Distinct Contributions of Replication and Transcription to Mutation
... SNP density than TS genes, which is contradictory with the viewpoint that mutation rate should be accelerated among highly-expressed genes under the process of transcription-coupled DNA damage or TCR (9, 12). Therefore, we are now able to draw two conclusions. First, considering the weaker effect fr ...
... SNP density than TS genes, which is contradictory with the viewpoint that mutation rate should be accelerated among highly-expressed genes under the process of transcription-coupled DNA damage or TCR (9, 12). Therefore, we are now able to draw two conclusions. First, considering the weaker effect fr ...
Identifying Differentially Expressed Gene Categories
... • Based on a large body of past research, some information is known about many of the genes represented on a microarray. • The information might include tissues in which a gene is known to be expressed, the biological process in which a gene’s protein is known to act, or other general or quite speci ...
... • Based on a large body of past research, some information is known about many of the genes represented on a microarray. • The information might include tissues in which a gene is known to be expressed, the biological process in which a gene’s protein is known to act, or other general or quite speci ...
Leukaemia Section t(2;8)(p23;p11) KAT6A/ASXL2 Atlas of Genetics and Cytogenetics in Oncology and Haematology
... ASXL2 is an enhancer of PcG activity. ASXL2 and the histone methyltansferase EZH2 (7q36) directly represses MYH7 (14q11) (BetaMyosin Heavy Chain) (Lai et al., 2012). ASXL2 is implicated in prostate, breast, pancreatic cancers (review in Katoh, 2013). EPC1-ASXL2 fusion gene has been found in adult T- ...
... ASXL2 is an enhancer of PcG activity. ASXL2 and the histone methyltansferase EZH2 (7q36) directly represses MYH7 (14q11) (BetaMyosin Heavy Chain) (Lai et al., 2012). ASXL2 is implicated in prostate, breast, pancreatic cancers (review in Katoh, 2013). EPC1-ASXL2 fusion gene has been found in adult T- ...
Separating derived from ancestral features of mouse and human
... sequence for some time to come [5]. The ‘finished’ human genome sequence was reported in 2004 [5] and a similar sequence for mice will be reported elsewhere soon [6]. The purpose of the present review is to provide a brief overview of the similarities and differences between these two genome sequenc ...
... sequence for some time to come [5]. The ‘finished’ human genome sequence was reported in 2004 [5] and a similar sequence for mice will be reported elsewhere soon [6]. The purpose of the present review is to provide a brief overview of the similarities and differences between these two genome sequenc ...
Exploring a fatal outbreak of Escherichia coli using
... bacteria associated with the epidemic certain genes that had previously been associated with virulence (attA, aggR, aap, aggA, and aggC). In addition, these strains also carried the gene for a Shiga-toxin 2 variant (stx2a). In contrast, these same genomes were found to be missing other typical Shiga ...
... bacteria associated with the epidemic certain genes that had previously been associated with virulence (attA, aggR, aap, aggA, and aggC). In addition, these strains also carried the gene for a Shiga-toxin 2 variant (stx2a). In contrast, these same genomes were found to be missing other typical Shiga ...
Basic Sheep Genetics - UK College of Agriculture
... both parents are white-wooled phenotypically, there is a one-in-four chance that a mating of this type will produce a black-wooled (ww) offspring. Thus, heterozygous individuals do not breed true. White-wooled sheep are known to carry the black wool gene if they have at least one black-wooled lamb o ...
... both parents are white-wooled phenotypically, there is a one-in-four chance that a mating of this type will produce a black-wooled (ww) offspring. Thus, heterozygous individuals do not breed true. White-wooled sheep are known to carry the black wool gene if they have at least one black-wooled lamb o ...
Analysis of GDSL lipase (GLIP) family genes in rice (Oryza sativa)
... one of the lipases that exhibit a GDSL motif GxSxxxxG, in which the active site Serine is located near the N-terminus and display a Gly-Asp-Ser-(Leu) [GDS(L)] motif in conserved block I. However, the knowledge about their roles in developmental processes and response to various stimuli are still ver ...
... one of the lipases that exhibit a GDSL motif GxSxxxxG, in which the active site Serine is located near the N-terminus and display a Gly-Asp-Ser-(Leu) [GDS(L)] motif in conserved block I. However, the knowledge about their roles in developmental processes and response to various stimuli are still ver ...
Additional file - Supplementary material
... a function of gene length, we generate a fit to the binary series given by each gene’s differential expression (1=DE, 0=not DE) as a function of each gene’s length (or read count). As the functional form of this dependence is unknown, we chose to use a cubic spline. Given that power for detecting DE ...
... a function of gene length, we generate a fit to the binary series given by each gene’s differential expression (1=DE, 0=not DE) as a function of each gene’s length (or read count). As the functional form of this dependence is unknown, we chose to use a cubic spline. Given that power for detecting DE ...
F 1
... determine the phenotype of an organism. Two parameters describe the effects: Penetrance is the proportion of individuals with a certain genotype that show the phenotype. Expressivity is the degree to which genotype is expressed in an individual. ...
... determine the phenotype of an organism. Two parameters describe the effects: Penetrance is the proportion of individuals with a certain genotype that show the phenotype. Expressivity is the degree to which genotype is expressed in an individual. ...
On Nature Versus And Nurture
... that I can show that this assumption [of dichotomizing of behavior or insensibly graduated mixtures of the two] is not only bad for research but completely unfounded and in all probability false” (p. 29). This was 1961 (the book was translated into English in 1965) [5]. So, why are nature and nurtur ...
... that I can show that this assumption [of dichotomizing of behavior or insensibly graduated mixtures of the two] is not only bad for research but completely unfounded and in all probability false” (p. 29). This was 1961 (the book was translated into English in 1965) [5]. So, why are nature and nurtur ...
Lecture 21: Macroevolution
... - 3' end expressed anterior; 5' end expressed posterior - 3' end expressed earlier in dev’t than 5' end ...
... - 3' end expressed anterior; 5' end expressed posterior - 3' end expressed earlier in dev’t than 5' end ...
Ding, Yi : Singular Value Decomposition applied to the building of class predictor
... different times or from different sources (patients belonging to different phenotype). This has a profound impact on the study of human diseases. By comparing the differentially expressed profiles, we can find out the mechanism of gene expression, hence obtain information useful for clinical diagnos ...
... different times or from different sources (patients belonging to different phenotype). This has a profound impact on the study of human diseases. By comparing the differentially expressed profiles, we can find out the mechanism of gene expression, hence obtain information useful for clinical diagnos ...
The new genes of rice: a closer look
... the known human genes that were used for predictions in the human genome contained up to 9000 or more coding sequences. Several long sequences had been studied in detail, with the help of experiments, to trap coding DNA and identify the non-coding DNA [21]. Second, in some cases, higher scores were ...
... the known human genes that were used for predictions in the human genome contained up to 9000 or more coding sequences. Several long sequences had been studied in detail, with the help of experiments, to trap coding DNA and identify the non-coding DNA [21]. Second, in some cases, higher scores were ...
fgdfgdgsty - Latvijas universitāte
... The study involved S.epidermidis cultures from clinical and control groups isolated in 2009-2010. 81 cultures were isolated from blood (n=45) and intravenous catheters (n=36) in a case of laboratory confirmed bacteraemia from patients of four hospitals in Riga, Latvia. Fifty-five S.epidermidis isola ...
... The study involved S.epidermidis cultures from clinical and control groups isolated in 2009-2010. 81 cultures were isolated from blood (n=45) and intravenous catheters (n=36) in a case of laboratory confirmed bacteraemia from patients of four hospitals in Riga, Latvia. Fifty-five S.epidermidis isola ...
Learning about the Human Genome Explore the 23andMe Browse
... genes in our genome. Does this sound like a little or a lot? Compare this to the genome size of Polychaos dubium (amoeba), C. elegans (round worm), and Mus musculus (house mouse). ...
... genes in our genome. Does this sound like a little or a lot? Compare this to the genome size of Polychaos dubium (amoeba), C. elegans (round worm), and Mus musculus (house mouse). ...
Development of the Custom AtMtDEFL Array and Robust Data
... that multiple family members (nearly always two or three paralogs) were exactly matched by all probes in the probe set. At that time, however, there was no primary assembly of the Medicago genome. Instead, we had to construct probe sets from a compilation of our gene predictions in the scattered (so ...
... that multiple family members (nearly always two or three paralogs) were exactly matched by all probes in the probe set. At that time, however, there was no primary assembly of the Medicago genome. Instead, we had to construct probe sets from a compilation of our gene predictions in the scattered (so ...
Week 8 - GEA
... Table Report is a gene-centric view which lists the genes and their associated annotation terms (selected only). There is no statistics applied in this report __________________________________________________________________________________________________ ...
... Table Report is a gene-centric view which lists the genes and their associated annotation terms (selected only). There is no statistics applied in this report __________________________________________________________________________________________________ ...
2.4.databases_ensembl - T
... • Genomes sequences are becoming available very rapidly – Large and difficult to handle computationally – Everyone expects to be able to access them immediately • Bench Biologists – Has my gene been sequenced? – What are the genes in this region? – Where are all the GPCRs – Connect the genome to oth ...
... • Genomes sequences are becoming available very rapidly – Large and difficult to handle computationally – Everyone expects to be able to access them immediately • Bench Biologists – Has my gene been sequenced? – What are the genes in this region? – Where are all the GPCRs – Connect the genome to oth ...
Table S10
... prototypical VirB system, again, is renowned for introducing T-DNA of the Ti plasmid of Agrobacterium tumefaciens into plant hosts [8]. T4SS homologs are ubiquitous in Alcaligenaceae, with the relevant operons being chromosomal in Te and Bb but borne on the plasmids pWTk445 and pA81 in Tk and A8 res ...
... prototypical VirB system, again, is renowned for introducing T-DNA of the Ti plasmid of Agrobacterium tumefaciens into plant hosts [8]. T4SS homologs are ubiquitous in Alcaligenaceae, with the relevant operons being chromosomal in Te and Bb but borne on the plasmids pWTk445 and pA81 in Tk and A8 res ...
Problem Set 4 Genetics 371 Winter 2010 1. A dihybrid YyZz is test
... Note that 3.5 + 18.4 = 21.9 cM is slightly larger than the 21.7 cM distance calculated above. The combined distance between C and S and S and W is a more accurate measure of distance between C and W because it compensates for undetectable double-crossovers in each interval. Finally, it is also possi ...
... Note that 3.5 + 18.4 = 21.9 cM is slightly larger than the 21.7 cM distance calculated above. The combined distance between C and S and S and W is a more accurate measure of distance between C and W because it compensates for undetectable double-crossovers in each interval. Finally, it is also possi ...
Gene Finding in Viral Genomes
... Consider Figure 3. Figure 3 is concerned with the first nucleotide position in reading frame 2 (so nucleotide loci 2,5,8, etc). State 1 is the Non-Gene state and if the previous nucleotide were in this state then it is possible that the nucleotide under consideration could describe the first positio ...
... Consider Figure 3. Figure 3 is concerned with the first nucleotide position in reading frame 2 (so nucleotide loci 2,5,8, etc). State 1 is the Non-Gene state and if the previous nucleotide were in this state then it is possible that the nucleotide under consideration could describe the first positio ...
The relation of genetics to physiology and medicine
... the chemist calls autocatalytic. The comparison is at present too vague to be reliable. The relative stability of the gene is an inference from genetic evidence. For thousands - perhaps many millions - of subdivisions of its material it remains constant. Nevertheless, on rare occasions, it may chang ...
... the chemist calls autocatalytic. The comparison is at present too vague to be reliable. The relative stability of the gene is an inference from genetic evidence. For thousands - perhaps many millions - of subdivisions of its material it remains constant. Nevertheless, on rare occasions, it may chang ...
Mendel and Punnett Notes
... • A tool to predict the probability of certain traits in offspring that shows the different ways alleles can combine • A way to show phenotype & genotype • A chart that shows all the possible combinations of alleles that can result ...
... • A tool to predict the probability of certain traits in offspring that shows the different ways alleles can combine • A way to show phenotype & genotype • A chart that shows all the possible combinations of alleles that can result ...
Essential gene
Essential genes are those genes of an organism that are thought to be critical for its survival. However, being essential is highly dependent on the circumstances in which an organism lives. For instance, a gene required to digest starch is only essential if starch is the only source of energy. Recently, systematic attempts have been made to identify those genes that are absolutely required to maintain life, provided that all nutrients are available. Such experiments have led to the conclusion that the absolutely required number of genes for bacteria is on the order of about 250-300. These essential genes encode proteins to maintain a central metabolism, replicate DNA, translate genes into proteins, maintain a basic cellular structure, and mediate transport processes into and out of the cell. Most genes are not essential but convey selective advantages and increased fitness.