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Pre-class video slides - University of Toronto Physics
Pre-class video slides - University of Toronto Physics

- Philsci
- Philsci

... Indeterminists have produced two different responses to this argument. First, they have questioned the irrelevance of quantum indeterminism in biology by thinking up scenarios how quantum effects could “percolate up” to the macro-level. For example, Robert Brandon and Scott Carson (1996) have develo ...
Do neurons have a reserve of sodium channels for the generation of
Do neurons have a reserve of sodium channels for the generation of

... Currents were elicited from a holding potential of ±80 mV with voltage steps to ±20 mV (duration 5 ms, interpulse interval 4 s). The recordings are corrected for leakage currents. Action potentials were elicited from a membrane potential of ±84 to ±91 mV by current injections of 0.5 nA (duration 2 m ...
Through the Cell Membrane
Through the Cell Membrane

... membrane and is insoluble in lipids, so it cannot dissolve in the lipid bilayer. How then do molecules such as glucose get in and out of the cell? This is where many of the proteins studded in the cell membrane play a role. Specialized transport proteins in the cell membrane help different kinds of ...
Renal Physiology - e-safe
Renal Physiology - e-safe

... to happen. Glomerular filtration produces up to 125ml filtrate per minute, most of which needs to be quickly reabsorbed. Proximal convoluted tubule (PCT) The PCT is responsible for the majority of the reabsorption. There are four different mechanisms by which solute transport occurs: 1. Passive dif ...
Available here - Durham University
Available here - Durham University

... be focused by a lens of given numerical aperture in the absence of any aberrations. In principle, then, one would expect that if the size of the beam at its source is reduced, the emittance will also get smaller, and the beam can therefore be focused to a smaller spot. However, when focusing is limi ...
Neurons and action potential
Neurons and action potential

... 2. Insert a paper clip and penny into a neurotransmitter. 3. Using alligator clips make a connection between two neurons by sending a neurotransmitter from one neuron to another. ...
Sodium in plants: perception, signalling, and
Sodium in plants: perception, signalling, and

... et al., 2006). Alternatively, distortion of cell wall-membrane geometry can be relayed by mechanosensitive ion channels which open in response to membrane stretching. The fairly non-selective properties of these transporters means that channel opening would cause large membrane depolarizations and, ...
Regulation of Action-Potential Firing in Spiny Neurons of the Rat
Regulation of Action-Potential Firing in Spiny Neurons of the Rat

... significantly more depolarized in the spontaneously firing than in the silent spiny neurons. There were no significant differences in the threshold, the amplitude of the noiselike fluctuations of membrane potential in the UP state, or in the proportion of time that the membrane potential was in the ...
Ionic Mechanism of the Slow Afterdepolarization Induced by
Ionic Mechanism of the Slow Afterdepolarization Induced by

... of the slow afterdepolarization induced by muscarinic receptor activation in rat prefrontal cortex. J. Neurophysiol. 80: 1197–1210, 1998. The mammalian prefrontal cortex receives a dense cholinergic innervation from subcortical regions. We previously have shown that cholinergic stimulation of layer ...
role of potassium in human and animal nutrition 2
role of potassium in human and animal nutrition 2

... Cation Balance: Where there is a significant imbalance between available K and the other major cations (Primarily Calcium, Magnesium, and sometimes Hydrogen, Aluminum, or Sodium), it may affect the availability of K to the crop. ...
The Estrogen Trinity: Membrane, Cytosolic, and - Rose
The Estrogen Trinity: Membrane, Cytosolic, and - Rose

Adsorption of large ions from an electrolyte solution: a modified
Adsorption of large ions from an electrolyte solution: a modified

... between equally charged surfaces in the presence of multivalent counterions [27,28]. Consequently, there have been numerous attempts to improve upon the standard Poisson–Boltzmann approach [29–39]. In this study we focus on the second case, where highly charged surfaces attract a large amount of fre ...
do reactions of hydroxyl radicals with metal ion go via outer sphere
do reactions of hydroxyl radicals with metal ion go via outer sphere

Document
Document

... - the organization involves the precursor region, pro-peptide region and mature region ...
Resistive communications based on neuristors
Resistive communications based on neuristors

... in the number of processing elements and memory bits available to system developers. This growth has provided orders of magnitude improvements in speed, power consumption, and reliability, together with significant reductions in the cost per device but trends like this are direct consequences of fre ...
Nervous System
Nervous System

... Synapse - area where two or more neurons communicate with each other ...
Synapses and Neurotransmitters
Synapses and Neurotransmitters

... Although acetylcholine is considered an excitatory neurotransmitter, there are some cases where it can also be inhibitory. Inhibitory neurotransmitters cause the membrane of the postsynaptic neuron to become more permeable to potassium ions. This leads to a hyperpolarization of the membrane which me ...
Action potential - Scranton Prep Biology
Action potential - Scranton Prep Biology

... 28.4 A nerve signal begins as a change in the membrane potential  A stimulus is any factor that causes a nerve signal to be generated. A stimulus – alters the permeability of a portion of the membrane, – allows ions to pass through, and – changes the membrane’s voltage. ...
last lecture neurophysiology - Evans Laboratory: Environmental
last lecture neurophysiology - Evans Laboratory: Environmental

Membrane Transport
Membrane Transport

Cell membranes
Cell membranes

... Sphingolipids (particularly glycosphingolipids) in the plasma membrane outer leaflet tend to separate out from glycerophospholipids, & co-localize with cholesterol in microdomains called lipid rafts. Lipid rafts are resistant to detergent solubilization, which has facilitated their isolation and cha ...
The basement membrane anchors epithelium to the
The basement membrane anchors epithelium to the

... The basement membrane is the fusion of two lamina, the basal lamina and the reticular lamina (or lamina reticularis). The lamina reticularis is attached to the basal lamina with anchoring fibrils (type VII collagen fibers) and microfibrils (fibrillin). The primary function of the basement membrane i ...
Lecture Herbicide x Plant Interactions Absorption and Translocation
Lecture Herbicide x Plant Interactions Absorption and Translocation

... pH outside the cell is lower at 5.0 to 5.5 (higher H+ concentration) vs. inside the cell at 7.2 to 8.0 (lower H+ concentration) weak acid herbicide outside the cell picks up a H+ and becomes protonated [R-COO - ≡ RCOOH (noncharged )] and loses its negative charge. The herbicide is now uncharged (mol ...
Memristance can explain Spike-Time- Dependent
Memristance can explain Spike-Time- Dependent

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Membrane potential



Membrane potential (also transmembrane potential or membrane voltage) is the difference in electric potential between the interior and the exterior of a biological cell. With respect to the exterior of the cell, typical values of membrane potential range from –40 mV to –80 mV.All animal cells are surrounded by a membrane composed of a lipid bilayer with proteins embedded in it. The membrane serves as both an insulator and a diffusion barrier to the movement of ions. Ion transporter/pump proteins actively push ions across the membrane and establish concentration gradients across the membrane, and ion channels allow ions to move across the membrane down those concentration gradients. Ion pumps and ion channels are electrically equivalent to a set of batteries and resistors inserted in the membrane, and therefore create a voltage difference between the two sides of the membrane.Virtually all eukaryotic cells (including cells from animals, plants, and fungi) maintain a non-zero transmembrane potential, usually with a negative voltage in the cell interior as compared to the cell exterior ranging from –40 mV to –80 mV. The membrane potential has two basic functions. First, it allows a cell to function as a battery, providing power to operate a variety of ""molecular devices"" embedded in the membrane. Second, in electrically excitable cells such as neurons and muscle cells, it is used for transmitting signals between different parts of a cell. Signals are generated by opening or closing of ion channels at one point in the membrane, producing a local change in the membrane potential. This change in the electric field can be quickly affected by either adjacent or more distant ion channels in the membrane. Those ion channels can then open or close as a result of the potential change, reproducing the signal.In non-excitable cells, and in excitable cells in their baseline states, the membrane potential is held at a relatively stable value, called the resting potential. For neurons, typical values of the resting potential range from –70 to –80 millivolts; that is, the interior of a cell has a negative baseline voltage of a bit less than one-tenth of a volt. The opening and closing of ion channels can induce a departure from the resting potential. This is called a depolarization if the interior voltage becomes less negative (say from –70 mV to –60 mV), or a hyperpolarization if the interior voltage becomes more negative (say from –70 mV to –80 mV). In excitable cells, a sufficiently large depolarization can evoke an action potential, in which the membrane potential changes rapidly and significantly for a short time (on the order of 1 to 100 milliseconds), often reversing its polarity. Action potentials are generated by the activation of certain voltage-gated ion channels.In neurons, the factors that influence the membrane potential are diverse. They include numerous types of ion channels, some of which are chemically gated and some of which are voltage-gated. Because voltage-gated ion channels are controlled by the membrane potential, while the membrane potential itself is influenced by these same ion channels, feedback loops that allow for complex temporal dynamics arise, including oscillations and regenerative events such as action potentials.
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