Search algorithms as a framework for the optimization of drug
... screening of large libraries of compounds in multi-well plate formats, is now more and more available to the scientific community. It is useful to regard the information processing by our experimental systems as parallel biological computations, since the algorithms we are using are indeed derived f ...
... screening of large libraries of compounds in multi-well plate formats, is now more and more available to the scientific community. It is useful to regard the information processing by our experimental systems as parallel biological computations, since the algorithms we are using are indeed derived f ...
Formulation and Evaluation of Trimetazidine Dihydrochloride
... release behaviour. Similarity factor (f2) analysis: In vitro drug release profile of the marketed trimetzidine dihydrochloride sustained release tablets was compared with the drug release profile of test product under similar experimental conditions. The data obtained from this drug release studies ...
... release behaviour. Similarity factor (f2) analysis: In vitro drug release profile of the marketed trimetzidine dihydrochloride sustained release tablets was compared with the drug release profile of test product under similar experimental conditions. The data obtained from this drug release studies ...
Effect of Dextromethorphan, Diphenhydramine, and
... respiratory tract infections (URIs), and each year results in more ambulatory health care visits than any other symptom in the United States.” [Interesting] “The use of codeine or dextromethorphan (DM) [Robitussin, Vicks 44], the most common over-the- counter (OTC) antitussive, for treatment of coug ...
... respiratory tract infections (URIs), and each year results in more ambulatory health care visits than any other symptom in the United States.” [Interesting] “The use of codeine or dextromethorphan (DM) [Robitussin, Vicks 44], the most common over-the- counter (OTC) antitussive, for treatment of coug ...
Full-Text PDF
... agents were included as one of the factors indicating poor prognosis [7]. Currently, the preferred drugs for treating onychomycosis are oral itraconazole and terbinafine, in combination with topical nail lacquers such as ciclopirox and amorolfine [8]. In spite of the combination therapy, cure rates ...
... agents were included as one of the factors indicating poor prognosis [7]. Currently, the preferred drugs for treating onychomycosis are oral itraconazole and terbinafine, in combination with topical nail lacquers such as ciclopirox and amorolfine [8]. In spite of the combination therapy, cure rates ...
Overview of drug-interactions between coumarin
... undesirable effects like adverse drug reactions (ADRs) at an effective dose of a medicinal product [1], which also includes a risk of drug-interactions. A drug group where it is particularly important to monitor for drug-interactions are the coumarin-derivatives. Phenprocoumon (Marcoumar®), acenocou ...
... undesirable effects like adverse drug reactions (ADRs) at an effective dose of a medicinal product [1], which also includes a risk of drug-interactions. A drug group where it is particularly important to monitor for drug-interactions are the coumarin-derivatives. Phenprocoumon (Marcoumar®), acenocou ...
MedChem5_LeadDevelopment
... Modifications of tight junctions: Co-addition of certain toxins or polymeric materials (dangerous, because that may allow passage of potential harmful compounds from the gut into systemic circulation) ...
... Modifications of tight junctions: Co-addition of certain toxins or polymeric materials (dangerous, because that may allow passage of potential harmful compounds from the gut into systemic circulation) ...
Executive Director Hunterdon Drug Awareness Program, Inc.
... Leopard,” “Aura,” and “Hurricane Charlie.” While they have become popular under the guise of selling as ‘bath salts’, they are sometimes sold as other products such as insect repellant, or plant food with names like “Bonsai Grow” among others. Much like the marketing of Synthetic Cannabinoids (Spice ...
... Leopard,” “Aura,” and “Hurricane Charlie.” While they have become popular under the guise of selling as ‘bath salts’, they are sometimes sold as other products such as insect repellant, or plant food with names like “Bonsai Grow” among others. Much like the marketing of Synthetic Cannabinoids (Spice ...
Conclusion - Computing Services
... "immunology & Proteomics", Mannheim, Germany; 2Max-Planck Institute for Immunobiology, Freiburg, Germany; 3Novartis Pharma AG, BioMarker Development, CH-4002 Basel, Switzerland Background: Nickel (Ni) represents the most common occupational contact allergen, affecting 10-15% of the human population. ...
... "immunology & Proteomics", Mannheim, Germany; 2Max-Planck Institute for Immunobiology, Freiburg, Germany; 3Novartis Pharma AG, BioMarker Development, CH-4002 Basel, Switzerland Background: Nickel (Ni) represents the most common occupational contact allergen, affecting 10-15% of the human population. ...
Prevalence and predictors of potential drug
... under the mandatory health insurance scheme. The database does not include information on over-the counter drugs, herbal medicines and dietary supplements. In the study, it was included data on year of birth, sex and diagnoses of subjects, as well as date of the prescribing, strength, dose regimen, ...
... under the mandatory health insurance scheme. The database does not include information on over-the counter drugs, herbal medicines and dietary supplements. In the study, it was included data on year of birth, sex and diagnoses of subjects, as well as date of the prescribing, strength, dose regimen, ...
EA_QA214.4_COCandSJW - Specialist Pharmacy Service
... Health professionals supplying hormonal contraception should ask women about their current and previous drug use including prescription, over the counter, herbal, recreational drugs and dietary supplements. Women using hormonal contraception should be informed about the potential for interactions wi ...
... Health professionals supplying hormonal contraception should ask women about their current and previous drug use including prescription, over the counter, herbal, recreational drugs and dietary supplements. Women using hormonal contraception should be informed about the potential for interactions wi ...
Revised 10 September 2008 AN:00250/2008 SUMMARY OF
... unstable being very deliquescent, and consequently the drug is used in the form of the more stable salts. The adipate, citrate, hydrochloride, phosphate, sulphate and tartrate salts are white crystalline powders with a saline taste and are readily soluble in water except the insoluble phosphate and ...
... unstable being very deliquescent, and consequently the drug is used in the form of the more stable salts. The adipate, citrate, hydrochloride, phosphate, sulphate and tartrate salts are white crystalline powders with a saline taste and are readily soluble in water except the insoluble phosphate and ...
... considerable excitement in the medical community.This antidepressant drugs is one of the most widely used in the world and millions of people around the world are willing to pay large sums for it and similar drugs. In fact, the effect of fluoxetine is not significantly different with tricyclic antid ...
TECHtalkCE - Canadian Healthcare Network
... legislators observe these trends in illegal use or diversion of products, and try to counter such activities.9 Technicians and pharmacists can work together to note these trends, report them and avoid being unwitting accomplices in drug abuse. Since the abused medications are constantly changing and ...
... legislators observe these trends in illegal use or diversion of products, and try to counter such activities.9 Technicians and pharmacists can work together to note these trends, report them and avoid being unwitting accomplices in drug abuse. Since the abused medications are constantly changing and ...
The rationale for recommending fixed
... There is considerable exigency to take all necessary steps to cure tuberculosis cases and prevent further emergence of drug-resistant tuberculosis. The most important of these steps is to ensure that the treatment, particularly of sputum smear-positive cases, is adequate and that patients adhere to ...
... There is considerable exigency to take all necessary steps to cure tuberculosis cases and prevent further emergence of drug-resistant tuberculosis. The most important of these steps is to ensure that the treatment, particularly of sputum smear-positive cases, is adequate and that patients adhere to ...
Beta-Lactam Antibiotics and Vancomycin Beta
... determine susceptibility. Gram negative organisms have an outer cell wall, a lipoprotein barrier studded with protein channels or porins. Charged antibiotics, such as the ß-lactams, must get through the porin proteins to reach their targets, the PBP’s which are on the inside of the outer lipoprotein ...
... determine susceptibility. Gram negative organisms have an outer cell wall, a lipoprotein barrier studded with protein channels or porins. Charged antibiotics, such as the ß-lactams, must get through the porin proteins to reach their targets, the PBP’s which are on the inside of the outer lipoprotein ...
ORALLY DISINTEGRATING DOSAGE FORMS: BREAKTHROUGH SOLUTION FOR NON-COMPLIANCE Review Article
... issue that causes therapeutic failure and increase in health care cost. It is a significant challenge in public health sector today [1-2]. Noncompliance is defined as the degree to which a patient does not carry out the clinical recommendations of a treating physician [3]. In US, it is estimated tha ...
... issue that causes therapeutic failure and increase in health care cost. It is a significant challenge in public health sector today [1-2]. Noncompliance is defined as the degree to which a patient does not carry out the clinical recommendations of a treating physician [3]. In US, it is estimated tha ...
View the letter to participants
... Most participants in the TDM arm were allowed to increase the dose a second time if their NIQ remained less than 1, depending on which protease inhibitor they were taking. The main goal of the study was to find out whether people in the TDM and SOC arms had different viral load responses 20 week ...
... Most participants in the TDM arm were allowed to increase the dose a second time if their NIQ remained less than 1, depending on which protease inhibitor they were taking. The main goal of the study was to find out whether people in the TDM and SOC arms had different viral load responses 20 week ...
ABCs - LSD
... become more important than family and (“high”), but this can quickly change to sadfriends. They may continue using even when ness or fear, and back again. Users may even their job or schoolwork is suffering, or when feel more than one emotion at the same time. they run into financial, spiritual, or ...
... become more important than family and (“high”), but this can quickly change to sadfriends. They may continue using even when ness or fear, and back again. Users may even their job or schoolwork is suffering, or when feel more than one emotion at the same time. they run into financial, spiritual, or ...
Treatment of poisoning caused by β
... property is commonly referred to as intrinsic sympathomimetic activity. In an overdose situation, receptor selectivity is lost, and effects not normally seen at therapeutic doses can occur.3 In addition, some β-blockers may antagonize cardiac sodium channels, producing quinidine-like effects that wi ...
... property is commonly referred to as intrinsic sympathomimetic activity. In an overdose situation, receptor selectivity is lost, and effects not normally seen at therapeutic doses can occur.3 In addition, some β-blockers may antagonize cardiac sodium channels, producing quinidine-like effects that wi ...
Effect of Alcohol on Drug Release Kinetics from HPMC
... In another report (5), United States statistical data showed that around 50% of the American population also routinely consumes alcoholic beverages. The potential effect of alcoholic drinks in significantly accelerating drug release from ER oral formulations has been of some concern in the recent pa ...
... In another report (5), United States statistical data showed that around 50% of the American population also routinely consumes alcoholic beverages. The potential effect of alcoholic drinks in significantly accelerating drug release from ER oral formulations has been of some concern in the recent pa ...
PHASE II DRUG METABOLISM: Glucuronidation and Sulfation
... •Glucose‐1‐P is derived from glycogen and the reactions are rapid, so co‐substrate depletion not often observed unless in starved animals. •Cosubstrate depletion has been observed in animals with very large doses of drugs (e.g. acetaminophen), but recovery of UDPGA is rapid. Unlikely to occur in ...
... •Glucose‐1‐P is derived from glycogen and the reactions are rapid, so co‐substrate depletion not often observed unless in starved animals. •Cosubstrate depletion has been observed in animals with very large doses of drugs (e.g. acetaminophen), but recovery of UDPGA is rapid. Unlikely to occur in ...
drug-free school and workplace - New Professions Technical Institute
... abuse of alcohol by students and employees. The Drug-Free Schools and Communities Act Amendment of 1989, Public Law 101-226, Title 20 (Education), Chapter 28 (Higher Education Resources and Student Assistance), Subchapter XII (General Provision see 1145g (Drug and Alcohol Abuse Prevention) states th ...
... abuse of alcohol by students and employees. The Drug-Free Schools and Communities Act Amendment of 1989, Public Law 101-226, Title 20 (Education), Chapter 28 (Higher Education Resources and Student Assistance), Subchapter XII (General Provision see 1145g (Drug and Alcohol Abuse Prevention) states th ...
Cholinergics and Anticholinergics
... Anticholinesterase Drugs cont. • Anticholinesterase drugs are either reversible or irreversible inhibitors of acetylcholinesterase • Reversible agents are such drugs as:edrophodium (Tensilon). Used to diagnose myasthenia gravis and for reversal of non‐ depolarizing neuromuscular blockers ...
... Anticholinesterase Drugs cont. • Anticholinesterase drugs are either reversible or irreversible inhibitors of acetylcholinesterase • Reversible agents are such drugs as:edrophodium (Tensilon). Used to diagnose myasthenia gravis and for reversal of non‐ depolarizing neuromuscular blockers ...
Preparation and Evaluation of Minoxidil Gels
... glycol:water:ethanol (15:15:70) was suggested as optimal when commercial tablets are used as the source of minoxidil4. Minoxidil topical solution has also been used in combination with topical retinoids5. However, minoxidil was developed originally, as an antihypertensive drug. Hair growth was a sid ...
... glycol:water:ethanol (15:15:70) was suggested as optimal when commercial tablets are used as the source of minoxidil4. Minoxidil topical solution has also been used in combination with topical retinoids5. However, minoxidil was developed originally, as an antihypertensive drug. Hair growth was a sid ...