(acts directly to convert plasminogen into plasmin).
... • Anisoylated plasminogen-streptokinase activator complex • Is a complex of purified human plasminogen + bacterial streptokinase that rendered inactive by introducing anisoyl group at its active site. • It is a prodrug, de-acylated in circulation into the active plasminogen-streptokinase complex (ac ...
... • Anisoylated plasminogen-streptokinase activator complex • Is a complex of purified human plasminogen + bacterial streptokinase that rendered inactive by introducing anisoyl group at its active site. • It is a prodrug, de-acylated in circulation into the active plasminogen-streptokinase complex (ac ...
a novel approach using hydrotropic solubalization technique
... Objective: Analysis of drug utilized the organic solvent which are costlier, toxic, and causing environment pollution. Hydrotropic solution may be a proper choice to preclude the use of organic solvents so that an attempt has been made to develop simple, accurate, novel, safe and precise spectrophot ...
... Objective: Analysis of drug utilized the organic solvent which are costlier, toxic, and causing environment pollution. Hydrotropic solution may be a proper choice to preclude the use of organic solvents so that an attempt has been made to develop simple, accurate, novel, safe and precise spectrophot ...
Medicines and Falls – Guidance on Causes and Risks
... An attempt should be made to reduce the number and dosage of medications, where possible. Ensure they are appropriate and not causing undue side effects. Falls can be caused by almost any drug that acts on the brain or on the circulation. Usually the mechanism leading to a fall is one or more of: • ...
... An attempt should be made to reduce the number and dosage of medications, where possible. Ensure they are appropriate and not causing undue side effects. Falls can be caused by almost any drug that acts on the brain or on the circulation. Usually the mechanism leading to a fall is one or more of: • ...
Herbal CNS stimulants - International Journal of Herbal Medicine
... orthostatic tachycardia syndrome [5]. The effect of stimulants depends upon the substance, its potency and dosage, it reduces hyperactivity and being generally free of serious side effects at moderate doses used in clinical medicine [5]. CNS Stimulants exert their effects through a number of differe ...
... orthostatic tachycardia syndrome [5]. The effect of stimulants depends upon the substance, its potency and dosage, it reduces hyperactivity and being generally free of serious side effects at moderate doses used in clinical medicine [5]. CNS Stimulants exert their effects through a number of differe ...
Determinants of the Sensitivity of Human Small
... were the first to demonstrate that acute rises in intracellular MTX binding capacity could be a determinant ofdrug resistance in patients with acute leukemia. More recently it has been shown that in vivo resistance after MTX treatment may be due to DHFR gene amplification and elevated target enzyme ...
... were the first to demonstrate that acute rises in intracellular MTX binding capacity could be a determinant ofdrug resistance in patients with acute leukemia. More recently it has been shown that in vivo resistance after MTX treatment may be due to DHFR gene amplification and elevated target enzyme ...
SEMINAR ON BUCCAL DRUG DELIVERY SYSTUM
... -ORA-VESCENT :This drug delivery system have been designed to promote drug absorption through oral mucosa(buccal) This may enable more rapid absorption of drug that have a long Tmax. In case where the patient is vomiting frequently. Or in migraine gastric transit may be so severely compromised. ...
... -ORA-VESCENT :This drug delivery system have been designed to promote drug absorption through oral mucosa(buccal) This may enable more rapid absorption of drug that have a long Tmax. In case where the patient is vomiting frequently. Or in migraine gastric transit may be so severely compromised. ...
Hallucinogens - LSD, Peyote, Psilocybin, and PCP
... Hallucinogenic compounds found in some plants and mushrooms (or their extracts) have been used—mostly during religious rituals—for centuries. Almost all hallucinogens contain nitrogen and are classified as alkaloids. Many hallucinogens have chemical structures similar to those of natural neurotransm ...
... Hallucinogenic compounds found in some plants and mushrooms (or their extracts) have been used—mostly during religious rituals—for centuries. Almost all hallucinogens contain nitrogen and are classified as alkaloids. Many hallucinogens have chemical structures similar to those of natural neurotransm ...
INSITU GELLING OPHTHALMIC DRUG DELIVERY SYSTEM: AN OVERVIEW Review Article
... conventional ophthalmic solutions due to rapid precorneal elimination of the drug may be overcome by the use of a gel system that are instilled as drops into the eye and undergo a sol‐gel transition in the culdesac 3. For the therapeutic treatment of most ocular problem ...
... conventional ophthalmic solutions due to rapid precorneal elimination of the drug may be overcome by the use of a gel system that are instilled as drops into the eye and undergo a sol‐gel transition in the culdesac 3. For the therapeutic treatment of most ocular problem ...
ANALYTICAL METHODS FORTAXANES QUANTIFICATION IN DILUTED FORMULATIONS AND
... work made a bibliographic review and comparison of currently available analytical methods for these objectives. High performance liquid chromatography (HPLC), liquid chromatography-tandem mass spectrometry (LC-MS/MS) and micellar electro-kinetic chromatography(MEKC) analytical methods were considere ...
... work made a bibliographic review and comparison of currently available analytical methods for these objectives. High performance liquid chromatography (HPLC), liquid chromatography-tandem mass spectrometry (LC-MS/MS) and micellar electro-kinetic chromatography(MEKC) analytical methods were considere ...
Antifungal Pharmacology - LSU School of Medicine
... immunosuppressants; mycoses: especially candidiasis and aspergillosis ii. Natural diseases: AIDS; mycoses: especially candidiasis and cryptococcosis iii. Mean age of population is increasing; mycoses: especially candidiasis b. Special problems associated with immunocompromised. i. Mycoses often are ...
... immunosuppressants; mycoses: especially candidiasis and aspergillosis ii. Natural diseases: AIDS; mycoses: especially candidiasis and cryptococcosis iii. Mean age of population is increasing; mycoses: especially candidiasis b. Special problems associated with immunocompromised. i. Mycoses often are ...
... beings or their representatives, except specific investigational drug or biologic consent requirementsThe ICWRG would not be.feasible in certain where they deem it not feasible, or in included senior management of FDA their professional judgment, contrary to circumstances, and to grant a waiver and ...
DiphenhydrAMINE Hydrochloride Injection, USP
... with narrow-angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy, or bladder-neck obstruction. Local necrosis has been associated with the use of subcutaneous or intradermal use of intravenous diphenhydramine hydrochloride. Use in Pediatric Patients - ...
... with narrow-angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy, or bladder-neck obstruction. Local necrosis has been associated with the use of subcutaneous or intradermal use of intravenous diphenhydramine hydrochloride. Use in Pediatric Patients - ...
Basic Principles of GMP - World Health Organization
... of worldwide significance in the safeguarding of patient welfare and public health. Its clinical, public health and economic importance has been demonstrated, but it needs to be better understood and appreciated by politicians, the media and the public. ...
... of worldwide significance in the safeguarding of patient welfare and public health. Its clinical, public health and economic importance has been demonstrated, but it needs to be better understood and appreciated by politicians, the media and the public. ...
ACCELERATED STABILITY TESTING OF BETAMETHASONE DIPROPIONATE NANOEMULSION
... temperature (25ºC) during 3-months of storage period. However, the changes in these parameters were not statistically significant (p ≥0.05). The shelf-life of optimized nanoemulsion formulation was found to be 2.66 years at room temperature. These results indicated that the stability (physical and c ...
... temperature (25ºC) during 3-months of storage period. However, the changes in these parameters were not statistically significant (p ≥0.05). The shelf-life of optimized nanoemulsion formulation was found to be 2.66 years at room temperature. These results indicated that the stability (physical and c ...
Steroids - Montana Narcotics Officers Association
... Although different types of steroids exist naturally in humans, the drugs commonly known as anabolic steroids are synthetic chemical compounds designed to create certain effects that natural hormones cause in the body. Steroid is the generic name given to compounds having a basic ring structure simi ...
... Although different types of steroids exist naturally in humans, the drugs commonly known as anabolic steroids are synthetic chemical compounds designed to create certain effects that natural hormones cause in the body. Steroid is the generic name given to compounds having a basic ring structure simi ...
Starlix - Novartis Pharmaceuticals Corporation
... Factors which may increase the risk of hypoglycemia include changes in meal pattern (e.g., macronutrient content), changes in level of physical activity, changes to coadministered medication [see Drug Interactions (7)], and concomitant use with other antidiabetic agents. Patients with renal or hepat ...
... Factors which may increase the risk of hypoglycemia include changes in meal pattern (e.g., macronutrient content), changes in level of physical activity, changes to coadministered medication [see Drug Interactions (7)], and concomitant use with other antidiabetic agents. Patients with renal or hepat ...
Commonly Used Chemotherapy Drugs Part 1
... for most dogs; however, metoclopramide given for 4 to 5 days following each doxorubicin dose will reduce risk of nausea. I usually dispense the medication so owners can start it at their discretion at the first sign of nausea. As with pain, nausea is easier to prevent than to treat. ● For severe vom ...
... for most dogs; however, metoclopramide given for 4 to 5 days following each doxorubicin dose will reduce risk of nausea. I usually dispense the medication so owners can start it at their discretion at the first sign of nausea. As with pain, nausea is easier to prevent than to treat. ● For severe vom ...
Pharmacovigilance of drug allergy and hypersensitivity using
... parameters). These aspects of the history and the examinations represent a common denominator within the different European centres using this protocol. Skin tests represent an essential tool for the diagnosis of drug allergy, although many drugs cannot be tested (21–23). The standardized procedure f ...
... parameters). These aspects of the history and the examinations represent a common denominator within the different European centres using this protocol. Skin tests represent an essential tool for the diagnosis of drug allergy, although many drugs cannot be tested (21–23). The standardized procedure f ...
HERBAL TREATMENT FOR URINARY STONES
... Herbs and herbal drugs have created interest among the people by its clinically proven effects like immunomodulation, adaptogenic and antimutagenic. Also, the overuse of synthetic drugs, which results in higher incidence of adverse drug reactions, has motivated humans to return to nature for safe re ...
... Herbs and herbal drugs have created interest among the people by its clinically proven effects like immunomodulation, adaptogenic and antimutagenic. Also, the overuse of synthetic drugs, which results in higher incidence of adverse drug reactions, has motivated humans to return to nature for safe re ...
Research Paper-Noorah Al-Fraywan-HLTH 1050
... The first step in the heroin addiction treatment process is a period of time spent going through heroin detox (projectknow.com). During detox, the drugs are removed from the patient's body using one of two processes. The first process is rapid detox, a quick flushing of the body while under anesthes ...
... The first step in the heroin addiction treatment process is a period of time spent going through heroin detox (projectknow.com). During detox, the drugs are removed from the patient's body using one of two processes. The first process is rapid detox, a quick flushing of the body while under anesthes ...
Baclofen - UNC School of Medicine
... “I try to be open-minded, but I have my own reservations about using a high dose because of safety,” he said. “My point is that we need a rigorous scientific basis in order to prove safety and efficacy — that’s the bottom line.” It’s too soon to say whether baclofen, with its proven safety (at a low ...
... “I try to be open-minded, but I have my own reservations about using a high dose because of safety,” he said. “My point is that we need a rigorous scientific basis in order to prove safety and efficacy — that’s the bottom line.” It’s too soon to say whether baclofen, with its proven safety (at a low ...
In the scientific literature, which countries first appeared term
... A. Preparations different manufacturing plants B. Preparations made by manufacturers of different countries C. Preparations are making one plant, but in different series D. Preparations are making one plant, but one series E. Preparations different manufacturing plants, Preparations are making one p ...
... A. Preparations different manufacturing plants B. Preparations made by manufacturers of different countries C. Preparations are making one plant, but in different series D. Preparations are making one plant, but one series E. Preparations different manufacturing plants, Preparations are making one p ...
NIDA InfoFacts: Steroids (Anabolic-Androgenic)
... The immediate effects of AAS in the brain are mediated by their binding to androgen (male sex hormone) and estrogen (female sex hormone) receptors on the surface of a cell. This AAS–receptor complex can then shuttle into the cell nucleus to influence patterns of gene expression. Because of this, the ...
... The immediate effects of AAS in the brain are mediated by their binding to androgen (male sex hormone) and estrogen (female sex hormone) receptors on the surface of a cell. This AAS–receptor complex can then shuttle into the cell nucleus to influence patterns of gene expression. Because of this, the ...
In vitro and in vivo evaluation of a new sublingual tablet system for
... formulation almost instantly. Plasma concentrations of fentanyl were obtained within 10 min, with no second peak. These results indicated that the bioadhesive component prevented the fentanyl from being swallowed (the fraction swallowed was considered smaller compared to other mucosal delivery syste ...
... formulation almost instantly. Plasma concentrations of fentanyl were obtained within 10 min, with no second peak. These results indicated that the bioadhesive component prevented the fentanyl from being swallowed (the fraction swallowed was considered smaller compared to other mucosal delivery syste ...
Enzymes
... -The electronic effects of various substituents will effect on a drug's ionization or polarity. -effect on a drug can pass through cell membranes and strongly bind to a receptor. -measure of the electron withdrawing (+ σ) or electron donating ability (-σ) of a substituent ...
... -The electronic effects of various substituents will effect on a drug's ionization or polarity. -effect on a drug can pass through cell membranes and strongly bind to a receptor. -measure of the electron withdrawing (+ σ) or electron donating ability (-σ) of a substituent ...