A New Therapeutic Applications for Drug Repositioning
... may be new uses for existing drugs as repositioning candidates have frequently been through several phases of development (ADMET, absorption, distribution, metabolism, excretion and toxicity; EMEA, European Medicines Agency; FDA, Food and Drug Administration; IP, intellectual property; MHLW, Ministr ...
... may be new uses for existing drugs as repositioning candidates have frequently been through several phases of development (ADMET, absorption, distribution, metabolism, excretion and toxicity; EMEA, European Medicines Agency; FDA, Food and Drug Administration; IP, intellectual property; MHLW, Ministr ...
PHARMACEUTICAL ASPECTS OF NICORANDIL
... in unstable angina; the pain is more frequent, more severe, long lasting, occurs at rest and are not relieved by nitroglycerin under the tongue1. Angina pectoris is the most common form of cardiovascular diseases that require constant monitoring and therapy. Potassium channel openers ...
... in unstable angina; the pain is more frequent, more severe, long lasting, occurs at rest and are not relieved by nitroglycerin under the tongue1. Angina pectoris is the most common form of cardiovascular diseases that require constant monitoring and therapy. Potassium channel openers ...
Biochemical Markers as Tools to Increase Efficiency in Drug
... Figure shows the idealised critical path, modified from ‘Challenge and Opportunity on the Critical Path to New Medical Products’, published by the US Food and Drug Administration (FDA) in 2004.1 It provides an outline of the different components of the FDA critical path. Starting with ‘basic researc ...
... Figure shows the idealised critical path, modified from ‘Challenge and Opportunity on the Critical Path to New Medical Products’, published by the US Food and Drug Administration (FDA) in 2004.1 It provides an outline of the different components of the FDA critical path. Starting with ‘basic researc ...
Cardiovascular System Drugs – Summary
... that can be presented in a patient. Stable angina results from the inability of the hearts coronary circulation to meet the metabolic demands of heart tissue. There is an imbalance between the oxygen delivery and oxygen requirements of the tissue. Unstable angina is when the fibrous cap of the plaqu ...
... that can be presented in a patient. Stable angina results from the inability of the hearts coronary circulation to meet the metabolic demands of heart tissue. There is an imbalance between the oxygen delivery and oxygen requirements of the tissue. Unstable angina is when the fibrous cap of the plaqu ...
FDA Safety Reviews on Drugs, Biologics, and Vaccines: 2007–2013
... Revised to clearly state that the use of maintenance of non-untubated pediatric patients be contraindicated Include information about neuropsychiatric events in the Warnings and Precautions section of the label and in the patient package insert Include information about AEs (eg, weight loss, bone mi ...
... Revised to clearly state that the use of maintenance of non-untubated pediatric patients be contraindicated Include information about neuropsychiatric events in the Warnings and Precautions section of the label and in the patient package insert Include information about AEs (eg, weight loss, bone mi ...
Developments in Community Drug Treatment
... reduced injection related risk behaviour reduced HIV infection reduced mortality improved psycho-social well-being increased employment ...
... reduced injection related risk behaviour reduced HIV infection reduced mortality improved psycho-social well-being increased employment ...
Chinese Traditional Medicines Face Crucial Challenges in the New
... from the previous biomedical model to “bio-psychosocial medical model”. The development of medicine has also made us gradually realize that the complexity of human disease is far more than the human science and technology progress. Therefore mainstream medicine, traditional medicine or alternative m ...
... from the previous biomedical model to “bio-psychosocial medical model”. The development of medicine has also made us gradually realize that the complexity of human disease is far more than the human science and technology progress. Therefore mainstream medicine, traditional medicine or alternative m ...
pps - Chair of Computational Biology
... In the rarest cases bioisosters (similar chemical space) will show the same activity profile (similar biological space) than the compound they have been derived from. Aimed are following properties: better mode of action improved selectivity increased bioavailability less toxic fewer adverse side ef ...
... In the rarest cases bioisosters (similar chemical space) will show the same activity profile (similar biological space) than the compound they have been derived from. Aimed are following properties: better mode of action improved selectivity increased bioavailability less toxic fewer adverse side ef ...
Drug reaction with eosinophilia and systemic symptoms
... possible1 (Table 1). On the other hand, the Japanese Research Committee on Severe Cutaneous Adverse Reaction presented another set of diagnostic criteria, including the importance of VH6 in its etiopathogenesis, and classified according to a score of 7 for a typical DRESS syndrome and only a score o ...
... possible1 (Table 1). On the other hand, the Japanese Research Committee on Severe Cutaneous Adverse Reaction presented another set of diagnostic criteria, including the importance of VH6 in its etiopathogenesis, and classified according to a score of 7 for a typical DRESS syndrome and only a score o ...
Psychotropic Drugs and Ocular Side Effects
... ocular smooth muscles, thus visual haze and/or myopia develop. Cycloplegia is related to the paretic effect on ciliary muscle. Mydriasis and cyclopegia rise in result of TCAs’ anticholinergic effect. Moreover, noradrenaline uptake blockage and alphaadrenergic receptor blockages should also be consid ...
... ocular smooth muscles, thus visual haze and/or myopia develop. Cycloplegia is related to the paretic effect on ciliary muscle. Mydriasis and cyclopegia rise in result of TCAs’ anticholinergic effect. Moreover, noradrenaline uptake blockage and alphaadrenergic receptor blockages should also be consid ...
JV Poster Barcelona 2012
... The development of novel memory enhancers for treating cognitive deficits associated with neurological and psychiatric disorders remains a primary focus of study in central nervous system research. Glutamatergic system has been identified as a central element in this purpose. Indeed, low-affinity bl ...
... The development of novel memory enhancers for treating cognitive deficits associated with neurological and psychiatric disorders remains a primary focus of study in central nervous system research. Glutamatergic system has been identified as a central element in this purpose. Indeed, low-affinity bl ...
NEW WAYS TO BE ADDICTED: LATEST TRENDS IN SUBSTANCE
... European Monitoring Center for Drugs and Drug Addiction (EMCDDA) – Annual Report 2014 ...
... European Monitoring Center for Drugs and Drug Addiction (EMCDDA) – Annual Report 2014 ...
3 Perinatal Pharmacology
... The volume of distribution for many drugs is increased in pregnancy, likely due to an increase in plasma volume and body fat. However, clearance of some drugs may be decreased (thiopental), unchanged (succinylcholine), or increased (vecuronium). Because sensitivity to many anesthetic drugs is increa ...
... The volume of distribution for many drugs is increased in pregnancy, likely due to an increase in plasma volume and body fat. However, clearance of some drugs may be decreased (thiopental), unchanged (succinylcholine), or increased (vecuronium). Because sensitivity to many anesthetic drugs is increa ...
Glivec
... Marketing authorisation holder: Novartis Europharm Ltd Availability: National Health Service Variations: Data from small retrospective case series and case reports showed that longitudinal bone growth ...
... Marketing authorisation holder: Novartis Europharm Ltd Availability: National Health Service Variations: Data from small retrospective case series and case reports showed that longitudinal bone growth ...
Presentation
... Profiled BAL30072 in vitro and in vivo against MDR bacteria including those expressing ESBL, NDM-1, CTX-M, VIM10/VEB, AmpC and OXA Demonstrated that the in vivo efficacy of BAL30072 against most Enterobacteriaceae and P. aeruginosa isolates was time dependent and rapid in vivo bactericidal activ ...
... Profiled BAL30072 in vitro and in vivo against MDR bacteria including those expressing ESBL, NDM-1, CTX-M, VIM10/VEB, AmpC and OXA Demonstrated that the in vivo efficacy of BAL30072 against most Enterobacteriaceae and P. aeruginosa isolates was time dependent and rapid in vivo bactericidal activ ...
Abuse of Prescription drugs
... measures to prevent the diversion and illicit manufacture of prescription drugs, as an effective way to prevent abuse. 292. Some psychotropic substances, all of them central nervous system stimulants, are used mainly in the treatment of attention deficit hyperactivity disorder (ADHD), a mental and b ...
... measures to prevent the diversion and illicit manufacture of prescription drugs, as an effective way to prevent abuse. 292. Some psychotropic substances, all of them central nervous system stimulants, are used mainly in the treatment of attention deficit hyperactivity disorder (ADHD), a mental and b ...
Modern Methods in Drug Discovery
... Generate k QSAR equations using a subset as test set and the remaining k-1 subsets as training set respectively. This gives you an average error from the k QSAR equations. In practice k = 10 has shown to be reasonable (= 10-fold cross validation) 6th lecture ...
... Generate k QSAR equations using a subset as test set and the remaining k-1 subsets as training set respectively. This gives you an average error from the k QSAR equations. In practice k = 10 has shown to be reasonable (= 10-fold cross validation) 6th lecture ...
racemic drugs
... enantiomer, the second one distinguishes them an R and S enantiomer (see fly-leaf). Almost all biological organisms produce only one of the 2 enantiomers, usually the levorotatory one. For this reason, production, experimentation and clinical use of substances of natural origin are ...
... enantiomer, the second one distinguishes them an R and S enantiomer (see fly-leaf). Almost all biological organisms produce only one of the 2 enantiomers, usually the levorotatory one. For this reason, production, experimentation and clinical use of substances of natural origin are ...
![STV(])FES O!}{(])CJ(vq POqt£/ffl1flLS](http://s1.studyres.com/store/data/016575417_1-aba7121b9567f1c5ba5243ddcf13ada3-300x300.png)
STV(])FES O!}{(])CJ(vq POqt£/ffl1flLS
... several early discoveries of drug-bearing plants. Two of these plants contain alkaloids of worldwide importance that have become modern drugs. They are cocaine and quinine. Cocaine's potential for addiction was known and used with sinister intent by South American Indian chiefs hundreds of years ago ...
... several early discoveries of drug-bearing plants. Two of these plants contain alkaloids of worldwide importance that have become modern drugs. They are cocaine and quinine. Cocaine's potential for addiction was known and used with sinister intent by South American Indian chiefs hundreds of years ago ...
(Agonist) of Nuclear Receptor
... AIDS EVALUATION OF MEDICAL LITERATURE: • Better assessment of new modalities for using drugs • Better assessment of new indications for drugs • Better assessment of new concerns regarding risk-benefit ...
... AIDS EVALUATION OF MEDICAL LITERATURE: • Better assessment of new modalities for using drugs • Better assessment of new indications for drugs • Better assessment of new concerns regarding risk-benefit ...
Biomarkers and surrogate endpoints: How and when might they
... A surrogate endpoint is a biomarker that correlates very well with the activity and/or toxicity of the molecule. It is generally an acceptable endpoint for registration of a molecule with regulatory agencies. A biomarker qualifies as a surrogate endpoint for a clinical endpoint after controlled clin ...
... A surrogate endpoint is a biomarker that correlates very well with the activity and/or toxicity of the molecule. It is generally an acceptable endpoint for registration of a molecule with regulatory agencies. A biomarker qualifies as a surrogate endpoint for a clinical endpoint after controlled clin ...
Reducing Impaired Driving Recidivism
... effects of alcohol. Certain generalizations can be made: high doses generally have a larger effect than small doses; well-learned tasks are less affected than novel tasks; and certain variables, such as prior exposure to a drug, can either reduce or accentuate expected effects, depending on circumst ...
... effects of alcohol. Certain generalizations can be made: high doses generally have a larger effect than small doses; well-learned tasks are less affected than novel tasks; and certain variables, such as prior exposure to a drug, can either reduce or accentuate expected effects, depending on circumst ...
DISCOVERY OF NOVEL IKK-Β INHIBITOR BY STRUCTURAL MODIFICATIONS OF
... Objective: Diabetes Mellitus (Type II) is one of the predominant diseases which has seen rise globally. Kappa-B kinase beta (IKK-β) - a protein subunit of IKappa-B kinase, is an emerging target for treatment of non-insulin dependent diabetes mellitus (NIDDM). Chlorpropamide(diabinese) and nateglinid ...
... Objective: Diabetes Mellitus (Type II) is one of the predominant diseases which has seen rise globally. Kappa-B kinase beta (IKK-β) - a protein subunit of IKappa-B kinase, is an emerging target for treatment of non-insulin dependent diabetes mellitus (NIDDM). Chlorpropamide(diabinese) and nateglinid ...
Drug Administration
... 20.9 Pediatric and geriatric patients require extreme care when calculating doses due to the differences in how their bodies absorb, metabolize, eliminate, and distribute the medications. Treat pediatric patients with special care and communication to make the experience as positive as possible. Res ...
... 20.9 Pediatric and geriatric patients require extreme care when calculating doses due to the differences in how their bodies absorb, metabolize, eliminate, and distribute the medications. Treat pediatric patients with special care and communication to make the experience as positive as possible. Res ...
Pharmaceutical industry
The pharmaceutical industry develops, produces, and markets drugs or pharmaceuticals for use as medications. Pharmaceutical companies may deal in generic or brand medications and medical devices. They are subject to a variety of laws and regulations that govern the patenting, testing, safety, efficacy and marketing of drugs.