Conclusion - Shodhganga
... Hippo-08 produced no toxicity with the limit dose of 2000mg/kg body weight. The sub acute toxicity results showed the biochemical constituents, haematological parameters, liver marker enzymes noted to be within the normal range. The histology study of liver cells showed no toxic symptoms. Chronic st ...
... Hippo-08 produced no toxicity with the limit dose of 2000mg/kg body weight. The sub acute toxicity results showed the biochemical constituents, haematological parameters, liver marker enzymes noted to be within the normal range. The histology study of liver cells showed no toxic symptoms. Chronic st ...
Liver disease
... • To interpret these, the physician will look at the entire picture of the hepatocellular disease and biliary tract disease to determine which is the primary abnormality • Acute liver disease • Chronic liver disease ...
... • To interpret these, the physician will look at the entire picture of the hepatocellular disease and biliary tract disease to determine which is the primary abnormality • Acute liver disease • Chronic liver disease ...
Toxic Responses of the lung
... acetylcholinesterase. It is nearly 38 times less toxic when given orally to rats than applied topically to houseflies. ...
... acetylcholinesterase. It is nearly 38 times less toxic when given orally to rats than applied topically to houseflies. ...
2003 Plants Diet and Health 10 Key Facts
... 1. Science has helped to reveal important information about plant-derived macronutrients and micronutrients, but there are many tens of thousands of plant components included in the diet, and research is beginning to find out about the potential of these compounds for human health. 2. The many thous ...
... 1. Science has helped to reveal important information about plant-derived macronutrients and micronutrients, but there are many tens of thousands of plant components included in the diet, and research is beginning to find out about the potential of these compounds for human health. 2. The many thous ...
Assessment of Lipid Peroxidation in Rat Tissues in Subacute
... longer (a few minute) half-life. Therefore, lipid aldehydes can react with other molecules far away from the site of their origin [14, 16]. The increased formation of reactive oxygen species and the cell dysfunction they induce have been observed in many diseases, such as arrhythmia, hypertension, d ...
... longer (a few minute) half-life. Therefore, lipid aldehydes can react with other molecules far away from the site of their origin [14, 16]. The increased formation of reactive oxygen species and the cell dysfunction they induce have been observed in many diseases, such as arrhythmia, hypertension, d ...
effects of dietary micromelum minutum leaves on the metabolizing
... The susceptibility of biological systems to chemical carcinogenesis is partly controlled by the balance between phase I enzyme systems (cytochrome P450[P450]-dependent mono-oxygenases) and phase II enzymes (i.e. glutathione-S-transferase [GST], UDP-glucuronyltransferase(UGT) and NAD(P)H:quinone redu ...
... The susceptibility of biological systems to chemical carcinogenesis is partly controlled by the balance between phase I enzyme systems (cytochrome P450[P450]-dependent mono-oxygenases) and phase II enzymes (i.e. glutathione-S-transferase [GST], UDP-glucuronyltransferase(UGT) and NAD(P)H:quinone redu ...
Chapter 15: Environmental Health, Pollution, and Toxicology
... change in the environment – introduction of harmful materials or the production of harmful conditions. ...
... change in the environment – introduction of harmful materials or the production of harmful conditions. ...
งานนำเสนอ PowerPoint
... -OH with sulphate to give sulphates -NH2, -CONH2, amino acids, sulpha drugs with acetyl- to give acetylated derivatives -halo, -nitrate, epoxide, sulphate with glutathione to give glutathione conjugates all tend to be less lipid soluble and therefore better ...
... -OH with sulphate to give sulphates -NH2, -CONH2, amino acids, sulpha drugs with acetyl- to give acetylated derivatives -halo, -nitrate, epoxide, sulphate with glutathione to give glutathione conjugates all tend to be less lipid soluble and therefore better ...
Detoxification of substances by the liver
... water-soluble so that it may then be excreted from the body via watery fluids such as bile or urine. There are six phase 2 detoxification pathways: 1.Glutathione conjugation 2. Amino acid conjugation 3. Sulfation 4. Acetylation 5. Glucuronidation These conjugation molecules join with specific enzyme ...
... water-soluble so that it may then be excreted from the body via watery fluids such as bile or urine. There are six phase 2 detoxification pathways: 1.Glutathione conjugation 2. Amino acid conjugation 3. Sulfation 4. Acetylation 5. Glucuronidation These conjugation molecules join with specific enzyme ...
Chapter 19 Homework questions KEY
... controlled and huge amounts of data can be collcted. Also, the data are compared to control groups. However, often those data are collected using non-human test subjects and the effects of doses on non-humans may not correlate directly with human responses Epidemiological Studies compare the health ...
... controlled and huge amounts of data can be collcted. Also, the data are compared to control groups. However, often those data are collected using non-human test subjects and the effects of doses on non-humans may not correlate directly with human responses Epidemiological Studies compare the health ...
File
... Although pollution is increasing on the brighter side there have been significant progress in disease treatments Disability- adjusted life years (DALYs)- measure of disease burden, premature deaths & loss of healthy life cause of illness or disability ...
... Although pollution is increasing on the brighter side there have been significant progress in disease treatments Disability- adjusted life years (DALYs)- measure of disease burden, premature deaths & loss of healthy life cause of illness or disability ...
POLYCYCLIC AROMATIC HYDROCARBON (PAH’S)
... • Organ Damage – Such as lungs, liver, skin, and kidneys can be damaged by exposure. Depending if the person exposure is physical or from smoking/drinking. ...
... • Organ Damage – Such as lungs, liver, skin, and kidneys can be damaged by exposure. Depending if the person exposure is physical or from smoking/drinking. ...
Basic Toxicology Reference
... The lower the value of the LD50 and LC50 the more toxic the substance. Although the lethal dose varies between test animal species and animals and humans, the relative toxicity of substances is usually constant. Therefore a highly toxic substance in an animal model is likely to be highly toxic to hu ...
... The lower the value of the LD50 and LC50 the more toxic the substance. Although the lethal dose varies between test animal species and animals and humans, the relative toxicity of substances is usually constant. Therefore a highly toxic substance in an animal model is likely to be highly toxic to hu ...
1-Bromopropane
... Mechanistic Studies Exactly how 1-bromopropane causes cancer is not fully known. However, exposure to 1-bromopropane has been shown to cause biological changes that relate to cancer development, including DNA damage and mutations, changes to the body’s immune system, antioxidant depletion, and build ...
... Mechanistic Studies Exactly how 1-bromopropane causes cancer is not fully known. However, exposure to 1-bromopropane has been shown to cause biological changes that relate to cancer development, including DNA damage and mutations, changes to the body’s immune system, antioxidant depletion, and build ...
Pesticide Toxicology - Plant Health Atlantic
... He was hospitalized for five days and treated for renal failure and pulmonary fibrosis. On the fifth day he was removed from life support and passed away. ...
... He was hospitalized for five days and treated for renal failure and pulmonary fibrosis. On the fifth day he was removed from life support and passed away. ...
... an example, the status of p-nitrosodiphenylamine as a human carcinogen based on liver tumors reported in B6C3F1 mice was later revoked by the NTP (5th and 6th Annual Report on Carcinogens). c) In the case of pulegone, toxicity is shown to be the result of the reactive menthofuran metabolites, which ...
day 1 intro
... Effects of Toxins • Effects of toxins do not cause VISIBLE changes in the body in living people or during an autopsy. • Medical Examiner will collect fluids and tissues for testing – Toxins are sneaky! Biotransformation can change one chemical into another within the body due to metabolism. – The t ...
... Effects of Toxins • Effects of toxins do not cause VISIBLE changes in the body in living people or during an autopsy. • Medical Examiner will collect fluids and tissues for testing – Toxins are sneaky! Biotransformation can change one chemical into another within the body due to metabolism. – The t ...
Causation of Chronic Diseases Including Cancer
... Success in mapping the human genome has fostered the complementary concept of the "Exposome“ (Wild, IARC,2005). The Exposome can be defined as: “the measure of all the exposures of an individual in a lifetime and how those exposures relate to ...
... Success in mapping the human genome has fostered the complementary concept of the "Exposome“ (Wild, IARC,2005). The Exposome can be defined as: “the measure of all the exposures of an individual in a lifetime and how those exposures relate to ...
Lecture No. 2
... Definition of toxin: • Toxin is any substance that even in small quantities or low concentrations, after a single administration or repeated exposure, cause severe damage to, or the death of, the organism • To quote Professor Švagr, "any substance qualitatively or quantitatively foreign to the orga ...
... Definition of toxin: • Toxin is any substance that even in small quantities or low concentrations, after a single administration or repeated exposure, cause severe damage to, or the death of, the organism • To quote Professor Švagr, "any substance qualitatively or quantitatively foreign to the orga ...
Chapter 15: Environmental Health, Pollution, and Toxicology
... be closer because they are annuals often and develop resistance sooner than other plant groups – Farther away, trees and shrubs may be able to grow ...
... be closer because they are annuals often and develop resistance sooner than other plant groups – Farther away, trees and shrubs may be able to grow ...
Chapter 15: Environmental Health, Pollution, and Toxicology
... be closer because they are annuals often and develop resistance sooner than other plant groups – Farther away, trees and shrubs may be able to grow ...
... be closer because they are annuals often and develop resistance sooner than other plant groups – Farther away, trees and shrubs may be able to grow ...
Environment Pathology and Disease
... Penetrating when the instruments pieces the tissue & Perforating when it traverses a tissue to also create an exit wound ...
... Penetrating when the instruments pieces the tissue & Perforating when it traverses a tissue to also create an exit wound ...
Environmental Health, Pollution and Toxicology
... • The idea that in spite of the fact that full scientific certainty is often not available to prove cause and effect, we should still take cost-effective precautions to solve environmental problems where there exists a threat of potentially serious and/ or irreversible environmental damage • Manufac ...
... • The idea that in spite of the fact that full scientific certainty is often not available to prove cause and effect, we should still take cost-effective precautions to solve environmental problems where there exists a threat of potentially serious and/ or irreversible environmental damage • Manufac ...
Chapter 15: Environmental Health, Pollution, and Toxicology
... are poisonous to people and other living things. – Toxicology is the science that studies chemicals that are known to be or may be toxic based upon animal studies. ...
... are poisonous to people and other living things. – Toxicology is the science that studies chemicals that are known to be or may be toxic based upon animal studies. ...
Fumonisin B1
Fumonisin B1 is the most prevalent member of a family of toxins, known as fumonisins, produced by several species of Fusarium molds, such as Fusarium verticillioides, which occur mainly in maize (corn), wheat and other cereals. Fumonisin B1 contamination of maize has been reported worldwide at mg/kg levels. Human exposure occurs at levels of micrograms to milligrams per day and is greatest in regions where maize products are the dietary staple.Fumonisin B1 is hepatotoxic and nephrotoxic in all animal species tested. The earliest histological change to appear in either the liver or kidney of fumonisin-treated animals is increased apoptosis followed by regenerative cell proliferation. While the acute toxicity of fumonisin is low, it is the known cause of two diseases which occur in domestic animals with rapid onset: equine leukoencephalomalacia and porcine pulmonary oedema syndrome. Both of these diseases involve disturbed sphingolipid metabolism and cardiovascular dysfunction.