![Dr. Srivastava](http://s1.studyres.com/store/data/006001894_1-5795608cb8d16869b4f7b709b809184f-300x300.png)
Dr. Srivastava
... Spolectin is an important chemical required by body for smooth joint movement Spolectin is also antihistaminic It is also analgesic and antipyretic Spolectin have been found 5 times more effective than aspirin Significant analgesic of noni in mice on hot plate was demonstrated in a laboratory in Fra ...
... Spolectin is an important chemical required by body for smooth joint movement Spolectin is also antihistaminic It is also analgesic and antipyretic Spolectin have been found 5 times more effective than aspirin Significant analgesic of noni in mice on hot plate was demonstrated in a laboratory in Fra ...
Absorption
... ¾ Bioavailability and area under plasma conc. time curve are important factors in absorption kinetics ¾ The completeness of absorption is of primary importance in therapeutic situations. ¾ The bioavailability, F, is proportional to the total area under plasma-time curve (AUC) irrespective to its sha ...
... ¾ Bioavailability and area under plasma conc. time curve are important factors in absorption kinetics ¾ The completeness of absorption is of primary importance in therapeutic situations. ¾ The bioavailability, F, is proportional to the total area under plasma-time curve (AUC) irrespective to its sha ...
Antihypertensive Drugs 1
... and bradykinin stimulates prostaglandin biosynthesis, bradykinin and/or prostaglandins may contribute to the pharmacological effects of ACE inhibitors. In a healthy, Na+ replete person, a single oral dose of an ACE inhibitor has little effect on blood pressure, but repeated doses over several Angiot ...
... and bradykinin stimulates prostaglandin biosynthesis, bradykinin and/or prostaglandins may contribute to the pharmacological effects of ACE inhibitors. In a healthy, Na+ replete person, a single oral dose of an ACE inhibitor has little effect on blood pressure, but repeated doses over several Angiot ...
Acetaminophen
... hepatotoxicity; in the absence of this cytochrome P450 enzyme, toxicity will only be apparent at high concentrations. The N-hydroxyamide is then converted to a reactive toxic metabolite, an acetimidoquinone, which has been suggested to produce the nephrotoxicity and hepatotoxicity associated with ...
... hepatotoxicity; in the absence of this cytochrome P450 enzyme, toxicity will only be apparent at high concentrations. The N-hydroxyamide is then converted to a reactive toxic metabolite, an acetimidoquinone, which has been suggested to produce the nephrotoxicity and hepatotoxicity associated with ...
Single Dose Pharmacokinetics and Bioavailability of Glucosamine in
... with free access to their regular food and those deprived from the latter for 12 h (Table 1, Figure 2). This suggests that the presence of food may not explain the poor bioavailability of GLcNBu. After incubation of GLcNBu with everted intestine for 2 h, only 20% of the drug is found to cross the me ...
... with free access to their regular food and those deprived from the latter for 12 h (Table 1, Figure 2). This suggests that the presence of food may not explain the poor bioavailability of GLcNBu. After incubation of GLcNBu with everted intestine for 2 h, only 20% of the drug is found to cross the me ...
A Novel Model for the Prediction of Drug
... studying clinical pharmacokinetic drug-drug interactions (DDIs) of drugs that are primarily metabolized by CYP3A4/5. However, ketoconazole at therapeutic, high concentrations also inhibits cytochromes P450 (P450) other than CYP3A4/5, which has made the predictions of DDIs less accurate. Determining ...
... studying clinical pharmacokinetic drug-drug interactions (DDIs) of drugs that are primarily metabolized by CYP3A4/5. However, ketoconazole at therapeutic, high concentrations also inhibits cytochromes P450 (P450) other than CYP3A4/5, which has made the predictions of DDIs less accurate. Determining ...
NIH Public Access
... The pharmacokinetics of FK 506 after IV administration has previously been reported.4 Similar pharmacokinetic parameters were also obtained in the present study. Following IV infusion, FK 506 concentration declines rapidly initially and at a slower rate after reaching distribution equilibrium (Fig 1 ...
... The pharmacokinetics of FK 506 after IV administration has previously been reported.4 Similar pharmacokinetic parameters were also obtained in the present study. Following IV infusion, FK 506 concentration declines rapidly initially and at a slower rate after reaching distribution equilibrium (Fig 1 ...
View the letter to participants
... We would like to share with you the final results of the A5146 study, “A Phase II Randomized Controlled Trial Evaluating the Impact of Therapeutic Drug Monitoring (TDM) on Virologic Response to a Salvage Regimen in Subjects with a Normalized Inhibitory Quotient (NIQ) 1 to One or More Protease Inhi ...
... We would like to share with you the final results of the A5146 study, “A Phase II Randomized Controlled Trial Evaluating the Impact of Therapeutic Drug Monitoring (TDM) on Virologic Response to a Salvage Regimen in Subjects with a Normalized Inhibitory Quotient (NIQ) 1 to One or More Protease Inhi ...
06_Multiple dosing Extravascular Administration
... QJ is a 67-year-old, 80-kg male being treated for chronic obstructive pulmonary disease. Sustained-release oral theophylline is being added to his drug regimen. Assuming F = 1.0, V = 40 L, and t1/2 = 5 hours, compute an oral theophylline dose to be administered every 12 hours that would achieve a Cs ...
... QJ is a 67-year-old, 80-kg male being treated for chronic obstructive pulmonary disease. Sustained-release oral theophylline is being added to his drug regimen. Assuming F = 1.0, V = 40 L, and t1/2 = 5 hours, compute an oral theophylline dose to be administered every 12 hours that would achieve a Cs ...
Bioequivalence Study of Two Loperamide Hydrochloride 2 mg
... Loperamide, a phenylpiperidine derivative [1], is an anti-diarrhoeal medication which acts selectively on peripheral μ-opioid receptors [2]. It is widely used for acute and chronic diarrhoea. Its efficacy is also proven in treating patients with irritable bowel syndrome who suffer predominantly from ...
... Loperamide, a phenylpiperidine derivative [1], is an anti-diarrhoeal medication which acts selectively on peripheral μ-opioid receptors [2]. It is widely used for acute and chronic diarrhoea. Its efficacy is also proven in treating patients with irritable bowel syndrome who suffer predominantly from ...
HYPOLIPIDEMICS
... All of the fibrate drugs are absorbed rapidly and efficiently (>90%) when given with a meal but less efficiently when taken on an empty stomach. More than 95% of these drugs in plasma are protein-bound, nearly exclusively to albumin. Half-lives differ significantly within this group. Gemfibrozil has ...
... All of the fibrate drugs are absorbed rapidly and efficiently (>90%) when given with a meal but less efficiently when taken on an empty stomach. More than 95% of these drugs in plasma are protein-bound, nearly exclusively to albumin. Half-lives differ significantly within this group. Gemfibrozil has ...
voltaren - GuildLink
... however, the total AUC was not significantly different for the two formulations. Following oral or rectal administration, about half the active substance is metabolised during its first passage through the liver ("first pass" effect). Diclofenac becomes bound to serum proteins to the extent of 99.7% ...
... however, the total AUC was not significantly different for the two formulations. Following oral or rectal administration, about half the active substance is metabolised during its first passage through the liver ("first pass" effect). Diclofenac becomes bound to serum proteins to the extent of 99.7% ...
Kinetics of Oral Dosing
... Understand the plasma concentration-time profiles of single-dose orally administered drugs Estimate relevant kinetic parameters of oral drug alone or in conjunction with IV kinetics Know the major differences in the kinetics of oral drugs and IV bolus injections Review the factors influencing the dr ...
... Understand the plasma concentration-time profiles of single-dose orally administered drugs Estimate relevant kinetic parameters of oral drug alone or in conjunction with IV kinetics Know the major differences in the kinetics of oral drugs and IV bolus injections Review the factors influencing the dr ...
analgesic and anti-inflammatory activity of different fractions of
... The following acute and sub acute models were selected to evaluate the anti-inflammatory activity. Carrageenan-induced rat paw edema model has been commonly used as an experimental animal model for acute inflammation and is believed to be biphasic. The early phase (1-2 h) of the carrageenan model is ...
... The following acute and sub acute models were selected to evaluate the anti-inflammatory activity. Carrageenan-induced rat paw edema model has been commonly used as an experimental animal model for acute inflammation and is believed to be biphasic. The early phase (1-2 h) of the carrageenan model is ...
(HMG-CoA) Reductase Inhibitors
... dispensing of HMG-CoA reductase inhibitors. Additionally, periodic monitoring of hepatic function should occur with HMG-CoA reductase inhibitor administration. Hepatic function should also be reviewed following any dosage increase or medication addition which may potentiate a drug interaction. Infor ...
... dispensing of HMG-CoA reductase inhibitors. Additionally, periodic monitoring of hepatic function should occur with HMG-CoA reductase inhibitor administration. Hepatic function should also be reviewed following any dosage increase or medication addition which may potentiate a drug interaction. Infor ...
Single Exposure of Human Oral Mucosa Fibroblasts to
... derived from human oral mucosa (HOM), primary cultures of HOM fibroblasts were irradiated with a single dose of 30 or 60 mJ/cm2 of UVB light or shamirradiated. Fibroblast proliferation was assessed from 3 to 48 hrs after UVB-irradiation utilizing [3H]-thymidine incorporation and MTT assays. In addit ...
... derived from human oral mucosa (HOM), primary cultures of HOM fibroblasts were irradiated with a single dose of 30 or 60 mJ/cm2 of UVB light or shamirradiated. Fibroblast proliferation was assessed from 3 to 48 hrs after UVB-irradiation utilizing [3H]-thymidine incorporation and MTT assays. In addit ...
Hepatitis C Virus Direct-Acting Antiviral Drug Interactions - IAS-USA
... and 40 mg daily of atorvastatin (a P-gp and OATP substrate). For other statins, the dose can be halved during simeprevir administration. Levels of digoxin (a P-gp substrate) should be monitored when coadministered with simeprevir. Potential interactions between simeprevir and immunosuppressants are ...
... and 40 mg daily of atorvastatin (a P-gp and OATP substrate). For other statins, the dose can be halved during simeprevir administration. Levels of digoxin (a P-gp substrate) should be monitored when coadministered with simeprevir. Potential interactions between simeprevir and immunosuppressants are ...
Angiotensin-Receptor Blockade in Acute Myocardial Infarction — A
... affect the care of high-risk patients after acute myocardial infarction? Given that valsartan was as effective as captopril in reducing the rates of death and other cardiovascular events, the ultimate question raised by this trial is whether high-risk patients should receive ACE inhibitors or angiot ...
... affect the care of high-risk patients after acute myocardial infarction? Given that valsartan was as effective as captopril in reducing the rates of death and other cardiovascular events, the ultimate question raised by this trial is whether high-risk patients should receive ACE inhibitors or angiot ...
Discovery and development of cyclooxygenase 2 inhibitors
![](https://commons.wikimedia.org/wiki/Special:FilePath/DuP-697.png?width=300)
Cyclooxygenases are enzymes that take part in a complex biosynthetic cascade that results in the conversion of polyunsaturated fatty acids to prostaglandins and thromboxane(s).Their main role is to catalyze the transformation of arachidonic acid into the intermediate prostaglandin H2, which is the procursor of a variety of prostanoids with diverse and potent biological actions.Cyclooxygenases have two main isoforms that are called COX-1 and COX-2 (as well as a COX-3). COX-1 is responsible for the synthesis of prostaglandin and thromboxane in many types of cells, including the gastro-intestinal tract and blood platelets. COX-2 plays a major role in prostaglandin biosynthesis in inflammatory cells and in the central nervous system. Prostaglandin synthesis in these sites is a key factor in the development of inflammation and hyperalgesia.COX-2 inhibitors have analgesic and anti-inflammatory activity by blocking the transformation of arachidonic acid into prostaglandin H2 selectively.