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Enterobacteriaceae - Cal State L.A. - Cal State LA
Enterobacteriaceae - Cal State L.A. - Cal State LA

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... Francisella tularensis, the bacterial agent of tularemia, is a highly infectious Tier I bioterrorism agent. Inhalation of as few as 25 F. tularensis bacteria can cause a potentially fatal pneumonic tularemia. F. tularensis has a type VI secretion system (T6SS), a multi-component membrane-puncturing ...
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... -31 species -80,000 deaths per year in the US -produce many enterotoxins -produce biofilms -can cause food poisoning -commonly lives on the skin and mucous membrane ...
Signals and Structural Features Involved in Integral Membrane
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... into pSVK3 that had been digested with EcoRI and KpnI. This construct was called pSV-HA. The sequence encoding CHL from amino acid 24 to amino acid 131 was inserted into pSV-HA using a PCR product from nucleotide +185 to nucleotide +508 of CHL eDNA (Mellow et al., 1988). The PCR product was generate ...
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Trimeric autotransporter adhesin



In molecular biology, trimeric autotransporter adhesins (TAAs), are proteins found on the outer membrane of Gram-negative bacteria. Bacteria use TAAs in order to infect their host cells via a process called cell adhesion. TAAs also go by another name, oligomeric coiled-coil adhesins, which is shortened to OCAs. In essence, they are virulence factors, factors that make the bacteria harmful and infective to the host organism.TAAs are just one of many methods bacteria use to infect their hosts, infection resulting in diseases such as pneumonia, sepsis, and meningitis. Most bacteria infect their host through a method named the secretion pathway. TAAs are part of the secretion pathway, to be more specific the type Vc secretion system.Trimeric autotransporter adhesins have a unique structure. The structure they hold is crucial to their function. They all appear to have a head-stalk-anchor structure. Each TAA is made up of three identical proteins, hence the name trimeric. Once the membrane anchor has been inserted into the outer membrane, the passenger domain passes through it into the host extracellular environment autonomously, hence the description of autotransporter. The head domain, once assembled, then adheres to an element of the host extracellular matrix, for example, collagen, fibronectin, etc.
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