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Antibiotics in Dentistry
Antibiotics in Dentistry

... completion is the KEY issue in their effectiveness. He cites a study in which less than 50% of patients complied with taking Pen VK 500mg qid but over 75% complied taking amoxicillin 875mg bid. Patients can better remember to take their medication when only required to do so twice a day. Therefore, ...
Sedation for Dental Procedures
Sedation for Dental Procedures

WELCOME TO THE TOXIC FAMILY & ADDICTION TRAINING - MI-PTE
WELCOME TO THE TOXIC FAMILY & ADDICTION TRAINING - MI-PTE

... and lorazepam) 100,784 drug abuse cases in 2002 opioid pain relievers (e.g., oxycodone, hydrocodone, morphine, methadone, and combinations that include these drugs). 119,000 Taken due to Drug addiction and desired psychoactive effects ...
Anti-depressants
Anti-depressants

... vi. Can’t concentrate or make decisions vii.Thoughts of death or suicide ...
Dr. Phil Rowe Reader in Pharmaceutical Computing
Dr. Phil Rowe Reader in Pharmaceutical Computing

... Active transport Structurally specific groups of chemicals that fit a carrier molecule ...
Degenerative joint disease is the number one cause of chronic pain
Degenerative joint disease is the number one cause of chronic pain

... preventing progression of damage. Numerous products are available on the market; some are best combined with others and some cannot be combined. What we do know is that arthritis pain is best addressed by what is called a “multi-modal approach,” meaning that several approaches combined yield better ...
Preventing Anticoagulation Errors with Clinical Dashboards
Preventing Anticoagulation Errors with Clinical Dashboards

... Rapid onset compared to warfarin Patient must be able to afford dabigatran ...
AWTTC Polypharmacy Review - GP-one
AWTTC Polypharmacy Review - GP-one

... – NSAID long term for mild joint pain osteoarthritis – Long-term opiates or neuroleptics in patients with recurrent falls (1+ fall in last 3 months) Gallagher P et al. (2008). STOPP (Screening Tool of Older Persons’ Prescriptions) and START (Screening Tool to Alert Doctors to Right ...
Mendel and The Gene Idea
Mendel and The Gene Idea

... 2. Reflect mechanisms by which specific alleles are expressed in phenotype and do not involve the ability of one allele to subdue another at the level of the DNA. 3. They do no determine or correlate with the relative abundance of alleles in a population. ...
The Connectivity Map: using gene-expression signatures
The Connectivity Map: using gene-expression signatures

... used in order to pinpoint genetic abnormalities in a disease of interest. By examining genes that are upregulated and downregulated in a disease state as opposed to a normal state, we can create a genetic profile of a disease. In addition, microarrays have been used to monitor changes in gene expres ...
Discussion-Activity-GATTACA
Discussion-Activity-GATTACA

... condition, 42% of being manic depressive, 89% of having ADD, 99% of having heart disease. How accurate are these predictions for the various disorders? Diagnosis is generally given based on studied correlation of what has happened to people with the same genetic allele in the past. Hence, it is a st ...
The Ohio Northern University Raabe College of Pharmacy
The Ohio Northern University Raabe College of Pharmacy

... pressure than Caucasians and Asians. This was found to be true for aliskiren as well. 3 The recommended starting dose for aliskiren is 150 mg once daily with no adjustment for mild to moderate renal failure, hepatic failure, or in the elderly. There is limited data involving patients with severe ren ...
Multi-omics Analysis - RD
Multi-omics Analysis - RD

... This set-up may prepare for personalized drug treatment, the medicine of the future Knowledge of e.g. transcript or protein expression associated with particular variants may be useful in establishing gene function and plausibility of variant pathogenicity Capturing individual-level data also allows ...
Required Patient Information
Required Patient Information

... Include the name and birth date of the family members who have had genetic testing (ie, proband): __________________________________________________________________________________________________________ Indicate the family member’s relationship to the patient: _____________________________________ ...
Objectives of the presentation
Objectives of the presentation

... drug products are safe and effective – The authority requires basic PK information to understand the features of the drug and factor variation ...
Protect BeneficiaryAccess to their Vital Medications Under Six
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... E lderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. NUPLAZID is not approved for the treatment of patients with dementia-related psychosis unrelated to the hallucinations and delusions associated with Parkinson’s disease psychosis. Q ...
Adverse Drug Reactions: Common and Lesser Known
Adverse Drug Reactions: Common and Lesser Known

... Adverse drug reactions involving the skin are notorious for being attributed to other causes such as infection, allergy, or idiopathic immune-mediated disease. Drugs or classes of drugs that have been associated with cutaneous adverse reactions include antiparasitics (amitraz, metaflumizone, ivermec ...
Mid-semester test 2008 - The University of Auckland
Mid-semester test 2008 - The University of Auckland

... A drug must first pass through the liver before it will exert any biological activity A drug is metabolized before it reaches the systemic circulation Some drugs are not effective on their first pass through the circulation but are increasingly more effective through subsequent passes A drug must bi ...
CH3L2
CH3L2

... contributions of genes & environment in the development of behavior •Hold genetic make-up constant to study effects of the environment alone (VT=VE) •cross-fostering experiments & twin studies •Hold environment constant & explore effects of genes alone (VT=VG) •selective breeding experiments •use of ...
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... Synergistic effect - when 2 drugs having the same biological response, NOT by the same MOA, are given together, the effect is greater than the sum of the effects of each drug if given alone. ...
ANESTHESIOLOGY Paulo Vilanova Jr., MD Medstudents
ANESTHESIOLOGY Paulo Vilanova Jr., MD Medstudents

... state) due to interactions with the neurotransmiter glutamic acid, mainly at limbic system level. The drug is avaliable for parenteral use, with clinical effects observed within 30 seconds after the dose (peak within 1 minute). It is metabolized by liver into several derivatives (some with intrinsic ...
`We are all virtually identical twins`
`We are all virtually identical twins`

... Scientists at the National Cancer Institute have traced this event back to only about 700 years ago. It turns out that the same variation in those genes leads to resistance to the plague. Obviously, millions of people in Europe without this variation were killed. The plague clearly did not have the ...
Solutions: October 2011: Addiction by Prescription — For All Ages
Solutions: October 2011: Addiction by Prescription — For All Ages

... 1. Keep your doctor informed. Inform your health care professional about any history of substance abuse. All patients treated with opioids for pain require careful monitoring by their health care professional for signs of abuse and addiction, and to determine when these analgesics are no longer need ...
. SEP 2 9  iXNbl
. SEP 2 9 iXNbl

... normal range. The sameprinciple applies to claims about the control of blood glucose levels; that is, a claim that does not establish that the claim is about blood glucoselevels that are already within normal limits implies that the product is intended to treat elevated blood glucose (diabetes),whic ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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