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About this Book
About this Book

... Leading experts from the University of Minnesota's renowned Lillehei Heart Institute and scientists from Medtronic, Inc., have assembled a concise yet detailed and comprehensive reference source of information on the anatomic features, underlying physiologic mechanisms, and treatments for diseases o ...
Compound heterozygous or homozygous truncating
Compound heterozygous or homozygous truncating

... Hypertrophic cardiomyopathy (HCM) is a major cause of sudden cardiac death in people younger than age 35 years under physical stress, and a major cause of mortality and morbidity in the elderly. It has an estimated prevalence of 1 in 500 individuals. In ~ 60% of cases, a pathogenic variant in one of ...
Heart
Heart

... The normal ECG consists of a P wave, a QRS complex, and a T wave. The P wave, which is the result of action potentials that cause depolarization of the atrial myocardium, signals the onset of atrial contraction. The QRS complex is composed of three individual waves: the Q, R, and S waves. The QRS co ...
11/8/12 The Cardiovascular System: Session 32
11/8/12 The Cardiovascular System: Session 32

... contractility E. increases with increasing end systolic volume 17. Cardiac output A. is the volume of blood pumped by both ventricles per minute B. is the product of the heart beats per minute and the amount of blood ejected by each ventricle per minute C. will increase up to 20 times resting output ...
Pathology Dr. M.M. Lena September 26, 2003 DISEASE OF THE
Pathology Dr. M.M. Lena September 26, 2003 DISEASE OF THE

... 3. Chronic ischemic cardiomyopathy 4. Sudden cardiac death (arrhythmia)  Myocardial Infarction: o Left anterior descending artery is atherosclerotic (most commonly affected) The Coronary Artery Pathology in Ischemic Heart Disease Syndrome 1. Stable Angina 2. Unstable Angina 3. Myocardial Infarction ...
Name: Dr
Name: Dr

... Heart failure is a disease with high morbidity and mortality. It is also the commonest cause of medical ward admission in developed countries. The incidence of heart failure has been increasing world-wide in the past two decades. Studies observed that at least a quarter of patients with heart failur ...
S_Paeme_NCBME2012
S_Paeme_NCBME2012

... of Liège (ULg), GIGA-Cardiovascular Sciences, Liège, Belgium ...
tutorial 1
tutorial 1

... 243. A patient undergoes cardiac transplantation for severe idiopathic cardiomyopathy. Upon release from the hospital, the patient is referred to a cardiac rehabilitation program. The exercise technologist starts the patient on a walking regimen. In transplant patients, stroke volume may increase d ...
Selective Ventricular Chamber Enlargement
Selective Ventricular Chamber Enlargement

... so typical as ...
Heart structure and function
Heart structure and function

... • Heart rate is variable - related especially to age and fitness. ...
Practical - ISpatula
Practical - ISpatula

... changing size, and not contracting, it is only generating force, to increase the pressure in ventricle to be enough to open the valves and cause the ventricular systole-second phase. ...
The Cardiovascular System
The Cardiovascular System

... distributor and passes the action potential to the Bundle of His, which, together with the branching Purkinje fibres, spread the excitation throughout the ventricles. • There is a delay of about 0.1 second from the time when the A.V. node receives stimulation, to when it distributes action potential ...
Approach to Thoracic and Cardiac Disease
Approach to Thoracic and Cardiac Disease

... in the course of the disease when the ventricle eventually fails, resulting in:  exertional dyspnea  decreased exercise capacity  orthopnea. ...
Assessment of Left Ventricular Function in Aortic Stenosis using
Assessment of Left Ventricular Function in Aortic Stenosis using

... Calcific Aortic Stenosis (CAS) is defined as progressive narrowing of the aortic valve leading to subsequent increased afterload which triggers the development of left ventricular hypertrophy. The severity of both valve narrowing and ventricular hypertrophy determine how quickly patients with CAS de ...
Doppler Hemodynamics
Doppler Hemodynamics

... the apex shows a systolic jet flowing away from the apex. The diagnosis is unlikely to be aortic stenosis or subaortic obstruction, because the flow starts during the isovolumic contraction phase (during the QRS complex on the ECG). Ejection flow jets across the aortic valve will start after the com ...
Cardiovascular toxicity Cardiac Structure The cardiovascular system
Cardiovascular toxicity Cardiac Structure The cardiovascular system

... Abnormal Heart Rhythm The normal human heart rate at rest is approximately 70 beats per minute. A rapid resting heart rate (i.e., above 100 beats per minute) is known as tachycardia, whereas a slow heart rate (i.e., below 60 beats per minute) is known as bradycardia. Any variation from normal rhythm ...
References
References

... aortic arch. A 7-0 silk suture was placed around the aorta between the left common carotid artery and brachiocephalic trunk. A 27-gauge needle was placed on top of the exposed aortic arch. Tying a suture around the needle and its subsequent removal produced stenosis. Sham animals underwent same surg ...
SO_cyprus_heart_pericardium_14-15_30
SO_cyprus_heart_pericardium_14-15_30

... crest Opening of pulmonary trunk (has 3 semilunar cuspsR+L+Ant) ...
HOCMP - rasimenar.com
HOCMP - rasimenar.com

... • Signs of both LHF and RHF are common . • Apical beat: Is replaced left, lateral and inferiorly because of LV dilatation. Left sternal impuls are palpable because of RV dilatation. • JVP: Is raised, and may show systolic wave of TR. (large V wave). • MR/TR: Both MR and TR murmurs of I – III/IV degr ...
Normal Hearts with Abnormal Beats Introduction
Normal Hearts with Abnormal Beats Introduction

... Department (ED) with palpitations and chest pain that awoke her from sleep. • She rated the chest pain as 10/10 in severity with radiation to her jaw. It was accompanied by dyspnea, diaphoresis, nausea, and weakness. • Her palpitations were constant lasting for 6 hours without any alleviating or agg ...
Tunnel type left ventricular outflow tract obstruction: An unusual
Tunnel type left ventricular outflow tract obstruction: An unusual

... subvalvar, valvar, and supravalvar. These obstructions to forward flow may present alone or in concert, as in the frequent association of a bicuspid aortic valve with coarctation of the aorta. LVOTOS are congenital in the vast majority of individuals younger than 50 years old. The subaortic stenosis ...


... performed. The bidimensional echocardiogram showed presence of mobile mass inside the left atrium. The tumor presented lobules, projecting into the left ventricle during the diastole and provoking turbulence. The patient underwent surgical resection with postoperative course needing re-operation for ...
The Human Heart
The Human Heart

... blood to the R atrium from all parts of the body. Pulmonary Artery: takes blood away from the R ventricle to the to the lungs for oxygen. ...
Dog heart coronary artery cast - Online Veterinary Anatomy Museum
Dog heart coronary artery cast - Online Veterinary Anatomy Museum

... intez,uentv,iculav' branch ...
Cardiomyopathies
Cardiomyopathies

... • Restrictive cardiomyopathy refers to a group of disorders in which the heart chambers are unable to fill with blood properly because of stiffness of the heart. • In restrictive cardiomyopathy, the heart is normal in size or only slightly enlarged, but it cannot relax normally during diastole (that ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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