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Harms and benefits of screening young people to prevent sudden
Harms and benefits of screening young people to prevent sudden

... US study of 1339 students, 916 (68%) reported at least one positive response on a questionnaire with heart health questions. After review by a physician, 421/1339 (31.4%) had at least one relevant response that required additional cardiac evaluation.22 Electrocardiography will pick up only some of t ...
Active myocyte shortening during the `isovolumetric relaxation
Active myocyte shortening during the `isovolumetric relaxation

... active, energy consuming cellular event with calcium uptake [5,4,9]. However, the existence of such a contracting element is counterintuitive in the sense that its contracting action (like any contracting element) should only result in the shortening of some linear dimension and subsequently in an i ...
Downloaded
Downloaded

... and investigated the presence of PPCM; in addition, they also examined PPCM patients and performed cardiac screening of their first-degree relatives. Their data suggest that a subset of PPCM is an initial manifestation of familial DCM and this was corroborated by the identification of a causative mu ...
Print - Circulation
Print - Circulation

... it mnay surprise many that there have beeni only two studies of ventricular septation at the time of and after closure of the interventricular septum in which scale reproduction-s of original human nmaterial were used.5 6 And there are no published accounts using reconstruction methods with human ma ...
Pattern of mortality in sudden death: an autopsy study
Pattern of mortality in sudden death: an autopsy study

... The present study shows that 82.3%% of sudden cardiac deaths were due to coronary heart disease. 21 (42%) cases of ischemic heart disease are associated with atherosclerosis and 6 cases (12%) show only atherosclerosis without any other findings. The Zheng ZJ et al had 62% of sudden cardiac deaths we ...
Comparative Hemodynamic Effects of Inotropic and
Comparative Hemodynamic Effects of Inotropic and

... vascular resistance was consequently lower than during either drug infusion given alone. The cardiac output rose less in these five subjects during infusion of nitroprusside alone and dobutamine alone than the average response to these drugs in the other 12 patients. The apparently diminished respon ...
Cardiac magnetic resonance imaging of systemic amyloidosis
Cardiac magnetic resonance imaging of systemic amyloidosis

... investigated. Five patients with normal left ventricular ejection fraction were selected. The heart function of the patients was diagnosed by two-dimensional transthoracic echocardiography. The main MR sequences include an inversion recovery prepared echo planar imaging perfusion sequence, inversion ...
A Tale of Two "Pulseless Electrical Activity" Cardiac Arrest Rhythms
A Tale of Two "Pulseless Electrical Activity" Cardiac Arrest Rhythms

... arrest. Profound hypovolemia of various causes (eg, dehydration, hemorrhage) is the most frequently encountered event in patients with PEA, although other events (eg, cardiac tamponade, tension pneumothorax, large pulmonary embolism) can also impair adequate circulation. The heart increases its rate ...
LEFT-TO-RIGHT CARDIAC SHUNT: PERIOPERATIVE
LEFT-TO-RIGHT CARDIAC SHUNT: PERIOPERATIVE

... relaxation induced by the left-to-right shunt-associated endothelial dysfunction and its associated biochemical changes. The support for this theory is the study of MacLean with experimental pulmonary hypertension associated with left-to-right shunt. This study revealed that intracellular cAMP was r ...
Assessment of diastolic dysfunction and heart failure with integrated
Assessment of diastolic dysfunction and heart failure with integrated

... from the literature. An E/Ea ratio >5.6 by the Sonos system showed the optimal ...
Normal myocardial function in severe right ventricular volume
Normal myocardial function in severe right ventricular volume

... This difference between RV and LV volume overloading may also be related, at least speculatively, to the following additional factors. First, the initial hemodynamic burden caused by sudden and severe atrioventricular valvular incompetence may be greater when imposed on the high-systolic-pressure LV ...
Arrhythmia Management - SPCN – The Society of Pediatric
Arrhythmia Management - SPCN – The Society of Pediatric

... Candace Morton, MSN, CPNP-PC/AC, Children’s Hospital of Wisconsin Elizabeth Daley, BA, BSN, RN, CCRN, Children’s Hospital of Los Angeles Introduction to the Problem: Arrhythmias are relatively common in the pediatric cardiac intensive care unit. Grosse-Wortmann et al studied 494 patients revealing 5 ...
Neonatal and Pediatric Guidelines for Arrhythmia
Neonatal and Pediatric Guidelines for Arrhythmia

... Candace Morton, MSN, CPNP-PC/AC, Children’s Hospital of Wisconsin Elizabeth Daley, BA, BSN, RN, CCRN, Children’s Hospital of Los Angeles Introduction to the Problem: Arrhythmias are relatively common in the pediatric cardiac intensive care unit. Grosse-Wortmann et al studied 494 patients revealing 5 ...
PDF - Journal of the American Heart Association
PDF - Journal of the American Heart Association

... function with optimal treatment; however, little is known about the evolution and long-term outcome of this subgroup, which shows apparent healing. This study assesses whether real healing actually exists in dilated cardiomyopathy . ...
Enhanced Inotropic State of the Failing Left Ventricle by Cardiac
Enhanced Inotropic State of the Failing Left Ventricle by Cardiac

... to changes in loading conditions that may have occurred during the 2 hours of follow-up. A control group of HF dogs also followed under anesthesia for 2 hours showed no changes in indexes of LV function. With the growing number of patients with advanced HF in whom pharmacologic therapy has been opti ...
STICH M19.RV dysfunction.Kukulski-JTCVS
STICH M19.RV dysfunction.Kukulski-JTCVS

... Objective: Whether right ventricular dysfunction affects clinical outcome after coronary artery bypass grafting with or without surgical ventricular reconstruction is still unknown. The aim of the study was to assess the impact of right ventricular dysfunction on clinical outcome in patients with is ...
Age-Related Changes in Echocardiographic
Age-Related Changes in Echocardiographic

... y the year 2035, ⬇1 in 4 individuals in the United States will be ⱖ65 years of age.1 Increasing age is associated with an exponential rise in cardiovascular morbidity and mortality, with heart failure (HF) being the most common cause of hospitalization in elderly individuals.2 Over the past 2 decade ...
Corrected Transposition of the Great Arteries
Corrected Transposition of the Great Arteries

... baffle procedure • It eliminates complications related to the superior limb of the atrial baffle • It reduces flow across an RV-pulmonary trunk conduit • It likely increases conduit longevity ...
Implication of right ventricular dysfunction on long
Implication of right ventricular dysfunction on long

... Objective: Whether right ventricular dysfunction affects clinical outcome after coronary artery bypass grafting with or without surgical ventricular reconstruction is still unknown. The aim of the study was to assess the impact of right ventricular dysfunction on clinical outcome in patients with is ...
Sudden cardiac death: role of heart rate
Sudden cardiac death: role of heart rate

... been commonly used in the assessment of value of HR variability in predicting arrhythmic deaths [9,17,19,22– 29]. Information obtained by this type of studies may have practical importance, but the study designs are also confounded by some biases, which prevent generalisation of the results. A major ...
Contemporary Management of Acute Right Ventricular Failure: A
Contemporary Management of Acute Right Ventricular Failure: A

... overdistend the RV and thereby increase wall tension, decrease contractility, aggravate tricuspid regurgitation, increase ventricular interdependence, impair left ventricular filling, and ultimately reduce systemic cardiac output.46 Cautious volume loading guided by central venous pressure monitorin ...
Navigational error in the heart leads to premature ventricular excitation
Navigational error in the heart leads to premature ventricular excitation

... manifested ventricular preexcitation and formation of left-sided accessory pathways equipped with fast conduction property (Figure 1D and ref. 2). Ectopic expression of high conductance gap junction and Na+ channel proteins in the left-sided AV canal contributed to fast conduction of the aberrant AV ...
chapter 1. overview - IMIB-CHD
chapter 1. overview - IMIB-CHD

... in the lower panels of Figures 1-1 and 1-2. In the majority of the hearts of this kind, both features coexist. The hearts described as ‘criss-cross hearts’ almost invariably show the inlet of one ventricle located superior to the inlet of the other ventricle. The right ventricular inlet is almost al ...
Assessment of left ventricular diastolic function in bronchial asthma
Assessment of left ventricular diastolic function in bronchial asthma

... are sensitive to filling impairment in many types of heart disease18,19,20,21 but their interpretation can be difficult because they are influenced not only by changes in the intrinsic LV diastolic properties, but also by age, heart rate, valvular disease, loading conditions, and contractility of bo ...
Echocardiographic Assessment of Diastolic Function
Echocardiographic Assessment of Diastolic Function

... a result of a combination of systolic and diastolic abnormalities, but in approximately one-third of patients, heart failure symptoms are primarily caused by diastolic dysfunction, as LV systolic function is relatively preserved. The pathophysiological basis of diastolic dysfunction is that adequate ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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