An Overview of Herbal Ecstacy and Other Stimulants
... injury reports associated with ephedra-containing substances, including herbal "ecstacy". The FDA has also published a proposed rule that would limit serving size and require warning in labeling for all ephedrine supplements.12 Many countries and states have also banned or restricted the marketing o ...
... injury reports associated with ephedra-containing substances, including herbal "ecstacy". The FDA has also published a proposed rule that would limit serving size and require warning in labeling for all ephedrine supplements.12 Many countries and states have also banned or restricted the marketing o ...
Opioid Analgesics and Antagonists
... This drug has a longer duration of action than naloxone, and a single oral dose of naltrexone blocks the effect of injected heroin for up to 48 hours. Naltrexone is used in opiate-dependence maintenance programs and may also be beneficial in treating chronic alcoholism. ...
... This drug has a longer duration of action than naloxone, and a single oral dose of naltrexone blocks the effect of injected heroin for up to 48 hours. Naltrexone is used in opiate-dependence maintenance programs and may also be beneficial in treating chronic alcoholism. ...
Multi compartment models (Delayed distribution models)
... • Method of residuals : the biexponential disposition curve obtained after i. v. bolus of a drug that fits two compartment model can be resolved into its individual exponents by the method of residuals. C = A e-at + B e-bt From graph the initial decline due to distribution is more rapid than the te ...
... • Method of residuals : the biexponential disposition curve obtained after i. v. bolus of a drug that fits two compartment model can be resolved into its individual exponents by the method of residuals. C = A e-at + B e-bt From graph the initial decline due to distribution is more rapid than the te ...
History of anticoagulant therapy
... • Normal PT and PTT do not rule out significant blood level of NOAC • If PT or PTT elevated → assume significant blood levels of NOAC • Thrombin time very sensitive to dabigatran effect – normal TT implies no drug on board – Rivaroxaban & apixaban do not affect TT ...
... • Normal PT and PTT do not rule out significant blood level of NOAC • If PT or PTT elevated → assume significant blood levels of NOAC • Thrombin time very sensitive to dabigatran effect – normal TT implies no drug on board – Rivaroxaban & apixaban do not affect TT ...
Sinarest LP Tab/Susp
... The safety and effectiveness of Sinarest-LP Suspension in pediatric patients under 2 years of age have not been established. WARNINGS Sinarest-LP should not be taken with: ♦ Other medicines including those containing paracetamol for the relief of flu, colds or congestion. ♦ Drugs for heart problems ...
... The safety and effectiveness of Sinarest-LP Suspension in pediatric patients under 2 years of age have not been established. WARNINGS Sinarest-LP should not be taken with: ♦ Other medicines including those containing paracetamol for the relief of flu, colds or congestion. ♦ Drugs for heart problems ...
Formulation and Evaluation of sustained release Pellets of
... done as per ICH guide lines15. These studies are ...
... done as per ICH guide lines15. These studies are ...
FORMULATION AND EVALUATION OF TASTE MASKED ORAL DISPERSIBLE TABLETS OF
... formulations prepared from these techniques differ from each other on the basis of the factors like mechanical strength of final product, drug and dosage form stability, mouth feel, taste, rate of dissolution of the formulation in saliva, rate of absorption from saliva and overall drug bioavailabili ...
... formulations prepared from these techniques differ from each other on the basis of the factors like mechanical strength of final product, drug and dosage form stability, mouth feel, taste, rate of dissolution of the formulation in saliva, rate of absorption from saliva and overall drug bioavailabili ...
- The University of Liverpool Repository
... As highlighted by Denning and Bromley (23), the antifungal pipeline has failed to produce new antifungal drugs with mechanisms of action different to existing classes since caspofungin was licensed in 2001. Many potential antifungal targets have been investigated but translating these early stage p ...
... As highlighted by Denning and Bromley (23), the antifungal pipeline has failed to produce new antifungal drugs with mechanisms of action different to existing classes since caspofungin was licensed in 2001. Many potential antifungal targets have been investigated but translating these early stage p ...
DEVELOPMENT AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF SALBUTAMOL SULPHATE Research Article
... smooth muscle. It is believed that salbutamol sulphate increases cAMP production by activating adenylate cyclase and the action of salbutamol sulphate are mediated by cAMP. Increase intracellular cAMP increase the activity of cAMP dependent protein kinase, which inhibits ...
... smooth muscle. It is believed that salbutamol sulphate increases cAMP production by activating adenylate cyclase and the action of salbutamol sulphate are mediated by cAMP. Increase intracellular cAMP increase the activity of cAMP dependent protein kinase, which inhibits ...
FDA accepts for filing a New Drug Application (NDA) for
... Bengtsson BA, Acta Med Scan 223:327-335, 1988), acromegaly affects approximately 15,000 people in the United States and Canada and is most commonly found in middle-aged adults. Studies estimate an all-cause mortality rate associated with acromegaly of at least twice the normal population, and a redu ...
... Bengtsson BA, Acta Med Scan 223:327-335, 1988), acromegaly affects approximately 15,000 people in the United States and Canada and is most commonly found in middle-aged adults. Studies estimate an all-cause mortality rate associated with acromegaly of at least twice the normal population, and a redu ...
WHO Drug Information - World Health Organization
... development, the INN Programme was inherently linked to progress in drug research and its success was reliant on the ability to deal appropriately with each new group of medicinal products that entered into therapeutic use. In the 1980s, the development of biotechnology products based on recombinant ...
... development, the INN Programme was inherently linked to progress in drug research and its success was reliant on the ability to deal appropriately with each new group of medicinal products that entered into therapeutic use. In the 1980s, the development of biotechnology products based on recombinant ...
Pobierz plik
... (8-11). PknB is necessary for the survival of M. tuberculosis, and also plays an important role in the growth of M. tuberculosis (12-14). Phosphorylation or the changes of expression index and activity of PknB can lead to the alteration of growth rate and morphology of M. tuberculosis, due to the de ...
... (8-11). PknB is necessary for the survival of M. tuberculosis, and also plays an important role in the growth of M. tuberculosis (12-14). Phosphorylation or the changes of expression index and activity of PknB can lead to the alteration of growth rate and morphology of M. tuberculosis, due to the de ...
September 2015 - State Pharmaceuticals Corporation of Sri Lanka
... without modification but most drugs are low molecular weight compounds (Table 2) that are not immunogenic unless modified through a process called haptenation, when a drug or its metabolite forms chemical bonds with the patient's cell surface, soluble proteins, and other molecules with free amino or ...
... without modification but most drugs are low molecular weight compounds (Table 2) that are not immunogenic unless modified through a process called haptenation, when a drug or its metabolite forms chemical bonds with the patient's cell surface, soluble proteins, and other molecules with free amino or ...
Effect of acidic Ph. and heat on the degradation of omeprazole and
... The drawbacks are mainly related to the physicochemical instability to heat, light and acidic media, even with coated formulations. Moreover the low aqueous solubility of OMZ, ~0.4% at 25 oC, is responsible for small dissolution rates and so low bioavailability [7]. OMZ is acid labile and a prodrug. ...
... The drawbacks are mainly related to the physicochemical instability to heat, light and acidic media, even with coated formulations. Moreover the low aqueous solubility of OMZ, ~0.4% at 25 oC, is responsible for small dissolution rates and so low bioavailability [7]. OMZ is acid labile and a prodrug. ...
Inglés
... 10-100um diameter drug loaded microporous beads which aids in controlled delivery of drugs [3]. Rubbing, moisture, pH, friction, or ambient skin temperature are triggering factors for the controlled release of drug from microsponges by diffusion through skin. Microsponges has the facility to load wi ...
... 10-100um diameter drug loaded microporous beads which aids in controlled delivery of drugs [3]. Rubbing, moisture, pH, friction, or ambient skin temperature are triggering factors for the controlled release of drug from microsponges by diffusion through skin. Microsponges has the facility to load wi ...
Quantitative Rationalization of Gemfibrozil Drug Interactions
... Subsequently, several studies were conducted to understand the mechanisms involved, and it was determined that gemfibrozil (twice a day for 5 days) increases cerivastatin oral AUC about 5-fold, which however was not assumed from the interaction potency of gemfibrozil alone (Backman et al., 2002). Si ...
... Subsequently, several studies were conducted to understand the mechanisms involved, and it was determined that gemfibrozil (twice a day for 5 days) increases cerivastatin oral AUC about 5-fold, which however was not assumed from the interaction potency of gemfibrozil alone (Backman et al., 2002). Si ...
INTERACTION BETWEEN GRAPEFRUIT JUICE AND DRUGS*
... affected by grapefruit juice, followed by felodipine, nicardipine, and nitrendipine, while the effect on nifedipine and amlodipine are negligible. It is known that the magnitude of the effect of grapefruit juice is proportional to the first-pass effect (the greater the first-pass effect, the lower t ...
... affected by grapefruit juice, followed by felodipine, nicardipine, and nitrendipine, while the effect on nifedipine and amlodipine are negligible. It is known that the magnitude of the effect of grapefruit juice is proportional to the first-pass effect (the greater the first-pass effect, the lower t ...
New psychoactive substances in Europe - Emcdda
... being ‘food supplements’ (Figure 4). These products are aimed not at recreational drug users but at the growing number of people looking to enhance their body and mind, allowing new psychoactive substances to reach new groups of consumers. One such substance that was detected for the first time in E ...
... being ‘food supplements’ (Figure 4). These products are aimed not at recreational drug users but at the growing number of people looking to enhance their body and mind, allowing new psychoactive substances to reach new groups of consumers. One such substance that was detected for the first time in E ...
Antipsychotics
... used mainly in the treatment of schizophrenia, they are also used in the treatment of other psychoses associated with depression and manic-depressive illness, and psychosis associated with Alzheimer’s disease. These conditions are life-long and disabling. ...
... used mainly in the treatment of schizophrenia, they are also used in the treatment of other psychoses associated with depression and manic-depressive illness, and psychosis associated with Alzheimer’s disease. These conditions are life-long and disabling. ...
N Gokal Counting the Costs
... as a whole or by the patient. These may well be significant, but may be of less concern to the hospital. There will also be a related cost associated with patient discomfort or well-being, but this is very difficult to quantify. Staff in theater ‘Time is money’ which is no less true than for operati ...
... as a whole or by the patient. These may well be significant, but may be of less concern to the hospital. There will also be a related cost associated with patient discomfort or well-being, but this is very difficult to quantify. Staff in theater ‘Time is money’ which is no less true than for operati ...
Heart Failure
... additive effect on BP. Submaximal doses of 2 drugs results in larger response of BP & fewer side effects eg: Diuretic + B-blocker Diuretic + ACE inhibitor Ca-channel blocker + ACE inhibitor Fixed dose combination may be convenient and are acceptable when monotherapy is ...
... additive effect on BP. Submaximal doses of 2 drugs results in larger response of BP & fewer side effects eg: Diuretic + B-blocker Diuretic + ACE inhibitor Ca-channel blocker + ACE inhibitor Fixed dose combination may be convenient and are acceptable when monotherapy is ...
cerebrolysin and piracetam
... piracetam in GII. In contrast, in the first systematic review, which included 3 X-ray diagnostic complexes involving 1002 patients, there was an increase in the frequency of deaths in case of taking piracetam as compared to placebo by 32%. Based on the results of meta-analysis, which included 10 cli ...
... piracetam in GII. In contrast, in the first systematic review, which included 3 X-ray diagnostic complexes involving 1002 patients, there was an increase in the frequency of deaths in case of taking piracetam as compared to placebo by 32%. Based on the results of meta-analysis, which included 10 cli ...
IMPROVING THE PREDICTION OF PHARMACOGENES USING
... features, structural similarity and indication set similarity. The more similar the drugs in the local network of the gene are to the query drug, the higher the score the gene will receive. The original PGxPipeline9 used PharmGKB as a source of “genetic” drug-gene relationships, DrugBank as a source ...
... features, structural similarity and indication set similarity. The more similar the drugs in the local network of the gene are to the query drug, the higher the score the gene will receive. The original PGxPipeline9 used PharmGKB as a source of “genetic” drug-gene relationships, DrugBank as a source ...
Formulation and Evaluation of Trimetazidine Dihydrochloride
... release behaviour. Similarity factor (f2) analysis: In vitro drug release profile of the marketed trimetzidine dihydrochloride sustained release tablets was compared with the drug release profile of test product under similar experimental conditions. The data obtained from this drug release studies ...
... release behaviour. Similarity factor (f2) analysis: In vitro drug release profile of the marketed trimetzidine dihydrochloride sustained release tablets was compared with the drug release profile of test product under similar experimental conditions. The data obtained from this drug release studies ...