Coadministration of Oral Cyclosporin A Enables Oral Therapy with
... a single agent at a dose of 60 mg/m2 during course 1 and paclitaxel i.v. at a dose of 175 mg/m2 administered as a 3-h infusion during course 2. In the second part of the study, it was planned that eight evaluable patients would receive paclitaxel on two randomized occasions. On one occasion, they wo ...
... a single agent at a dose of 60 mg/m2 during course 1 and paclitaxel i.v. at a dose of 175 mg/m2 administered as a 3-h infusion during course 2. In the second part of the study, it was planned that eight evaluable patients would receive paclitaxel on two randomized occasions. On one occasion, they wo ...
ACETYLCYSTEINE Solution, USP
... In a teratology study of acetylcysteine in the rabbit, oral doses of 500 mg/kg/day (2.6 times the human mucolytic dose) were administered to pregnant does by intubation on days 6 through 16 of gestation. Acetylcysteine was found to be nonteratogenic under the conditions of study. In the rabbit, two ...
... In a teratology study of acetylcysteine in the rabbit, oral doses of 500 mg/kg/day (2.6 times the human mucolytic dose) were administered to pregnant does by intubation on days 6 through 16 of gestation. Acetylcysteine was found to be nonteratogenic under the conditions of study. In the rabbit, two ...
CEDIA® Buprenorphine Assay
... dependence that can be prescribed in the US in a physician’s work place.6 It has also been shown that buprenorphine has abuse potential and may itself cause dependency. In addition, a number of deaths have been recorded as a result of overdose with intravenously injected buprenorphine in conjunction ...
... dependence that can be prescribed in the US in a physician’s work place.6 It has also been shown that buprenorphine has abuse potential and may itself cause dependency. In addition, a number of deaths have been recorded as a result of overdose with intravenously injected buprenorphine in conjunction ...
Effects of grapefruit juice on the pharmacokinetics of selected
... About ten years ago, grapefruit juice was observed to increase the plasma concentrations and effects of felodipine. Since then, grapefruit juice has been found to interact with more than 20 different drugs. However, many factors affecting the susceptibility of drugs to interaction with grapefruit ju ...
... About ten years ago, grapefruit juice was observed to increase the plasma concentrations and effects of felodipine. Since then, grapefruit juice has been found to interact with more than 20 different drugs. However, many factors affecting the susceptibility of drugs to interaction with grapefruit ju ...
Actions of bufalin and cinobufotalin, two bufadienolides respectively
... the addition of non-labelled ouabain, bufalin and cinobufotalin are shown in Fig. 1.All nine blood samples were tested separately over the range 10-9-10-6 mol/l for ouabain and cinobufotalin and 10- l o - l O - h mol/l for bufalin. The curve with bufalin is shifted to the left compared with that of ...
... the addition of non-labelled ouabain, bufalin and cinobufotalin are shown in Fig. 1.All nine blood samples were tested separately over the range 10-9-10-6 mol/l for ouabain and cinobufotalin and 10- l o - l O - h mol/l for bufalin. The curve with bufalin is shifted to the left compared with that of ...
Effects of different doses of venlafaxine on serotonin and
... reuptake processes was performed at baseline (day 0) and on day 7 with the last dose being taken about 2–3 h before testing. Taking into account these gradual titrations, the half-life of the drugs and that of their metabolites, it was deemed that 5 d at the same dose would be sufficient to achieve st ...
... reuptake processes was performed at baseline (day 0) and on day 7 with the last dose being taken about 2–3 h before testing. Taking into account these gradual titrations, the half-life of the drugs and that of their metabolites, it was deemed that 5 d at the same dose would be sufficient to achieve st ...
Pharmacogenetic Determinants of Codeine Induction by Rifampin
... Inter- and intraphenotypic comparisons were carried out by twoway ANOVA with repeated measurements, followed if appropriate by paired or unpaired Student’s t test or nonparametric test (Wilcoxon signed rank test), as indicated. Linear and Spearman correlation tests were used to evaluate the relation ...
... Inter- and intraphenotypic comparisons were carried out by twoway ANOVA with repeated measurements, followed if appropriate by paired or unpaired Student’s t test or nonparametric test (Wilcoxon signed rank test), as indicated. Linear and Spearman correlation tests were used to evaluate the relation ...
BoNT_A Presentation UMass Dartmouth 081029
... intoxication with BoNTs, new small-molecule inhibitors of these toxins are critically needed. ...
... intoxication with BoNTs, new small-molecule inhibitors of these toxins are critically needed. ...
Carbamazepine-induced liver injury requires CYP3A
... with idiosyncratic adverse effects, such as liver injury, aplastic anemia and agranulocytosis (Zaccara et al., 2007; Björnsson and Olsson, 2005). It is reported that patients who developed CBZ-induced serious liver injury were under drug treatment for an average of 30 weeks (Bjornsson, 2008), sugges ...
... with idiosyncratic adverse effects, such as liver injury, aplastic anemia and agranulocytosis (Zaccara et al., 2007; Björnsson and Olsson, 2005). It is reported that patients who developed CBZ-induced serious liver injury were under drug treatment for an average of 30 weeks (Bjornsson, 2008), sugges ...
67Dihydroxybergamottin Contributes to the Grapefruit
... grapefruit juice– drug interactions. The 2 most abundant furanocoumarins present in the juice are bergamottin and 6',7'-dihydroxybergamottin (DHB). Bergamottin is the “parent” furanocoumarin and has been shown to be both a reversible and a mechanism-based inhibitor of CYP3A4.5,6 DHB, as its name imp ...
... grapefruit juice– drug interactions. The 2 most abundant furanocoumarins present in the juice are bergamottin and 6',7'-dihydroxybergamottin (DHB). Bergamottin is the “parent” furanocoumarin and has been shown to be both a reversible and a mechanism-based inhibitor of CYP3A4.5,6 DHB, as its name imp ...
Model-based Analysis of the Effects of Thioridazine Enantiomers on the... Papillary Action Potential
... IKr inhibition determined at higher doses were very similar to those found using the forward method. However, the shortening observed at 0.1 mg L-1 meant that zero IKr inhibition was determined. In addition, even attributing ICaL inhibition entirely to the (+)-enantiomer (inverse method B), the magn ...
... IKr inhibition determined at higher doses were very similar to those found using the forward method. However, the shortening observed at 0.1 mg L-1 meant that zero IKr inhibition was determined. In addition, even attributing ICaL inhibition entirely to the (+)-enantiomer (inverse method B), the magn ...
Dabigatran etexilate for the prevention of stroke in patients with
... the oral capsule was designed with dabigatrancoated pellets with a tartaric acid core that creates an acidic microenvironment independent of gastric pH [20] . The capsule should never be opened or crushed as this significantly increases the bioavailability and plasma drug levels. While pharmacok in ...
... the oral capsule was designed with dabigatrancoated pellets with a tartaric acid core that creates an acidic microenvironment independent of gastric pH [20] . The capsule should never be opened or crushed as this significantly increases the bioavailability and plasma drug levels. While pharmacok in ...
INHIBITION OF OAT3-MEDIATED RENAL UPTAKE AS A
... biliary excretion. Interactions of fexofenadine with drugs and food have been reported. The interactions with rifampicin (Hamman et al., 2001), St John’s wort (Wang et al., 2002), and fruit juice (Dresser et al., 2002) caused a reduction in the AUC of fexofenadine after oral administration, and thes ...
... biliary excretion. Interactions of fexofenadine with drugs and food have been reported. The interactions with rifampicin (Hamman et al., 2001), St John’s wort (Wang et al., 2002), and fruit juice (Dresser et al., 2002) caused a reduction in the AUC of fexofenadine after oral administration, and thes ...
Diclofenac Sodium 4% Spray Gel
... Therefore, Diclofenac Sodium 4 % Spray Gel should be used with caution and only if clearly necessary during the first six months of pregnancy and must not be applied to a large area of the skin (i.e. more than 600 square centimetres of the body surface). It must not be used for long-term treatment ( ...
... Therefore, Diclofenac Sodium 4 % Spray Gel should be used with caution and only if clearly necessary during the first six months of pregnancy and must not be applied to a large area of the skin (i.e. more than 600 square centimetres of the body surface). It must not be used for long-term treatment ( ...
the PDF
... The pharmacokinetics of galantamine were reported [183–187]. Many publications described the clinical trial results of galanthamine in AD (in chronological order) [188–201 [1]]. Galantamine improved and stabilized cognitive performance, activities of daily living, and behavioral symptoms over the co ...
... The pharmacokinetics of galantamine were reported [183–187]. Many publications described the clinical trial results of galanthamine in AD (in chronological order) [188–201 [1]]. Galantamine improved and stabilized cognitive performance, activities of daily living, and behavioral symptoms over the co ...
Duloxetine Inhibits Effects of MDMA (``Ecstasy``) In Vitro and in
... effects of 3,4–methylenedioxy-methamphetamine (MDMA, ecstasy) in vitro and in 16 healthy subjects. The clinical study used a double-blind, randomized, placebo-controlled, four-session, crossover design. In vitro, duloxetine blocked the release of both 5-HT and NE by MDMA or by its metabolite 3,4-met ...
... effects of 3,4–methylenedioxy-methamphetamine (MDMA, ecstasy) in vitro and in 16 healthy subjects. The clinical study used a double-blind, randomized, placebo-controlled, four-session, crossover design. In vitro, duloxetine blocked the release of both 5-HT and NE by MDMA or by its metabolite 3,4-met ...
Inhibitory Effects of Fruit Juices on Cytochrome P450
... 30 min were 79.4%, 72.4%, 64.9%, and 55.1% respectively. These data suggest that pineapple juice causes irreversible inhibition of human CYP2C9 activity. Thus, we discovered that pineapple juice potently inhibited the CYP2C9-mediated metabolism of diclofenac and tolbutamide in vitro. Bromelain inhib ...
... 30 min were 79.4%, 72.4%, 64.9%, and 55.1% respectively. These data suggest that pineapple juice causes irreversible inhibition of human CYP2C9 activity. Thus, we discovered that pineapple juice potently inhibited the CYP2C9-mediated metabolism of diclofenac and tolbutamide in vitro. Bromelain inhib ...
Clopidogrel Markedly Increases the Plasma Concentrations of the
... Phospholipid cartridges (30 mg, SUPELCO, Bellefonte, PA). The resulting filtrate was evaporated and the residue was reconstituted in 80 μl of mobile phase, and injected (5 µl) to liquid chromatography instrument. Chromatography was performed on XTerra RP C18 column (3.9x100 mm; Waters Corporation, M ...
... Phospholipid cartridges (30 mg, SUPELCO, Bellefonte, PA). The resulting filtrate was evaporated and the residue was reconstituted in 80 μl of mobile phase, and injected (5 µl) to liquid chromatography instrument. Chromatography was performed on XTerra RP C18 column (3.9x100 mm; Waters Corporation, M ...
Activity and Enzyme Kinetics of Human UDP
... Human UDP-glucuronosyltransferases (UGTs) are important in the metabolic elimination of xenobiotics and endogenous compounds from the body. These enzymes transfer glucuronic acid moiety from the cosubstrate, UDP-glucuronic acid (UDPGA), to nucleophilic groups of small organic molecules, such as hydr ...
... Human UDP-glucuronosyltransferases (UGTs) are important in the metabolic elimination of xenobiotics and endogenous compounds from the body. These enzymes transfer glucuronic acid moiety from the cosubstrate, UDP-glucuronic acid (UDPGA), to nucleophilic groups of small organic molecules, such as hydr ...
Recommendations for Management of Clinically Significant Drug
... result in altered absorption, distribution, metabolism, or excretion of a medication. A pharmacodynamic DDI occurs when 1 medication modifies the pharmacological effect of another in an additive, a synergistic, or an antagonistic fashion. It is estimated that ≈2.8% of hospital admissions occur as a ...
... result in altered absorption, distribution, metabolism, or excretion of a medication. A pharmacodynamic DDI occurs when 1 medication modifies the pharmacological effect of another in an additive, a synergistic, or an antagonistic fashion. It is estimated that ≈2.8% of hospital admissions occur as a ...
Fexofast Presentation
... days were given to three healthy subjects. In another study with 40 subjects, a dose of 400 mg every 12 hours was given for 6.5 days. No clinically significant adverse events were reported in these studies. Clinical signs of toxicity and effects on body weight or food consumption were not observed i ...
... days were given to three healthy subjects. In another study with 40 subjects, a dose of 400 mg every 12 hours was given for 6.5 days. No clinically significant adverse events were reported in these studies. Clinical signs of toxicity and effects on body weight or food consumption were not observed i ...
Pr VIAGRA*
... Geriatrics (> 65 years of age): Healthy elderly volunteers had a reduced clearance of sildenafil, with free plasma concentrations approximately 40% greater than those seen in younger volunteers (18 to 45 years). Since higher plasma levels may increase both the pharmacological action and incidence of ...
... Geriatrics (> 65 years of age): Healthy elderly volunteers had a reduced clearance of sildenafil, with free plasma concentrations approximately 40% greater than those seen in younger volunteers (18 to 45 years). Since higher plasma levels may increase both the pharmacological action and incidence of ...
Homocysteine: A Risk Factor for Coronary Artery Disease?
... A correlation between total homocysteine levels and HDL and LDL has been found in many studies. Recent studies show that homocysteine is an independent prognostic index for the development of atherosclerosis in dyslipidaemic patients.2,4,12 Total homocysteine levels are related with increased blood ...
... A correlation between total homocysteine levels and HDL and LDL has been found in many studies. Recent studies show that homocysteine is an independent prognostic index for the development of atherosclerosis in dyslipidaemic patients.2,4,12 Total homocysteine levels are related with increased blood ...
Discovery and development of cyclooxygenase 2 inhibitors
Cyclooxygenases are enzymes that take part in a complex biosynthetic cascade that results in the conversion of polyunsaturated fatty acids to prostaglandins and thromboxane(s).Their main role is to catalyze the transformation of arachidonic acid into the intermediate prostaglandin H2, which is the procursor of a variety of prostanoids with diverse and potent biological actions.Cyclooxygenases have two main isoforms that are called COX-1 and COX-2 (as well as a COX-3). COX-1 is responsible for the synthesis of prostaglandin and thromboxane in many types of cells, including the gastro-intestinal tract and blood platelets. COX-2 plays a major role in prostaglandin biosynthesis in inflammatory cells and in the central nervous system. Prostaglandin synthesis in these sites is a key factor in the development of inflammation and hyperalgesia.COX-2 inhibitors have analgesic and anti-inflammatory activity by blocking the transformation of arachidonic acid into prostaglandin H2 selectively.