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Capítulo 1: Descrição geral da tese - RUN
Capítulo 1: Descrição geral da tese - RUN

... cohort for evaluation of CRT intervention effects and mechanisms. During the period from January 2012 to March 2015, all patients with chronic heart failure and criteria for cardiac resynchronization were evaluated. The exercise training program started 1 month after cardiac resynchronizer implant a ...
Techniques of Cardiovascular Magnetic Resonance Imaging for
Techniques of Cardiovascular Magnetic Resonance Imaging for

... morphologic right ventricle anteriorly and to the right is recognized by its triangular configuration, the thick muscular trabeculations, tricuspid valve papillary muscles originating from the interventricular septum and the free wall of the right ventricle, the moderator band at its apex, and the r ...


... number and expressing it per square centimetre of tissue section as measured by planimetry. Although this method has been used frequently in the past, the most accurate way of quantifying numbers of pulmonary endocrine cells is to express them in terms of the total epithelial population (e.g. endocr ...
Single Ventricle Palliation: Stage One Reconstruction
Single Ventricle Palliation: Stage One Reconstruction

... – MBTS: afterload reduction, vasopressors for DBP, manipulation of ventilation – RVPAS: maintain RVEF for PBF, inotrope, volume, HR control Migliavacca F et al. Modeling of the Norwood circulation: effectsof shunt size, vascular resistances and heart rate. Am J Physiol Heart Circ Physiol. ...
Use of intensive lipid-lowering therapy in patients hospitalized with
Use of intensive lipid-lowering therapy in patients hospitalized with

... LDL, and triglycerides were significantly higher in the LLT group. Even among those with LDL N130 mg/dL, 50% or less received LLT. Predictors of LLT at discharge included LLT before admission, hyperlipidemia, prior coronary artery disease, increasing body mass index, and in-hospital percutaneous cor ...
20-1 Anatomy of the Heart
20-1 Anatomy of the Heart

... • 20-1 Describe the anatomy of the heart, including vascular supply and pericardium structure, and trace the flow of blood through the heart, identifying the major blood vessels, chambers, and heart valves. • 20-2 Explain the events of an action potential in cardiac muscle, indicate the importance o ...
Print this article - International Journal of Reproduction
Print this article - International Journal of Reproduction

... shifting lies the heart of its normal position caused by the pressure.1,2,7 Location of the heart can be shifted to the right or insistence towards the front approaching the anterior thoracic wall.).6,7 CDH suspicion can be enforced were no stomach appearance in the abdominal cavity, mediastinal shi ...
Effect of Different Formulations of Magnesium Chloride Used As
Effect of Different Formulations of Magnesium Chloride Used As

... The heart beats spontaneously and does not require pacing at this temperature. Under these conditions, aortic pressure, heart rate, aortic, and coronary flow were measured for 15–20 min to assess their stability; if parameters had not stabilized within the range established in previous studies the e ...
Heart rate modulates the slow enhancement of contraction due to
Heart rate modulates the slow enhancement of contraction due to

... that allowed a stable level of diastolic pressure and a positive pressure without artifacts during contraction. The deflated volume was associated with a negative diastolic pressure in all cases. In each study, left ventricular pressure was recorded while the balloon was at the deflated volume and a ...
mechanical properties of the heart
mechanical properties of the heart

... the cardiac cycle consist of changes in pressure in the ventricular chamber which cause blood to move in and out of the ventricle. Thus, we can characterize the cardiac cycle by tracking changes in pressures and volumes in the ventricle as shown in the Figure 1 where ventricular volume (LVV), ventri ...
Elective PCI Without On-Site Cardiac Surgery: Standard of Care?
Elective PCI Without On-Site Cardiac Surgery: Standard of Care?

Investigations cardiaques et AVC-AIT
Investigations cardiaques et AVC-AIT

... or TIA and may indicate a poorer prognosis and a higher risk of stroke, MI, and impossible to determine if AF is the cause or the effect of cTnI levels but poor in those with high cTnI levels. In fact, death at 3 months. Key Words: Acute stroke—atrial fibrillation—cardiac emboli— theattack. stroke. ...
WHY STUDY SYMPATHETIC NERVOUS SYSTEM?
WHY STUDY SYMPATHETIC NERVOUS SYSTEM?

... stable angina did not differ from that in control subjects (15). This observation may at least in part explain why patients with both myocardial infarction and unstable ischemic syndromes are at increased risk of sudden cardiac death. There is also a growing body of evidence that elevated sympatheti ...
Supraventricular tachycardia: Implications for the intensivist
Supraventricular tachycardia: Implications for the intensivist

... benign prognosis; however, the initial presentation may be ventricular fibrillation (11). Accessory pathways generally have conduction properties similar to myocardium. Decremental conduction (characteristic of the AV node) is uncommon. Pathways may, therefore, be capable of very rapid antegrade (AV ...
Physiological systolic and diastolic changes of the left and right
Physiological systolic and diastolic changes of the left and right

... Methods: We studied 20 healthy, normal trained volunteers (10 male). All participants underwent an echocardiography at rest and during exercise. Results: At peak exercise, higher echocardiography values were achieved in men for the tissue Doppler imaging (TDI) s’ at the mitral valve annulus (MVA). D ...
Metabolic Syndrome is Associated With Higher Wall Motion Score
Metabolic Syndrome is Associated With Higher Wall Motion Score

... National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines published in 2001. Myocardial infarction size was compared between the two groups of patients using peak CK-MB and cTnI level in 72 hours after the onset of symptoms. Results: Peak CK-MB and cTnI in 72 hours w ...
Product Specifications
Product Specifications

... § symptomatic bradycardia-tachycardia syndrome or sinus node dysfunction (sinus bradycardia/sinus pauses), as an alternative to atrial or dual chamber pacing when atrial lead placement is considered difficult, high risk, or not deemed necessary for effective therapy Rate-responsive pacing is indica ...
The Anatomical Substrates of Wolff-Parkinson-White
The Anatomical Substrates of Wolff-Parkinson-White

... syncopal attacks. The site of the anticipated accessory atrioventricular connection was predicted to be left sided and posterior, close to the crux of the heart (fig. 2). The patient died suddenly at home. There were no abnormal findings during gross examination of the heart. Histopathological studi ...
THE ROLE OF AUTONOMIC AND MYOCARDIAL FACTORS I.N
THE ROLE OF AUTONOMIC AND MYOCARDIAL FACTORS I.N

Arterial switch operation for transposition of great arteries: late
Arterial switch operation for transposition of great arteries: late

... the advantage to simultaneously assess both myocardial ischemia and ventricular contractile reserve during stress. This is an important issue in ASO patients, as adequacy of the left ventricle is vital to ensure suitability for anatomic repair of TGA. Previous studies have shown a good mid-term prog ...
full text pdf
full text pdf

... in the same time allowing identification and characterization of both calcified and non-calcified coronary atherosclerotic plaques, with high sensitivity and specificity [1,2]. One of the advantages of this method is the ability to estimate the degree of calcification of atheromatous plaques via cor ...
Curriculum Vitae: Rachel Lampert
Curriculum Vitae: Rachel Lampert

... DB, Mueller, PS, Padeletti, L, Pozuelo, L, Schoenfeld, MH, Vardas, PE, Wiegand, DL, Zellner, R: HRS Expert Consensus Statement on the Management of Cardiovascular Implantable Electronic Devices (CIEDs) in patients nearing end of life or requesting withdrawal of therapy. Heart Rhythm, 2010; ...
THE ROLE OF AUTONOMIC AND MYOCARDIAL FACTORS I.N
THE ROLE OF AUTONOMIC AND MYOCARDIAL FACTORS I.N

... pointed out by Rushmer (5). Even in experimental animals, the role of increase of stroke voltume and, by inference. of intrinsic myocardial factors, is difficult to assess because such factors, if present, are obscured by powerful autonomic effects. The need for quantitative studies in which autonom ...
The Role of Collateral Circulation in Preserving Myocardial Function
The Role of Collateral Circulation in Preserving Myocardial Function

... The normal human heart has been found to contain a profusion of small, anastomotic vessels classified as “homocoronary”anastomoses if they connect segments of the same artery and “intercoronary” anastomoses if they connect branches of different arteries. Althought the anastomoses can be identified in a ...
Clinical Medicine Reviews in Vascular Health Efficacy and Safety of
Clinical Medicine Reviews in Vascular Health Efficacy and Safety of

... Current guidelines agree that the aim of treatment should not only be to control a single risk factor, but also to reduce overall cardiovascular risk through a multifactorial intervention, treating all risk factors and conditions as associated.28 However, when current control rates are analyzed, the ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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