Molecular and Cellular Basis for Diastolic Dysfunction
... metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) [21]. In HFpEF, matrix degradation is decreased because of altered expression of MMPs and up-regulation of TIMPs [22–25]. Previously, serological markers of collagen turnover significantly predicted diastolic dysfunction and HFpEF, with ...
... metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) [21]. In HFpEF, matrix degradation is decreased because of altered expression of MMPs and up-regulation of TIMPs [22–25]. Previously, serological markers of collagen turnover significantly predicted diastolic dysfunction and HFpEF, with ...
Thrombolytics in Cardiac Arrest
... Pathophysiology of Cardiac Arrest4—6 Cardiac arrest is associated with activation of the coagulation cascade, without compensatory activation of intrinsic fibrinolysis Imbalance leads to widespread development of microthrombi, even after 5—10 minutes of cardiopulmonary resuscitation (CPR) ...
... Pathophysiology of Cardiac Arrest4—6 Cardiac arrest is associated with activation of the coagulation cascade, without compensatory activation of intrinsic fibrinolysis Imbalance leads to widespread development of microthrombi, even after 5—10 minutes of cardiopulmonary resuscitation (CPR) ...
Backgrounder: The Risk of Stroke in Atrial Fibrillation (AF)
... factors, such as changes in diet or concomitant medications. As a result, safe and effective utilisation of chronic warfarin therapy requires frequent monitoring. 23 The FDA’s Adverse Event Reporting System indicated that warfarin is among the top 10 drugs with the largest number of serious adverse ...
... factors, such as changes in diet or concomitant medications. As a result, safe and effective utilisation of chronic warfarin therapy requires frequent monitoring. 23 The FDA’s Adverse Event Reporting System indicated that warfarin is among the top 10 drugs with the largest number of serious adverse ...
PDF Fulltext - Electronic Physician Journal
... associated defects in patients were tricuspid valve (TV) anomalies, which occurred in ninety one percent of cases, VSD in seventy eight percent and pulmonary outflow tract obstruction in forty four percent. Indications for surgery in this anomaly are directly related to the severity of the associate ...
... associated defects in patients were tricuspid valve (TV) anomalies, which occurred in ninety one percent of cases, VSD in seventy eight percent and pulmonary outflow tract obstruction in forty four percent. Indications for surgery in this anomaly are directly related to the severity of the associate ...
Uncontrolled hypertension due to volume
... to higher blood pressure (BP) and increased left ventricular mass index (LVMI). Methods. Seventy-four CAPD patients were included in the final analysis. All patients underwent echocardiographic examination and received ABPM. Patients undergoing CAPD were categorized into two groups: ‘uncontrolled HT ...
... to higher blood pressure (BP) and increased left ventricular mass index (LVMI). Methods. Seventy-four CAPD patients were included in the final analysis. All patients underwent echocardiographic examination and received ABPM. Patients undergoing CAPD were categorized into two groups: ‘uncontrolled HT ...
Portal vein thrombosis of a newborn with corrected total anomalous
... drainage of pulmonary venous blood into the systemic venous system. It may present as an isolated lesion or in combination with other cardiac defects. The clinical symptoms and signs are variable and depend on the associated cardiac anomaly. The prognosis of these patients is poor without surgical t ...
... drainage of pulmonary venous blood into the systemic venous system. It may present as an isolated lesion or in combination with other cardiac defects. The clinical symptoms and signs are variable and depend on the associated cardiac anomaly. The prognosis of these patients is poor without surgical t ...
Full Text - Crescent Journal of Medical and Biological Sciences
... the world. Most of those who die annually, suffer from these diseases than any other reason. In 2008, 17.5 million people died of this disease in the world (about 30% of all deaths). Interventional studies suggest that lack of physical activities were related strongly to these diseases (1,2). Regula ...
... the world. Most of those who die annually, suffer from these diseases than any other reason. In 2008, 17.5 million people died of this disease in the world (about 30% of all deaths). Interventional studies suggest that lack of physical activities were related strongly to these diseases (1,2). Regula ...
Atrial Fibrillation
... This procedure slows the ventricular rate in some people who have atrial fibrillation or flutter. If this procedure is not successful, radiofrequency ablation is used to destroy the entire atrioventricular node, completely stopping conduction from the atria to the ventricles. In such cases, a perman ...
... This procedure slows the ventricular rate in some people who have atrial fibrillation or flutter. If this procedure is not successful, radiofrequency ablation is used to destroy the entire atrioventricular node, completely stopping conduction from the atria to the ventricles. In such cases, a perman ...
Zaporozhye State Medical University
... The U wave is a small upward deflection following the T wave. It is seldom present, but may occur when the serum potassium level is low. The QT interval represents the time from the beginning of the Q wave (downward deflection following the P wave) through the QRS and the T wave. It includes the tim ...
... The U wave is a small upward deflection following the T wave. It is seldom present, but may occur when the serum potassium level is low. The QT interval represents the time from the beginning of the Q wave (downward deflection following the P wave) through the QRS and the T wave. It includes the tim ...
Predictive Value of Silent Myocardial Ischemia for
... a normal ECG stress test (2). Other studies have shown that a positive exercise ECG test predicts a 3–14 times higher rate of major cardiac events (3,4). Silent ischemic episodes during 24-h ECG monitoring have also been shown to be associated with a higher rate of major cardiac events in patients w ...
... a normal ECG stress test (2). Other studies have shown that a positive exercise ECG test predicts a 3–14 times higher rate of major cardiac events (3,4). Silent ischemic episodes during 24-h ECG monitoring have also been shown to be associated with a higher rate of major cardiac events in patients w ...
Characteristics, Treatments, and Outcomes of Hospitalized Heart
... records on patient demographics, medical ...
... records on patient demographics, medical ...
Norske abstrakter/postere på EuroPrevent 2008
... Introduction: The European Heart Survey on Congenital Heart Disease described follow-up data in 902/634 adult patients with isolated atrial or ventricular septal defect (ASD or VSD). The reported prevalence of pulmonary hypertension was 18% in both closed ASD and closed VSD which was surprisingly hi ...
... Introduction: The European Heart Survey on Congenital Heart Disease described follow-up data in 902/634 adult patients with isolated atrial or ventricular septal defect (ASD or VSD). The reported prevalence of pulmonary hypertension was 18% in both closed ASD and closed VSD which was surprisingly hi ...
The influence of altered circulating blood volume on ventricular
... and interventricular septum (Fig. 1B, C), the persistence of immature trabeculae with large interfascicular spaces, and wide spaces between the endocardium and myocardium containing abundant residual matrix fibrils. The group with altered trabeculation patterns was characterized by the presence of a ...
... and interventricular septum (Fig. 1B, C), the persistence of immature trabeculae with large interfascicular spaces, and wide spaces between the endocardium and myocardium containing abundant residual matrix fibrils. The group with altered trabeculation patterns was characterized by the presence of a ...
REMAC LVAD Advisory
... An increasing number of individuals are discharged home implanted with a left ventricular assist device or left ventricular assist system (LVAD/LVAS) to sustain life while either waiting for a heart transplant, treatment for congestive heart failure, or as destination therapy. The most common device ...
... An increasing number of individuals are discharged home implanted with a left ventricular assist device or left ventricular assist system (LVAD/LVAS) to sustain life while either waiting for a heart transplant, treatment for congestive heart failure, or as destination therapy. The most common device ...
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... 1. Heart Failure: (1) Systolic failure: the mechanical pumping action (contractility) and the ejection fraction of the heart are reduced. (2) Diastolic failure: stiffening and loss of adequate relaxation plays a major role in reducing cardiac output and ejection fraction may be normal. e.g. Pericard ...
... 1. Heart Failure: (1) Systolic failure: the mechanical pumping action (contractility) and the ejection fraction of the heart are reduced. (2) Diastolic failure: stiffening and loss of adequate relaxation plays a major role in reducing cardiac output and ejection fraction may be normal. e.g. Pericard ...
Differential left ventricular remodelling and longitudinal function
... and moderate (n ¼ 75, yellow shade) aortic stenosis (AS). Horizontal and vertical lines represent current cut-offs for AVA and MG for severe AS, respectively. Solid black, dashed blue, and dashed green lines represent curve fit for all, preserved EF, normal flow, and low-flow AS patients, respective ...
... and moderate (n ¼ 75, yellow shade) aortic stenosis (AS). Horizontal and vertical lines represent current cut-offs for AVA and MG for severe AS, respectively. Solid black, dashed blue, and dashed green lines represent curve fit for all, preserved EF, normal flow, and low-flow AS patients, respective ...
Management of Common Arrhythmias
... intolerance; therefore, it should be reserved for use in patients who are relatively immobile, who cannot tolerate other treatment options, or who have significant ventricular dysfunction. Paroxysmal Supraventricular Tachycardias Based on duration, supraventricular tachycardias are usually categoriz ...
... intolerance; therefore, it should be reserved for use in patients who are relatively immobile, who cannot tolerate other treatment options, or who have significant ventricular dysfunction. Paroxysmal Supraventricular Tachycardias Based on duration, supraventricular tachycardias are usually categoriz ...
Atrial fibrillation is seen in all except
... d) Bisoprolol A 36 years old female recurrent chest pain and palpitation varying in duration and severity and 6-7 ectopics perminute (possibly supraventricular) not related to exertion. The ideal investigation is a) Echocardiography *b) Holter monitoring c) Thallium study d) Technetium pyrophosphate ...
... d) Bisoprolol A 36 years old female recurrent chest pain and palpitation varying in duration and severity and 6-7 ectopics perminute (possibly supraventricular) not related to exertion. The ideal investigation is a) Echocardiography *b) Holter monitoring c) Thallium study d) Technetium pyrophosphate ...
and Atrial Fibrillation - Chronic Obstructive Pulmonary Disease
... airway disease performed concluded that the initiation of treatment increases heart rate and reduces potassium concentrations compared to placebo and it causes adverse cardiovascular events like CHF, AF, etc. likely through these mechanisms along with β-1 adrenergic stimulation [14]. At the same tim ...
... airway disease performed concluded that the initiation of treatment increases heart rate and reduces potassium concentrations compared to placebo and it causes adverse cardiovascular events like CHF, AF, etc. likely through these mechanisms along with β-1 adrenergic stimulation [14]. At the same tim ...
RADIONUCLIDE VENTRICULOGRAPY Vs CHEST X-RAY
... including measurement of left ventricular ejection fraction in 46. Coronary angiography was undertaken later (mean 2.3 months) in 51. ...
... including measurement of left ventricular ejection fraction in 46. Coronary angiography was undertaken later (mean 2.3 months) in 51. ...
The Effect of Liver Cirrhosis Severity on Left Ventricular Systolic and
... cirrhotic patients is blunted, with subnormal responses in echocardiographic ejection fraction and contraction time [6] . Cardiac dysfunction can be reversible and can improve due to effective medical treatment and also after liver transplantation. Echocardiography is essential tool for recognizing ...
... cirrhotic patients is blunted, with subnormal responses in echocardiographic ejection fraction and contraction time [6] . Cardiac dysfunction can be reversible and can improve due to effective medical treatment and also after liver transplantation. Echocardiography is essential tool for recognizing ...
Saladin 5e Extended Outline
... ii. Desmosomes interrupt the fascia adherens here and there; these are weldlike mechanical junctions between cells. c. Electrical junctions. The intercalated discs contain gap junctions that allow the flow of ions between cardiocytes, enabling coordinated contraction of each network of cardiocytes. ...
... ii. Desmosomes interrupt the fascia adherens here and there; these are weldlike mechanical junctions between cells. c. Electrical junctions. The intercalated discs contain gap junctions that allow the flow of ions between cardiocytes, enabling coordinated contraction of each network of cardiocytes. ...
Cardiac Pacemakers
... patients can even participate in more strenuous activities such as marathons or scuba diving after consultation with their cardiologists. Any activity restrictions usually result from other medical problems and not from the pacemaker. “With my pacemaker I cannot travel.” By always carrying the ident ...
... patients can even participate in more strenuous activities such as marathons or scuba diving after consultation with their cardiologists. Any activity restrictions usually result from other medical problems and not from the pacemaker. “With my pacemaker I cannot travel.” By always carrying the ident ...
The occurrence of cardiovascular disease during 5-year follow
... with patients in sinus rhythm without a cardiovascular diagnosis. It shows that in clinical practice almost half of the patients originally diagnosed with idiopathic AF develops CVD within merely 5 years follow-up. Cardiovascular disease develops more often, at younger age and with a more severe dis ...
... with patients in sinus rhythm without a cardiovascular diagnosis. It shows that in clinical practice almost half of the patients originally diagnosed with idiopathic AF develops CVD within merely 5 years follow-up. Cardiovascular disease develops more often, at younger age and with a more severe dis ...
Cardiac contractility modulation
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Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.