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Articles in PresS. Am J Physiol Heart Circ Physiol (January 22, 2016
Articles in PresS. Am J Physiol Heart Circ Physiol (January 22, 2016

... hypertrophy (38) and to decline with healthy ageing (41). The rapid relaxation resulting ...
Articles in PresS. Am J Physiol Heart Circ Physiol (January 22, 2016
Articles in PresS. Am J Physiol Heart Circ Physiol (January 22, 2016

... hypertrophy (38) and to decline with healthy ageing (41). The rapid relaxation resulting ...
Beneficial Effect of Continuous Normobaric Hypoxia on Ventricular
Beneficial Effect of Continuous Normobaric Hypoxia on Ventricular

... explain the beneficial effect of CNH. Similar attenuation of LV dilatation has been observed in infarcted rats ...
A new concept of the contraction–extension
A new concept of the contraction–extension

... The minor difference was seen from beat to beat and among the subjects, but the general tendency was unequivocal. The heart rate gave the difference in the absolute value of the length of each phase, but there was little influence on the sequence of the SR distribution, at least among the normal subj ...
Assessment of diastolic dysfunction and heart failure with integrated
Assessment of diastolic dysfunction and heart failure with integrated

... Diastolic dysfunction and diastolic heart failure In population based studies the prevalence of heart failure is 2-3%, but in the elderly it can reach the 20%, out of whom approximately 50% have diastolic heart failure with a similar prognosis (DHF). Similar studies have shown that the prevalence of ...
Active myocyte shortening during the `isovolumetric relaxation
Active myocyte shortening during the `isovolumetric relaxation

... Aortic pressure, LVP, dP/dt, and sonomicrometer crystals data were digitally processed by specific hardware and software (Sonometrics, London, Ont., Canada). Velocity of sound through cardiac tissue was fixed to 1590 m/s. Sonomicrometer measurements were recorded with a sampling rate of 95.8 samples ...
Echocardiographic Assessment of Cardiac Anatomy
Echocardiographic Assessment of Cardiac Anatomy

... SUMMARY Cardiovascular complications are a major source of morbidity and mortality in hypertensive patients. To assess the prevalence of anatomic and functional abnormalities of the heart in such patients, we studied 234 asymptomatic subjects with mild-to-moderate systemic hypertension by echocardio ...
Regional cardiac sympathetic denervation in patients with
Regional cardiac sympathetic denervation in patients with

... patients were women (26, 29, 40, and 67 years old, respectively) with no history suggestive of coronary artery disease . Two of these four patients had normal findings on exercise stress tests and echocardiography, one patient had a normal exercise stress test result with echocardiographic evidence ...
A mathematical model of left ventricular contraction and
A mathematical model of left ventricular contraction and

... association. The processes involved on heart failure have been investigated for many decades but despite this the underlying pathophysiology remains poorly understood [10]. This has led some authorities to circumvent defining heart failure by using a collection of signs, symptoms and the results of ...
Twist Mechanics of the Left Ventricle
Twist Mechanics of the Left Ventricle

... For example, LV systolic twisting and untwisting can almost double with short-term exercise because of augmented rotation of both apical and basal levels (40), storing additional potential energy that is released for improving diastolic suction (41,42). Long-term exercise training may, however, redu ...
Right Ventricular Ejection Fraction During Exercise in Normal
Right Ventricular Ejection Fraction During Exercise in Normal

... SUMMARY The response of right ventricular ejection fraction (RVEF) during exercise and its relationship to the location and extent of coronary artery disease are not fully understood. We have recently developed and validated a new method for scintigraphic evaluation of RVEF using rapid multiple-gate ...
Preview of the Medifocus Guidebook on: Atrial Fibrillation Updated
Preview of the Medifocus Guidebook on: Atrial Fibrillation Updated

... properly. In atrial fibrillation, there is a storm of electrical activity across both atria causing them to fibrillate (quiver) 300-600 times per minute. Only a small number of these electrical impulses are picked up by the ventricles, but the ventricular rate can approach 180 or higher. Whether at ...
Role of neural modulation in the pathophysiology of atrial fibrillation
Role of neural modulation in the pathophysiology of atrial fibrillation

... system (ICANS). Po et al51 caused focal firing in either the right or left superior PV after injecting the neurotransmitter acetylcholine (ACh) into the GP anatomically adjacent to those PVs. Further, Lemola et al52 performed PV isolation in dogs while preserving the GP and then ablated the GP while ...
Ultrafast Computed Tomography Analysis of Regional Radius
Ultrafast Computed Tomography Analysis of Regional Radius

... Each study was set up so that the tomographic images obtained at the mid left ventricle were as close as possible to a true short-axis scan, analogous to twodimensional echocardiographic images. However, unlike echocardiography, ultrafast CT acquires sequential and parallel tomograms. Thus, although ...
CLINICAL REVIEW Management of atrial fibrillation
CLINICAL REVIEW Management of atrial fibrillation

... maintain sinus rhythm. To restore sinus rhythm, pharmacological or electrical cardioversion can be used, always after adequate anticoagulation. Pharmacological cardioversion can be tried with antiarrhythmic drugs, administered intravenously or orally; patients receive the treatment usually as inpati ...
Arrhythmogenic right ventricular cardiomyopathy (ARVC
Arrhythmogenic right ventricular cardiomyopathy (ARVC

... Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is one of the most arrhythmogenic forms of inherited cardiomyopathy and a frequent cause of sudden death in the young. Affected individuals typically present between the second and fourth decade of life with arrhythmias coming from the right ven ...
Heart Failure with Preserved Ejection Fraction and Diabetes Mellitus
Heart Failure with Preserved Ejection Fraction and Diabetes Mellitus

... systemic vascular resistance index, and lower increase in cardiac index during exercise when compared with controls while LVEDV increased similarly in both groups. These findings suggest that in HFpEF both the chronotropic and vasodilatory reserves are diminished [15]. The latter would result in red ...
carl john wiggers - National Academy of Sciences
carl john wiggers - National Academy of Sciences

... part-time clinical work led him to conclude that it was hindering, not helping, his academic career, and reinforced his decision to make physiology his sole activity. In 1910 Professor Lombard took a sabbatical year to study abroad, and Wiggers became acting head of the department. He mentioned late ...
Welcome to Renton Technical College
Welcome to Renton Technical College

... Atrial flutter occurs when the electrical impulses take an abnormal path through the atria, typically circulating around the tricuspid valve in the right atrium. The abnormal path of the impulses makes the atria contract very rapidly. These rapid contractions are slowed when they reach the AV node o ...
Diastolic Dysfunction and Its Management in Elderly Patients
Diastolic Dysfunction and Its Management in Elderly Patients

... The pathophysiology of diastolic CHF is incompletely understood, and a universally accepted definition is lacking.5 Except for persons with evidence of significant systolic dysfunction, ischemic or valvular heart disease, and pulmonary diseases, CHF patients can be expected to have diastolic dysfunc ...
Ventricular Relaxation and Diastolic Chamber Stiffness Induced by
Ventricular Relaxation and Diastolic Chamber Stiffness Induced by

... Effects of hypoxia compared with adenosine (n = 6). The pressure and volume in the coronary vasculature may be one determinant of ventricular diastolic compliance (18-20). To further isolate the potential effects of coronary vasodilatation and engorgement of the ventricular wall (erectile effect), t ...
The Current Status of Performing Left Ventriculography in Taiwan
The Current Status of Performing Left Ventriculography in Taiwan

... examinations. However, the LVG procedure requires cardiac catheterization and contrast medium, which involves the associated risks of renal injury and allergic reaction. Many new noninvasive techniques have been developed and could also be used to evaluate left ventricular function. So LVG may be un ...
Recommendations for chamber quantification
Recommendations for chamber quantification

... obtained during held end-expiration, care must be taken to avoid a Valsalva maneuver, which can degrade image quality. Digital capture and display of images on the echocardiographic system or on a workstation should optimally display images at a rate of at least 30 frames/second. In routine clinica ...
Cardiac Resynchronisation Therapy: The Optimal QRS Duration
Cardiac Resynchronisation Therapy: The Optimal QRS Duration

... with PR interval prolongation and left ventricular ejection fraction (LVEF) <30 %, but with a QRS duration ≥130 ms.6 Patients with QRS >130 ms may also respond to CRT even if LVEF >30 %.7 These data are reflected in the recently published ESC guidelines on heart failure.8 In contrast to previous ESC ...
Left ventricular hypertrophy in athletes
Left ventricular hypertrophy in athletes

... focused on Caucasian athletes aged 18–35 years. These studies provide insight into the magnitude and determinants of cardiac size in athletes and are invaluable in aiding the differentiation of physiological left ventricular hypertrophy (LVH) (athlete’s heart) from hypertrophic cardiomyopathy (HCM), ...
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Ventricular fibrillation



Ventricular fibrillation (V-fib or VF) is a condition in which there is uncoordinated contraction of the cardiac muscle of the ventricles in the heart, making them quiver rather than contract properly. Ventricular fibrillation is the most commonly identified arrhythmia in cardiac arrest patients. While there is some activity, the lay person is usually unable to detect it by palpating (feeling) the major pulse points of the carotid and femoral arteries. Such an arrhythmia is only confirmed by electrocardiography. Ventricular fibrillation is a medical emergency that requires prompt Advanced Life Support interventions. If this arrhythmia continues for more than a few seconds, it will likely degenerate further into asystole (""flatline""). This condition results in cardiogenic shock and cessation of effective blood circulation. As a consequence, sudden cardiac death (SCD) will result in a matter of minutes. If the patient is not revived after a sufficient period (within roughly 5 minutes at room temperature), the patient could sustain irreversible brain damage and possibly become brain-dead, due to the effects of cerebral hypoxia. On the other hand, death often occurs if sinus rhythm is not restored within 90 seconds of the onset of VF, especially if it has degenerated further into asystole.
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