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Combined right ventricular systolic and diastolic dysfunction
Combined right ventricular systolic and diastolic dysfunction

... and with other prognostic markers has not yet been systematically studied. The aim of this study was to assess the prognostic impact of combined right ventricular systolic and diastolic dysfunction in patients with symptomatic heart failure due to ischemic or idiopathic dilated cardiomyopathy. Metho ...
Cost-utility analysis of percutaneous mitral valve repair in inoperable
Cost-utility analysis of percutaneous mitral valve repair in inoperable

... clinical effectiveness was determined based on the results of the Transcatheter Implantation of Carillon Mitral Annuloplasty Device (TITAN) trial. The mean age of the target population was 62 years, 77 % of the patients were males, 64 % of the patients had severe FMR and all patients had New York He ...
Mitral annular plane systolic excursion on
Mitral annular plane systolic excursion on

... tion (LVEF)¼60 + 7%] with reduced VO2 max (18.6 + 5.2 mL/min/kg) and 36 control subjects (LVEF¼62 + 7%, VO2 max 29.4 + 4.8 mL/min/kg) were studied. MAPSE at rest was significantly lower in patients (10.9 + 2.1 vs. 12.1 + 2.2 mm in controls, P ¼ 0.008) which was even more pronounced on exercise (12.0 ...
Malignant neurilemmoma of left atrium
Malignant neurilemmoma of left atrium

... in the left atrium is extremely rare. In this case the primary retroperitoneal tumour arose in the sacral plexus and metastasised to the left atrium after passing through the pulmonary circulation, both the cardiac and the sacral tumours showing the typical naked eye and cytological pattern of a neu ...
G Govender Perioperative management of patients
G Govender Perioperative management of patients

... The third position is the most confusing. The most frequently used programs are the DDD (dual chamber pacing and sensing, both triggered and inhibited mode), VVI (for single chamber, ventricular pacing in the inhibited mode), VDD (ventricular pacing with atrial tracking), and DDI (dual chamber pacin ...
Long-term prognosis after a normal exercise stress Tc
Long-term prognosis after a normal exercise stress Tc

... Ron T. van Domburg, PhD,b and Don Poldermans, MD, PhDb Background. Patients with a normal stress technetium 99m sestamibi study were shown to have a favorable outcome at intermediate-term follow-up. However, long-term survival has not been studied. The aim of this study was to evaluate the incidence ...
Slide 1
Slide 1

...  Some types of pacemakers, application of a magnetic field is a step required to initiate reprogramming of the generator.  Random reprogramming when exposed to magnetic fields. ...
Use of ECG for Screening for Coronary Heart Disease in
Use of ECG for Screening for Coronary Heart Disease in

... abnormalities for detecting coronary heart disease events in asymptomatic individuals is low.11-13 A systematic review by Pewsner D et al included studies done on asymptomatic hypertensive patients and reported that the sensitivity of the six most commonly used 12 lead electrocardiogram criteria was ...
Successful treatment of cardiogenic shock by stenting of the left main
Successful treatment of cardiogenic shock by stenting of the left main

... study which determined long term clinical outcomes in patients with ostial or bifurcation LM stentning adverse events (myocardial infarction, sudden death) occurred during the follow-up period (mean 28 mos) in both groups with equal frequency. The two-year outcomes of the patients with unprotected L ...
Heart Lecture Test Questions – Set 2
Heart Lecture Test Questions – Set 2

... a. the heart is positioned more to the left of the body's midline b. the ventricular conducting system is more extensive than the atrial system c. this prolongs its action, to prevent overlap with atrial systole d. this produces a milking action which squeezes the maximum amount of blood into the ao ...
the effects of various swimming training protocols on cardiac
the effects of various swimming training protocols on cardiac

... Swimming Training and Cardiac Capacity Furthermore, it is important to note that the aerobic swimming exercise of moderate duration and low to moderate intensity caused similar increasing level of the ventricular fibrillation threshold. Moreover, that effect was demonstrated after 8 training weeks ...
Ischemic Heart Disease (IHD)
Ischemic Heart Disease (IHD)

... HR × SBP). The DP does not consider changes in contractility (an independent variable), and because only changes in pressure are considered, volume loading of the left ventricle and increased MVO2 related to ventricular dilation are underestimated. • The caliber of the resistance vessels delivering ...
Nursing Care Plan
Nursing Care Plan

... 6. Monitoring intake and output is an important indicator of fluid balance. If a person is taking in more fluid than they are excreting and their cardiac output is low, it can exacerbate their peripheral and pulmonary edema. The patient cardiac output is low she had Bilateral lower extremities 1+ pi ...
Heart Sounds. - Sinoe Medical Association
Heart Sounds. - Sinoe Medical Association

... ¾ It is created when the atrial contraction rapidly distends the ventricle. When the stiff, non-complient ventricular wall reaches its physical limits it tenses, and the S4 is created. ¾ Only patient swith atrial contraction can have an S4 (atrial fibrillation and junctional rhythms should not have ...
Fibroblast Growth Factor-23, Cardiovascular Prognosis, and
Fibroblast Growth Factor-23, Cardiovascular Prognosis, and

... of Events with Angiotensin-Converting Enzyme) Trial was a randomized trial of trandolapril versus placebo in 8,290 participants age 50 years with SIHD, left ventricular ejection fraction >40%, and serum creatinine 2.0 mg/dl ...
Tetralogy of Fallot - American Heart Association
Tetralogy of Fallot - American Heart Association

... If tetralogy of Fallot has been repaired with surgery, and there’s no obstruction or leak in the pulmonary valve, you may be able to participate in normal activities without much increased risk. You may need to limit your activity if there is leftover obstruction or a pulmonary valve leak, which is ...
Restoration of Regional Wall Motion by
Restoration of Regional Wall Motion by

... the loading conditions of the ventricle. Distinct worsening of wall motion has been demonstrated following interventions such as atrial pacing and intravenously administered pr~pranolol.'~"In both cases, the mechanism was said to be due to an imbalance of the myocardial oxygen demand-tosupply ratio, ...
Congenital Heart Defects in Adulthood
Congenital Heart Defects in Adulthood

... septal defects (VSD). The figure shows that especially in upper sinus venosus defects, attention should be paid to associated anomalous pulmonary venous connection. TV, tricuspid valve ...
Heart Failure in Children: Clinical Aspect and Management
Heart Failure in Children: Clinical Aspect and Management

... 70%, it occurred in the first year of life. Overall mortality in children with HF was 14%, more than double when compared to mortality in all heart disease patients.4 One large database from US found out that the heart failure in children (<18 years of age) was complicated by more frequent procedure ...
AORTIC ANEURYSMS AND DISSECTION Aorta is about 1 inch or 2
AORTIC ANEURYSMS AND DISSECTION Aorta is about 1 inch or 2

... c. EKG – electrical alternans: alteration of QRS complex amplitude or axis between beats i. Due to pendular swinging of heart; it is a motion artifact; not diagnostic tho d. Cardiac catheterization – equalization of all pressures in all chambers of the heart i. Shows elevated right atrial pressure w ...
Respiratory muscle dysfunction in idiopathic pulmonary arterial hypertension
Respiratory muscle dysfunction in idiopathic pulmonary arterial hypertension

... Patients included in the study showed no clinical or radiological signs of cardiopulmonary decompensation, concomitant left heart disease or other pulmonary disease. The study was approved by the local ethics committee and was in accordance with the recommendation found in the Helsinki Declaration [ ...
SSC – Perspectives On Medical Advances
SSC – Perspectives On Medical Advances

... from the unexpanded lungs, but normally closes after birth when the lungs are viable.11 Due to the varying times it takes the ductus to close after birth, she found that patients with Fallot’s tetralogy tended to become cyanosed following the closure of the ductus. From this Taussig proposed the man ...
utmj submission template - University of Toronto Medical Journal
utmj submission template - University of Toronto Medical Journal

... with aspirin (75-300 mg/day) and intermediate and high risk patients are recommended anticoagulation with warfarin (INR: 2.0-3.0). A final treatment protocol for anticoagulation that requires mention is anticoagulation treatment before either pharmacological or electrical cardioversion. Pharmacologi ...
Oxygen Supplementation and Cardiac
Oxygen Supplementation and Cardiac

... section. The problem with this approach is that as the time window is made shorter the frequency resolution decreases, resulting in a lessened ability to accurately determine the frequency content. In other words, there is a tradeoff between time resolution and frequency resolution. The time-frequen ...
PDF file - Via Medica Journals
PDF file - Via Medica Journals

... syndrome or cardiogenic shock, LV dysfunction, use of inotropic agents and complex therapies were associated with greater risk of mortality or rehospitalizations. All these variables have been associated with worse outcome in previous publications. The novel information provided by this study is the ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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