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A plastic axonal hotspot
A plastic axonal hotspot

... is restricted to developmental and pathological conditions, or whether it is a normal physiological mechanism that could dynamically regulate excitability. The studies identify distinct mechanisms for modulating neuronal excitability — either displacement or extension of the AIS (Fig. 1 a, b). It wi ...
Melting the Iceberg
Melting the Iceberg

... modular, i.e., they are repeated across cortical areas to apply similar computations to different purposes. If so, our best bet to understand them might be to study the primary visual cortex (V1). Area V1 is arguably the ‘‘giant squid axon’’ of cortical neurophysiology: we can control its sensory in ...
Drivers and modulators from push-pull and balanced synaptic input
Drivers and modulators from push-pull and balanced synaptic input

... Abstract: In 1998, Sherman and Guillery proposed that there are two types of inputs to cortical neurons; drivers and modulators. These two forms of input are required to explain how, for example, sensory driven responses are controlled and modified by attention and other internally generated gating ...
input output - Brian Nils Lundstrom
input output - Brian Nils Lundstrom

... First, we considered the case when the time-varying stimuli had steady state stimulus statistics, that is, how action potential generation depended on the stimulus’s statistical properties when those properties were fixed, i.e. they did not change in time. Previous in vitro experimental observations ...
Predicting voluntary movements from motor cortical activity with
Predicting voluntary movements from motor cortical activity with

... in green during the preparatory phase turned red with the response signal. On each experimental day, blocks of trials corresponding to each experimental condition (one, two or three targets during preparatory phase) were presented to the monkey in random order. During each block, the target directio ...
Neurons and Glia
Neurons and Glia

The Autonomic Nervous System
The Autonomic Nervous System

Functional organization of inferior parietal lobule convexity in the
Functional organization of inferior parietal lobule convexity in the

... Dipartimento di Psicologia, Università di Parma, B.go Carissimi, Parma, Italy ...
Neurons eat glutamate to stay alive
Neurons eat glutamate to stay alive

Decoding Motor Commands in Cortico-Basal Ganglia Circuits for the
Decoding Motor Commands in Cortico-Basal Ganglia Circuits for the

... the rat during movement bouts. The axes values have been left out as the focus is the shape of the bouts in relation to each other. . . . 6.7 Tracked position (from the point marked on the head) of the rat during movement bouts. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6.8 Example of ...
A part of the cholinergic fibers in mouse superior cervical ganglia
A part of the cholinergic fibers in mouse superior cervical ganglia

Ch9. Motor System
Ch9. Motor System

... • Noxious cutaneous information can result in a withdrawl reflex ...
The Autonomic Nervous System
The Autonomic Nervous System

... •  However, NA can also activate β receptor: β1 has about the same affinity for NA and A; β2 has a higher affinity for A than for NA •  However, A can also activate α receptor •  Vasoconstriction is an α1 effect •  Vasodilation is a β2 effect •  Many blood vessels are populated with a mixture of α a ...
text
text

powerpoint
powerpoint

... •The ‘mapping’ of these compounds probably occurs by matching to memory templates stored in the brain • A smell is categorized based on one’s previous experiences of it and on the other sensory stimuli correlated with its appearance. ...
What is the other 85% of V1 doing?
What is the other 85% of V1 doing?

... bursty or tonic? Do they tend to be encountered in particular layers of cortex? And most importantly, are they merely unresponsive to bars and gratings, or are they also equally uninterpretable in their responses to a wider variety of stimuli, such as natural images? A seasoned experimentalist who h ...
Pictures of pain: their contribution to the
Pictures of pain: their contribution to the

... neurons? Images of pain have been known to trigger emotional responses for millennia. For instance, classical sculptors were extraordinarily adept at depicting pain amongst other emotions, witness famous sculptures such as the Laocoön or the Flaying of Marsyas. There is no doubt that in these sculp ...
ANPS 019 Beneyto 11-06
ANPS 019 Beneyto 11-06

Analysis of Firing Correlations Between Sympathetic Premotor
Analysis of Firing Correlations Between Sympathetic Premotor

... Currently there is little information regarding the nature of the driving inputs to sympathetic premotor neurons. We reasoned that there were two main possibilities. First the sympathetic premotor neurons may themselves form part of the generator network, in which case the premotor neurons must dire ...
LESSON 4.3 WORKBOOK What makes us go to sleep, and what
LESSON 4.3 WORKBOOK What makes us go to sleep, and what

... When we are awake and alert, most of the neurons in our brain – especially those in our forebrain – are active, which enables us to pay attention to sensory information, to think about what we are perceiving, to retrieve and think about memories, and to engage in the variety of behaviors that we hav ...
Sequencing the connectome. - Cold Spring Harbor Laboratory
Sequencing the connectome. - Cold Spring Harbor Laboratory

... input from layer 4 to layer 2/3 appears to consist of at least two independent “subnetworks” which happen to overlap in space. In a different set of experiments, Chklovskii and colleagues [10] used whole cell methods to assess connectivity among triplets of neurons. By enumerating all 16 possible wa ...
Modeling stability in neuron and network function: the role of activity
Modeling stability in neuron and network function: the role of activity

... burster, but rather fired three spikes per burst.(26) In this case, averaging fails because the phenotype depends not on one single conductance, but on the correlated levels of several and illustrates that, although building models from average data is often reliable, it is not necessarily so. Unfor ...
Nervous System
Nervous System

... Primary motor area Broca’s area ...
PDF file
PDF file

... wt1 i,j and wt2 i,j are top-down weights received from “where” and “what” motors, respectively. y1 i,j and y2 i,j are the top-down inputs from the “where” motor and “what” motor, respectively. β (0 ≤ β ≤ 1) is the weight that controls the maximum contribution by the “what” motor. V. N EURON C OMPETI ...
A Gaussian Approach to Neural Nets with Multiple Memory Domains
A Gaussian Approach to Neural Nets with Multiple Memory Domains

... model are the same as in previous work [6,7] In previous studies [1-3], the dynamical and the mathematical formalism is similar to behaviour of isolated and non-isolated neural that of isolated networks [4]. Neural nets are nets with chemical markers and high assumed to be constructed of discrete se ...
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Mirror neuron

A mirror neuron is a neuron that fires both when an animal acts and when the animal observes the same action performed by another. Thus, the neuron ""mirrors"" the behavior of the other, as though the observer were itself acting. Such neurons have been directly observed in primate species. Birds have been shown to have imitative resonance behaviors and neurological evidence suggests the presence of some form of mirroring system. In humans, brain activity consistent with that of mirror neurons has been found in the premotor cortex, the supplementary motor area, the primary somatosensory cortex and the inferior parietal cortex.The function of the mirror system is a subject of much speculation. Many researchers in cognitive neuroscience and cognitive psychology consider that this system provides the physiological mechanism for the perception/action coupling (see the common coding theory). They argue that mirror neurons may be important for understanding the actions of other people, and for learning new skills by imitation. Some researchers also speculate that mirror systems may simulate observed actions, and thus contribute to theory of mind skills, while others relate mirror neurons to language abilities. Neuroscientists such as Marco Iacoboni (UCLA) have argued that mirror neuron systems in the human brain help us understand the actions and intentions of other people. In a study published in March 2005 Iacoboni and his colleagues reported that mirror neurons could discern if another person who was picking up a cup of tea planned to drink from it or clear it from the table. In addition, Iacoboni has argued that mirror neurons are the neural basis of the human capacity for emotions such as empathy.It has also been proposed that problems with the mirror neuron system may underlie cognitive disorders, particularly autism. However the connection between mirror neuron dysfunction and autism is tentative and it remains to be seen how mirror neurons may be related to many of the important characteristics of autism.Despite the excitement generated by these findings, to date, no widely accepted neural or computational models have been put forward to describe how mirror neuron activity supports cognitive functions such as imitation. There are neuroscientists who caution that the claims being made for the role of mirror neurons are not supported by adequate research.
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