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Expert Opin. Ther. Pat. 2016, 27, 179–189
... Introduction: Drug conjugates are trend topics in Chemical Biology. These entities are an emerging class of highly potent biopharmaceutical drugs, best known in the field of oncology, that have been also designed as a targeted therapy/diagnosis for the treatment/prevention of several bacterial disea ...
... Introduction: Drug conjugates are trend topics in Chemical Biology. These entities are an emerging class of highly potent biopharmaceutical drugs, best known in the field of oncology, that have been also designed as a targeted therapy/diagnosis for the treatment/prevention of several bacterial disea ...
Metabolic Characteristics of Oxcarbazepine (®Trileptal
... (cf. Fig. 2). Cytosolic aldo-keto reductases are reported to be non-inducible, and glucuronyltransferases do not appear to be very responsive to induction in general. The latter enzyme system is particularly important for oxcarbazepine, because it controls the elimination of the active metabolite MH ...
... (cf. Fig. 2). Cytosolic aldo-keto reductases are reported to be non-inducible, and glucuronyltransferases do not appear to be very responsive to induction in general. The latter enzyme system is particularly important for oxcarbazepine, because it controls the elimination of the active metabolite MH ...
A New Crescent-shaped Spindle for Drug Dissolution Testing—But
... In our laboratory, we became aware of the issue when as a regulatory organization, we tried to set reproducibility standards for dissolution testing between 5 to 10% CV (coefficient of variation) based on USP Calibrator Tablets testing. Unfortunately by analyzing the archival dissolution results of ...
... In our laboratory, we became aware of the issue when as a regulatory organization, we tried to set reproducibility standards for dissolution testing between 5 to 10% CV (coefficient of variation) based on USP Calibrator Tablets testing. Unfortunately by analyzing the archival dissolution results of ...
In vitro - In vivo Correlation: From Theory to
... Cmax. Therefore, it represents a single point correlation and doses not reflect the entire shape of the plasma drug concentration curve, which is indeed a crucial factor that is a good indicative of the performance of modified-release products (2, 3). This is the weakest level of correlation as part ...
... Cmax. Therefore, it represents a single point correlation and doses not reflect the entire shape of the plasma drug concentration curve, which is indeed a crucial factor that is a good indicative of the performance of modified-release products (2, 3). This is the weakest level of correlation as part ...
our guide to drug detox.
... Don’t just watch a bunch of detox videos from people who’ve been there. Listen to what they say about coming out of it — how that’s when you first see a glimmer of hope. That’s when recovery finally starts to seem possible. ...
... Don’t just watch a bunch of detox videos from people who’ve been there. Listen to what they say about coming out of it — how that’s when you first see a glimmer of hope. That’s when recovery finally starts to seem possible. ...
DESIGN AND DEVELOPMENT OF MUCOADHESIVE BUCCAL DELIVERY FOR PANTOPRAZOLE
... prevented the decomposition of pantoprazole in acidic gastric fluid which penetrated into the enteric coating walls, since they provided the alkali environment for pantoprazole. In the formulation of the pantoprazole buccal adhesive tablet, these alkali materials were also used as stabilizers of pan ...
... prevented the decomposition of pantoprazole in acidic gastric fluid which penetrated into the enteric coating walls, since they provided the alkali environment for pantoprazole. In the formulation of the pantoprazole buccal adhesive tablet, these alkali materials were also used as stabilizers of pan ...
Is there an interaction between erythromycin and statins?
... Concomitant use of erythromycin (500mg four times daily for 7 days) and a single 80mg dose of rosuvastatin in 11 healthy subjects resulted in a 20% decrease in AUC and a 30% decrease in Cmax of rosuvastatin [18]. This interaction may be caused by the increase in gut motility caused by erythromycin. ...
... Concomitant use of erythromycin (500mg four times daily for 7 days) and a single 80mg dose of rosuvastatin in 11 healthy subjects resulted in a 20% decrease in AUC and a 30% decrease in Cmax of rosuvastatin [18]. This interaction may be caused by the increase in gut motility caused by erythromycin. ...
The neural basis of drug craving: an incentive
... causes excessive incentive salience to be attributed to the act of drug taking and to stimuli associated with drug taking. It is specifically the sensitization of incentive salience, therefore, that transforms ordinary ‘wanting’ into excessive drug craving. (4) It is further proposed that sensitizat ...
... causes excessive incentive salience to be attributed to the act of drug taking and to stimuli associated with drug taking. It is specifically the sensitization of incentive salience, therefore, that transforms ordinary ‘wanting’ into excessive drug craving. (4) It is further proposed that sensitizat ...
Abstract: Long Project
... Dr. Jean-Christophe Leroux, "Injectable nanocarriers for biodetoxification" nature nanotechnology | VOL 2 | NOVEMBER 2007 doi:10.1038/nnano.2007.339 Image: http://www.technologyreview.com/read_article.aspx?id=17578&ch=nanotech&a=f ...
... Dr. Jean-Christophe Leroux, "Injectable nanocarriers for biodetoxification" nature nanotechnology | VOL 2 | NOVEMBER 2007 doi:10.1038/nnano.2007.339 Image: http://www.technologyreview.com/read_article.aspx?id=17578&ch=nanotech&a=f ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... is often difficult. At present, only rectal diazepam has been approved by the Food and Drug Administration (FDA) for use in these situations. This formulation, however, is expensive and difficult for many parents to administer, especially during seizures occurring outside the home. Many older childr ...
... is often difficult. At present, only rectal diazepam has been approved by the Food and Drug Administration (FDA) for use in these situations. This formulation, however, is expensive and difficult for many parents to administer, especially during seizures occurring outside the home. Many older childr ...
Two Decades Coordinating Medication Safety Efforts
... Recommendations for Administration The Council also wanted to ensure that health care professionals who administer medications are knowledgeable about the drugs they administer and have easilyaccessible product information. In June 1999, the Council adopted recommendations to reduce errors related t ...
... Recommendations for Administration The Council also wanted to ensure that health care professionals who administer medications are knowledgeable about the drugs they administer and have easilyaccessible product information. In June 1999, the Council adopted recommendations to reduce errors related t ...
based Micro and Nanoparticles for the Controlled Drug Delivery of
... potential disadvantages cannot be ignored: possible toxicity or nonbiocompatibility of the materials used, undesirable by-products of degradation, the fact that surgery may be required to implant or remove the system, the possibility of patient discomfort caused by the delivery device, and the highe ...
... potential disadvantages cannot be ignored: possible toxicity or nonbiocompatibility of the materials used, undesirable by-products of degradation, the fact that surgery may be required to implant or remove the system, the possibility of patient discomfort caused by the delivery device, and the highe ...
27 Gastrointestinal drugs
... The gastrointestinal adverse effects of alvimopan are expected to be greater in those who have recently taken opioids. Alvimopan does not appear to alter the pharmacokinetics of intravenous morphine. Antibacterials that affect gut flora and drugs that inhibit gastric acid secretion appear to reduce ...
... The gastrointestinal adverse effects of alvimopan are expected to be greater in those who have recently taken opioids. Alvimopan does not appear to alter the pharmacokinetics of intravenous morphine. Antibacterials that affect gut flora and drugs that inhibit gastric acid secretion appear to reduce ...
THE TITLE: Pharmacokinetic Drug Interaction with Gemfibrozil
... ng.h.ml in healthy volunteers after 4 mg single dose of rosiglitazone and an another study carried out in Philadelphia [14] had reported 319 ± 97 ng/ml and 1552 ± 416 ng.h.ml-1 of Cmax and AUC0-∞ respectively. While our study group showed higher concentrations at tmax as 427.822 ± 35.13 ng/ml-1 and ...
... ng.h.ml in healthy volunteers after 4 mg single dose of rosiglitazone and an another study carried out in Philadelphia [14] had reported 319 ± 97 ng/ml and 1552 ± 416 ng.h.ml-1 of Cmax and AUC0-∞ respectively. While our study group showed higher concentrations at tmax as 427.822 ± 35.13 ng/ml-1 and ...
Stimulants - Australian Indigenous HealthInfoNet
... History of stimulant use Naturally occurring plant-based stimulants have been used by many cultures for thousands of years. Often used for their healing effects, stimulants were typically used for specific purposes at specific times. Examples include coca leaves and areca nut (also known as betel nu ...
... History of stimulant use Naturally occurring plant-based stimulants have been used by many cultures for thousands of years. Often used for their healing effects, stimulants were typically used for specific purposes at specific times. Examples include coca leaves and areca nut (also known as betel nu ...
Sulfamethoxazole / Trimethoprim Sulfamethoxazole / Trimethoprim
... dosage must be monitored carefully. Because SMX-TMP possesses anti-folate properties, the drug could theoretically increase the incidence of folate deficiencies induced by other drugs, such as phenytoin, when used concomitantly. Concomitant administration of usual dosages of SMX-TMP and phenytoin ca ...
... dosage must be monitored carefully. Because SMX-TMP possesses anti-folate properties, the drug could theoretically increase the incidence of folate deficiencies induced by other drugs, such as phenytoin, when used concomitantly. Concomitant administration of usual dosages of SMX-TMP and phenytoin ca ...
In vitro available for inhalation from different formulations P.W. Barry, C. O'Callaghan
... Airomir® and Ventolin® MDI. We did not measure the static charge of the aerosol particles, but differences in either the charge or the static dissipative properties of the aerosol constituents may also have contributed to the observed differences in drug delivery. Our work confirms the principle tha ...
... Airomir® and Ventolin® MDI. We did not measure the static charge of the aerosol particles, but differences in either the charge or the static dissipative properties of the aerosol constituents may also have contributed to the observed differences in drug delivery. Our work confirms the principle tha ...
Molecules that changed our Lives Synthetic Organic
... Dr. Phani: Well, I shall give some basic information for discussion. We can touch upon each area though briefly without going deep into the scientific details. Organic medicinal substances may be of natural or synthetic origin. The drugs obtained from natural sources are many alkaloids, glycosides, ...
... Dr. Phani: Well, I shall give some basic information for discussion. We can touch upon each area though briefly without going deep into the scientific details. Organic medicinal substances may be of natural or synthetic origin. The drugs obtained from natural sources are many alkaloids, glycosides, ...
Toxic Doses
... o To find the relative safety of a drug, TI is calculated as follows: TI = the ratio of the dose producing toxicity to the dose needed to produce the desired therapeutic response, TD/ED or LD/ED. o TI calculation commonly uses the 50% dose-response points, TD50 and ED50. o For example, if the TD50 i ...
... o To find the relative safety of a drug, TI is calculated as follows: TI = the ratio of the dose producing toxicity to the dose needed to produce the desired therapeutic response, TD/ED or LD/ED. o TI calculation commonly uses the 50% dose-response points, TD50 and ED50. o For example, if the TD50 i ...
Synergism and Antagonism in Toxicity of Mixtures
... pharmaceuticals, leaving the water contaminated with some pharmaceutical drugs (Langford, 2009, Dokianakis, 2004). With improved medical treatment and rising human population the number of prescriptions dispensed per year is also steadily increasing (Huggett et al., 2003A; Huggett et al., 2003B; Kop ...
... pharmaceuticals, leaving the water contaminated with some pharmaceutical drugs (Langford, 2009, Dokianakis, 2004). With improved medical treatment and rising human population the number of prescriptions dispensed per year is also steadily increasing (Huggett et al., 2003A; Huggett et al., 2003B; Kop ...
... Postmarketing studies are essential in assessing optimal use of drugs and biologics. Results from such studies have made significant changes to how products are used. Listed below are a few examples of improvement to health care through better treatment regimens or decreased toxicity: Interferon alf ...
Cytochrome P450 Genotyping
... The AmpliChip® (Roche Molecular Systems) was cleared for marketing by FDA in January 2005. The AmpliChip® is a microarray consisting of many DNA sequences complementary to two CYP450 genes and applied in microscopic quantities at ordered locations on a solid surface (chip). The AmpliChip® tests the ...
... The AmpliChip® (Roche Molecular Systems) was cleared for marketing by FDA in January 2005. The AmpliChip® is a microarray consisting of many DNA sequences complementary to two CYP450 genes and applied in microscopic quantities at ordered locations on a solid surface (chip). The AmpliChip® tests the ...
effects of cytochrome p450 enzyme inhibitors on the
... The desirable and undesirable effects of a drug are usually related to its concentration at the sites of action, which in turn depends on the amount of a drug administered, and on the pharmacokinetic behavior of a drug. Pharmacokinetics refers to the movement of drug into, through, and out of the bo ...
... The desirable and undesirable effects of a drug are usually related to its concentration at the sites of action, which in turn depends on the amount of a drug administered, and on the pharmacokinetic behavior of a drug. Pharmacokinetics refers to the movement of drug into, through, and out of the bo ...