Drugs of Abuse in Saliva: A Review
... an ultrafiltrate of interstitial lluid and contains the free component of drugs, it has the potential to better indicate a state of intoxication. Therefore, saliva has been increasingly used as the diagnostic medium for the measurement of therapeutic drugs and endogenous markers (I-5). The concentra ...
... an ultrafiltrate of interstitial lluid and contains the free component of drugs, it has the potential to better indicate a state of intoxication. Therefore, saliva has been increasingly used as the diagnostic medium for the measurement of therapeutic drugs and endogenous markers (I-5). The concentra ...
Effects of a Novel Cholecystokinin (CCK)
... infusion reproducing postprandial bioactive plasma concentrations of the hormone have demonstrated that physiologic concentrations of CCK stimulate gallbladder contraction and delay gastric emptying of liquids (3-5). However, prior difficulties in measuring circulating concentrations of CCK and the ...
... infusion reproducing postprandial bioactive plasma concentrations of the hormone have demonstrated that physiologic concentrations of CCK stimulate gallbladder contraction and delay gastric emptying of liquids (3-5). However, prior difficulties in measuring circulating concentrations of CCK and the ...
2/10/2015 Tetrahydrocannabinolic acid (THCA) – Plant Precursor to THC
... Effects last 2 3 hours or less if smoked longer if taken orally Effects last 2‐3 hours or less if smoked – longer if taken orally Smoking/vaporizing allows titration of desired dose Distribution Accumulates in lipophilic tissues ...
... Effects last 2 3 hours or less if smoked longer if taken orally Effects last 2‐3 hours or less if smoked – longer if taken orally Smoking/vaporizing allows titration of desired dose Distribution Accumulates in lipophilic tissues ...
BIOAVAILABILITY OF ORAL PROPOFOL IN HUMANS Victor
... the oxygen saturation of any volunteer. Discussion: The absorption of orally administered propofol is trivial. In 5 of 6 volunteers the propofol concentrations over the first hour were at or below the limits of quantitation. In one volunteer a trivial dose of 11 mg was absorbed following oral ingest ...
... the oxygen saturation of any volunteer. Discussion: The absorption of orally administered propofol is trivial. In 5 of 6 volunteers the propofol concentrations over the first hour were at or below the limits of quantitation. In one volunteer a trivial dose of 11 mg was absorbed following oral ingest ...
Document
... up to the increased rate of RBC destruction Prolonged hemolysis may lead to precipitation of bilirubin salts in the gall bladder and biliary network result in formation of gallstones and conditions such as cholecystitis and biliary obstruction ...
... up to the increased rate of RBC destruction Prolonged hemolysis may lead to precipitation of bilirubin salts in the gall bladder and biliary network result in formation of gallstones and conditions such as cholecystitis and biliary obstruction ...
A REVIEW ON ANALYTICAL METHODOLOGIES FOR THE DETERMINATION OF PIPERACILLIN
... aeruginosa.The combination of piperacillin and tazobactum is used to reduce the development of drug-resistant bacteria.. It is a penicillinate sulfone, structurally related to sulbactam being a betalactamase inhibitor; it is synergistic with many beta-lactamase liable drugs such as penicillins and c ...
... aeruginosa.The combination of piperacillin and tazobactum is used to reduce the development of drug-resistant bacteria.. It is a penicillinate sulfone, structurally related to sulbactam being a betalactamase inhibitor; it is synergistic with many beta-lactamase liable drugs such as penicillins and c ...
Lopinavir/ritonavir combined with twice
... Both indinavir and lopinavir/ritonavir are metabolized by cytochrome P450 (CYP3A4) isoenzyme; indinavir, lopinavir and ritonavir are inhibitors of CYP3A4, and therefore co-administration of these drugs can lead to significant drug interactions. Nonetheless, favourable pharmacokinetics have been demo ...
... Both indinavir and lopinavir/ritonavir are metabolized by cytochrome P450 (CYP3A4) isoenzyme; indinavir, lopinavir and ritonavir are inhibitors of CYP3A4, and therefore co-administration of these drugs can lead to significant drug interactions. Nonetheless, favourable pharmacokinetics have been demo ...
Cytochrome P4502C9: an enzyme of major importance in human
... three dimensional model of CYP2C9 has been constructed [21]. Although potential substrate recognition sites distal to the porphyrin were identified, the resolution of the homology model was considered to be low and of little value in the prediction of substrate binding. Pharmacophore models of the C ...
... three dimensional model of CYP2C9 has been constructed [21]. Although potential substrate recognition sites distal to the porphyrin were identified, the resolution of the homology model was considered to be low and of little value in the prediction of substrate binding. Pharmacophore models of the C ...
Pharmacokinetics and pharmacodynamics of oral oxycodone in
... O-demethylation of codeine has been shown to account for most, if not all, of the analgesic activity of codeine.6,7 Oxymorphone is a remarkably potent -opioid ligand, with 2 to 5 times higher -opioid receptor affinity and in vivo analgesic potency than morphine.8 –11 However, recent data showed th ...
... O-demethylation of codeine has been shown to account for most, if not all, of the analgesic activity of codeine.6,7 Oxymorphone is a remarkably potent -opioid ligand, with 2 to 5 times higher -opioid receptor affinity and in vivo analgesic potency than morphine.8 –11 However, recent data showed th ...
Ex vivo effects of low-dose rivaroxaban on specific coagulation
... lupus anticoagulant (LA) in patients given vitamin K antagonist therapy is difficult due to the coagulation defect induced by the anticoagulants, which leads to prolongation of all phospholipiddependent clotting times. The influence of rivaroxaban on thrombophilia screening assays including determin ...
... lupus anticoagulant (LA) in patients given vitamin K antagonist therapy is difficult due to the coagulation defect induced by the anticoagulants, which leads to prolongation of all phospholipiddependent clotting times. The influence of rivaroxaban on thrombophilia screening assays including determin ...
The pharmacokinetics and metabolism of ivermectin in domestic
... Small differences in formulations may result in substantial changes in the antiparasitic activity of ivermectin. This property has been extensively studied in cattle. Absorption is greater and faster with an aqueous vehicle than with propylene glycol:glycerol-formal (60:40 v/v), and the drug’s biolog ...
... Small differences in formulations may result in substantial changes in the antiparasitic activity of ivermectin. This property has been extensively studied in cattle. Absorption is greater and faster with an aqueous vehicle than with propylene glycol:glycerol-formal (60:40 v/v), and the drug’s biolog ...
Systemic effects of salbutamol and salmeterol in patients
... drugs. The dose equivalence for fall in plasma potassium concentration and diastolic blood pressure was 7-8, which agrees closely with estimates from our previous study; the dose equivalence for heart rate was greater at 17 7. It is possible that the dose equivalence is an overestimate since the dos ...
... drugs. The dose equivalence for fall in plasma potassium concentration and diastolic blood pressure was 7-8, which agrees closely with estimates from our previous study; the dose equivalence for heart rate was greater at 17 7. It is possible that the dose equivalence is an overestimate since the dos ...
The safety of carprofen, flunixin and phenylbutazone Gyps coprotheres study.
... 3.29± 0.75 L/kg (FXN) and 0.13 ± 0.03 L/kg (PBZ). Area under the curve until the last time point was 21.72± 20.10; 0.78± 0.28 and 263.35 ±68.69 µg/mL*h for CRP, FXN and PBZ respectively. Glucuronidation was identified in FXN and CRP treated birds. The long half-life of PBZ and CRP creates concern th ...
... 3.29± 0.75 L/kg (FXN) and 0.13 ± 0.03 L/kg (PBZ). Area under the curve until the last time point was 21.72± 20.10; 0.78± 0.28 and 263.35 ±68.69 µg/mL*h for CRP, FXN and PBZ respectively. Glucuronidation was identified in FXN and CRP treated birds. The long half-life of PBZ and CRP creates concern th ...
Theracurmin | Information Sheet
... Theracurmin and two other commercially available curcumin formulations. In this double-blind, 3-way crossover study, healthy male (n=5) and female (n=4) volunteers aged between 24-32 years were administered consecutive single oral doses of each curcumin supplement. Dosing of the commercial products ...
... Theracurmin and two other commercially available curcumin formulations. In this double-blind, 3-way crossover study, healthy male (n=5) and female (n=4) volunteers aged between 24-32 years were administered consecutive single oral doses of each curcumin supplement. Dosing of the commercial products ...
EFFECT OF VALERIAN ROOT EXTRACTS (VALERIANA
... (Cmax) and a decrease in time to reach the maximum plasma concentration (tmax), but did not affect the area under the plasma concentration-time curve (AUC) or half life. As these results were unexpected, human hepatocyte cultures were used to determine if enzyme induction potential of some component ...
... (Cmax) and a decrease in time to reach the maximum plasma concentration (tmax), but did not affect the area under the plasma concentration-time curve (AUC) or half life. As these results were unexpected, human hepatocyte cultures were used to determine if enzyme induction potential of some component ...
Anticonvulsant Pharmacokinetics
... occurs in 30-60 minutes Distribution to the brain is very rapid The mean volume of distribution is comparable to total body water: 0.6-0.7 Liters/kg. Phenytoin binds primarily to albumin, with approximately 10 percent of the drug normally unbound. ...
... occurs in 30-60 minutes Distribution to the brain is very rapid The mean volume of distribution is comparable to total body water: 0.6-0.7 Liters/kg. Phenytoin binds primarily to albumin, with approximately 10 percent of the drug normally unbound. ...
Review Nucleotide prodrugs for HCV therapy
... boceprevir. Each of these compounds has completed Phase III clinical investigation and both have been shown to be efficacious in treating HCV infection when given in combination with SOC. However, each of these first generation protease inhibitors suffers from the lack of genotype coverage, undesire ...
... boceprevir. Each of these compounds has completed Phase III clinical investigation and both have been shown to be efficacious in treating HCV infection when given in combination with SOC. However, each of these first generation protease inhibitors suffers from the lack of genotype coverage, undesire ...
panadol osteo data sheet
... layer at the matrix periphery. The drug is then released from the matrix by a combination of diffusion and erosion of the gel layer. PANADOL OSTEO releases drug at a rate which ensures that therapeutically active plasma paracetamol concentrations are rapidly attained and maintained until up to 8 hou ...
... layer at the matrix periphery. The drug is then released from the matrix by a combination of diffusion and erosion of the gel layer. PANADOL OSTEO releases drug at a rate which ensures that therapeutically active plasma paracetamol concentrations are rapidly attained and maintained until up to 8 hou ...
Naproxen Naproxen Sodium
... For the symptomatic treatment of osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis, but excluding acute gouty arthritis), the usual adult dosage of naproxen is 250–500 mg (275–550 mg of naproxen sodium) twice daily in the morning and evening. Alternatively, 250 mg of naproxen (275 mg o ...
... For the symptomatic treatment of osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis, but excluding acute gouty arthritis), the usual adult dosage of naproxen is 250–500 mg (275–550 mg of naproxen sodium) twice daily in the morning and evening. Alternatively, 250 mg of naproxen (275 mg o ...
as a PDF
... use of cocktail method, and specific potent CYP2J2 inhibitor can also facilitate the evaluation of the role that CYP2J2 plays in liver microsomal metabolism and DDI in vivo. Several metabolic reactions have been reported to date to be primarily mediated by CYP2J2; these include astemizole O-demethyl ...
... use of cocktail method, and specific potent CYP2J2 inhibitor can also facilitate the evaluation of the role that CYP2J2 plays in liver microsomal metabolism and DDI in vivo. Several metabolic reactions have been reported to date to be primarily mediated by CYP2J2; these include astemizole O-demethyl ...
Discovery and development of cyclooxygenase 2 inhibitors
Cyclooxygenases are enzymes that take part in a complex biosynthetic cascade that results in the conversion of polyunsaturated fatty acids to prostaglandins and thromboxane(s).Their main role is to catalyze the transformation of arachidonic acid into the intermediate prostaglandin H2, which is the procursor of a variety of prostanoids with diverse and potent biological actions.Cyclooxygenases have two main isoforms that are called COX-1 and COX-2 (as well as a COX-3). COX-1 is responsible for the synthesis of prostaglandin and thromboxane in many types of cells, including the gastro-intestinal tract and blood platelets. COX-2 plays a major role in prostaglandin biosynthesis in inflammatory cells and in the central nervous system. Prostaglandin synthesis in these sites is a key factor in the development of inflammation and hyperalgesia.COX-2 inhibitors have analgesic and anti-inflammatory activity by blocking the transformation of arachidonic acid into prostaglandin H2 selectively.