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process development and optimization for moisture activated dry
process development and optimization for moisture activated dry

... Granulation is one of the most important unit operations in the production of pharmaceutical oral dosage forms. Granulation is the process in which primary powder particles are made to adhere to form larger, multi particle aggregates called granules. After granulation process the granules will eithe ...
Hydrocodone Bitartrate
Hydrocodone Bitartrate

... antitussive, hydrocodone is prescribed for a limited duration to manage cough and upper respiratory symptoms associated with the common cold or allergies in adults and pediatric patients 6 years of age and older. In isolated cases, hydrocodone may be prescribed for an extended time period in those ...
Bulletin #115
Bulletin #115

... (g) For treatment of ankylosing spondylitis (A.S.) according to the following criteria: 1) For patients who have already been treated conventionally with two or more NSAIDs taken sequentially at maximum tolerated or recommended doses for four weeks without symptom control. AND 2) Satisfy New York di ...
High-Throughput Screening - Journal of Applied Pharmaceutical
High-Throughput Screening - Journal of Applied Pharmaceutical

... only method. HTS not only helps in drug discovery but also in development of present drug moieties to optimize their activity. In past years many advances in science and technology and economic pressures have kept every researcher to develop speedy and precise drug development and screening technolo ...
Ion Exchange Resins: Drug Delivery and Therapeutic
Ion Exchange Resins: Drug Delivery and Therapeutic

... exchange resins depending upon the nature of the exchangeable ion of the resin as a cation or anion, respectively. The degree of cross-linking and particle size of the resin substantially modify its properties and applications. Ion exchange resins can be used to overcome various pharmaceutical formu ...
Cocaine - South Carolina Department of Alcohol and Other Drug
Cocaine - South Carolina Department of Alcohol and Other Drug

... consists of a state of euphoria with feelings of increased energy, confidence, mental alertness and sexual arousal. The drug stimulates neurotransmitters (the body’s chemical messengers that send information to the brain). In the early “honeymoon” stage of cocaine use there are a lot of positive fee ...
midazolam sedation in paediatrics: comparative study of intranasal
midazolam sedation in paediatrics: comparative study of intranasal

... psychological consequences in children.2 The unfamiliar faces and the environment inside MRI, compound a sense of insecurity in children.3 In a busy radiology department time taken for the procedure becomes an important factor when choosing the technique used for sedation. Pharmacological agents are ...
PROTECTIVE EFFECT OF NIGELLA SATIVA AGAINST ASPIRIN INDUCED GASTRIC DAMAGE IN RATS  Original Article
PROTECTIVE EFFECT OF NIGELLA SATIVA AGAINST ASPIRIN INDUCED GASTRIC DAMAGE IN RATS Original Article

... Aspirin breaches gastric defense mechanism in two different manners: PG-dependent and PG-independent manner. Since PGs play a critical role in maintaining gastric mucosal defense system, the irreversible inhibition of COX by aspirin leading to decreased mucosal PGs synthesis. Aspirin damages the muc ...
DOXYCYCLINE HYCLATE TABLETS, USP Rev. 06/11
DOXYCYCLINE HYCLATE TABLETS, USP Rev. 06/11

... In venereal disease, when co-existent syphilis is suspected, dark field examinations should be done before treatment is started and the blood serology repeated monthly for at least 4 months. In long-term therapy, periodic laboratory evaluation of organ systems, including hematopoietic, renal, and he ...
Atorvastatin
Atorvastatin

... inhibitors. In a dose-dependent manner, atorvastatin lowers LDL cholesterol by as much as 60%; doses as low as 2.5 mg/day were as effective as lower doses of other HMG-CoA reductase inhibitors.[1378] Atorvastatin doses of 10—80 mg once daily result in mean LDL reductions ranging from 43—60%. Triglyc ...
pharmacy technical assistance - Ministère de l`Éducation et de l
pharmacy technical assistance - Ministère de l`Éducation et de l

... A situational competency describes the situation in which students are placed to acquire learning, and allows for actions and results to vary from one student to another. It consists of the following features: The statement of the competency is the result of the job analysis, the orientations and ge ...
effects of cytochrome p450 enzyme inhibitors and inducers
effects of cytochrome p450 enzyme inhibitors and inducers

... when one drug or herb affects the absorption, distribution, metabolism or excretion of another drug (Magro et al. 2012). These drug-drug interactions (DDIs) occur during drug metabolism. Cytochrome P450 (CYP) enzymes, in the liver and intestine, play a major role in the metabolism of drugs and other ...


... and/or graduate courses in the area of biostatistics. This book series will provide comprehensive and unified presentations of statistical designs and analyses of important applications in biostatistics, such as those in biopharmaceuticals. A well-balanced summary will be given of current and recentl ...
Formulary and Medication Policy Updates - Q1 2008
Formulary and Medication Policy Updates - Q1 2008

... Added coverage criteria for diagnostic testing of adrenocortical function. Coverage criteria requires: 1) being used for diagnostic testing of adrenocortical function in an outpatient setting, and 2) being used to distinguish between secondary and tertiary adrenal insufficiency following an initial ...
PHARMACEUTICAL BENEFITS ADVISORY COMMITTEE (PBAC
PHARMACEUTICAL BENEFITS ADVISORY COMMITTEE (PBAC

... circumstances, consumers will be able to comment on items in other sections of the agenda. The submissions for which input is sought will be listed in alphabetical order by drug name. There is no provision for consumer comments to the PBAC on agenda item 8 which relates to pricing matters. Pharmaceu ...
PDF version of March 2015 PBAC Meeting Agenda
PDF version of March 2015 PBAC Meeting Agenda

... circumstances, consumers will be able to comment on items in other sections of the agenda. The submissions for which input is sought will be listed in alphabetical order by drug name. There is no provision for consumer comments to the PBAC on agenda item 8 which relates to pricing matters. Pharmaceu ...
July 2014 - Positive Recommendations (Word 79KB)
July 2014 - Positive Recommendations (Word 79KB)

... The PBAC recommended listing collagenase clostridium histolyticum as an Authority required benefit for the treatment of Dupuytren’s contracture in patients meeting certain criteria, on a cost analysis basis that assumes equivalent overall treatment costs between CCH and surgical fasciectomy, but acc ...
Positive and negative ion mode ESI-MS and MS/MS for - ORBi
Positive and negative ion mode ESI-MS and MS/MS for - ORBi

... minor groove is narrower and surrounded by the sugar-phosphate-sugar chains. Minor groove binders are synthetic molecules that interact with B-DNA in the minor groove. They have a crescent shape and fit in the minor groove without distorting the double helix. Hydrogen bond donor groups at the inner ...
WHAT ARE THE POSSIBLE SIDE EFFECTS OF DICLOFENAC
WHAT ARE THE POSSIBLE SIDE EFFECTS OF DICLOFENAC

... Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. In these patients, administration of a nonsteroidal anti-infl ...
SIMULTANEOUS DETERMINATION OF CLOPIDOGREL AND
SIMULTANEOUS DETERMINATION OF CLOPIDOGREL AND

... The formulation tablets of Pioglitazone (ACTOS -45mg) and Clopidogrel (Plavix -75mg) were crushed to give finely powdered material. Powder equivalent to 10 mg of drug was taken separately in 10 ml of volumetric flask containing 5 ml of Methanol and was shaken to dissolve the drug and then filtered t ...
Antiretroviral Agents presentation
Antiretroviral Agents presentation

... TMC278 (rilpivirine; Tibotec),Most advanced stage of development(phase2b). Very few patients experienced virologic failure with resistance-associated mutations.Most commonly observed mutations were 184V and 134k but not sure how many mutations are sufficient to confer resistance to TMC287. IDX899 ; ...
Lupin Launches InspiraChamber Anti
Lupin Launches InspiraChamber Anti

... Chamber (VHC) under a strategic licensing agreement with the New Jersey based respiratory research and development company InspiRX Inc. (InspiRX). The agreement grants Lupin exclusive rights to promote, distribute and market InspiraChamber® VHC in the United States. In 2010, the National Centers for ...
Tybost - Gilead Sciences, Inc.
Tybost - Gilead Sciences, Inc.

... ---------------------------INDICATIONS AND USAGE---------------------------TYBOST is a CYP3A inhibitor indicated to increase systemic exposure of atazanavir or darunavir (once daily dosing regimen) in combination with other antiretroviral agents in the treatment of HIV-1 infection. (1) Limitations o ...
Cefuroxime Basics
Cefuroxime Basics

... Antacids: May decrease the serum concentration of Cefuroxime. Management: Consider administering antacids and cefuroxime at least 2 hours apart. Risk D: Consider therapy modification BCG: Antibiotics may diminish the therapeutic effect of BCG. Risk X: Avoid combination H2-Antagonists: May decrease t ...
Forensic Toxicology PPT
Forensic Toxicology PPT

... Date Rape Drugs • Rohypnot, Ketamine, GHB, Ecstacy. • GHB (depressant) effects can be felt within 15 minutes after ingestion. Mixed with alcohol GHB can cause the central nervous system to shut down, lead to loss of consciousness, and possibly result in a coma or death. • Rohypnol (depressant) effe ...
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