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Aritavi gastro-resistant capsule, hard ENG SmPC
Aritavi gastro-resistant capsule, hard ENG SmPC

... sodium lower than 110 mmol/l. Hyponatraemia may be due to a syndrome of inappropriate anti-diuretic hormone secretion (SIADH). The majority of cases of hyponatraemia were reported in the elderly, especially when coupled with a recent history of, or condition pre-disposing to, altered fluid balance. ...
Trental (pentoxifylline)
Trental (pentoxifylline)

... agents. Patients receiving these agents require blood pressure monitoring and possibly a dose reduction of the antihypertensive agents. Anticoagulants: There have been reports of bleeding and/or prolonged prothrombin time in patients treated with Trental with and without anticoagulants, including vi ...
Guideline for Monitoring and Management of Pediatric Patients
Guideline for Monitoring and Management of Pediatric Patients

... to a painful stimulus, is not considered as the only ageappropriate purposeful response (eg, it must be accompanied by another response, such as pushing away the painful stimulus so as to confirm a higher cognitive function). With moderate sedation, no intervention is required to maintain a patent a ...
lustral - Pharmaline
lustral - Pharmaline

... should be used during pregnancy only if the perceived benefits outweigh the risks.. Exposure during late pregnancy to SSRIs may have an increased risk for persistent pulmonary hypertension of the newborn (PPHN). PPHN occurs in 1-2 per 1,000 live births in the general population and is associated wit ...
354 KB
354 KB

... Persistent increases (to more than 3X ULN) in serum transaminases have occurred in a few adult patients who received simvastatin. When the drug was interrupted or discontinued in these patients, the transaminase levels usually fell slowly to pretreatment levels. The increases were not associated wit ...
Select Important Safety Information
Select Important Safety Information

... reports are insufficient to establish or exclude a causal relationship between MTC and GLP-1 RA use in humans. If serum calcitonin is measured and found to be elevated or thyroid nodules are noted on physical examination or neck imaging, the patient should be further evaluated. Pancreatitis: Has bee ...
Licensed Medications, “Generic” Medications, Compounding, and
Licensed Medications, “Generic” Medications, Compounding, and

... chain consisting of 10,000 –12,000 disaccharide units.13 Studies in humans and animals have determined the molecular weight of synovial fluid HA to be 2– 6 million daltons.14 HA is an integral component of both synovial fluid and articular cartilage in normal synovial joints. It is synthesized by th ...
NEW ZEALAND DATA SHEET SERETIDE® Inhaler (with
NEW ZEALAND DATA SHEET SERETIDE® Inhaler (with

... Results from the retrospective epidemiological study did not find an increased risk of major congenital malformations (MCMs) following exposure to fluticasone propionate when compared to other inhaled corticosteroids, during the first trimester of pregnancy (see Clinical Trial Data). Reproductive to ...
JAP Mar. 86/3 - Journal of Applied Physiology
JAP Mar. 86/3 - Journal of Applied Physiology

... ANTITUSSIVE DRUGS, such as codeine and dextromethorphan, are among the most commonly used prescription and over-the-counter drugs in the world (12). These drugs are broadly classified into two groups based on their site of action: peripheral or central. Peripheral antitussive drugs act outside the c ...
GENETIC CALCULATOR (BUDGERIGAR) Help File
GENETIC CALCULATOR (BUDGERIGAR) Help File

... button. Selecting NORMAL from this list means that the selected bird contains no other genes from list, but may or may not contain genes from other lists in other Variety Combination windows, VARIETY INFORMATION The complete genetic picture for Crests is still not known. It is believed that Crests a ...
digibind - GSK Australia
digibind - GSK Australia

... Standard therapy for digitalis intoxication includes withdrawal of the drug and correction of factors that may contribute to toxicity, such as electrolyte disturbances, hypoxia, acid-base disturbances and agents such as catecholamines. Also, treatment of arrhythmias may include judicious potassium s ...
english, pdf
english, pdf

... as stroke, thyroid disorder, Parkinson’s disease and other neurological disorders like multiple sclerosis and cerebral palsy. Dysphagia is a condition marked by the difficulty in swallowing and it has been reported that about 35 % of the general population, in addition to 30–40 % of elderly institut ...
Marijuana Dosing Issues: Notes From the Literature
Marijuana Dosing Issues: Notes From the Literature

... has many variables that do not fit well with the typical medical model for drug prescribing. If the plant is used, the variations are extreme. Plants vary immensely by phenotypes, and even the time of harvest affects which cannabinoids are present and in what percentages. An individual may be much m ...
Hypophosphataemia in Adults - Nottingham University Hospitals
Hypophosphataemia in Adults - Nottingham University Hospitals

... randomisation 3b at least one other type of well-designed quasiexperimental study ...
Product Monograph  January 4, 2017
Product Monograph January 4, 2017

... moderate to moderately severe pain. TRAMACET® has not been systematically evaluated beyond 12 weeks in controlled clinical trials. Therefore, the physician who elects to use TRAMACET® for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient ...
24-hour blood pressure monitoring: its efficacy and
24-hour blood pressure monitoring: its efficacy and

... sustained hypertension and to be, therefore, unsuitable for the study [19]. Moreover, patients with WCH may respond differently to antihypertensive drugs and develop more side effects [20]. ABPM helps prevent inappropriate patients from being recruited for clinical trials to assess BP-lowering drugs ...
how to solve genetics problems
how to solve genetics problems

... the range before they can reproduce. Assuming that this man has good fences which can keep out stray bulls, how could this be explained? One of this farmer’s original cattle was a hornless carrier animal for the gene for horns. When the original cattle reproduce, most of their offspring will be horn ...
PowerPoint Presentation - Meningitis Research Foundation
PowerPoint Presentation - Meningitis Research Foundation

... two meningococcal serogroups are commonly associated with the disease, namely B and C, representing ...
Anxiolytic-Like Effects of κ-Opioid Receptor Antagonists in Models of
Anxiolytic-Like Effects of κ-Opioid Receptor Antagonists in Models of

... were tested sequentially in each of three behavioral paradigms, with the exception of rats treated with fluoxetine and chlordiazepoxide, which were not tested in the FPS paradigm. Rats received i.p. injections of norBNI or JDTic 48 h before the first behavioral test (EPM test) and did not receive ad ...
Simulated Biological Fluids with Possible Application in Dissolution
Simulated Biological Fluids with Possible Application in Dissolution

... light meal, and Ensure Plus, which has physicochemical properties that are similar to those of the standard meal recommended by FDA for the effects of food in bioavailability and bioequivalence studies (12). One way of modeling composition changes is to develop “snapshot” media, each corresponding t ...
Perspectives and challenges of interferon-free therapy for chronic hepatitis C Zeuzem
Perspectives and challenges of interferon-free therapy for chronic hepatitis C Zeuzem

... treatment success because a slow decline of HCV viral load during triple therapy is associated with a high risk for the selection of resistance associated variants (RAVs) [5]. Consequently, viral breakthrough of drug resistant variants was observed in a significant number of patients with partial- o ...
Untitled - System Components
Untitled - System Components

... Circadian clock: the circadian clock is an endogenous, internally maintained biochemical oscillation with a period of approximately a day. Circadian rhythms consist of two elements, a period and an amplitude of oscillation, without which there is no rhythm. The circadian clock is involved in the dai ...
GBL
GBL

... Withdrawal can be managed on an ambulatory basis, but needs: • Supportive home environment • Potential rapid access to in-patient care • early and aggressive management • close monitoring • ongoing monitoring over weeks ...
Molecular Signatures of Natural Selection for Polymorphic Genes of
Molecular Signatures of Natural Selection for Polymorphic Genes of

... of polymorphisms in genes of the dopaminergic and serotonergic systems. Along with this, there has been considerable interest in the possibility that these polymorphisms have developed and/or been maintained due to the action of natural selection. Episodes of natural selection on a gene are expected ...
here.
here.

... high quality care. The QOF has had considerable influence on the way GPs work, including their prescribing. For example, it includes targets for managing particular conditions, such as hypertension, which have an effect on prescribing. 4. Prescribing is also influenced by clinical guidelines, which ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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