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Effects of a Left Ventricular Assist Device with a Centrifugal Pump on
Effects of a Left Ventricular Assist Device with a Centrifugal Pump on

... when LVAD is driven with full bypass, the mitral valve is open continuously. When the isovolumic phase does not exist, then the LV becomes a simple conduit in which blood simply flows. According to this theory, although left ventricular isovolumic relaxation is affected, the 75% assist is the most e ...
Demystifying the Pediatric Cardiomyopathies
Demystifying the Pediatric Cardiomyopathies

... Cardiomyopathy presenting in the pre-adolescent differs significantly in possible causes, clinical expression and prognosis from that occurring in the adolescent or adult[1, 2]. Even within the pre-adolescent age group cardiomyopathy has different clinical manifestations and management concerns at d ...
Cardiac Memory and Review
Cardiac Memory and Review

... faster.5 Differences in protocol and pacing site (chamber and epicardial vs endocardial impulse initiation) likely account for the contrasting observations, although species variability also may be an issue. The mechanisms determin- ...
Echocardiographic Assessment of Cardiac Anatomy
Echocardiographic Assessment of Cardiac Anatomy

... detected by echocardiography, less than 10% of the hypertensive subjects had abnormal 12-lead ECGs or abnormal chest x-rays. These findings demonstrate a high prevalence of cardiac abnormalities in a population of asymptomatic hypertensive subjects. These abnormalities can be detected by echocardiog ...
Heart WaLL, cHambers, and VaLVes
Heart WaLL, cHambers, and VaLVes

... When the volume of blood returned to the ventricles is increased (as when exercise stimulates skeletal muscles to contract and force more blood back to the heart), the muscle bundles are stretched beyond their normal resting state to accommodate. The force of this switch is the preload. According to ...
tricuspid valve surgery - Heart
tricuspid valve surgery - Heart

... haemodynamic abnormalities in patients needing mitral valve replacement. In particular we studied the effect on portal venous flow in the presence or absence of associated tricuspid regurgitation. Patients with normal left ventricular function undergoing coronary artery bypass grafting served as con ...
Imaging to improve the results of cardiac resynchronization therapy
Imaging to improve the results of cardiac resynchronization therapy

... therapy (CRT). Echocardiographic techniques, especially those based on tissue Doppler, may help to assess and quantify mechanical dyssynchrony and thus enable better selection of candidates for CRT. However, available echocardiographic techniques do not appear to be ready for routine practice, becau ...
ARVD Review Rhythm 2.. - Tehran Arrhythmia Center
ARVD Review Rhythm 2.. - Tehran Arrhythmia Center

... diagnosing ARVD/C in a Task Force report on ARVD/C. The diagnosis of ARVD/C is based on several major and minor criteria involving structural, histologic, ECG, arrhythmic, and genetic factors (Table 1). In 2002, Hamid et al12 proposed a modification of the Task Force criteria for diagnosing ARVD/C i ...
Intramural Myocardial Shear During the Cardiac Cycle
Intramural Myocardial Shear During the Cardiac Cycle

... great to demonstrate differences in shear due to position or direction. In an organ as complex as the heart it is quite possible that such differences exist, but they were not demonstrated in these experiments. On the strength of the large number of determinations made in this study, it is probably ...
Early origins of heart disease: Low birth weight and the... the insulin-like gro wth factor system in cardiac hypertrophy
Early origins of heart disease: Low birth weight and the... the insulin-like gro wth factor system in cardiac hypertrophy

... Intrauterine growth restriction (IUGR) is associated with cardiac hypertrophy in infants14,17 and adults,18-20 and results in an elevated risk of cardiovascular disease independent of blood pressure, smoking and cholesterol concentrations.6,7 IUGR is defined clinically as having a birth weight below ...
PATIENTS THAT MAY BENEFIT
PATIENTS THAT MAY BENEFIT

...  Patients who have not responded to CRT  Patients with an acute or chronic CS lead issue  Patients with known risk associated with a CRT upgrade ...
PDF - Cardio
PDF - Cardio

... the kinetics of the dynamic restitution function cannot be determined directly at diastolic intervals (DIs) between 0 (or even negative DI values) and approximately 50 ms. He suggests that an S2 protocol allows determination of electrical restitution at short DIs in humans without the risk of induci ...
Right Ventricular Failure in Patients With Preserved Ejection
Right Ventricular Failure in Patients With Preserved Ejection

... venous vasoconstrictor, binds to the of pulmonary hypertension. It was right ventricle. This leads to a reducendothelin receptor on smooth muscle shown that pulmonary hypertension tion in wall stress for any given intracells, which leads to vasoconstriction in patients with LV dysfunction is not cav ...
Prognostic Implications of Left Ventricular Mass and Geometry
Prognostic Implications of Left Ventricular Mass and Geometry

... patterns, we used a multivariable Cox proportional hazards model. The adjustment model included predictors of mortality identified from the overall VALIANT study: age (in years), primary percutaneous transluminal coronary angioplasty, atrial fibrillation complicating MI, history of diabetes, history ...
Cardiorespiratory responses to exercise training
Cardiorespiratory responses to exercise training

... peak heart rate, power output, and oxygen consumption (V02), and provided guidelines for the exercise prescription; loadings were increased by 16.7 W each minute until the patient could no longer pedal at 60 rpm. At each load the patient indicated his perception of effort with reference to the Borg ...
Cardioprotective Effects of Acute Normovolemic
Cardioprotective Effects of Acute Normovolemic

... renewed interest for acute normovolemic hemodilution (ANH) in major surgery.5 With this technique, the adequacy of tissue oxygenation and organ function is maintained by compensatory increases in cardiac output, improved blood flow distribution, and higher oxygen extraction ratios.5–7 In the myocard ...
Prevalence of myocardial infarction in congestive heart failure
Prevalence of myocardial infarction in congestive heart failure

... Minor criteria include bilateral ankle edema, nocturnal cough, dyspnea on ordinary exertion, hepatomegaly, pleural effusion, decrease in vital capacity by 33% from maximal value record and tachycardia (rate ≥120 beats/min). The diagnosis of heart failure must have at least two major criteria or one ...
HRO_Europace_revisionV4 - Spiral
HRO_Europace_revisionV4 - Spiral

... Introduction Cardiac resynchronisation therapy (CRT) is an established treatment for patients with heart failure and left bundle branch block (LBBB) or complete heart block. However, despite treatment, morbidity and mortality remain high1. The current assumption is that the predominant mechanism of ...
Systolic and Diastolic Myocardial Mechanics in Patients with
Systolic and Diastolic Myocardial Mechanics in Patients with

... of the Baylor College of Medicine. Consecutive patients clinically referred to the cardiac catheterization laboratory for coronary angiography were screened for recruitment. Patients with moderate or greater aortic or mitral valve stenosis or regurgitation or prosthetic valves were excluded because ...
Chapter 22-Heart
Chapter 22-Heart

... Blood flow into right ventricle Ventricles relax and fill with blood both passively and then by atrial contraction as AV valves remain open. ...
Pulmonary function test in disease lmonary function test in mitral
Pulmonary function test in disease lmonary function test in mitral

... Human heart has four valves to regulate blood flow. They are as follows: Rheumatic heart disease is commonest disorder in childhood and young adults in our country. In Rheumatic heart disease, mitral valve is most commonly affected. Approximately 25% of all patients with rheumatic heart disease have ...
Influence of Body Height on Pulsatile Arterial Hemodynamic
Influence of Body Height on Pulsatile Arterial Hemodynamic

... body height to CHD, short stature and a predisposition for CHD are both known to “run in families” (10,13). This could be explained in part by an analysis of the Coronary Artery Surgery Study (CASS) registry data, which showed that among patients who underwent coronary artery bypass graft surgery, t ...
Low-Flow, Low-Gradient Aortic Stenosis With Normal and
Low-Flow, Low-Gradient Aortic Stenosis With Normal and

... LVEF in 10% to 25% of patients with severe AS (17–25). This LF state bears analogy with normal LVEF heart failure and is, in large part, due to a restrictive physiology whereby there is pronounced and/or exaggerated myocardial concentric remodeling, small LV cavity size, and reductions in LV complia ...
Transcatheter closure of atrial septal defect preserves - Heart
Transcatheter closure of atrial septal defect preserves - Heart

... Surgical repair of ASD is well established, with a low morbidity and a mortality approaching zero. However, potential advantages of ASD device closure include avoidance of the chest opening, adverse inflammatory responses,26–28 and transiently impaired cardiac output that accompany cardiopulmonary b ...
perioperativeCardiacTamponade
perioperativeCardiacTamponade

... Atrial septal defect Increased LVEDP Cardiac adhesions ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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