and older. No overall differences in safety were observed between these patients and younger patients, but greater sensitivity of some older individuals cannot be ruled out. With regard to efficacy, clinical studies of ZYRTEC for each approved indica ...
Molecular imaging with SPECT as a tool for drug
Molecular imaging with SPECT as a tool for drug

... C.M. Gomes et al. / Advanced Drug Delivery Reviews xxx (2010) xxx–xxx ...
Pedigree Problems:
Pedigree Problems:

... or heterozygous individuals)- examples of conditions caused by dominant alleles include polydactyly (presence of extra fingers), achondroplasia (a type of dwarfism), neurofibromatosis (a nervous disorder), and a disease known as familial hypercholesterolemia in which affected individuals suffer from ...
Chronic unpredicted mild stress-induced depression alter
Chronic unpredicted mild stress-induced depression alter

... a high risk of mortality in people with depression (Van Dooren et al., 2013). In recent years, many researchers use chronic unpredicted mild stress (CUMS)-induced depression to simulate animal models of depression. Rats are exposed to a variety of mild stressors sequentially over a period of weeks i ...
Introduction to Genetic Algorithms - computer science
Introduction to Genetic Algorithms - computer science

... Genetic Algorithms (GAs) are search algorithms based on the mechanics of the natural selection process (biological evolution). The most basic concept is that the strong tend to adapt and survive while the weak tend to die out. That is, optimization is based on evolution, and the "Survival of the fit ...
D F PHARMACOKINETICS AND INTRODUCTION
D F PHARMACOKINETICS AND INTRODUCTION

... overactivity.1 Children with ADHD may struggle with low self-esteem, troubled relationships, and poor performance in school.1,2 In 2006 in the U.S., ADHD was diagnosed in about 4.5 million children 5 to 17 years of age.3 From 3% to 7% of school-aged children have ADHD. In some studies, estimated rat ...
Anesthesia and Blood Gas Monitoring
Anesthesia and Blood Gas Monitoring

... ment will maintain adequate oxygenation for the procedure through recovery. Conversely, poorly managed anesthesia provides insufficient tissue oxygen levels and can lead to cell death, organ failure, and ultimately patient death. A thorough knowledge of available anesthetic drugs and their potential ...
Zathrin side effects azithromycin medications
Zathrin side effects azithromycin medications

... azithromycin medications What can result Zithromax a report empty zathrin side effects azithromycin medications or and dark the zathrin side effects azithromycin medications colored stools or fainting) may hours. In and 2013 Buy Drug FDA USA Zithromax (which it antacids on patients of zathrin side e ...
relpax utilization management criteria
relpax utilization management criteria

... 2. Dizziness, paresthesia, headache, dry mouth, fatigue, and flushing are the most common adverse effects. 3. Pfizer Medical Information: 800-438-1985 MISUSE AND CHRONIC DAILY HEADACHE: Chronic Daily Headache (CDH) is a syndrome that consists of a group of disorders that can be subclassified into pr ...
Lesson Overview - Enfield High School
Lesson Overview - Enfield High School

Cephalexin Product Information Australia DRAFT
Cephalexin Product Information Australia DRAFT

... susceptible to alternative, clinically feasible drugs, the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where high dosage of drug can be used. This category also provides a buffer zone, wh ...
EFFECT OF FSH β-SUB UNIT AND FSHR GENES
EFFECT OF FSH β-SUB UNIT AND FSHR GENES

... affecting alteration of FSH function. Since same homozygous in human affecting azoospermia in male (Lindstedt et al., 1998; Phillip et al., 1998; Layman et al., 2002), did not detect CC genotype in bulls, it might have been caused by elimination in selection process (Dai et al., 2009). In the presen ...
APOE distribution in World populations
APOE distribution in World populations

... Spatial autocorrelation analysis depicts that the variation at this locus is influenced by ‘isolation by distance’ with a strong positive correlation for lower distances up to 1313 (distance class 2) kilometres. Correspondence analysis plot assigns most populations according to major ethnic grouping ...
Warfarin-herb interactions: a review and study based on assessment
Warfarin-herb interactions: a review and study based on assessment

... reportes de casos clínicos de interacciones warfarina-hierbas para evaluar las fiabilidades de dichos reportes. Se revisó la literatura clínica ...
032797 The Effects of Ibuprofen on the Physiology
032797 The Effects of Ibuprofen on the Physiology

... tachycardia, hypoxemia, and lactic acidosis), and what potential adverse effects the drug has in the sepsis syndrome. METHODS Study Patients Seven medical centers in the United States and Canada participated in this trial, which was approved by the institutional review board at each center. Consent ...
cataflam - Novartis
cataflam - Novartis

... Cardiovascular Thrombotic Events Clinical trials of several COX-2 selective and nonselective NSAIDs of up to three years duration have shown an increased risk of serious cardiovascular (CV) thrombotic events, including myocardial infarction (MI) and stroke, which can be fatal. Based on available dat ...
CE EN Evidence-based Pharmacy Practice (EBPP): DYSLIPIDAEMIA
CE EN Evidence-based Pharmacy Practice (EBPP): DYSLIPIDAEMIA

... A random total cholesterol test is sufficient for screening patients for dyslipidaemia, but if the total cholesterol is > 5 mmol/l a fasting lipoprotein profile should be undertaken.7 A complete history and physical examination should also be undertaken. A full fasting lipogram should be the initial ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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