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A chemist has discovered a drug that blocks
A chemist has discovered a drug that blocks

... you're flipping the switch, you get a call from your secretary. "Francesca," he says. "We've got a dead kid up here that you'll want to look at right away. Might be foul play." Thinking of your four-year old daughter waiting for you at home, you grimace. "OK Jon, I'm heading to the morgue." Performi ...
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8.2 HL Respiration pPractice Questions

... o The remaining two-carbon molecule (acetyl group) reacts with reduced coenzyme A, and, at the same time, one NADH + H+ is formed. o This is known as the link reaction. o In the Krebs cycle, each acetyl group (CH3CO) formed in the link reaction yields two CO2. o The names of the intermediate compoun ...
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The Organellar Genome and Metabolic Potential
The Organellar Genome and Metabolic Potential

... cockroach species. It has numerous hydrogen-producing organelles that are intimately associated with endosymbiotic methane–producing archaea that use the hydrogen produced by the organelles. Despite the hydrogenosomal metabolism of this organelle, we have found that it actually has a genome (Akhmano ...
aciduria—lessons from 50 genes and 977 3-Methylglutaconic patients
aciduria—lessons from 50 genes and 977 3-Methylglutaconic patients

... had a genetically proven diagnosis and in the other 31 patients single or multiple OXPHOS enzyme deficiencies were found in muscle. Patients in whom a decreased ATPproduction was found without evidence for single or multiple OXPHOS enzyme deficiency were considered as “possible” mitochondrial disord ...
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... (REF #1526) for culture of embryos from Day 1 until Day 3, and Quinn’s Advantage® Protein Plus Blastocyst Medium (REF #1529) for culture from Day 3 to Day 5/6. The media require no protein supplement. ...
CO 2 - cloudfront.net
CO 2 - cloudfront.net

... • Normally the electron transport chain is tightly coupled to ATP levels so if we have too much ATP then the complex making the ATP stops working. Since the only way for the H+ ions to get back across the membranes fast enough is via the ATPase making ATP then the gradient of H+ ions builds up and t ...
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An Arabidopsis Dual-Localized Pentatricopeptide

... Genetic analysis of mutants defective in organellar functions in yeast, Chlamydomonas reinhardtii, and land plants has revealed many nuclear-encoded posttranscriptional regulators of organelle gene expression. It is likely that these proteins act as adaptors; they bind specific RNA transcripts and r ...
Mitochondrial Functions in Mood Disorders
Mitochondrial Functions in Mood Disorders

... brain. Normally the H2O2 is then inactivated by glutathione peroxidase but it can be convert‐ ed, chemically, by Fe2+ ions (Fenton reaction) into the highly reactive hydroxyl radical. This radical has widespread deleterious effects which can cause neuronal damage and death and may account for associ ...
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The Concentration of Phosphatidylethanolamine in

... of type 2 diabetes is increasing, and therefore understanding the underlying physiology is of major importance. Up to 75% of patients with obesity and diabetes also suffer from nonalcoholic fatty liver disease (NAFLD) (1,2), indicating that the liver plays an important role in the etiology of obesit ...
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... c. Synthetic uncouplers: Electron transport and phosphorylation can be uncoupled by compounds that increase the permeability of the inner mitochondrial membrane to protons. The classic example is a 2,4-dinitrophenol, lipophilic proton carrier that readily diffuses through the mitochondial membrane. ...
Drosophila melanogaster
Drosophila melanogaster

... fresh medium stimulates females to lay eggs that have been held for a while. The second egg collection can be used to test the injection conditions, such as dryness of eggs and sharpness of needle. There are three ways to remove chorion: • cutting egg shell using tungsten or sharp dissecting needle ...
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Bez nadpisu

... of which enters the citric acid cycle at a different point. This scheme represents the major catabolic pathways in vertebrate animals, but there are minor variations from organism to organism. ...
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... proteins and replication of the genome (Fig. 19-3). Targeting and sorting signals built into the mitochondrial proteins that are synthesized in the cytoplasm direct them to their destinations (see Fig. 18-4). Similar to cells, mitochondria divide, but unlike most cells, they also fuse with other mit ...
Multiple Molecular Mechanisms Cause Reproductive Isolation
Multiple Molecular Mechanisms Cause Reproductive Isolation

... 1%), suggesting that there is strong postzygotic reproductive isolation between these yeast species [12]. Because yeast differs from flies in cellular complexity, life style, and population structure, studies in yeast will greatly expand our knowledge of ...
emboj7601444-sup
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... between the two moieties, was expressed in E. coli BL-21 (DE3) cells, similar to the method described previously (Wynn et al., 1994). Mutations were introduced using the QuickChange site-directed mutagenesis system from Stratagene (La Jolla, CA). The fusion proteins were purified with amylose resin, ...
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... The CAC extracts high energy electrons from acetylCoA, which are held by NADH and FADH2 and are passed on to the respiratory chain in the inner membrane. 13. In the inner membrane, a chemiosmotic process converts oxidation energy into ATP from ADP + Pi. 14. None of the reactions leading to the produ ...
Skodova-Euk-Cell-2013
Skodova-Euk-Cell-2013

... Phospholipid extraction and TLC analysis. A 5-ml volume of exponential culture was centrifuged and washed in STE buffer, and pelleted cells were resuspended in 1 ml of a chloroform:methanol:water mixture (10:10:3). The mixture was then transferred into a clean glass tube, and upon the addition of 10 ...
Faculty of Medicine (5th semester)
Faculty of Medicine (5th semester)

... This course comprises a series of tutorials, laboratory seminars and lectures. The tutorials will mostly concentrate on genetic counselling in various clinical settings, the laboratory seminars will feature presentations of laboratory methods and techniques used in diagnosing genetic diseases. The l ...
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Mitochondrial replacement therapy

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