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Impact of temperature exposure on stability of drugs in a real
Impact of temperature exposure on stability of drugs in a real

... transferred monthly into the emergency physician transport vehicle assigned to respond first on EMS request. Refrigerator ampoules were stored in a refrigerator located in the laboratory performing the pharmacologic analysis. Ampoules were removed at the designated intervals. Room temperature and em ...
Adverse Drug Reaction–Related Hospitalizations Among
Adverse Drug Reaction–Related Hospitalizations Among

... seniors claimed and the numbers of prescribers and pharmacies visited in 2009–2010. Discharge abstracts were used to determine whether or not the seniors had been hospitalized, for an ADR or another reason, during that same year. The dependent variable captured whether or not seniors were hospitaliz ...
Research Protocol - Newcastle University
Research Protocol - Newcastle University

... (ONS) reported 56 deaths in England and Wales in 2012 where an NPS was mentioned on the death certificate following a drug-related death, almost double the figure for 2011.27 ONS also reported increases in deaths related to specific newer recreational drugs including cathinones (from 6 to 18) and pa ...
Newsletter What’s Inside
Newsletter What’s Inside

... information. Viruses are a typical example of such supramolecular structures, which can also be called nanovehicles. Although there are numerous types of viruses, they always form a sophisticated nanostructure in which DNAs or RNAs forming a compact structure are regularly coated by a protein shell ...
IN TRIHYDRATE  Research Article
IN TRIHYDRATE Research Article

... swallowing intact or chewing to deliver a precise dosage of medication to patients. The pills, which include tablets and capsules, are able to retain their shapes under moderate pressure. However, some patients, particularly pediatric, geriatric, bedridden, psychiatry and traveling patients have dif ...
RAYMOND GEORGE RESEARCH SYNOPSIS
RAYMOND GEORGE RESEARCH SYNOPSIS

... Drug Discovery and Development for Neuropsychiatric Disorders The laboratory is on track to an Investigational New Drug (IND) Application regarding novel drug(s) that target brain serotonin receptors for treatment of neuropsychiatric disorders, including, autism spectrum disorder, obsessive-compulsi ...
APhA BOOKS AND ELECTRONIC PRODUCTS 2014
APhA BOOKS AND ELECTRONIC PRODUCTS 2014

... assertiveness, and conflict management; provide help for patients in accepting the behavior changes needed to manage their illness; and explore ways to become culturally competent to provide quality care for all patients. ...
Chapter 10 Pharmacology
Chapter 10 Pharmacology

... 1. Natural sources such as plants and animals. 2. Microscopic organisms such as bacteria, fungi, and molds. 3. Synthetics and bioengineering. ...
VALIDATED ZERO ORDER AND FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC  AZEOTROPIC MIXTURE Original Article
VALIDATED ZERO ORDER AND FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC AZEOTROPIC MIXTURE Original Article

... There was no interference from the excipients commonly present in the tablets. The drug content was found to be 100.01% with a % R.S.D. of 0.14 and 99.93% with a % R.S.D. of 0.37 for zero order and first order derivative spectrophotometric methods respectively. It may therefore be inferred that degr ...
floating bilayer tablet: a review - international journal of advances in
floating bilayer tablet: a review - international journal of advances in

... due to which it swells when comes in contact with gastric fluid and it also maintain its shape. These systems may be referred to as the ‘plug-type systems’ since they have a tendency to remain stuck near the pyloric sphincter. The most commonly used excipient in non effervescent floating drug delive ...
PUBLIC ASSESSMENT REPORT of the Medicines Evaluation Board
PUBLIC ASSESSMENT REPORT of the Medicines Evaluation Board

... It reflects the scientific conclusion reached by the MEB and all concerned member states at the end of the evaluation process and provides a summary of the grounds for approval of a marketing authorisation. This report is intended for all those involved with the safe and proper use of the medicinal ...
Issues around the Prescription of Half Tablets in Northern
Issues around the Prescription of Half Tablets in Northern

... strong antagonism of 5HT2 receptors and weak antagonism of D2 receptors [12]. It is approved for the treatment of schizophrenia and bipolar disorders [13] and is widely used mainly because it does not induce agranulocytosis [14] and thus does not require blood monitoring. Its substantial advantage i ...
What is the equivalent dose of oral prednisolone to intravenous (IV)
What is the equivalent dose of oral prednisolone to intravenous (IV)

... The biological half-life of prednisolone is 12 to 36 hours (5,7), which allows once-daily dosing. Hydrocortisone has a shorter biological half-life ranging from 8 to 12 hours (5,7). Consequently the dose of hydrocortisone is usually repeated three to four times in 24 hours (8). If the equivalent ant ...
FORMULATION, EVALUATION AND OPTIMIZATION OF SOLID DISPERSION OF GLIPIZIDE
FORMULATION, EVALUATION AND OPTIMIZATION OF SOLID DISPERSION OF GLIPIZIDE

... stimulating the release of insulin from the pancreas and is typically prescribed to treat non insulin dependent diabetes mellitus12. The drug is insoluble in water, and its dissolution is considered to be a rate-determining step (i.e., an effective factor) in its absorption from the gastrointestinal ...
DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR DETERMINATION
DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR DETERMINATION

... The present study describes a simple, accurate, precise and cost effective UV-Spectrophotometric method for the estimation of Tramadol Hydrochloride, an Analgesic, in bulk and pharmaceutical dosage form. The drug was first dissolved in N-N-dimethylformamide and final volume was made up with distille ...
Polypharmacy, Adverse Drug Reactions, and Geriatric
Polypharmacy, Adverse Drug Reactions, and Geriatric

KPGA Formulary Update August 2012
KPGA Formulary Update August 2012

Comments Submitted by Immel Resources LLC
Comments Submitted by Immel Resources LLC

... microorganisms may compromise subsequent purification steps… Endotoxin levels may be minimized by controlling the introduction of microorganisms and microbial proliferation in the system.” If the agency wishes to harmonize with world regulatory requirements for source water used for pharmaceutical p ...
FDA`s Efforts to Encourage Biomarker Development and Qualification
FDA`s Efforts to Encourage Biomarker Development and Qualification

... Take Home Points  Biomarkers can be integrated into drug development through either of the two pathways: 1. Regulatory submissions for drug approval in the context of a single drug or 2. Biomarker qualification ...
An Overview of the FDA Pregnancy and Lactation Labeling Rule
An Overview of the FDA Pregnancy and Lactation Labeling Rule

Prescribing - North Essex Partnership University NHS Foundation
Prescribing - North Essex Partnership University NHS Foundation

...  Be satisfied there is sufficient evidence or experience of using the medicine to demonstrate its safety and efficacy  Take responsibility for prescribing the medicine and for overseeing the patient’s care, monitoring, and any follow up treatment, or ensure that arrangements are made for another s ...
Generic substitution in the treatment of epilepsy
Generic substitution in the treatment of epilepsy

... that the change to the generic was the reason for the loss of seizure control. Several other smaller case reports offer similar, albeit anecdotal, evidence that generic substitution can lead to breakthrough seizures. In one report, eight patients had increased seizures after being switched from bran ...
Investigating the Suitability of Isomalt and Liquid Glucose as Sugar
Investigating the Suitability of Isomalt and Liquid Glucose as Sugar

... problem of dysphagia which is commonly associated with pediatric, geriatric, patients suffering from nausea (in cancer patients) and other patients having a problem in swallowing tablets. Hard candy lozenges prepared from Isomalt alone and in combination with corn syrup (liquid glucose) exhibits goo ...
Slides - Food and Drug Law Institute
Slides - Food and Drug Law Institute

... Prohibits the sale of “flavored tobacco products,” “samples of such products,” and “accessories” within 500 feet of a school – “Flavored tobacco product” means “any tobacco product that contains a constituent that imparts a characterizing flavor” – “Characterizing flavor” defined as a “distinguishab ...
Optimal Futures for Risk Evaluation and Mitigation Strategies (REMS)
Optimal Futures for Risk Evaluation and Mitigation Strategies (REMS)

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Pharmaceutical marketing

Pharmaceutical marketing, sometimes called medico-marketing or pharma marketing in some countries, is the business of advertising or otherwise promoting the sale of pharmaceuticals or drugs.Many countries have measures in place to limit advertising by pharmaceutical companies.Pharmaceutical company spending on marketing far exceeds that of its research budget. In Canada, $1.7 billion was spent in 2004 to market drugs to physicians; in the United States, $21 billion was spent in 2002. In 2005, money spent on pharmaceutical marketing in the United States was estimated at $29.9 billion with one estimate as high as $57 billion. When the U.S. numbers are broken down, 56% was free samples, 25% was pharmaceutical sales representative ""detailing"" (promoting drugs directly to) physicians, 12.5% was direct to user advertising, 4% on detailing to hospitals, and 2% on journal ads. There is some evidence that marketing practices can negatively affect both patients and the health care profession.
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