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ACTION POTENTIAL THRESHOLD OF HIPPOCAMPAL
ACTION POTENTIAL THRESHOLD OF HIPPOCAMPAL

... potential between action potentials is expected to in£uence the threshold of subsequent action potentials. We tested this hypothesis by triggering hyperpolarizing current injections (0.1^2 nA for 60 ms) immediately following spontaneous action potentials. Figure 6A shows a spontaneous train of actio ...
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... lots of ions: there are many different ions inside and outside your cells (usually we talk about K+, Na+, Cl-, and then lump the rest together as anonymous anions, or A-). Each of these ions can (under certain circumstances) affect the diffusion-voltage equilibrium. And they are all operating at the ...
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here
here

... Although
the
ANS
is
considered
to
be
involuntary,
this
is
not
entirely
true.

A
certain
amount
of
conscious
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can
be
exerted
over
it
as
has
long
been
demonstrated
by
practitioners
of
yoga
and
Zen
Buddhism.

 During
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 of
 meditation,
 these
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 are
 able
 to
 alter
 a
 numb ...
MEMBRANE MODEL: The Bubble Lab
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... Depolarization means that there is a decrease in the membrane potential (and a decrease in the difference between inside and outside of the cell). Repolarization means that there is an increase in the membrane potential (and an increase in the difference between inside and outside of the cell). You ...
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... across the neuronal membrane: INa IK and IA. The first two are the same currents as in the Hodgkin-Huxley equations, but IA is the transient potassium current. This is activated quickly when a cell is depolarized (made less negative). The presence of IA allows a greater range of firing frequencies a ...
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... Graded potentials are generated at the dendrites and are conducted along the membrane to the axon hillock If the summated activity at the axon hillock raises the membrane potential past threshold, an action potential (AP) will occur During the AP, NA+ ions flow into the cell raising the membrane pot ...
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Action potential



In physiology, an action potential is a short-lasting event in which the electrical membrane potential of a cell rapidly rises and falls, following a consistent trajectory. Action potentials occur in several types of animal cells, called excitable cells, which include neurons, muscle cells, and endocrine cells, as well as in some plant cells. In neurons, they play a central role in cell-to-cell communication. In other types of cells, their main function is to activate intracellular processes. In muscle cells, for example, an action potential is the first step in the chain of events leading to contraction. In beta cells of the pancreas, they provoke release of insulin. Action potentials in neurons are also known as ""nerve impulses"" or ""spikes"", and the temporal sequence of action potentials generated by a neuron is called its ""spike train"". A neuron that emits an action potential is often said to ""fire"".Action potentials are generated by special types of voltage-gated ion channels embedded in a cell's plasma membrane. These channels are shut when the membrane potential is near the resting potential of the cell, but they rapidly begin to open if the membrane potential increases to a precisely defined threshold value. When the channels open (in response to depolarization in transmembrane voltage), they allow an inward flow of sodium ions, which changes the electrochemical gradient, which in turn produces a further rise in the membrane potential. This then causes more channels to open, producing a greater electric current across the cell membrane, and so on. The process proceeds explosively until all of the available ion channels are open, resulting in a large upswing in the membrane potential. The rapid influx of sodium ions causes the polarity of the plasma membrane to reverse, and the ion channels then rapidly inactivate. As the sodium channels close, sodium ions can no longer enter the neuron, and then they are actively transported back out of the plasma membrane. Potassium channels are then activated, and there is an outward current of potassium ions, returning the electrochemical gradient to the resting state. After an action potential has occurred, there is a transient negative shift, called the afterhyperpolarization or refractory period, due to additional potassium currents. This mechanism prevents an action potential from traveling back the way it just came.In animal cells, there are two primary types of action potentials. One type is generated by voltage-gated sodium channels, the other by voltage-gated calcium channels. Sodium-based action potentials usually last for under one millisecond, whereas calcium-based action potentials may last for 100 milliseconds or longer. In some types of neurons, slow calcium spikes provide the driving force for a long burst of rapidly emitted sodium spikes. In cardiac muscle cells, on the other hand, an initial fast sodium spike provides a ""primer"" to provoke the rapid onset of a calcium spike, which then produces muscle contraction.
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