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Drug Discovery and Development
Drug Discovery and Development

... • Pharmaceutical companies have prepared thousands of compounds • These are stored (in the freezer!), cataloged and screened on new targets as these new targets are identified ...
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illegal drugs

... Lesson 1: Health Risks of Drug Use  Substance abuse includes the use of illegal substances, as well as the misuse of legal substances  Factors that influence teens o Peer pressure o Family members o Role models o Media messages o Perceptions of drug behavior o Misleading information  How drugs af ...
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... ● Increased body fat- reduces plasma levels of lipid soluble drugs ● Decreased total body water- increases concentration of water soluble drugs and intensity of response ● Reduced concentration of serum albuminmalnourishment decreases albumin and results in increased drug levels ...
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... heart failure, asthma, bronchitis, or other chronic lung diseases. It should be used with caution in animals with severe heart disease, abnormal heart rhythms, kidney or liver impairment, or high blood pressure. Theophylline has been shown to cause stomach irritation and nervous system stimulation. ...
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... early detection of hitherto unknown ADRs detection of increases in frequency of known ADRs identification of risk factors and possible mechanisms underlying ADRs estimation of benefit/risk dissemination of information ...
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WHO database on rational drug use studies

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...  Drugs that are mainly excreted via the kidney are likely to a c c u m u l a t e in patients in their seventies and eighties if given in doses suitable for young adults.  Examples of drugs requiring dose adjustment in the elderly: aminoglycosides, atenolol, diazepam, digoxin, oral hypoglycemic age ...
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... 41. The transdermal route of drug administration is an effective one for most drugs. 42. Metabolites of some drugs cause unwanted side effects while those of other drugs cause desired psychoactive effects. 43. Drug potency is another name for effective dose. 44. Expectancy effects are most prominent ...
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... expected action, events occurring from drug withdrawal, and unexpected events not listed in labeling. Events that are both serious and unexpected must be reported to the FDA within 15 days. In January 2006, the FDA announced a new prescription drug information format to improve patient safety by imp ...
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... Drug product selection: The process of selecting dosage form in which the drug product will be manufactured. ...
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... exposure to the experimental drug. • IND is an ongoing file at FDA containing data on drug as it passes through the development process. • Inexperienced companies often hire consultants to help. ...
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... warfarin. Patients already on any of these drugs may be started on warfarin and the dose adjusted as required. Drug interactions with warfarin tend to be variable and unpredictable and on the whole affect a fairly small proportion of patients. If any of the drugs below are to be started in these pat ...
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... efficacious than Drug Y. Efficacy is defined as the maximum effect that can be produced by a drug, regardless of dose. Drug X can only produce a 50% change in resistance, whereas Drug Y can produce a 75% change in resistance. Therefore, Drug X is less efficacious than Drug Y. ...
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Prescription costs

Prescription costs are a common health care cost for many people and also the source of considerable economic hardship for some. These costs are sometimes referred to as out-of-pocket prescription costs, since for those with insurance, the total cost of their prescriptions may include expenses covered by a third party, such as an insurance company, as well as the individual. Out-of-pocket prescription costs include deductibles, co-payments, and upper limits in coverage.
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